High dose concentration administration of ascorbic acid inhibits tumor growth in BALB/C mice implanted with sarcoma 180 cancer cells via the restriction of angiogenesis

To test the carcinostatic effects of ascorbic acid, we challenged the mice of seven experimental groups with 1.7 × 10-4 mol high dose concentration ascorbic acid after intraperitoneal administrating them with sarcoma S-180 cells. The survival rate was increased by 20% in the group that received high dose concentration ascorbic acid, compared to the control. The highest survival rate was observed in the group in which 1.7 × 10-4 mol ascorbic acid had been continuously injected before and after the induction of cancer cells, rather than just after the induction of cancer cells. The expression of three angiogenesis-related genes was inhibited by 0.3 times in bFGF, 7 times in VEGF and 4 times in MMP2 of the groups with higher survival rates. Biopsy Results, gene expression studies, and wound healing analysis in vivo and in vitro suggested that the carcinostatic effect induced by high dose concentration ascorbic acid occurred through inhibition of angiogenesis

One-Step Synthesis of Transition Metal Dichalcogenide Quantum Dots Using Only Alcohol Solvents for Indoor-Light Photocatalytic Antibacterial Activity

In this study, we report a one-step direct synthesis of molybdenum disulfide (MoS2) and tungsten disulfide (WS2) quantum dots (QDs) through a solvothermal reaction using only alcohol solvents and efficient Escherichia coli (E. coli) decompositions as photocatalytic antibacterial agents under visible light irradiation. The solvothermal reaction gives the scission of molybdenum-sulfur (Mo-S) and tungsten-sulfur (W-S) bonding during the synthesis of MoS2 and WS2 QDs. Using only alcohol solvent does not require a residue purification process necessary for metal intercalation. As the number of the CH3 groups of alcohol solvents among ethyl, isopropyl, and tert(t)-butyl alcohols increases, the dispersibility of MoS2/WS2 increases. The CH3 groups of alcohols minimize the surface energy, leading to the effective exfoliation and disintegration of the bulk under heat and pressure. The bulky t-butyl alcohol with the highest number of methyl groups shows the highest exfoliation and yield. MoS2 QDs with a lateral size of about 2.5 nm and WS2 QDs of about 10 nm are prepared, exhibiting a strong blue luminescence under 365 nm ultraviolet (UV) light irradiation. Their heights are 0.68-3 and 0.72-5 nm, corresponding to a few layers of MoS2 and WS2, respectively. They offer a highly efficient performance in sterilizing E. coli as the visible-light-driven photocatalyst. © 2023 American Chemical Society11Nscopu

Binder-free TiO2 hydrophilic film covalently coated by microwave treatment

A binder-free attachment method for TiO2 on a substrate has been sought to retain high active photocatalysis. Here, we report a binder-free covalent coating of phase-selectively disordered TiO2 on a hydroxylated silicon oxide (SiO2) substrate through rapid microwave treatment. We found that Ti-O-Si and Ti-O-Ti bonds were formed through a condensation reaction between the hydroxyl groups of the disordered TiO2 and Si substrate, and the disordered TiO2 nanoparticles themselves, respectively. This covalent coating approach can steadily hold the active photocatalytic materials on the substrates and provide long-term stability. The binder-free disordered TiO2 coating film can have a thickness (above 38 mu m) with high surface integrity with a strong adhesion force (15.2 N) against the SiO2 substrate, which leads to the production of a rigid and stable TiO2 film. This microwave treated TiO2 coating film showed significant volatile organic compounds degradation abilities under visible light irradiation. The microwave coated selectively reduced TiO2 realized around 75% acetaldehyde degradation within 12 h and almost 90% toluene degradation after 9 h, also retains stable photodegradation performance during the cycling test. Thus, the microwave coating approach allowed the preparation of the binder-free TiO2 film as a scalable and cost-effective method to manufacture the TiO2 film that shows an excellent coating quality and strengthens the application as a photocatalyst under severe conditions.11Nsciescopu

Entrepreneurship in East Asian Regional Innovation Systems: Role of social capital

This paper analyzes the role of social capital in entrepreneurial RIS (Regional Innovation Systems). We disaggregate the features of mature entrepreneurial RIS into three dimensions of social capital: structural, relational, and cognitive. We apply these features of mature entrepreneurial RIS to the still-evolving entrepreneurial RIS from East Asia including Daedeok Innopolis of Korea and Hsinchu Science Park of Taiwan. The spawning effect of representative companies within focal industries, collaboration among the key organizational actors, and attraction and retention of talent are taken into account. The study uncovers a new aspect of still-evolving entrepreneurial RIS, which complements the existing typology categorizing RIS into institutional RIS and entrepreneurial RIS. Whereas the conventional literature has viewed the East Asian RIS as institutional RIS, the findings of this study allow scholars to view the East Asian RIS as entrepreneurial in their own distinctive manner. Meanwhile, we also find an important implication for making a shift from a top-down to a bottom-up approach in order for the still-evolving entrepreneurial RIS to vitalize cognitive social capital. Thus, we suggest the transitions from outward-looking social capital to inward-looking social capital