Could conscious sedation with midazolam for dental procedures be an alternative to general anesthesia?

Aim: The aim of our study was to evaluate the likelihood that conscious sedation (CS) with intravenous midazolam could become an alternative modality to general anesthesia (GA) for dental procedures.Materials and Methods: In our study, 58 and 47 American Society of Anesthesiologists (ASA).1 pediatric patients, aged 2.12 (mean 6) years, underwent dental procedures and minor oral surgical procedures under GA and CS with intravenous midazolam, respectively. The two groups were evaluated in terms of vital signs, duration of the treatment procedure, patient behavior, and the treatment comfort experienced by the physicians.Results: The oxygen saturation level was significantly lower (GA: 99.0 } 0.30, CS: 98.4 } 1.02; P < 0.001) and the duration of the treatment procedure was significantly shorter (P < 0.001) in the sedation group compared with the GA group. The physicians encountered various difficulties during implementation of the treatment strategy in cases wherethey used CS. Minor oral surgical procedures and tooth extraction  processes requiring no saline irrigation, however, could be performed successfully under CS.Conclusions: In cases requiring multiple dental management issues, the sedation method was not found to be a useful alternative to GA.Key words: Conscious sedation, general anesthesia, pediatric dentistr

Effect of anisotropy and destructuration on behavior of Haarajoki test embankment

This paper investigates the influence of anisotropy and destructuration on the behavior of Haarajoki test embankment, which was built by the Finnish National Road Administration as a noise barrier in 1997 on a soft clay deposit. Half of the embankment is constructed on an area improved with prefabricated vertical drains, while the other half is constructed on the natural deposit without any ground improvement. The construction and consolidation of the embankment is analyzed with the finite-element method using three different constitutive models to represent the soft clay. Two recently proposed constitutive models, namely S-CLAY1 which accounts for initial and plastic strain induced anisotropy, and its extension, called S-CLAY1S which accounts, additionally, for interparticle bonding and degradation of bonds, were used in the analysis. For comparison, the problem is also analyzed with the isotropic modified cam clay model. The results of the numerical analyses are compared with the field measurements. The simulations reveal the influence that anisotropy and destructuration have on the behavior of an embankment on soft clay

Generalized exclusion and Hopf algebras

We propose a generalized oscillator algebra at the roots of unity with generalized exclusion and we investigate the braided Hopf structure. We find that there are two solutions: these are the generalized exclusions of the bosonic and fermionic types. We also discuss the covariance properties of these oscillatorsComment: 10 pages, to appear in J. Phys.

Upregulation of virulence genes promotes Vibrio cholerae biofilm hyperinfectivity

Vibrio cholerae remains a major global health threat, disproportionately impacting parts of the world without adequate infrastructure and sanitation resources. In aquatic environments, V. cholerae exists both as planktonic cells and as biofilms, which are held together by an extracellular matrix. V. cholerae biofilms have been shown to be hyperinfective, but the mechanism of hyperinfectivity is unclear. Here we show that biofilm-grown cells, irrespective of the surfaces on which they are formed, are able to markedly outcompete planktonic-grown cells in the infant mouse. Using an imaging technique designed to render intestinal tissue optically transparent and preserve the spatial integrity of infected intestines, we reveal and compare three-dimensional V. cholerae colonization patterns of planktonic-grown and biofilm-grown cells. Quantitative image analyses show that V. cholerae colonizes mainly the medial portion of the small intestine and that both the abundance and localization patterns of biofilm-grown cells differ from that of planktonic-grown cells. In vitro biofilm-grown cells activate expression of the virulence cascade, including the toxin coregulated pilus (TCP), and are able to acquire the cholera toxin-carrying CTXФ phage. Overall, virulence factor gene expression is also higher in vivo when infected with biofilm-grown cells, and modulation of their regulation is sufficient to cause the biofilm hyperinfectivity phenotype. Together, these results indicate that the altered biogeography of biofilm-grown cells and their enhanced production of virulence factors in the intestine underpin the biofilm hyperinfectivity phenotype

X-ray detection with Micromegas with background levels below 10−6^{-6} keV−1^{-1}cm−2^{-2}s−1^{-1}

Micromegas detectors are an optimum technological choice for the detection of low energy x-rays. The low background techniques applied to these detectors yielded remarkable background reductions over the years, being the CAST experiment beneficiary of these developments. In this document we report on the latest upgrades towards further background reductions and better understanding of the detectors' response. The upgrades encompass the readout electronics, a new detector design and the implementation of a more efficient cosmic muon veto system. Background levels below 10$^{-6}$keV$^{-1}$cm$^{-2}$s$^{-1}$ have been obtained at sea level for the first time, demonstrating the feasibility of the expectations posed by IAXO, the next generation axion helioscope. Some results obtained with a set of measurements conducted in the x-ray beam of the CAST Detector Laboratory will be also presented and discussed

CAST microbulk micromegas in the Canfranc Underground Laboratory

During the last taking data campaigns of the CAST experiment, the micromegas detectors have achieved background levels of $\approx 5 \times 10^{-6}$keV$^{-1}$cm$^{-2}$s$^{-1}$ between 2 and 9 keV. This performance has been possible thanks to the introduction of the microbulk technology, the implementation of a shielding and the development of discrimination algorithms. It has motivated new studies towards a deeper understanding of CAST detectors background. One of the working lines includes the construction of a replica of the set-up used in CAST by micromegas detectors and its installation in the Canfranc Underground Laboratory. Thanks to the comparison between the performance of the detectors underground and at surface, shielding upgrades, etc, different contributions to the detectors background have been evaluated. In particular, an upper limit $< 2 \times 10^{-7}$keV$^{-1}$cm$^{-2}$s$^{-1}$ for the intrinsic background of the detector has been obtained. This work means a first evaluation of the potential of the newest micromegas technology in an underground laboratory, the most suitable environment for Rare Event Searches.Comment: 6 pages, 8 figures. To appear in the proceedings of the 2nd International Conference on Technology and Instrumentation for Particle Physics (TIPP 2011

Solar-like oscillations in the G8 V star tau Ceti

We used HARPS to measure oscillations in the low-mass star tau Cet. Although the data were compromised by instrumental noise, we have been able to extract the main features of the oscillations. We found tau Cet to oscillate with an amplitude that is about half that of the Sun, and with a mode lifetime that is slightly shorter than solar. The large frequency separation is 169 muHz, and we have identified modes with degrees 0, 1, 2, and 3. We used the frequencies to estimate the mean density of the star to an accuracy of 0.45% which, combined with the interferometric radius, gives a mass of 0.783 +/- 0.012 M_sun (1.6%).Comment: accepted for publication in A&