296 research outputs found
A Turnover in the Galaxy Main Sequence of Star Formation at for Redshifts
The relationship between galaxy star formation rates (SFR) and stellar masses
() is re-examined using a mass-selected sample of 62,000
star-forming galaxies at in the COSMOS 2-deg field. Using new
far-infrared photometry from -PACS and SPIRE and -MIPS 24
m, along with derived infrared luminosities from the NRK method based on
galaxies' locations in the restframe color-color diagram vs. , we are able to more accurately determine total SFRs for our complete
sample. At all redshifts, the relationship between median and
follows a power-law at low stellar masses, and flattens to nearly constant SFR
at high stellar masses. We describe a new parameterization that provides the
best fit to the main sequence and characterizes the low mass power-law slope,
turnover mass, and overall scaling. The turnover in the main sequence occurs at
a characteristic mass of about at all redshifts.
The low mass power-law slope ranges from 0.9-1.3 and the overall scaling rises
in SFR as a function of . A broken power-law fit below
and above the turnover mass gives relationships of below the turnover mass and above
the turnover mass. Galaxies more massive than have on average, a much lower specific star formation rate (sSFR) than
would be expected by simply extrapolating the traditional linear fit to the
main sequence found for less massive galaxies.Comment: 16 pages, 7 figures. Accepted for publication in Ap
Transcription Factor Competition Allows Embryonic Stem Cells to Distinguish Authentic Signals from Noise
Stem cells occupy variable environments where they must distinguish stochastic fluctuations from developmental cues. Here, we use optogenetics to investigate how the pluripotency network in embryonic stem cells (ESCs) achieves a robust response to differentiation cues but not to gene expression fluctuations. We engineered mouse ESCs to allow quantitative control over the endogenous mechanism of neural differentiation through a light-inducible Brn2 transgene and monitored differentiation status through a genome-integrated Nanog-GFP reporter. By exposing cells to pulses of Brn2, we find that the pluripotency network rejects Brn2 inputs that are below specific magnitude or duration thresholds, but allows rapid differentiation when both thresholds are satisfied. The filtering properties of the network arise through its positive feedback architecture and the intrinsic half-life of Nanog, which determines the duration threshold in the network. Together our results suggest that the dynamic properties of positive feedback networks might determine how inputs are classified as signal or noise by stem cells
The New Generation Atlas of Quasar Spectral Energy Distributions from Radio to X-rays
We have produced the next generation of quasar spectral energy distributions
(SEDs), essentially updating the work of Elvis et al. (1994) by using
high-quality data obtained with several space and ground-based telescopes,
including NASA's Great Observatories. We present an atlas of SEDs of 85
optically bright, non-blazar quasars over the electromagnetic spectrum from
radio to X-rays. The heterogeneous sample includes 27 radio-quiet and 58
radio-loud quasars. Most objects have quasi-simultaneous ultraviolet-optical
spectroscopic data, supplemented with some far-ultraviolet spectra, and more
than half also have Spitzer mid-infrared IRS spectra. The X-ray spectral
parameters are collected from the literature where available. The radio,
far-infrared, and near-infrared photometric data are also obtained from either
the literature or new observations. We construct composite spectral energy
distributions for radio-loud and radio-quiet objects and compare these to those
of Elvis et al., finding that ours have similar overall shapes, but our
improved spectral resolution reveals more detailed features, especially in the
mid and near-infrared.Comment: 46 pages, 10 figures, 10 tables, Accepted by ApJS. Composite SED data
files for radio-loud and radio-quiet quasars (rlmsedMR.txt, rqmsedMR.txt) are
included in the source (Other formats -> Source). Supplemental figures are
not include
Complete Plastid Genome Sequencing of Trochodendraceae Reveals a Significant Expansion of the Inverted Repeat and Suggests a Paleogene Divergence between the Two Extant Species
The early-diverging eudicot order Trochodendrales contains only two monospecific genera, Tetracentron and Trochodendron. Although an extensive fossil record indicates that the clade is perhaps 100 million years old and was widespread throughout the Northern Hemisphere during the Paleogene and Neogene, the two extant genera are both narrowly distributed in eastern Asia. Recent phylogenetic analyses strongly support a clade of Trochodendrales, Buxales, and Gunneridae (core eudicots), but complete plastome analyses do not resolve the relationships among these groups with strong support. However, plastid phylogenomic analyses have not included data for Tetracentron. To better resolve basal eudicot relationships and to clarify when the two extant genera of Trochodendrales diverged, we sequenced the complete plastid genome of Tetracentron sinense using Illumina technology. The Tetracentron and Trochodendron plastomes possess the typical gene content and arrangement that characterize most angiosperm plastid genomes, but both genomes have the same unusual ~4 kb expansion of the inverted repeat region to include five genes (rpl22, rps3, rpl16, rpl14, and rps8) that are normally found in the large single-copy region. Maximum likelihood analyses of an 83-gene, 88 taxon angiosperm data set yield an identical tree topology as previous plastid-based trees, and moderately support the sister relationship between Buxaceae and Gunneridae. Molecular dating analyses suggest that Tetracentron and Trochodendron diverged between 44-30 million years ago, which is congruent with the fossil record of Trochodendrales and with previous estimates of the divergence time of these two taxa. We also characterize 154 simple sequence repeat loci from the Tetracentron sinense and Trochodendron aralioides plastomes that will be useful in future studies of population genetic structure for these relict species, both of which are of conservation concern
X-UDS: The Chandra Legacy Survey of the UKIDSS Ultra Deep Survey Field
We present the X-UDS survey, a set of wide and deep Chandra observations
of the Subaru-XMM Deep/UKIDSS Ultra Deep Survey (SXDS/UDS) field. The
survey consists of 25 observations that cover a total area of 0.33
deg(2). The observations are combined to provide a nominal depth of
similar to 600 ks in the central 100 arcmin(2) region of the field that
has been imaged with Hubble/WFC3 by the CANDELS survey and similar to
200 ks in the remainder of the field. In this paper, we outline the
survey's scientific goals, describe our observing strategy, and detail
our data reduction and point source detection algorithms. Our analysis
has resulted in a total of 868 band-merged point sources detected with a
false-positive Poisson probability of <1 x 10(-4). In addition, we
present the results of an X-ray spectral analysis and provide
best-fitting neutral hydrogen column densities, N-H, as well as a sample
of 51 Compton-thick active galactic nucleus candidates. Using this
sample, we find the intrinsic Compton-thick fraction to be 30%-35%
over a wide range in redshift (z = 0.1-3), suggesting the obscured
fraction does not evolve very strongly with epoch. However, if we assume
that the Compton-thick fraction is dependent on luminosity, as is seen
for Compton-thin sources, then our results are consistent with a rise in
the obscured fraction out to z similar to 3. Finally, an examination of
the host morphologies of our Compton-thick candidates shows a high
fraction of morphological disturbances, in agreement with our previous
results. All data products described in this paper are made available
via a public website
Preparation and Evaluation of Poly(Ethylene Glycol)âPoly(Lactide) Micelles as Nanocarriers for Oral Delivery of Cyclosporine A
A series of monomethoxy poly(ethylene glycol)âpoly(lactide) (mPEGâPLA) diblock copolymers were designed according to polymerâdrug compatibility and synthesized, and mPEGâPLA micelle was fabricated and used as a nanocarrier for solubilization and oral delivery of Cyclosporine A (CyA). CyA was efficiently encapsulated into the micelles with nanoscaled diameter ranged from 60 to 96 nm with a narrow size distribution. The favorable stabilities of CyA-loaded polymeric micelles were observed in simulated gastric and intestinal fluids. The in vitro drug release investigation demonstrated that drug release was retarded by polymeric micelles. The enhanced intestinal absorption of CyA-loaded polymeric micelles, which was comparable to the commercial formulation of CyA (Sandimmun NeoralÂź), was found. These suggested that polymeric micelles might be an effective nanocarrier for solubilization of poorly soluble CyA and further improving oral absorption of the drug
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