(E)-3,4-Dihydroxy­benzaldehyde 4-ethyl­thio­semicarbazone

The title compound, C10H13N3O2S, was prepared by condensation of 3,4-dihydroxy­benzaldehyde with 4-ethyl-3-thio­semicarbazide. The mol­ecule adopts an E configuration with respect to the C=N bond. One of the OH substituents on the dihydroxy­benzene ring is disordered over the two possible 3-positions on either side of the ordered 4-hydr­oxy group. The occupancy of the major disorder component refined to 0.633 (7). The mol­ecule is essentially planar, with an r.m.s. deviation through all non-H atoms of 0.0862 Å. An intra­molecular N—H⋯N hydrogen bond forms between the outer amine residue and the imine N atom, generating an S(5) ring motif and contributing to the planarity of the mol­ecule. In the crystal structure, an extensive network of classical O—H⋯O, O—H⋯S and N—H⋯S hydrogen bonds and weak C—H⋯O and S⋯O [3.301 (3) Å] inter­actions link mol­ecules into sheets running approximately parallel to the ab plane

5-Amino-1-(4-nitro­phen­yl)-1H-pyrazole-3-carbonitrile

The title compound, C10H7N5O2, was synthesized by the reaction of 4-nitro­aniline and 2,3-dicyano­propionic acid ethyl ester. In the crystal, N—H⋯O and C—H⋯O hydrogen bonds link the mol­ecules, forming a three-dimensional network

(E)-5-Phenyl-N′-(1-phenyl­ethyl­idene)-1H-pyrazole-3-carbohydrazide

In the mol­ecule of the title compound, C18H16N4O, the intra­molecular N—H⋯N hydrogen bond results in the formation of a planar five-membered ring, which is also co-planar with the adjacent five-membered ring, being oriented at a dihedral angle of 1.23 (3)°. The dihedral angles formed by the planar pyrazole ring with the adjacent phenyl ring and the other phenyl ring are 7.29 and 11.21°, respectively. The dihedral angle between the two phenyl rings is 18.07°. In the crystal structure, inter­molecular N—H⋯O hydrogen bonds link the mol­ecules

(meso-5,7,7,12,14,14-Hexamethyl-1,4,8,11-tetra­azacyclo­tetra­deca-4,11-diene)copper(II) bis­[O,O′-bis­(4-methyl­phen­yl) dithio­phosphate]

The title compound, [Cu(C16H32N4)](C14H14O2PS2)2 or [Cu(trans[14]dien)][S2P(OC6H4Me-4)2]2, where trans[14]dien is meso-5,7,7,12,14,14-hexa­methyl-1,4,8,11-tetra­azacyclo­tetra­deca-4,11-diene, was obtained by the reaction of [Cu(trans[14]dien)](ClO4)2 and [(C2H5)2NH]2 [S2P(OC6H4Me-4)2]2. The CuII atom lies on a centre of inversion and possesses a relatively undistorted square-planar coordination arrangement with four N atoms of the macrocyclic tetra­mine trans[14]dien [Cu—N = 1.9716 (19) and 2.0075 (19) Å]. The two uncoordinated [(4-MeC6H4O)2PS2]− groups act as counter-ions to balance the charge and inter­act with the [Cu(trans[14]dien)]2+ complex cation through N—H⋯S hydrogen bonds

Multicolor Photometry Study of the Galaxy Cluster A2589: Dynamics, Luminosity Function and Star Formation History

In this paper we present a multicolor photometry for A2589 ($z=0.0414$) with 15 intermediate bands in the Beijing-Arizona-Taiwan-Connecticut (BATC) system which covers an optical wavelength range from 3000 \AA\ to 10000 \AA. The spectral energy distributions (SEDs) for more than 5000 sources are achieved down to {\it V} $\sim$ 20 mag in about 1 deg$^{2}$ field. A2589 has been also covered by the Sloan Digital Sky Survey (SDSS) in photometric mode only. A cross-identification of the BATC-detected galaxies with the SDSS photometric catalog achieves 1199 galaxies brighter than $i=19.5$ mag, among which 68 member galaxies with known spectroscopic redshifts are found. After combining the SDSS five-band photometric data and the BATC SEDs, the technique of photometric redshift is applied to these galaxies for selecting faint member galaxies. The color-magnitude relation is taken as a further restriction of early-type cluster galaxies. As a result, 106 galaxies are newly selected as member galaxies. Spatial distribution of member galaxies shows a north-south elongation which agrees with the X-ray brightness profile and the orientation of central cD galaxy, NGC 7647. No substructures are detected on the basis of positions and radial velocities of cluster galaxies, indicating that A2589 is a well-relaxed system. The luminosity function of A2589 exhibits a peak at $M_{R} \sim -20$ mag and a dip at $M_{R} \sim -19$ mag. The low-density outer regions are the preferred habitat of faint galaxies. With the evolutionary population synthesis model, PEGASE, the environmental effect on the star formation properties for 68 spectroscopically confirmed member galaxies is studied. The outlier faint galaxies tend to have longer time scales of star formation, shorter mean stellar ages, and lower metallicities of interstellar medium, which can be interpreted in the context of hierarchical cosmological scenario.Comment: 2011 Accepted to A

Competition of electronic correlation and reconstruction in La1-xSrxTiO3/SrTiO3 heterostructures

Electronic correlation and reconstruction are two important factors that play a critical role in shaping the magnetic and electronic properties of correlated low-dimensional systems. Here, we report a competition between the electronic correlation and structural reconstruction in La1-xSrxTiO3/SrTiO3 heterostructures by modulating material polarity and interfacial strain, respectively. The heterostructures exhibit a critical thickness (tc) at which a metal-to-insulator transition (MIT) abruptly occurs at certain thickness, accompanied by the coexistence of two- and three-dimensional (2D and 3D) carriers. Intriguingly, the tc exhibits a V-shaped dependence on the doping concentration of Sr, with the smallest tc value at x = 0.5. We attribute this V-shaped dependence to the competition between the electronic reconstruction (modulated by the polarity) and the electronic correlation (modulated by strain), which are borne out by the experimental results, including strain-dependent electronic properties and the evolution of 2D and 3D carriers. Our findings underscore the significance of the interplay between electronic reconstruction and correlation in the realization and utilization of emergent electronic functionalities in low-dimensional correlated systems

Characterizing the aftermath of a medium-sized outburst of Centaur 29P/Schwassmann-Wachmann 1 using HST/WFC3

Comet 29P/Schwassmann-Wachmann 1 (hereafter, 29P) is a highly active andprominent member of the Centaur population. Centaurs are icy bodies with orbits between Jupiter and Neptune, which dynamically link the Jupiter-family comets to the trans-Neptunian objects of the outer solar system. Hovering at large heliocentricdistances, where the sublimation of water ice is negligible, the mechanism driving the outbursts of comet 29P remains undetermined. We present target of opportunity observations collected with the Hubble Space Telescope (HST) Wide Field Camera 3 (WFC3), acquired following reports of a possible fragmentation event of 29P before Oct. 1.3, 2019 (M.S.P. Kelley, et al., ATEL 13164, 2019). Our observing cadence captured 29P within two days of a 0.9 mag, thus medium-sized outburst, and provided observations before and after the event for context and to probe the development of the ejecta. Between the purported fragmentation event and the HST observations, 29P underwent two small outbursts on Oct. 7 and Oct. 16, 2019 (both of amplitude 0.4-0.5 mag; Q. Z. Ye et al., ATEL 13179, 2019; M. S. P. Kelley, UMD, priv. comm.), followed by a medium-sized outburst with an amplitude of 0.9 mag around Oct. 19.5, 2019 (D. Bodewits, AU; R. Miles, BAA comet section, priv. comm). HST observed 29P three times, on Oct. 14.75, Oct. 20, and Oct. 28.5, 2019. A detailed characterization of the coma morphology, dynamics, and the results of deep, sub-km search for fragments will be provided in our presentation. Cross-listed as presentation #503.02

Blood-Based Biomarkers of Aggressive Prostate Cancer

Purpose: Prostate cancer is a bimodal disease with aggressive and indolent forms. Current prostate-specific-antigen testing and digital rectal examination screening provide ambiguous results leading to both under-and over-treatment. Accurate, consistent diagnosis is crucial to risk-stratify patients and facilitate clinical decision making as to treatment versus active surveillance. Diagnosis is currently achieved by needle biopsy, a painful procedure. Thus, there is a clinical need for a minimally-invasive test to determine prostate cancer aggressiveness. A blood sample to predict Gleason score, which is known to reflect aggressiveness of the cancer, could serve as such a test. Materials and Methods: Blood mRNA was isolated from North American and Malaysian prostate cancer patients/controls. Microarray analysis was conducted utilizing the Affymetrix U133 plus 2·0 platform. Expression profiles from 255 patients/controls generated 85 candidate biomarkers. Following quantitative real-time PCR (qRT-PCR) analysis, ten disease-associated biomarkers remained for paired statistical analysis and normalization. Results: Microarray analysis was conducted to identify 85 genes differentially expressed between aggressive prostate cancer (Gleason score ≥8) and controls. Expression of these genes was qRT-PCR verified. Statistical analysis yielded a final seven-gene panel evaluated as six gene-ratio duplexes. This molecular signature predicted as aggressive (ie, Gleason score ≥8) 55% of G6 samples, 49% of G7(3+4), 79% of G7(4+3) and 83% of G8-10, while rejecting 98% of controls. Conclusion: In this study, we have developed a novel, blood-based biomarker panel which can be used as the basis of a simple blood test to identify men with aggressive prostate cancer and thereby reduce the overdiagnosis and overtreatment that currently results from diagnosis using PSA alone. We discuss possible clinical uses of the panel to identify men more likely to benefit from biopsy and immediate therapy versus those more suited to an “active surveillance” strategy