Housing development and urbanisation in China

Rapid urbanisation and rising income have led to a strong demand for housing in urban China. However, housing development has been distorted by speculation, income inequality and lack of government support for low-cost houses. In recent years, house prices become so high, making the vast majority of urban residents unable to afford, whereas rich families are able to buy many and leave them vacant. Income inequality is a major cause for rising house prices, which, in turn, exaggerates income inequality further. This vicious relationship has caused social tension between the rich and the poor and unhappiness among the middle- and low-income groups. This paper discusses the factors responsible for the housing bubble in China and recommends appropriate policies to resolve this problem

The Determinants Of Corporate Social Responsibility Disclosure: Evidence From China

Employing the content analysis approach, this paper aims to identify the determinants of corporate social responsibility disclosure (CSRD) in China using the annual reports of over 800 A-share listed firms on the Shanghai Stock Exchange. We find that CSRD is positively associated with firm size, media exposure, share ownership concentration and institutional shareholding. Moreover, firms in High-Profile environmentally sensitive industries tend to disclose more corporate social responsibility (CSR) information than those in Low-Profile environmentally sensitive industries, supporting the view that political cost is the primary constraint for Chinese listed firms. Our results provide important insights for academics interested in the CSR issue in emerging economies, for enterprise managers interested in exploiting the annual reports as a strategy to legitimize their corporate social conduct, and for government regulators committed to improving CSR activities and information disclosure

Identification of Novel Potential β-N-Acetyl-D-Hexosaminidase Inhibitors by Virtual Screening, Molecular Dynamics Simulation and MM-PBSA Calculations

Chitinolytic β-N-acetyl-d-hexosaminidases, as a class of chitin hydrolysis enzyme in insects, are a potential species-specific target for developing environmentally-friendly pesticides. Until now, pesticides targeting chitinolytic β-N-acetyl-d-hexosaminidase have not been developed. This study demonstrates a combination of different theoretical methods for investigating the key structural features of this enzyme responsible for pesticide inhibition, thus allowing for the discovery of novel small molecule inhibitors. Firstly, based on the currently reported crystal structure of this protein (OfHex1.pdb), we conducted a pre-screening of a drug-like compound database with 8 × 106 compounds by using the expanded pesticide-likeness criteria, followed by docking-based screening, obtaining 5 top-ranked compounds with favorable docking conformation into OfHex1. Secondly, molecular docking and molecular dynamics simulations are performed for the five complexes and demonstrate that one main hydrophobic pocket formed by residues Trp424, Trp448 and Trp524, which is significant for stabilization of the ligand–receptor complex, and key residues Asp477 and Trp490, are respectively responsible for forming hydrogen-bonding and π–π stacking interactions with the ligands. Finally, the molecular mechanics Poisson–Boltzmann surface area (MM-PBSA) analysis indicates that van der Waals interactions are the main driving force for the inhibitor binding that agrees with the fact that the binding pocket of OfHex1 is mainly composed of hydrophobic residues. These results suggest that screening the ZINC database can maximize the identification of potential OfHex1 inhibitors and the computational protocol will be valuable for screening potential inhibitors of the binding mode, which is useful for the future rational design of novel, potent OfHex1-specific pesticides

Mutagenicity of Chinese traditional medicine Semen Armeniacae amarum by two modified Ames tests

<p>Abstract</p> <p>Background</p> <p>Semen armeniacae amarum (SAA) is a Chinese traditional medicine and has long been used to control acute lower respiratory tract infection and asthma, as a result of its expectorant and antiasthmatic activities. However, its mutagenicity <it>in vitro </it>and <it>in vivo </it>has not yet been reported. The Ames test for mutagenicity is used worldwide. The histidine contained in biological samples can induce histidine-deficient cells to replicate, which results in more <it>his</it>⁺colonies than in negative control cells, therefore false-positive results may be obtained. So, it becomes a prerequisite to exclude the effects of any residual histidine from samples when they are assayed for their mutagenicity. Chinese traditional herbs, such as SAA, are histidine-containing biological sample, need modified Ames tests to assay their <it>in vitro </it>mutagenicity.</p> <p>Methods</p> <p>The mutagenicity of SAA was evaluated by the standard and two modified Ames tests. The first modification used the plate incorporation test same as standard Ames teat, but with new negative control systems, in which different amounts of histidine corresponding to different concentrations of SAA was incorporated. When the number of his⁺revertants in SAA experiments was compared with that in new negative control, the effect of histidine contained in SAA could be eliminated. The second modification used a liquid suspension test similar to the standard Ames test, except with histidine-rich instead of histidine-limited medium. The aim of this change was to conceal the effect of histidine contained in SAA on the final counting of <it>his</it>⁺revertants, and therefore to exclude false-positive results of SAA in the Ames test. Furthermore, the effect of SAA on chromosomal aberration in mammalian bone marrow cells was tested.</p> <p>Results</p> <p>The standard Ames test showed a positive result for mutagenicity of SAA. In contrast, a negative response was obtained with the modified plate incorporation and modified suspension Ames tests. Moreover, no apparent chromosomal aberrations were observed in mammalian bone marrow cells treated with SAA.</p> <p>Conclusion</p> <p>The standard Ames test was not suitable for evaluating the mutagenicity of SAA, because false-positive result could be resulted by the histidine content in SAA. However, the two modified Ames tests were suitable, because the experimental results proved that the effect of histidine in SAA and therefore the false-positive result were effectively excluded in these two modified Ames tests. This conclusion needs more experimental data to support in the future. Moreover, the experimental results illustrated that SAA had no mutagenicity <it>in vitro </it>and <it>in vivo</it>. This was in agreement with the clinical safety of SAA long-term used in China.</p

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Can constraint energy-saving policy facilitate industrial green production performance in China?

The role of constraint energy-saving policy (ESP) playing in the coordinated development of energy conservation, emission reduction, and economic growth is of great significance to the country's sustainable progress. Applying a non-radial and non-oriented DEA model incorporating innovation output and multiple undesirable outputs, this paper measures the green production performance (GPP) of China's industrial sectors from 2002 to 2015. And then the effect of implementing energy-saving policy on GPP is investigated through Quasi-difference-in-differences (Quasi-DID) method. The results show that China's industrial GPP rises during 2002-2004 and then declines with fluctuations. Technology change (TC) is the dominant driver. Energy-saving policy positively affects industrial GPP in general yet further dynamic analysis reveals that such a positive effect remains unstable and finally manifests a reverse impact at the end of every five-year-plan period. Therefore, China should properly introduce market mechanisms, formulate comprehensive policy mix strategies to balance sustainable improvement of industrial economy and ecological environment

Can constraint energy-saving policy facilitate industrial green production performance in China?

The role of constraint energy-saving policy (ESP) playing in the coordinated development of energy conservation, emission reduction, and economic growth is of great significance to the country's sustainable progress. Applying a non-radial and non-oriented DEA model incorporating innovation output and multiple undesirable outputs, this paper measures the green production performance (GPP) of China's industrial sectors from 2002 to 2015. And then the effect of implementing energy-saving policy on GPP is investigated through Quasi-difference-in-differences (Quasi-DID) method. The results show that China's industrial GPP rises during 2002-2004 and then declines with fluctuations. Technology change (TC) is the dominant driver. Energy-saving policy positively affects industrial GPP in general yet further dynamic analysis reveals that such a positive effect remains unstable and finally manifests a reverse impact at the end of every five-year-plan period. Therefore, China should properly introduce market mechanisms, formulate comprehensive policy mix strategies to balance sustainable improvement of industrial economy and ecological environment

Co-Evaluation of Plant Leaf Nutrient Concentrations and Resorption in Response to Fertilization under Different Nutrient-Limited Conditions

Plant leaf nutrient concentrations and resorption are sensitive to fertilization, yet their co-responses under different nutrient-limited conditions have not been well studied. We conducted a meta-analysis from a global dataset of 43 reports, including 130 observations of studies with plant leaf nitrogen (N) or phosphorus (P) concentrations and nitrogen resorption efficiency (NRE) or phosphorus resorption efficiency (PRE), in response to fertilization under different nutrient-limited conditions divided by the thresholds of leaf N:P ratio values of 10 and 20. The results showed that N fertilization generally increased leaf N concentration and decreased NRE, with greater magnitudes under N-limited conditions. P fertilization also generally increased leaf P concentration and decreased PRE, with greater magnitudes under P-limited conditions. N fertilization decreased leaf P concentration and increased PRE only under the N-limited condition. Under the P-limited or N and P co-limited conditions, however, N fertilization increased leaf P concentration and did not change PRE. Moreover, P fertilization did not change leaf N concentration under all nutrient-limited conditions but significantly increased NRE under the N-limited or N and P co-limited conditions. These findings suggest that plants cope with fertilization-induced N limitation vs. P limitation at the leaf level with different nutrient-use strategies

Co-Evaluation of Plant Leaf Nutrient Concentrations and Resorption in Response to Fertilization under Different Nutrient-Limited Conditions

Plant leaf nutrient concentrations and resorption are sensitive to fertilization, yet their co-responses under different nutrient-limited conditions have not been well studied. We conducted a meta-analysis from a global dataset of 43 reports, including 130 observations of studies with plant leaf nitrogen (N) or phosphorus (P) concentrations and nitrogen resorption efficiency (NRE) or phosphorus resorption efficiency (PRE), in response to fertilization under different nutrient-limited conditions divided by the thresholds of leaf N:P ratio values of 10 and 20. The results showed that N fertilization generally increased leaf N concentration and decreased NRE, with greater magnitudes under N-limited conditions. P fertilization also generally increased leaf P concentration and decreased PRE, with greater magnitudes under P-limited conditions. N fertilization decreased leaf P concentration and increased PRE only under the N-limited condition. Under the P-limited or N and P co-limited conditions, however, N fertilization increased leaf P concentration and did not change PRE. Moreover, P fertilization did not change leaf N concentration under all nutrient-limited conditions but significantly increased NRE under the N-limited or N and P co-limited conditions. These findings suggest that plants cope with fertilization-induced N limitation vs. P limitation at the leaf level with different nutrient-use strategies