Tiny Medicine: Nanomaterial-Based Biosensors

Tiny medicine refers to the development of small easy to use devices that can help in the early diagnosis and treatment of disease. Early diagnosis is the key to successfully treating many diseases. Nanomaterial-based biosensors utilize the unique properties of biological and physical nanomaterials to recognize a target molecule and effect transduction of an electronic signal. In general, the advantages of nanomaterial-based biosensors are fast response, small size, high sensitivity, and portability compared to existing large electrodes and sensors. Systems integration is the core technology that enables tiny medicine. Integration of nanomaterials, microfluidics, automatic samplers, and transduction devices on a single chip provides many advantages for point of care devices such as biosensors. Biosensors are also being used as new analytical tools to study medicine. Thus this paper reviews how nanomaterials can be used to build biosensors and how these biosensors can help now and in the future to detect disease and monitor therapies

Pulsating flow behaviour in a twin-entry vaneless radial inflow turbine

Imperial Users onl

A new approach towards blood sugar monitoring : non-invasive/continuous/arterial

It has been overwhelming clear that frequent monitoring and tight control of blood glucose levels are necessary for effective management of diabetic mellitus and reduction of complication associated with this disease. The current "finger prick" method is invasive, painful and troublesome for day-to-day monitoring of blood glucose. And therefore patients have tendency to give it a miss. Hence the need for a non-invasive monitoring system for blood glucose

Mechanics of artificial heart valves

In this research, extensive works were carried out to study the mechanics of the bi-leaflet mechanical heart valve (MHV) through both numerical and experimental studies

Mechanics of artificial heart valves

158 p.Artificial Heart Valves with the bi-leaflet design was introduced clinically around 1977. This design has proven to be an effective alternative to other valve designs. Many surgeons who were skeptical of this bi-leaflet design concept have since switched to using this ever popular valve design. The bi-leaflet valve design offers lower profile and improved haemodynamics. However due to the complex hinge design, there were cases of valve leaflet rendered immobile due to blood clotting in the narrow flow channel in the hinge region. In the early 1990s, there were cases of reported valve leaflet failure and further investigation led to a new research areas relating to cavitation in mechanical heart valve. Despite the so claimed improved bi-leaflet valve design, these valves are not problem free. Many problems related to haemodynamics of the valve remains a challenge for researchers to address.RG 75/9

Development of mechanical heart valve

In this project, the main objective is to develop a mechanical heart value through innovative design feature that will address some of the short comings in current valve design.ARP 59/9

Experimental studies of force lobed mixer

Velocity and turbulence characteristics has been measured downstream of a forced lobe mixed with three different trailing edge configuration using a two component laser Doppler anemometer. Experiments were carried out with Reynolds number of 1.27 x 10 power of 4 based on a reference velocity of 10m/s and a nominal wavelength of the lobe at 33mm.ARP 62/9

Flowfield investigation of a bi-leaflet heart valve

This project describes the design and development of a pulsating flow test rig suitable for flow investigation of enlarged model mechanical hear valve (MHV). The test rig is designed with the concept of a plunger creating an oscillating flow.ARP 69/9