Image fusion for spatial enhancement of hyperspectral image via pixel group based non-local sparse representation

Restricted by technical and budget constraints, hyperspectral images (HSIs) are usually obtained with low spatial resolution. In order to improve the spatial resolution of a given hyperspectral image, a new spatial and spectral image fusion approach via pixel group based non-local sparse representation is proposed, which exploits the spectral sparsity and spectral non-local self-similarity of the hyperspectral image. The proposed approach fuses the hyperspectral image with a high-spatial-resolution multispectral image of the same scene to obtain a hyperspectral image with high spatial and spectral resolutions. The input hyperspectral image is used to train the spectral dictionary, while the sparse codes of the desired HSI are estimated by jointly encoding the similar pixels in each pixel group extracted from the high-spatial-resolution multispectral image. To improve the accuracy of the pixel group based non-local sparse representation, the similar pixels in a pixel group are selected by utilizing both the spectral and spatial information. The performance of the proposed approach is tested on two remote sensing image datasets. Experimental results suggest that the proposed method outperforms a number of sparse representation based fusion techniques, and can preserve the spectral information while recovering the spatial details under large magnification factors

Fuzzy Rule Based Interpolative Reasoning Supported by Attribute Ranking

Using fuzzy rule interpolation (FRI) interpolative reasoning can be effectively performed with a sparse rule base where a given system observation does not match any fuzzy rules. Whilst offering a potentially powerful inference mechanism, in the current literature, typical representation of fuzzy rules in FRI assumes that all attributes in the rules are of equal significance in deriving the consequents. This is a strong assumption in practical applications, thereby often leading to less accurate interpolated results. To address this challenging problem, this work employs feature selection (FS) techniques to adjudge the relative significance of individual attributes and therefore, to differentiate the contributions of the rule antecedents and their impact upon FRI. This is feasible because FS provides a readily adaptable mechanism for evaluating and ranking attributes, being capable of selecting more informative features. Without requiring any acquisition of real observations, based on the originally given sparse rule base, the individual scores are computed using a set of training samples that are artificially created from the rule base through an innovative reverse engineering procedure. The attribute scores are integrated within the popular scale and move transformation-based FRI algorithm (while other FRI approaches may be similarly extended following the same idea), forming a novel method for attribute ranking-supported fuzzy interpolative reasoning. The efficacy and robustness of the proposed approach is verified through systematic experimental examinations in comparison with the original FRI technique, over a range of benchmark classification problems while utilising different FS methods. A specific and important outcome is that supported by attribute ranking, only two (i.e., the least number of) nearest adjacent rules are required to perform accurate interpolative reasoning, avoiding the need of searching for and computing with multiple rules beyond the immediate neighbourhood of a given observationpublishersversionPeer reviewe

Model‐free scoring system for risk prediction with application to hepatocellular carcinoma study

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142930/1/biom12750_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142930/2/biom12750-sup-0001-SuppData-S1.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142930/3/biom12750.pd

DNMT3a in the hippocampal CA1 is crucial in the acquisition of morphine self‐administration in rats

Drug‐reinforced excessive operant responding is one fundamental feature of long-lasting addiction‐like behaviors and relapse in animals. However, the transcriptional regulatory mechanisms responsible for the persistent drug‐specific (not natural rewards) operant behavior are not entirely clear. In this study, we demonstrate a key role for one of the de novo DNA methyltransferase, DNMT3a, in the acquisition of morphine self‐administration (SA) in rats. The expression of DNMT3a in the hippocampal CA1 region but not in the nucleus accumbens shell was significantly up‐regulated after 1‐ and 7‐day morphine SA (0.3 mg/kg/infusion) but not after the yoked morphine injection. On the other hand, saccharin SA did not affect the expression of DNMT3a or DNMT3b. DNMT inhibitor 5‐aza‐2‐deoxycytidine (5‐aza) microinjected into the hippocampal CA1 significantly attenuated the acquisition of morphine SA. Knockdown of DNMT3a also impaired the ability to acquire the morphine SA. Overall, these findings suggest that DNMT3a in the hippocampus plays an important role in the acquisition of morphine SA and may be a valid target to prevent the development of morphine addiction. Includes Supplemental informatio

Simultaneous evolutionary expansion and constraint of genomic heterogeneity in multifocal lung cancer.

Recent genomic analyses have revealed substantial tumor heterogeneity across various cancers. However, it remains unclear whether and how genomic heterogeneity is constrained during tumor evolution. Here, we sequence a unique cohort of multiple synchronous lung cancers (MSLCs) to determine the relative diversity and uniformity of genetic drivers upon identical germline and environmental background. We find that each multicentric primary tumor harbors distinct oncogenic alterations, including novel mutations that are experimentally demonstrated to be functional and therapeutically targetable. However, functional studies show a strikingly constrained tumorigenic pathway underlying heterogeneous genetic variants. These results suggest that although the mutation-specific routes that cells take during oncogenesis are stochastic, genetic trajectories may be constrained by selection for functional convergence on key signaling pathways. Our findings highlight the robust evolutionary pressures that simultaneously shape the expansion and constraint of genomic diversity, a principle that holds important implications for understanding tumor evolution and optimizing therapeutic strategies.Across cancer types tumor heterogeneity has been observed, but how this relates to tumor evolution is unclear. Here, the authors sequence multiple synchronous lung cancers, highlighting the evolutionary pressures that simultaneously shape the expansion and constraint of genomic heterogeneity