Research on the Oxidative Stress Status of Patients with Phlegm-damp Polycystic Ovary Syndrome and the Intervention of Traditional Chinese Medicine

Objective: To study the oxidative stress status of patients with phlegmatic polycystic ovary syndrome and the effect of important interventions. Methods: Sixty patients with phlegm-damp polycystic ovary syndrome admitted to our hospital between January 2021 and January 2022 were selected. According to the random number table method, the patients were divided into control group (n=30) and observation group (n=30), the control group was treated with metformin hydrochloride tablets, and the observation group was treated with the formula of Jia Wei Qi Gong Wan, and the levels of basal sex hormones (LH, E2), FPG and FINS were compared before and after treatment between the two groups.Serum SOD, MDA, GSH-Px levels before and after treatment, Chinese medicine evidence score before and after treatment. Results: Before treatment, the levels of basal sex hormones, FPG and FINS were compared between the two groups (P > 0.05), and after treatment, the levels of basal sex hormones, FPG and FINS were better in the observation group than in the control group (P < 0.05). Before treatment, the serum SOD, MDA and GSH-Px levels of patients in both groups were compared (P＞0.05), and after treatment, the serum SOD, MDA and GSH-Px levels of patients in the observation group were better than those in the control group (P＜0.05). Before treatment, the TCM evidence points of patients in the two groups were compared (P > 0.05), and after treatment, the TCM evidence points of patients in the observation group were lower than those in the control group (P < 0.05). Conclusion: Patients with phlegm-damp polycystic ovary syndrome have shown remarkable results with herbal interventions, which is worth promoting

Expression and localization of nerve growth factor (NGF) in the testis of alpaca (llama pacos)

During alpaca testis development and spermatogenesis, nerve growth factor (NGF) may play an important role. The main aim of this study was to determine the expression and localization of NGF in the alpaca testis, and to discuss the important role of NGF in alpaca reproductive characteristics. Immunohistochemical staining technique and real-time PCR were used. The expression of NGF in the same cells one-month old (newborn) alpacas 12-month, and 24-month old alpacas showed significant differences (p < 0.05); 12- and 24-month old alpacas showed no significant differences (p > 0.05); NGF at different cell stages showed no significant differences (p > 0.05). It suggests that NGF may be involved in the regulation of spermatogenesis, which provides direct evidence for NGF action in the alpaca testis during postnatal development and spermatogenesis. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 1, pp. 55&#8211;61

Improving the sensitivity of a near-infrared nanocomposite photodetector by enhancing trap induced hole injection

We report the enhancement of the photoconductive gain of nanocomposite near-infrared photodetectors by a zinc oxide nanoparticles (ZnO NPs) rich surface at the nanocomposite/cathode interface. An argon plasma etching process was used to remove polymer at the surface of nanocomposite films, which resulted in a ZnO NPs rich surface. The other way is to spin-coat a thin layer of ZnO NPs onto the nanocomposite layer. The ZnO NPs rich surface, which acts as electron traps to induce secondary hole injection under reverse bias, increased hole injection, and thus the external quantum efficiency by 2–3 times. The darkcurrent declined one order of magnitude simultaneously as a result of etching the top nanocomposite layer. The specific detectivity at 800 nm was increased by 7.4 times to 1.11x1010 Jones due to the simultaneously suppressed noise and enhanced gain

Improving the sensitivity of a near-infrared nanocomposite photodetector by enhancing trap induced hole injection

We report the enhancement of the photoconductive gain of nanocomposite near-infrared photodetectors by a zinc oxide nanoparticles (ZnO NPs) rich surface at the nanocomposite/cathode interface. An argon plasma etching process was used to remove polymer at the surface of nanocomposite films, which resulted in a ZnO NPs rich surface. The other way is to spin-coat a thin layer of ZnO NPs onto the nanocomposite layer. The ZnO NPs rich surface, which acts as electron traps to induce secondary hole injection under reverse bias, increased hole injection, and thus the external quantum efficiency by 2–3 times. The darkcurrent declined one order of magnitude simultaneously as a result of etching the top nanocomposite layer. The specific detectivity at 800 nm was increased by 7.4 times to 1.11x1010 Jones due to the simultaneously suppressed noise and enhanced gain

Leaders’ response to employee overqualification:An explanation of the curvilinear moderated relationship

This research aimed to advance overqualification literature by examining how leaders’ perceived employee overqualification (LPEO) influences their empowering behaviour and employee work behaviours. Drawing upon the individualized leadership theory, we proposed that LPEO has an inverted U-shape relationship with their empowering behaviour such that leaders are more motivated to empower employees from low to moderate levels of overqualification, but this tendency decreases after a certain inflection point. We also predicted that the inflection point occurs at a lower level of employee overqualification when leaders perceive higher (vs. lower) status threats. Leader empowering behaviour was hypothesized to positively predict employees’ voice and negatively predict their withdrawal behaviour. Two multi-source and time-lagged studies were conducted to examine this moderated mediation curvilinear model. In Study 1, survey data from 372 leader–employee dyads supported the inverted U-shape mediation model from leaders’ perceived overqualification to empowering behaviour, then to employee outcomes (i.e., voice and withdrawal behaviour). In Study 2, we collected data from a sample of 73 team leaders and 286 employees, and the results supported the full model. Taken together, these findings offer a perspective to enrich the understanding of employee overqualification and have important practical implications.Practitioner pointsWhen leaders regard employees as overqualified, they can assist them via the means of appropriate empowerment to best utilize their skills to benefit the company.Leader empowerment can inspire employees’ voice behaviour but reduce their withdrawal behaviours.To minimize potentially negative aspects from highly overqualified employees, organizations should reduce leaders’ concern about the status threat, and encourage leaders’ proactive responses to these employees so as to achieve positive returns from overqualified employees

Leaders’ response to employee overqualification:An explanation of the curvilinear moderated relationship

This research aimed to advance overqualification literature by examining how leaders’ perceived employee overqualification (LPEO) influences their empowering behaviour and employee work behaviours. Drawing upon the individualized leadership theory, we proposed that LPEO has an inverted U-shape relationship with their empowering behaviour such that leaders are more motivated to empower employees from low to moderate levels of overqualification, but this tendency decreases after a certain inflection point. We also predicted that the inflection point occurs at a lower level of employee overqualification when leaders perceive higher (vs. lower) status threats. Leader empowering behaviour was hypothesized to positively predict employees’ voice and negatively predict their withdrawal behaviour. Two multi-source and time-lagged studies were conducted to examine this moderated mediation curvilinear model. In Study 1, survey data from 372 leader–employee dyads supported the inverted U-shape mediation model from leaders’ perceived overqualification to empowering behaviour, then to employee outcomes (i.e., voice and withdrawal behaviour). In Study 2, we collected data from a sample of 73 team leaders and 286 employees, and the results supported the full model. Taken together, these findings offer a perspective to enrich the understanding of employee overqualification and have important practical implications.Practitioner pointsWhen leaders regard employees as overqualified, they can assist them via the means of appropriate empowerment to best utilize their skills to benefit the company.Leader empowerment can inspire employees’ voice behaviour but reduce their withdrawal behaviours.To minimize potentially negative aspects from highly overqualified employees, organizations should reduce leaders’ concern about the status threat, and encourage leaders’ proactive responses to these employees so as to achieve positive returns from overqualified employees

Fast Growth of Thin MAPbI\u3csub\u3e3\u3c/sub\u3e Crystal Wafers on Aqueous Solution Surface for Efficient Lateral-Structure Perovskite Solar Cells

Solar-grade single or multiple crystalline wafers are needed in large quantities in the solar cell industry, and are generally formed by a top-down process from crystal ingots, which causes a significant waste of materials and energy during slicing, polishing, and other processing. Here, a bottom-up technique that allows the growth of wafer-size hybrid perovskite multiple crystals directly from aqueous solution is reported. Single-crystalline hybrid perovskite wafers with centimeter size are grown at the top surface of a perovskite precursor solution. As well as saving raw materials, this method provides unprecedented advantages such as easily tunable thickness and rapid growth of the crystals. These crystalline wafers show high crystallinity, broader light absorption, and a long carrier recombination lifetime, comparable with those of bulk single crystals. Lateral-structure perovskite solar cells made of these crystals demonstrate a record power conversion efficiency of 5.9%. Includes supplementary materials

Development of Large-And-Small Volume-Switching Rotary Compressor for Residential Multi-Connected Air-Conditioner

Residential Multi-Connected Air-Conditioner(RMAC) are widely used in urban residential in China, but they have low energy efficiency problems in daily use. They are mainly due to the air-conditioning habits of Chinese residents in part space and part time , Which makes RMAC most of the time only 1-2 indoor units are turned on, and 60% of the operating time is at a low load rate of less than 30%. During low load operation, the compressor\u27s efficiency drops sharply, and there is also the problem of frequent start and stop when the minimum output is too large. In order to solve this problem, a large-and-small volume switching compressor suitable for RMAC is developed. The compressor can choose single-cylinder small-volume operation or twin-cylinder large-volume operation according to the change of system load. The new compressor technology for RMAC improves the energy efficiency by 124% under 10% load, and avoids the problem of frequent start-stops at low loads, making RMAC more energy efficient and more comfortable

Interactions between p-Akt and Smad3 in injured muscles initiate myogenesis or fibrogenesis

In catabolic conditions such as aging and diabetes, IGF signaling is impaired and fibrosis develops in skeletal muscles. To examine whether impaired IGF signaling initiates muscle fibrosis, we generated IGF-IR+/- heterozygous mice by crossing loxP-floxed IGF-IR (exon 3) mice with MyoD-cre mice. IGF-IR+/- mice were studied because we were unable to obtain homozygous IGF-IR-KO mice. in IGF-IR+/- mice, both growth and expression of myogenic genes (MyoD and myogenin; markers of satellite cell proliferation and differentiation, respectively) were depressed. Likewise, in injured muscles of IGF-IR+/- mice, there was impaired regeneration, depressed expression of MyoD and myogenin, and increased expression of TGF-beta 1, alpha-SMA, collagen I, and fibrosis. To uncover mechanisms stimulating fibrosis, we isolated satellite cells from muscles of IGF-IR+/- mice and found reduced proliferation and differentiation plus increased TGF-beta 1 production. in C2C12 myoblasts (a model of satellite cells), IGF-I treatment inhibited TGF-beta 1-stimulated Smad3 phosphorylation, its nuclear translocation, and expression of fibronectin. Using immunoprecipitation assay, we found an interaction between p-Akt or Akt with Smad3 in wild-type mouse muscles and in C2C12 myoblasts; importantly, IGF-I increased p-Akt and Smad3 interaction, whereas TGF-beta 1 decreased it. Therefore, in muscles of IGF-IR+/- mice, the reduction in IGF-IR reduces p-Akt, allowing for dissociation and nuclear translocation of Smad3 to enhance the TGF-beta 1 signaling pathway, leading to fibrosis. Thus, strategies to improve IGF signaling could prevent fibrosis in catabolic conditions with impaired IGF signaling.Satellite HealthAmerican Diabetes AssociationNational Institute of Diabetes and Digestive and Kidney DiseasesBaylor Coll Med, Div Nephrol, Dept Med, Houston, TX 77030 USAEmory Univ, Dept Med, Div Renal, Atlanta, GA 30322 USACapital Med Univ, Beijing An Zhen Hosp, Beijing Inst Heart Lung & Blood Vessel Dis, Beijing, Peoples R ChinaUniversidade Federal de São Paulo, Div Nephrol, Dept Med, São Paulo, BrazilUniversidade Federal de São Paulo, Div Nephrol, Dept Med, São Paulo, BrazilAmerican Diabetes Association: 1-11-BS-194National Institute of Diabetes and Digestive and Kidney Diseases: R37-DK-37175National Institute of Diabetes and Digestive and Kidney Diseases: T32-DK-62706Web of Scienc