ESKNet-An enhanced adaptive selection kernel convolution for breast tumors segmentation

Breast cancer is one of the common cancers that endanger the health of women globally. Accurate target lesion segmentation is essential for early clinical intervention and postoperative follow-up. Recently, many convolutional neural networks (CNNs) have been proposed to segment breast tumors from ultrasound images. However, the complex ultrasound pattern and the variable tumor shape and size bring challenges to the accurate segmentation of the breast lesion. Motivated by the selective kernel convolution, we introduce an enhanced selective kernel convolution for breast tumor segmentation, which integrates multiple feature map region representations and adaptively recalibrates the weights of these feature map regions from the channel and spatial dimensions. This region recalibration strategy enables the network to focus more on high-contributing region features and mitigate the perturbation of less useful regions. Finally, the enhanced selective kernel convolution is integrated into U-net with deep supervision constraints to adaptively capture the robust representation of breast tumors. Extensive experiments with twelve state-of-the-art deep learning segmentation methods on three public breast ultrasound datasets demonstrate that our method has a more competitive segmentation performance in breast ultrasound images.Comment: 12 pages, 8 figure

A Low-Voltage, Pre-Modulation Terahertz Oscillator Based on a Carbon Nanotube Cold-Cathode

To develop miniaturized and compact vacuum electron devices, new approaches to device manufacturing must be embraced. Here, a terahertz oscillator based on carbon nanotube (CNT) cold cathode is investigated through particle-in-cell (PIC) simulations. The studies show that the high-frequency (HF) field excited by the device can modulate the field emission current efficiently, with an output power of 4.6 W at 139.4 GHz obtained at an operating voltage of 2.9 kV and an initial emission current and current density of 15.8 mA and 7.65 A/cm 2 , respectively, and the efficiency is 10.0%

Genome plasticity of Vibrio parahaemolyticus: microevolution of the 'pandemic group'

<p>Abstract</p> <p>Background</p> <p>Outbreak of <it>V. parahaemolyticus </it>infections occurred since 1996 was linked to a proposed clonal complex, the pandemic group. The whole genome sequence provides an unprecedented opportunity for dissecting genome plasticity and phylogeny of the populations of <it>V. parahaemolyticus</it>. In the present work, a whole-genome cDNA microarray was constructed to compare the genomic contents of a collection of 174 strains of <it>V. parahaemolyticus</it>.</p> <p>Results</p> <p>Genes that present variably in the genome accounted for about 22% of the whole gene pool on the genome. The phylogenetic analysis of microarray data generated a minimum spanning tree that depicted the phylogenetic structure of the 174 strains. Strains were assigned into five complexes (C1 to C5), and those in each complex were related genetically and phylogenetically. C3 and C4 represented highly virulent clinical clones. C2 and C3 constituted two different clonal complexes 'old-O3:K6 clone' and 'pandemic clone', respectively. C3 included all the 39 pandemic strains tested (<it>trh</it>^-, <it>tdh</it>⁺and GS-PCR⁺), while C2 contained 12 pre-1996 'old' O3:K6 strains (<it>trh</it>⁺, <it>tdh</it>^-and GS-PCR^-) tested herein. The pandemic clone (post-1996 'new' O3:K6 and its derivates O4:K68, O1:K25, O1:KUT and O6:K18) might be emerged from the old-O3:K6 clone, which was promoted by acquisition of <it>toxRS</it>/new sequence and genomic islands. A phylogenetic intermediate O3:K6 clade (<it>trh</it>^-, <it>tdh</it>^-and GS-PCR⁺) was identified between the pandemic and old-O3:K6 clones.</p> <p>Conclusion</p> <p>A comprehensive overview of genomic contents in a large collection of global isolates from the microarray-based comparative genomic hybridization data enabled us to construct a phylogenetic structure of <it>V. parahaemolyticus </it>and an evolutionary history of the pandemic group (clone) of this pathogen.</p

Study of an overmoded structure for megawatt Ka-band extended interaction klystron

For most applications in the millimeter wave band, corresponding to Ka and higher-frequency bands, relatively high atmospheric absorption necessitates the use of high-power sources. Here, a new approach for projecting an oversized beam tunnel in an overmoded structure by concentrating the axial field is demonstrated to meet the high-frequency and high-power demands of compact devices. Due to the enhanced intense beam loading capability of the interaction circuit, a six-cavity Ka-band extended interaction klystron with a four-coupling-hole disk-loaded structure is designed that can stably obtain high output power. An analysis of optimization tradeoffs from introducing high order modes for allowing the application of more powerful beams to improving high order mode field distribution for enhancing the electron-wave coupling and suppressing mode competition is reported. 3D particle-in-cell simulations show attainable output powers of 1.11 MW at 32.94 GHz with a saturated gain of 57 dB by injecting a 3.3 mm diameter electron beam with a current of 24 A.</p

Development of a ka-band circular waveguide TM01-rectangular waveguide TE10 mode converter

The output/input circuit is a core component in all high-power millimeter-wave (MMW) radiation sources, and its performance specifications and reliability directly impact upon the performance of the radiation source device. Central to achieving high power is the development of efficient mode converters. Here, we report on the development of a compact Ka-band circular TM 01 to rectangular TE 10 mode converter. The present mode converter adopts an all-metal waveguide structure and facilitates notable improvement in the system power capacity and is capable of realizing high-power propagation. The mode converter realizes effective mode conversion between high-order and fundamental modes, as well as allowing longitudinal and transverse transmission. Our simulation and empirical findings have shown mode purity ≥99.5% in the frequency range of 32.7-34.6 GHz, and the mode conversion efficiency is more than 96% at a center frequency of 32.9 GHz with a return loss S 11 of -19.3 dB. The bandwidth of the converter is 2.4 GHz with transmission coefficient S 21 ≥ -1 dB

Deformed Two-Mode Quadrature Operators in Noncommutative Space

Starting from noncommutative quantum mechanics algebra, we investigate the variances of the deformed two-mode quadrature operators under the evolution of three types of two-mode squeezed states in noncommutative space. A novel conclusion can be found and it may associate the checking of the variances in noncommutative space with homodyne detecting technology. Moreover, we analyze the influence of the scaling parameter on the degree of squeezing for the deformed level and the corresponding consequences.Comment: 11 pages, no figure

Formation conditions of vortex-like intermixing interfaces in cold spray

Experimental investigation was conducted to explore the formation conditions and provide new insights into the formation mechanisms of the unexplained intermixing phenomenon observed at the substrate-coatings interface of cold sprayed materials. The results indicate that the formation of intermixing interface significantly depends on the extent of plastic deformation at the coating-substrate interface, with severe deformation creating favorable conditions for the intermixing interface. Two factors have been identified to be critical for inducing the severe interfacial plastic deformation: low deposition efficiency and material properties. During low deposition efficiency cold spraying, most of the accelerated particles rebound after impact while inducing accumulative plastic deformation and thus intermixing at the coating-substrate interface. Considering the material properties, the coating materials must have sufficiently high density to attain enough kinetic energy for creating substantial plastic deformation of the first coating layer and the substrate upon their impact. Also, the substrate materials cannot be too hard so that plastic deformation can be induced. Based on the experimental analyses, the hypothesis of the intermixing interface formation mechanism is proposed in this paper

Long-term effect of transurethral partial cystectomy with a 2-micrometer continuous-wave laser for non-muscle-invasive bladder cancer

PurposeWe have reported the efficacy and safety of 2-micrometer continuous-wave laser cystectomy of non-muscle invasive bladder tumor (NMIBC) (J Urol. 2009;182:66–9). In this study, we evaluated the long-term outcomes of patients with NMIBC who underwent transurethral partial cystectomy with a 2-micrometer continuous-wave laser, and explored the risk factors for tumor recurrence.MethodsThis was a retrospective study of patients with NMIBC planned to undergo transurethral partial cystectomy with a 2-micrometer continuous-wave laser at the Fourth Medical Center of the PLA General Hospital between January 2012 and December 2014. The primary outcome was bladder cancer recurrence.ResultsA total of 75 patients were enrolled. Sixty-two (82.7%) were male. The patients were 59.8 ± 12.9 years of age. The mean operation time was 38.7 ± 20.4 min. No Clavien grade &gt;2 complications occurred. The duration of catheter indwelling was 3.6 ± 1.8 days. The hospital stay was 6.0 ± 2.3 days. The median follow-up was 80 months. A total of 17 patients had a recurrence during follow-up, and the recurrence-free survival (RFS) rate was 77.3%. In the multivariable analysis, the tumor risk group were independently associated with the recurrence of NMIBC (p = 0.026).ConclusionsAfter TURBT with a 2-micrometer continuous-wave laser, RFS was 77.3% at the median follow-up of 80 months. All complications were mild. Only tumor risk group was independently associated with the recurrence of NMIBC

Study of the B−→Λc+Λˉc−K−B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-} decay

The decay $B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-}$ is studied in proton-proton collisions at a center-of-mass energy of $\sqrt{s}=13$ TeV using data corresponding to an integrated luminosity of 5 $\mathrm{fb}^{-1}$ collected by the LHCb experiment. In the $\Lambda_{c}^+ K^{-}$ system, the $\Xi_{c}(2930)^{0}$ state observed at the BaBar and Belle experiments is resolved into two narrower states, $\Xi_{c}(2923)^{0}$ and $\Xi_{c}(2939)^{0}$, whose masses and widths are measured to be $$m(\Xi_{c}(2923)^{0}) = 2924.5 \pm 0.4 \pm 1.1 \,\mathrm{MeV}, \\ m(\Xi_{c}(2939)^{0}) = 2938.5 \pm 0.9 \pm 2.3 \,\mathrm{MeV}, \\ \Gamma(\Xi_{c}(2923)^{0}) = \phantom{000}4.8 \pm 0.9 \pm 1.5 \,\mathrm{MeV},\\ \Gamma(\Xi_{c}(2939)^{0}) = \phantom{00}11.0 \pm 1.9 \pm 7.5 \,\mathrm{MeV},$$ where the first uncertainties are statistical and the second systematic. The results are consistent with a previous LHCb measurement using a prompt $\Lambda_{c}^{+} K^{-}$ sample. Evidence of a new $\Xi_{c}(2880)^{0}$ state is found with a local significance of $3.8\,\sigma$, whose mass and width are measured to be $2881.8 \pm 3.1 \pm 8.5\,\mathrm{MeV}$ and $12.4 \pm 5.3 \pm 5.8 \,\mathrm{MeV}$, respectively. In addition, evidence of a new decay mode $\Xi_{c}(2790)^{0} \to \Lambda_{c}^{+} K^{-}$ is found with a significance of $3.7\,\sigma$. The relative branching fraction of $B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-}$ with respect to the $B^{-} \to D^{+} D^{-} K^{-}$ decay is measured to be $2.36 \pm 0.11 \pm 0.22 \pm 0.25$, where the first uncertainty is statistical, the second systematic and the third originates from the branching fractions of charm hadron decays.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-028.html (LHCb public pages