1,278 research outputs found
A novel mutation of the Keratin 12 gene responsible for a severe phenotype of Meesmann's corneal dystrophy
KMT-2016-BLG-1107: A New Hollywood-Planet Close/Wide Degeneracy
We show that microlensing event KMT-2016-BLG-1107 displays a new type of
degeneracy between wide-binary and close-binary Hollywood events in which a
giant-star source envelops the planetary caustic. The planetary anomaly takes
the form of a smooth, two-day "bump" far out on the falling wing of the light
curve, which can be interpreted either as the source completely enveloping a
minor-image caustic due to a close companion with mass ratio , or
partially enveloping a major-image caustic due to a wide companion with
. The best estimates of the companion masses are both in the planetary
regime ( and ) but differ by an even larger factor than the mass ratios due to
different inferred host masses. We show that the two solutions can be
distinguished by high-resolution imaging at first light on next-generation
("30m") telescopes. We provide analytic guidance to understand the conditions
under which this new type of degeneracy can appear.Comment: 23 pages, 7 figures, accepted for publication in A
Supramolecular chemistry enables vat photopolymerization 3D printing of novel water-soluble tablets
Vat photopolymerization has garnered interest from pharmaceutical researchers for the fabrication of personalised medicines, especially for drugs that require high precision dosing or are heat labile. However, the 3D printed structures created thus far have been insoluble, limiting printable dosage forms to sustained-release systems or drug-eluting medical devices which do not require dissolution of the printed matrix. Resins that produce water-soluble structures will enable more versatile drug release profiles and expand potential applications. To achieve this, instead of employing cross-linking chemistry to fabricate matrices, supramolecular chemistry may be used to impart dynamic interaction between polymer chains. In this study, water-soluble drug-loaded printlets (3D printed tablets) are fabricated via digital light processing (DLP) 3DP for the first time. Six formulations with varying ratios of an electrolyte acrylate monomer, [2-(acryloyloxy)ethyl]trimethylammonium chloride (TMAEA), and a co-monomer, 1-vinyl-2-pyrrolidone (NVP), were prepared to produce paracetamol-loaded printlets. 1H NMR spectroscopy analysis confirmed the integration of TMAEA and NVP in the polymer, and residual TMAEA monomers were found to be present only in trace amounts (0.71 - 1.37 %w/w). The apparent molecular mass of the photopolymerised polymer was found to exceed 300,000 Da with hydrodynamic radii of 15 - 20 nm, estimated based on 1H DOSY NMR measurements The loaded paracetamol was completely released from the printlets between 45 minutes to 5 hours. In vivo single-dose acute toxicity studies in rats suggest that the printlets did not cause any tissue damage. The findings reported in this study represent a significant step towards the adoption of vat photopolymerization-based 3DP to produce personalised medicines
KMT-2018-BLG-1990Lb: A Nearby Jovian Planet From A Low-Cadence Microlensing Field
We report the discovery and characterization of KMT-2018-BLG-1990Lb, a Jovian
planet orbiting a late M dwarf
, at a distance
(D_L=1.23_{-0.43}^{+1.06}\,\kpc), and projected at times the
snow line distance, i.e., a_{\rm snow}\equiv 2.7\,\au (M/M_\odot), This is
the second Jovian planet discovered by KMTNet in its low cadence () fields, demonstrating that this population will be well
characterized based on survey-only microlensing data.Comment: 24 pages, 7 figures, 4 table
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A 5-Enolpyruvylshikimate 3-Phosphate Synthase Functions as a Transcriptional Repressor in Populus.
Long-lived perennial plants, with distinctive habits of inter-annual growth, defense, and physiology, are of great economic and ecological importance. However, some biological mechanisms resulting from genome duplication and functional divergence of genes in these systems remain poorly studied. Here, we discovered an association between a poplar (Populus trichocarpa) 5-enolpyruvylshikimate 3-phosphate synthase gene (PtrEPSP) and lignin biosynthesis. Functional characterization of PtrEPSP revealed that this isoform possesses a helix-turn-helix motif in the N terminus and can function as a transcriptional repressor that regulates expression of genes in the phenylpropanoid pathway in addition to performing its canonical biosynthesis function in the shikimate pathway. We demonstrated that this isoform can localize in the nucleus and specifically binds to the promoter and represses the expression of a SLEEPER-like transcriptional regulator, which itself specifically binds to the promoter and represses the expression of PtrMYB021 (known as MYB46 in Arabidopsis thaliana), a master regulator of the phenylpropanoid pathway and lignin biosynthesis. Analyses of overexpression and RNAi lines targeting PtrEPSP confirmed the predicted changes in PtrMYB021 expression patterns. These results demonstrate that PtrEPSP in its regulatory form and PtrhAT form a transcriptional hierarchy regulating phenylpropanoid pathway and lignin biosynthesis in Populus
KMT-2018-BLG-1292: A Super-Jovian Microlens Planet in the Galactic Plane
We report the discovery of KMT-2018-BLG-1292Lb, a super-Jovian planet orbiting an F or G dwarf , which lies physically within {\cal O}(10\,\pc) of the
Galactic plane. The source star is a heavily extincted luminous
giant that has the lowest Galactic latitude, , of any planetary
microlensing event. The relatively blue blended light is almost certainly
either the host or its binary companion, with the first explanation being
substantially more likely. This blend dominates the light at band and
completely dominates at and bands. Hence, the lens system can be probed
by follow-up observations immediately, i.e., long before the lens system and
the source separate due to their relative proper motion. The system is well
characterized despite the low cadence -- of
observations and short viewing windows near the end of the bulge season. This
suggests that optical microlensing planet searches can be extended to the
Galactic plane at relatively modest cost.Comment: 35 pages, 3 Tables, 8 figure
A Planetary Microlensing Event with an Unusually Red Source Star: MOA-2011-BLG-291
We present the analysis of planetary microlensing event MOA-2011-BLG-291,
which has a mass ratio of and a source star that
is redder (or brighter) than the bulge main sequence. This event is located at
a low Galactic latitude in the survey area that is currently planned for NASA's
WFIRST exoplanet microlensing survey. This unusual color for a microlensed
source star implies that we cannot assume that the source star is in the
Galactic bulge. The favored interpretation is that the source star is a lower
main sequence star at a distance of kpc in the Galactic disk.
However, the source could also be a turn-off star on the far side of the bulge
or a sub-giant in the far side of the Galactic disk if it experiences
significantly more reddening than the bulge red clump stars. However, these
possibilities have only a small effect on our mass estimates for the host star
and planet. We find host star and planet masses of and from a Bayesian
analysis with a standard Galactic model under the assumption that the planet
hosting probability does not depend on the host mass or distance. However, if
we attempt to measure the host and planet masses with host star brightness
measurements from high angular resolution follow-up imaging, the implied masses
will be sensitive to the host star distance. The WFIRST exoplanet microlensing
survey is expected to use this method to determine the masses for many of the
planetary systems that it discovers, so this issue has important design
implications for the WFIRST exoplanet microlensing survey
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