Semantic Effect on Episodic Associations

We examined the influence of the pre-existing organiza-tion of the semantic memory on forming new episodic associations between words. Testing human subjects' performance we found that a semantic relationship be-tween words facilitates forming episodic associations be-tween them. Furthermore, the amount of facilitation in-creases linearly as a function of the number of co-occurrence of the words, up to a ceiling. Constrained by these empirical findings we developed a computational model, based on the theory of spreading activation over semantic networks. The model uses self-organizing maps to represent semantic relatedness, and lateral connections to represent the episodic associations. When two words are presented to the model, the interaction of the two ac-tivation waves is summed and added to the direct lateral connection between them. The main result is that the model is capable of replicating the empirical results. The model also makes several testable predictions: First, it should be easier to form an association from a word with few semantic neighbors to a word with many se-mantic neighbors than vice-versa. Second, after associat-ing an unrelated word pair it should be easier to associate another two words each related to one of the words in the first pair. Third, a less focused activation wave, which may be the cause of schizophrenic thought disor-der, should decrease the advantage in learning rate of re-lated over unrelated pairs

Disordered semantic representation in schizophrenic temporal cortex revealed by neuromagnetic response patterns

BACKGROUND: Loosening of associations and thought disruption are key features of schizophrenic psychopathology. Alterations in neural networks underlying this basic abnormality have not yet been sufficiently identified. Previously, we demonstrated that spatio-temporal clustering of magnetic brain responses to pictorial stimuli map categorical representations in temporal cortex. This result has opened the possibility to quantify associative strength within and across semantic categories in schizophrenic patients. We hypothesized that in contrast to controls, schizophrenic patients exhibit disordered representations of semantic categories. METHODS: The spatio-temporal clusters of brain magnetic activities elicited by object pictures related to super-ordinate (flowers, animals, furniture, clothes) and base-level (e.g. tulip, rose, orchid, sunflower) categories were analysed in the source space for the time epochs 170–210 and 210–450 ms following stimulus onset and were compared between 10 schizophrenic patients and 10 control subjects. RESULTS: Spatio-temporal correlations of responses elicited by base-level concepts and the difference of within vs. across super-ordinate categories were distinctly lower in patients than in controls. Additionally, in contrast to the well-defined categorical representation in control subjects, unsupervised clustering indicated poorly defined representation of semantic categories in patients. Within the patient group, distinctiveness of categorical representation in the temporal cortex was positively related to negative symptoms and tended to be inversely related to positive symptoms. CONCLUSION: Schizophrenic patients show a less organized representation of semantic categories in clusters of magnetic brain responses than healthy adults. This atypical neural network architecture may be a correlate of loosening of associations, promoting positive symptoms

Semantic categorization in the human brain : spatiotemporal dynamics revealed by magnetoencephalography

We examined the cortical representation of semantic categorization using magnetic source imaging in a task that revealed both dissociations among superordinate categories and associations among different base-level concepts within these categories. Around 200 ms after stimulus onset, the spatiotemporal correlation of brain activity elicited by base-level concepts was greater within than across superordinate categories in the right temporal lobe. Unsupervised clustering of data showed similar categorization between 210 and 450 ms mainly in the left hemisphere. This pattern suggests that well-defined semantic categories are represented in spatially distinct, macroscopically separable neural networks, independent of physical stimulus properties. In contrast, a broader, task-required categorization (natural/ man-made) was not evident in our data. The perceptual dynamics of the categorization process is initially evident in the extrastriate areas of the right hemisphere; this activation is followed by higher-level activity along the ventral processing stream, implicating primarily the left temporal lobe