Rotational Doppler effect in left-handed materials

We explain the rotational Doppler effect associated with light beams carrying with orbital angular momentum in left-handed materials (LHMs). We demonstrate that the rotational Doppler effect in LHMs is unreversed, which is significantly different from the linear Doppler effect. The physics underlying this intriguing effect is the combined contributions of negative phase velocity and inverse screw of wave-front. In the normal dispersion region, the rotational Doppler effect induces a upstream energy flow but a downstream momentum flow. In the anomalous dispersion region, however, the rotational Doppler effect produces a downstream energy flow but a upstream momentum flow. We theoretically predict that the rotational Doppler effect can induce a transfer of angular momentum of the LHM to orbital angular momentum of the beam.Comment: 6 pages, 3 figure

Electromagnetically induced transparency-based slow and stored light in warm atoms

This paper reviews recent efforts to realize a high-efficiency memory for optical pulses using slow and stored light based on electromagnetically induced transparency (EIT) in ensembles of warm atoms in vapor cells. After a brief summary of basic continuous-wave and dynamic EIT properties, studies using weak classical signal pulses in optically dense coherent media are discussed, including optimization strategies for stored light efficiency and pulse-shape control, and modification of EIT and slow/stored light spectral properties due to atomic motion. Quantum memory demonstrations using both single photons and pulses of squeezed light are then reviewed. Finally a brief comparison with other approaches is presented

Diffusion-induced Ramsey narrowing

A novel form of Ramsey narrowing is identified and characterized. For long-lived coherent atomic states coupled by laser fields, the diffusion of atoms in-and-out of the laser beam induces a spectral narrowing of the atomic resonance lineshape. Illustrative experiments and an intuitive analytical model are presented for this diffusion-induced Ramsey narrowing, which occurs commonly in optically-interrogated systems.Comment: 4 pages, 8 figure

AZI23'UTR Is a New SLC6A3 Downregulator Associated with an Epistatic Protection Against Substance Use Disorders

Regulated activity of SLC6A3, which encodes the human dopamine transporter (DAT), contributes to diseases such as substance abuse disorders (SUDs); however, the exact transcription mechanism remains poorly understood. Here, we used a common genetic variant of the gene, intron 1 DNP1B sequence, as bait to screen and clone a new transcriptional activity, AZI23'UTR, for SLC6A3. AZI23'UTR is a 3' untranslated region (3'UTR) of the human 5-Azacytidine Induced 2 gene (AZI2) but appeared to be transcribed independently of AZI2. Found to be present in both human cell nuclei and dopamine neurons, this RNA was shown to downregulate promoter activity through a variant-dependent mechanism in vitro. Both reduced RNA density ratio of AZI23'UTR/AZI2 and increased DAT mRNA levels were found in ethanol-naive alcohol-preferring rats. Secondary analysis of dbGaP GWAS datasets (Genome-Wide Association Studies based on the database of Genotypes and Phenotypes) revealed significant interactions between regions upstream of AZI23'UTR and SLC6A3 in SUDs. Jointly, our data suggest that AZI23'UTR confers variant-dependent transcriptional regulation of SLC6A3, a potential risk factor for SUDs

Glial βii spectrin contributes to paranode formation and maintenance

Action potential conduction along myelinated axons depends on high densities of voltage-gated Na channels at the nodes of Ranvier. Flanking each node, paranodal junctions (paranodes) are formed between axons and Schwann cells in the peripheral nervous system (PNS) or oligodendrocytes intheCNS. Paranodal junctions contribute to both no deassembly and maintenance. Despitetheir importance, the molecular mechanisms responsible for paranode assembly and maintenance remain poorly understood. βII spectrin is expressed in diverse cells and is an essential part of the submembranous cytoskeleton. Here, we show that Schwann cell βII spectrin is highly enriched at paranodes. To elucidate the roles of glial βII spectrin, we generated mutant mice lacking βII spectrin in myelinating glial cells by crossing mice with a floxed allele of Sptbn1 with Cnp-Cre mice, and analyzed both male and female mice. Juvenile (4 weeks) and middle-aged (60 weeks) mutant mice showed reduced grip strength and sciatic nerve conduction slowing, whereas no phenotype was observed between 8 and 24 weeks of age. Consistent with these findings, immunofluorescence microscopy revealed disorganized paranodes in the PNS and CNS of both postnatal day 13 and middle-aged mutant mice, but not in young adult mutant mice. Electron microscopy confirmed partial loss of transverse bands at the paranodal axoglial junction in the middle-aged mutant mice in both the PNS and CNS. These findings demonstrate that a spectrin-based cytoskeleton in myelinating glia contributes to formation and maintenance of paranodal junctions.Fil: Susuki, Keiichiro. Baylor College of Medicine; Estados UnidosFil: Zollinger, Daniel R.. Baylor College of Medicine; Estados UnidosFil: Chang, Kae Jiun. Baylor College of Medicine; Estados UnidosFil: Zhang, Chuansheng. Baylor College of Medicine; Estados UnidosFil: Huang, Claire Yu Mei. Baylor College of Medicine; Estados UnidosFil: Tsai, Chang Ru. Baylor College of Medicine; Estados UnidosFil: Galiano, Mauricio Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina. Baylor College of Medicine; Estados UnidosFil: Liu, Yanhong. Baylor College of Medicine; Estados UnidosFil: Benusa, Savannah D.. Virginia Commonwealth University; Estados UnidosFil: Yermakov, Leonid M.. Wright State University; Estados UnidosFil: Griggs, Ryan B.. Wright State University; Estados UnidosFil: Dupree, Jeffrey L.. Virginia Commonwealth University; Estados UnidosFil: Rasband, Matthew N.. Baylor College of Medicine; Estados Unido

Exploring ecological specialization in pipefish using genomic, morphometric and ecological evidence

AbstractAimTheory predicts that ecological specialization should be rare in marine ecosystems, given that dispersal barriers are less effective in the vastness of the sea compared with those in terrestrial settings. This paradigm, however, hardly fits with classical theories of local adaptation, raising the question of how marine diversity originates in a highly interconnected system. In the present study, we investigated how ecological specialization arises in a widely distributed marine species, the seaweed pipefish Syngnathus schlegeli.LocationChinese coastal waters.MethodsWe integrated morphological (geometric morphometry), genetic (RADseq) and ecological (species distribution models and n‐dimensional hypervolumes) evidence to shed light on population structuring in S. schlegeli.ResultsWe revealed the existence of a north‐to‐south phenotypic gradient in eye size among S. schlegeli populations. This morphological differentiation was paralleled by genetic divergence, with South China Sea populations emerging as relatively independent. We further investigated the ecological differentiation of S. schlegeli populations. We observed high niche differentiation among northern, central and southern populations, resulting from both niche expansion and niche shift processes. Projected habitat suitability onto the Last Glacial Maximum revealed the existence of historical barriers to dispersal between the South and East China seas.Main conclusionsWe showed that the effect of this historical segregation, in concert with niche‐driven ecological differentiation, might lead to the establishment of three distinct clades across the widely distributed marine pipefish. Ultimately, our study demonstrates that even the high connected sea environment maintains the potential for ecological specialization

Generation of cloned transgenic pigs rich in omega-3 fatty acids

Meat products are generally low in omega-3 (n-3) fatty acids, which are beneficial to human health. We describe the generation of cloned pigs that express a humanized Caenorhabditis elegans gene, fat-1, encoding an n-3 fatty acid desaturase. The hfat-1 transgenic pigs produce high levels of n-3 fatty acids from n-6 analogs, and their tissues have a significantly reduced ratio of n-6/n-3 fatty acids (P < 0.001). © 2006 Nature Publishing Group