Comparative anatomical and morphological characteristics of two subspecies of Melissa officinalis L. (Lamiaceae)

Received: February 23rd, 2022 ; Accepted: May 22nd, 2022 ; Published: July 30th, 2022 ; Correspondence: [email protected] aim of the research is to comprehensively compare the anatomical and morphological structures of plants of Melissa officinalis subsp. officinalis (‘Krymchanka’ and ‘Lada’ varieties) and of M. officinalis subsp. аltissima (Sm.) Arcang. These plants have pronounced differences in morphological features and production indexes. They are grown in the collection of aromatic plants of the Research Institute of Agriculture of the Crimea (Krymskaya Roza village, Belogorsky district of Crimea). These studies will allow us to supplement the botanical characteristics of both subspecies of M. officinalis, and also to evaluate their plasticity and possibilities of adaptation to growing conditions. For examination we collected plants in the flowering phase. Anatomical study was carried out using a fixed (alcohol: glycerin : water in a ratio of 1: 1: 1) and native preparation. A complex of mesomorphic and xeromorphic characters is established, that confirms the high plasticity and determines the adaptive capabilities of the species when introduced into various soil and climatic conditions. A variety of epidermal structures was revealed, which are represented by single and multicellular non-glandular trichomes and various types of glandular structures. Among them, trichomes with a multicellular pedicle and a unicellular head, which we found only in M. officinalis subsp. officinalis

Cellulite nécrosante descendante infectieuse d’origine dentaire à diffusion mammaire : Analyse de deux cas

Les cellulites nécrosantes descendantes d’origine dentaire sont graves et de prise en charge difficile. Leur diffusion se fait classiquement vers le médiastin, les cavités pleurales, voir le cerveau. La diffusion spécifique à la glande mammaire est atypique, rare et peu décrite. Nous rapportons 2 cas colligés en 15 ans de pratique de chirurgie thoracique. Il s’agissait de deux patientes, l’une âgée de 32 ans et l’autre de 25 ans toutes vivaient en milieu rural. Leurs itinéraires diagnostiques et thérapeutiques, les facteurs de risque, les moyens thérapeutiques utilisés et leurs pronostics ont été discutés. Le but de ce travail était de mettre l’accent sur la gravité de cette pathologie et inciter à la mise en œuvre d’une politique de prévention à l’échelle nationale

The Efficacy of Vortioxetine on Anhedonia in Patients With Major Depressive Disorder

Background: Anhedonia is a common, persistent, and disabling phenomenon in treated adults with Major Depressive Disorder (MDD). Hitherto, relatively few antidepressant agents have been evaluated with respect to their effect on anhedonia in MDD.Methods: This is a post-hoc analysis of a primary study that sought to evaluate the sensitivity to change of the THINC-integrated tool (THINC-it) in MDD (ClinicalTrials.gov Identifier: NCT03053362). Adults meeting DSM-5 criteria for MDD with at least moderate depressive symptom severity [i.e., Montgomery Åsberg Depression Rating Scale (MADRS) total score ≥20] were eligible. Subjects were recruited between October 2017 and August 2018 in Toronto, Ontario at the Brain and Cognition Discovery Foundation. All subjects received open-label vortioxetine (10–20 mg/day, flexibly-dosed) for 8 weeks. Herein, the primary outcome of interest was the change from baseline to endpoint in the Snaith-Hamilton Pleasure Scale (SHAPS) total score, as well as the MADRS anhedonia factor. The mediational effects of improvements in anhedonia on general function and quality of life, as measured by the Sheehan Disability Scale (SDS) and the 5-Item World Health Organization Well-Being Index (WHO-5), were secondarily assessed.Results: A total of 100 subjects with MDD were enrolled in the primary study and began treatment with vortioxetine. Vortioxetine significantly improved anhedonia as evidenced by significant baseline to endpoint improvements in SHAPS and MADRS anhedonia factor scores (p < 0.0001). Improvements in the SHAPS and the MADRS anhedonia factor correlated with improvements in general function (i.e., SDS) and quality of life (i.e., WHO-5) (p < 0.0001). Notably, improvements in anhedonia were found to mediate the association between improvements in overall depressive symptom severity (i.e., MADRS total score) and social functioning (i.e., social life component of the SDS) (p = 0.026).Conclusion: The unmet need in depression is to improve patient functioning and other patient-reported outcomes (e.g., quality of life). Antidepressant interventions capable of attenuating anhedonia as well as cognitive dysfunction in MDD may help in this regard, as improvement in these domains have been associated with improvement in psychosocial function and quality of life

Pendekatan Lean Manufacturing Untuk Meningkatkan Efisiensi Dalam Proses Produksi Dengan Menggunakan Value Stream Mapping Pada CV. Indospice

CV. INDOSPICE merupakan Perusahaan yang bergerak pada produksi pala, untuk terus mengoptimalkan kinerja produktifitasnya dan meningkatkatkan laba Perusahaan dengan berusaha menurunkan biaya, meningkatkan kualitas dan tepat waktu dalam pengiriman ke pelanggan. Penelitian ini bertujuan untuk mengetahui berbagai bentuk pemborosan (waste) apa saja yang sering terjadi sehingga dapat meningkatkan efisiensi produksi, karena itu diperlukan suatu pendekatan lean manufacturing. Lean Manufacturing merupakan sebuah pendekatan untuk meminimisasi pemborosan yang terjadi dalam proses produksi melalui value stream mapping untuk meningkatkan efisiensi. Metode yang digunakan dalam penelitian ini adalah deskriptif yang dilakukan dengan meneliti analisa pekerjaan dan aktifitas pada suatu obyek. Hasil penelitian menunjukan bahwa dalam proses produksi yang terjadi masih terdapat bentuk pemborosan berupa proses yang berlebih dan penggunaan mesin yang belum optimal. Untuk itu perlu upaya untuk meningkatkan efisisen berupa penambahan mesin penggiling pala dan pengadaan teknologi modern agar pengerjaan menjadi lebih cepat

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types

Euro plus Med-Checklist Notulae, 11

This is the eleventh of a series of miscellaneous contributions, by various authors, where hitherto unpublished data relevant to both the Med-Checklist and the Euro+Med (or Sisyphus) projects are presented. This instalment deals with the families Anacardiaceae, Asparagaceae (incl. Hyacinthaceae), Bignoniaceae, Cactaceae, Compositae, Cruciferae, Cyperaceae, Ericaceae, Gramineae, Labiatae, Leguminosae, Orobanchaceae, Polygonaceae, Rosaceae, Solanaceae and Staphyleaceae. It includes new country and area records and taxonomic and distributional considerations for taxa in Bidens, Campsis, Centaurea, Cyperus, Drymocallis, Engem, Hoffmannseggia, Hypopitys, Lavandula, Lithraea, Melilotus, Nicotiana, Olimarabidopsis, Opuntia, Orobanche, Phelipanche, Phragmites, Rumex, Salvia, Schinus, Staphylea, and a new combination in Drimia.Peer reviewe

Euro+Med-Checklist Notulae, 13

This is the thirteenth of a series of miscellaneous contributions, by various authors, where hitherto unpublished data relevant to both the Med-Checklist and the Euro+Med (or Sisyphus) projects are presented. This instalment deals with the families Amaryllidaceae (incl. Alliaceae), Apocynaceae, Caryophyllaceae, Chenopodiaceae, Compositae, Crassulaceae, Cucurbitaceae, Gramineae, Hydrocharitaceae, Iridaceae, Labiatae, Liliaceae, Malvaceae, Meliaceae, Myrtaceae, Orobanchaceae, Oxalidaceae, Papaveraceae, Pittosporaceae, Primulaceae (incl. Myrsinaceae), Ranunculaceae, Rhamnaceae, Rubiaceae, Solanaceae and Umbelliferae. It includes new country and area records and taxonomic and distributional considerations for taxa in Allium, Anthemis, Atriplex, Centaurea, Chasmanthe, Chenopodium, Delphinium, Digitaria, Elodea, Erigeron, Eucalyptus, Hypecoum, Leptorhabdos, Luffa, Malvaviscus, Melia, Melica, Momordica, Nerium, Oxalis, Pastinaca, Phelipanche, Physalis, Pittosporum, Salvia, Scorzoneroides, Sedum, Sesleria, Silene, Spartina, Stipa, Tulipa and Ziziphus, new combinations in Cyanus, Lysimachia, Rhaponticoides and Thliphthisa, and the reassessment of a replacement name in Sempervivum

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin

Neoliberalism and University Education in Sub-Saharan Africa

This article reviews the history of university development in Sub-Saharan Africa (SSA) and discusses the impact of neoliberal policies. This will be followed by an examination of the problems facing universities in the region. The following questions will be explored: (a) Are the existing universities in SSA serving the development needs of the region? (b) Are these universities up to the task of moving SSA out of the predicaments it faces such as famine, HIV/AIDS, poverty, diseases, debt, and human rights abuses? Finally, the article argues that for universities to play a role in the development of the region, a new paradigm that makes university education a public good should be established