Towards a Data Governance Framework for Third Generation Platforms

The fourth industrial revolution considers data as a business asset and therefore this is placed as a central element of the software architecture (data as a service) that will support the horizontal and vertical digitalization of industrial processes. The large volume of data that the environment generates, its heterogeneity and complexity, as well as its reuse for later processes (e.g. analytics, IA) requires the adoption of policies, directives and standards for its right governance. Furthermore, the issues related to the use of resources in the cloud computing must be taken into account with the aim of meeting the requirements of performance and security of the different processes. This article, in the absence of frameworks adapted to this new architecture, proposes an initial schema for developing an effective data governance programme for third generation platforms, that means, a conceptual tool which guides organizations to define, design, develop and deploy services aligned with its vision and business goals in I4.0 era.This work is partially funded by Spanish Government through the research project TIN2017-86520-C3-3-R

Multi-User MIMO Transmission in LTE Uplink

Projecte de mobiltat a la Technische Universität WienThis PFC is based on the evaluation and implementation in an LTE network simulator in the uplink the multiple users acccess based on MIMO, implementing different scheduling algorithms and different receivers with the aim of studying the advantages of multi-user MIMO and achieve the optimal performance.En este PFC se implementa y evalúa en un simulador de redes LTE el acceso de múltiples usuarios en el enlace de subida basado en técnicas MIMO, implementando diferentes algoritmos de scheduling y diferentes receptores, con el objetivo de estudiar las ventajas de MIMO multiusuario y conseguir el máximo rendimiento posible.En aquest PFC s'implementa i s'evalua en un simulador de xarxes LTE l'accés de múltiples usuaris en l'enllaç de pujada basat en tècniques MIMO, implementant diferents algoritmes de scheduling i diferents receptors, amb l'objectiu d'estudiar els aventatges de MIMO multiusuari i aconseguir el màxim rendiment possible

Newly Qualified Nurses’ Perception of Their Competency Achievement on Leaving University: A Qualitative Study

Thanks to all nurses, nursing students and independent researchers who voluntarily participated in this study.Background: After implementing the Tuning Educational Structures in Europe Project, numerous efforts have been made to define, establish, and evaluate nursing competences. The European Federation of Nurses Association played a key role in enacting the nursing competences included in Directive 2013/55/EU. Nevertheless, assessing competences remains elusive, and there is little research into nurses’ perceptions of the competency training provided by their universities. The purpose of the study was to explore the perceptions and experiences of newly qualified nurses about the competences they acquired during their university education. Methods: A qualitative research study was developed in a Spanish university. Twelve semi-structured interviews with newly qualified nurses were conducted, and two focus groups made up of twelve students were carried out in order to triangulate the results. Participants were recruited through email contact. Interviews focused on clinical training, theoretical content, and the reality of healthcare. Data was analyzed thematically. Results: Two main themes emerged: (1) improving theoretical content and (2) rethinking practical lessons and clinical training. A lack of knowledge about mental health, pharmacology, or critical care has been found; in addition, it was highlighted, among others, the need to improve communication skills in difficult and conflictive situations. Conclusions: Considering the participants’ perception of deficiency in some aspects of most of the competences established by the European Federation of Nurses Association, further research has been suggested to include other stakeholders’ views

NP7 protects from cell death induced by oxidative stress in neuronal and glial midbrain cultures from parkin null mice

AbstractParkin mutations produce Parkinson’s disease (PD) in humans and nigrostriatal dopamine lesions related to increased free radicals in mice. We examined the effects of NP7, a synthetic, marine derived, free radical scavenger which enters the brain, on H2O2 toxicity in cultured neurons and glia from wild-type (WT) and parkin null mice (PK-KO).NP7, 5–10μM, prevented the H2O2 induced apoptosis and necrosis of midbrain neuronal and glial cultures from WT and PK-KO mice. NP7 suppressed microglial activation and the H2O2 induced drop-out of dopamine neurons. Furthermore, NP7 prevented the increased phosphorylation of ERK and AKT induced by H2O2. NP7 may be a promising neuroprotector against oxidative stress in PD

High Sensitivity C Reactive Protein in Patients with Rheumatoid Arthritis Treated with Antibodies against IL-6 or Jak Inhibitors: A Clinical and Ultrasonographic Study

Background: We examined whether high-sensitivity CRP (hsCRP) reflected the inflammatory disease status evaluated by clinical and ultrasound (US) parameters in RA patients receiving IL-6 receptor antibodies (anti-IL-6R) or JAK inhibitors (JAKi). Methods: We conducted a cross-sectional study of patients with established RA receiving anti-IL-6R (tocilizumab, sarilumab) or JAKi (tofacitinib, baricitinib). Serum hsCRP and US synovitis in both hands were measured. Associations between hsCRP and clinical inflammatory activity were evaluated using composite activity indices. The association between hsCRP and US synovitis was analyzed. Results: 63 (92% female) patients (42 anti- IL-6R and 21 JAKi) were included, and the median disease duration was 14.4 (0.2–37.5) years. Most patients were in remission or had low levels of disease. Overall hsCRP values were very low, and significantly lower in anti-IL-6R patients (median 0.04 mg/dL vs. 0.16 mg/dL). Anti-IL-6R (82.4%) patients and 48% of JAKi patients had very low hsCRP levels (≤0.1 mg/dL) (p = 0.002). In the anti-IL-6R group, hsCRP did not correlate with the composite activity index or US synovitis. In the JAKi group, hsCRP moderately correlated with US parameters (r = 0.5) but not clinical disease activity, and hsCRP levels were higher in patients with US synovitis (0.02 vs. 0.42 mg/dL) (p = 0.001). Conclusion: In anti-IL-6R RA-treated patients, hsCRP does not reflect the inflammatory disease state, but in those treated with JAKi, hsCRP was associated with US synovitis

Cav-1 Protein Levels in Serum and Infarcted Brain Correlate with Hemorrhagic Volume in a Mouse Model of Thromboembolic Stroke, Independently of rt-PA Administration.

Thrombolytic therapy with recombinant tissue plasminogen activator (rt-PA) is currently the only FDA-approved drug for acute ischemic stroke. However, its administration is still limited due to the associated increased risk of hemorrhagic transformation (HT). rt-PA may exacerbate blood-brain barrier (BBB) injury by several mechanisms that have not been fully elucidated. Caveolin-1 (Cav-1), a major structural protein of caveolae, has been linked to the endothelial barrier function. The effects of rt-PA on Cav-1 expression remain largely unknown. Here, Cav-1 protein expression after ischemic conditions, with or without rt-PA administration, was analyzed in a murine thromboembolic middle cerebral artery occlusion (MCAO) and in brain microvascular endothelial bEnd.3 cells subjected to oxygen/glucose deprivation (OGD). Our results show that Cav-1 is overexpressed in endothelial cells of infarcted area and in bEnd.3 cell line after ischemia but there is disagreement regarding rt-PA effects on Cav-1 expression between both experimental models. Delayed rt-PA administration significantly reduced Cav-1 total levels from 24 to 72 h after reoxygenation and increased pCav-1/Cav-1 at 72 h in the bEnd.3 cells while it did not modify Cav-1 immunoreactivity in the infarcted area at 24 h post-MCAO. Importantly, tissue Cav-1 positively correlated with Cav-1 serum levels at 24 h post-MCAO and negatively correlated with the volume of hemorrhage after infarction, the latter supporting a protective role of Cav-1 in cerebral ischemia. In addition, the negative association between baseline serum Cav-1 levels and hemorrhagic volume points to a potential usefulness of baseline serum Cav-1 levels to predict hemorrhagic volume, independently of rt-PA administration.This work was supported by grants from Instituto de Salud Carlos III and co-fnanced by the European Development Regional Fund “A Way to Achieve Europe” Health Strategic Action Program PI13/02258 and PI17/02123 (MC), PI20/00535 (IL), and Spanish Stroke Research Network RETICS RD12/0014/0010 (MC), and RD16/0019/0003 (JS), RD16/0019/0004 (MC), and RD16/0019/0009 (IL); from Regional Madrid Government B2017/BMD- 3688 (IL); from Spanish Ministry of Science and Innovation PID2019-106581RBI00 (MAM); from Leducq Foundation for Cardiovascular Research TNE-19CVD01 (MAM); and from Fundación La Caixa HR17_00527 (MAM). P. Comajoan was a recipient of a predoctoral fellowship from the University of Girona (IF-UdG 2015).S

Minería de flujos de datos en entornos heterogéneos y distribuidos: aplicación en la Industria 4.0

Uno de los principales objetivos de la Industria 4.0 es lograr la necesaria integración horizontal y vertical del sistema de producción. Para ello es necesario desplegar una plataforma digital que integre y procese la ingente cantidad de datos generados en el entorno. Mucha de esta información procede del IoT, y, en concreto, corresponde a sensores que emiten flujos continuos de datos cuyo análisis mediante técnicas de minería de datos permitiría mejorar los procesos industriales, como por ejemplo construyendo modelos dirigidos al mantenimiento preventivo y predictivo de los sistemas físicos, donde aún hay retos abiertos. El objeto de este artículo es describir el punto de partida de esta investigación que es el resultado de un proyecto del plan nacional y discutir su extensión señalando las líneas de trabajo que se pretenden abordar y los resultados que se per-sigue conseguir para contribuir al avance de la I4.0.Este trabajo ha sido parcialmente apoyado por MCIN/ AEI /10.13039/501100011033/ FEDER "Una manera de hacer Europa" bajo la subvención TIN2017-86520-C3-3-R (PRECON-I4) y por la Ayuda Concepción Arenal del Programa de Personal Investigador en formación Predoctoral de la Universidad de Cantabria y el Gobierno de Cantabria (BOC 18-10-2021)

NMDA receptor gene variations as modifiers in Huntington disease: a replication study.

Several candidate modifier genes which, in addition to the pathogenic CAG repeat expansion, influence the age at onset (AO) in Huntington disease (HD) have already been described. The aim of this study was to replicate association of variations in the N-methyl D-aspartate receptor subtype genes GRIN2A and GRIN2B in the "REGISTRY" cohort from the European Huntington Disease Network (EHDN). The analyses did replicate the association reported between the GRIN2A rs2650427 variation and AO in the entire cohort. Yet, when subjects were stratified by AO subtypes, we found nominally significant evidence for an association of the GRIN2A rs1969060 variation and the GRIN2B rs1806201 variation. These findings further implicate the N-methyl D-aspartate receptor subtype genes as loci containing variation associated with AO in HD