A new bound for the 2/3 conjecture

We show that any n-vertex complete graph with edges colored with three colors contains a set of at most four vertices such that the number of the neighbors of these vertices in one of the colors is at least 2n/3. The previous best value, proved by Erdos, Faudree, Gould, Gy\'arf\'as, Rousseau and Schelp in 1989, is 22. It is conjectured that three vertices suffice

Invasive Bacterial Pathogens and their Antibiotic Susceptibility Patterns in Jimma University Specialized Hospital, Jimma, Southwest Ethiopia

BACKGROUND: Presence of microorganisms in the circulating blood whether continuously or intermittently is a threat to every organ in the body. Approximately 200,000 cases of bacteraemia occur annually with mortality rates ranging from 20-50%. Early diagnosis and appropriate treatment of these infections can make the difference between life and death. The aim of the present study was to determine the bacterial flora of the blood stream infections and their antibiotic susceptibility pattern. METHODS: A cross sectional study was conducted on 260 adult febrile patients in Jimma University Specialized Hospital from 27 October 2009 to 26 March 2010. The positive blood cultures were examined and the organisms were identified as per standard procedures. Antimicrobial testing was performed for all isolates by disk diffusion techniques, according to Clinical Laboratory Standards Institute guide lines. The data was analyzed using SPSS for windows version 16 and Microsoft Office Excel. RESULTS: From the total of two hundred sixty blood specimens only 23(8.8%) were positive to seven different types of bacteria. The isolated bacteria were: Coagulase negative staphylococci 6(26.1%), S. aureus 5 (21.7%), S. pyogens 3 (13.0%), E. coli 4(17.4%), K. pneumoniae 3(13.0%), Salmonella spp. 1(4.3%), and Citrobacter spp. 1(4.3%). The isolates showed high rates of resistance to most antibiotics tested. The range of resistance for gram positive bacteria were 0% to 85.7%, and for gram negative from 0% to 100%. None of the isolates were resistance to ciprofloxacin and ceftriaxone. CONCLUSION: Our study result showed the presence of invasive bacterial pathogens with high rate of resistance to most commonly used antibiotics used to treat bacterial infections. Therefore, timely investigation of bacterial flora of the blood stream infections and monitoring of their antibiotic resistance pattern plays an important role in reduction of the incidence of blood stream infections. KEYWORDS: invasive bacteria, antimicrobial resistance, Jimma, Ethiopi

Health Information Seeking and its Associated Factors among University Students: A Case in a Middle-Income Setting

This paper aims to describe health information seeking behaviour and identify its associated factors among undergraduate university students in developing countries. An online survey is used to collect data from 138 students. The data is analysed using the multivariate logistic regression analysis method. Results reveal that a substantial number of students have sought health information mostly from the Internet. Health literacy, perceived susceptibility to health problems and alcohol consumption are found to be the significant factors influencing health information seeking behaviour. Results provide an understanding of health information seeking behaviour in developing countries

DEVELOPMENT OF PRODUCTIVITY MEASUREMENT AND ANALYSIS FRAMEWORK FOR MANUFACTURING COMPANIES

The purpose of this research is to present an alternative approach for measuring productivity in manufacturing companies. To achieve the research objective, an in depth investigation on the existing productivity measurement and analysis practices of a case manufacturing company has been carried out through both qualitative and quantitative approaches. The investigation result has shown that there are serious problems in measuring and analyzing of productivity at company level. Following the existing practices analysis result, a new productivity measurement and analysis framework has been developed. The developed productivity measurement and analysis framework is found to be simple to understand, detects problem easily and realistically, compatible to modern management systems and tools, and potentially adaptable to similar manufacturing companies

Implementation of quality improvement for community-based health services: what worked, what didn’t, and why? A case study in Ethiopia

Background: Recently, there has been a growing interest in quality improvement (QI) interventions to enhance the health care services provision. However, applying QI interventions to community-based health services (CBHS) is still a limited practice. Strengthening Ethiopia’s Urban Health Program (SEUHP), implemented by John Snow, Inc., used QI principles to address certain challenges in the implementation of the urban health extension program (UHEP). QI activities aimed to improve referral systems between the UHEP and health centers (HCs), strengthen the defaulter tracing system, and enhance linkages and integration between facility-based primary health services and community-based extension services. Aim: This case study reviews the implementation and documents lessons learned from the SEUHP QI intervention. Method: Assessment and multiple case study design to review the implementation and document lessons learned. The study reviews multiple data sources and qualitatively analyzes the experience of QI teams (QIT) in different regions in Ethiopia. Findings: The functionality of the QIT varies across the regions. Where QI interventions function, demand for specific health services increased and QITs met targeted improvement objectives. The linkage and integration between the community-based UHEP extension services and facility health services improved as the result of QI intervention. Conclusion: This case study provides evidence that, despite challenges, QI interventions can be an important tool for facilitating health services. Functional QITs helped motivate Urban Health Extension Professionals (UHE-ps) to effectively execute their job. The QIT’s commitment, the regularity of QIT meetings, and the engagement of all staff and community groups are key factors in the successful implementation of QI initiatives that resulted in improved quality of service provision. [Ethiop. J. Health Dev. 2020; 34(Special issue 2):54-61] Keywords: Quality Improvement, Community, Urban Health, Ethiopi

Inflammatory markers as correlates of body composition and grip strength among adults with and without HIV: A cross-sectional study in Ethiopia

BACKGROUND: Changes in body composition and muscle strength are common among individuals with HIV. We investigated the associations of inflammation with body composition and grip strength in adults with and without HIV. METHODS: Cross-sectional study among Ethiopian treatment-naïve individuals with and without HIV. Fat mass and fat-free mass adjusted for height (kg/m2) were used as indicators of body composition. RESULTS: 288/100 individuals with/without HIV were included between July 2010 and August 2012. Females with HIV had lower fat mass index (FMI) and fat-free mass index (FFMI) than females without HIV, whereas no difference was seen between males with and without HIV. Males and females with HIV had lower grip strength than their counterparts without HIV. Serum alpha-1-acid glycoprotein (s-AGP) was negatively correlated with FMI (-0.71 kg/m2, 95% CI: -1.2; -0.3) among individuals with HIV, and those with HIV and serum C-reactive protein (s-CRP) ≥ 10 mg/l had 0.78 kg/m2 (95% CI -1.4; -0.2) lower FMI than those with s-CRP < 10 mg/l. In contrast, s-AGP was positively correlated with FMI (2.09 kg/m2, 95% CI 0.6; 3.6) in individuals without HIV. S-CRP and AGP were negatively associated with grip strength in individuals with HIV, while no correlation was observed among those without HIV. CONCLUSION: Inflammation was positively associated with FMI in individuals without HIV while it was negatively associated with FMI in those with HIV, indicating that inflammation may be one of the drivers of depleting energy reserves among treatment-naïve individuals with HIV. Inflammation was associated with decreased muscle quantity and functional capacity among individuals with HIV, but not in those without HIV

Serum creatinine and estimated glomerular filtration rates in HIV positive and negative adults in Ethiopia

<div><p>Background</p><p>Glomerular filtration rate estimating equations using serum creatinine are not validated in most African settings. We compared serum creatinine and estimated glomerular filtration rate (eGFR) in HIV positive and negative adults and assessed the performance of eGFR equations ((Cockcroft and Gault (CG), Modification of Diet in Renal Disease (MDRD), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI)) compared to 24-hour creatinine clearance in HIV positive adults.</p><p>Methods</p><p>Data were collected on demographic, anthropometric, body composition, clinical parameters and serum creatinine in HIV positive and negative adults. 24-hour urine was collected from some of the HIV positive adults who volunteered. Bias was calculated as mean difference between 24-hr creatinine clearance and eGFR (eGFR– 24 hour creatinine clearance) and the accuracy of each eGFR equation was calculated as the percentage of estimates within 30% of creatinine clearance.</p><p>Results</p><p>A total of 340 HIV positive and 100 HIV negative adults were included in this study. Creatinine clearance was determined for 46 of HIV positive adults. Serum creatinine increased with increasing age, weight, height, body surface area, fat free mass and grip strength in both HIV positive and negative adults (P<0.05). No difference was observed in eGFR between HIV positive and HIV negative adults. For all eGFR equations, the correlation between eGFR and 24-hr creatinine clearance was 0.45–0.53 and the accuracy within 30% of 24-hr creatinine clearance was 24–46%. Removing ethnic coefficient reduced the bias and improved accuracy of the CKD-EPI and the MDRD estimates.</p><p>Conclusion</p><p>Ethiopian HIV positive adults in the present study had good kidney function at the initiation of antiretroviral treatment. However, all eGFR equations overestimated 24-hr creatinine clearance in the study population. Creatinine based eGFR equations that accounts for low muscle mass and body surface area are needed.</p></div

National Ag-Data Hub project technical report - phase one

This document is a technical progress report of a work aimed to develop a national ag data hub in Ethiopia. The document is not a full technical implementation report of the national ag data hub. It is the technical report of the first phase as per the agreement entered between CIAT and ACATECH TECHNOLOGY PLC to implement the system in a phase by phase approach. This report has two main parts. The first part provides background information about the project which includes a brief introduction about the first phase deliverables. This shows the scope of the project to be completed in the first phase (i.e. in the last three months). The second part describes the project activities and progress in contrast to the plan set at the beginning. This part clearly showed the progress achieved so far

Severe hemolysis during primaquine radical cure of Plasmodium vivax malaria: two systematic reviews and individual patient data descriptive analyses

Primaquine (PQ) kills Plasmodium vivax hypnozoites but can cause severe hemolysis in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency. We conducted two systematic reviews. The first used data from clinical trials to determine the variety of definitions and frequency of hematological serious adverse events (SAEs) related to PQ treatment of vivax malaria. The second used data from prospective studies and case reports to describe the clinical presentation, management, and outcome of severe PQ-associated hemolysis necessitating hospitalization. In the first review, SAEs were reported in 70 of 249 clinical trials. There were 34 hematological SAEs among 9,824 patients with P. vivax malaria treated with PQ, nine of which necessitated hospitalization or blood transfusion. Criteria used to define SAEs were diverse. In the second review, 21 of 8,487 articles screened reported 163 patients hospitalized after PQ radical cure; 79.9% of whom (123 of 154) were prescribed PQ at ≥ 0.5 mg/kg/day. Overall, 101 patients were categorized as having probable or possible severe PQ-associated hemolysis, 96.8% of whom were G6PD deficient (< 30% activity). The first symptoms of hemolysis were reported primarily on day 2 or 3 (45.5%), and all patients were hospitalized within 7 days of PQ commencement. A total of 57.9% of patients (77 of 133) had blood transfusion. Seven patients (6.9%) with probable or possible hemolysis died. Even when G6PD testing is available, enhanced monitoring for hemolysis is warranted after PQ treatment. Clinical review within the first 5 days of treatment may facilitate early detection and management of hemolysis. More robust definitions of severe PQ-associated hemolysis are required