Prenylated Dihydrostilbenes From Macaranga rubiginosa

Phytochemical isolation of the methanol extract of Macaranga rubiginosa leaves afforded five prenylated dihydrostilbenes. Two of them were known dihydrostilbenes laevifolins A (1) and B (2), while the other three were new compounds, trivially named macarubiginosins A–C (3–5). The structures of the new compounds were elucidated based on their UV, 1D and 2D NMR, and HR-ESI-MS spectral data. Compounds 1–5 were tested for their cytotoxicity against P-388 cells, showing that compound 1 was the most active with IC 50 4.3 µM

ISOLASI DAN KARAKTERISASI METABOLIT SEKUNDER DARI EKSTRAK ASETON DAUN MACARANGA PRUINOSA BANGKA BELITUNG

Macaranga is a large genus in Euphorbiaceae, locally known as "Mahang-mahangan", and consisting about 300 species. Distribution of Macaranga is widespread from Africa and Madagascar in the west to the tropical regions of Asia including Indonesia. Based on previous research of the M. pruinosa, secondary metabolites that have been reported are flavonoid, and stilbenoid derivatives from Borneo. M. pruinosa that grow in South Sumatra produce poilanoat acid (diterpene). Therefore, this research is done to investigate phytochemical constituent of leaves of M. pruinosa from Bangka Belitung Islands. Isolation is done by maceration in acetone, separation and purification using vacuum liquid chromatography and radial chromatography. Structure determination were elucidated by 1H-NMR,13C-NMR, 2D NMR. Two compounds are identified as flavanon derivatives. They are nymphaeol B, and 6-farnesil-3',4',5,7-tetrahidroksiflavanon. These compounds are substituted with terphenyl group, known as geranyl (C10), and farnesyl (C15). Nymphaeol B (1) and compound of 6-farnesil-3', 4', 5,7-tetrahidroksiflavanon (2) have been found in other species of Macaranga. In conclusion, we here acquired two phenolic derivatives substituted by terphenyl groups from acetone extracts of leaves of M. pruinosa from Bangka Belitung. They are nymphaeol B, and 6-farnesil-3',4',5,7-tetrahidroksiflavanon. The result showed that M.pruinosa can produce different secondary metabolites depend on where they grow.

Antibacterial Curcuma xanthorrhiza Extract and Fractions

An acetone extract of Curcuma xanthorrhiza rhizomes and the n-hexane and chloroform fractions obtained from it were tested on eight pathogenic bacteria. The results showed that the acetone extract and the nhexane fraction exhibited significant activities against Bacillus subtilis, Pseudomonas aeruginosa, and Staphylococcus aureus, and weak activities against Shigella dysenteriae and Vibrio cholerae. They were inactive against Escherichia coli, Enterobacter aerogenes and Salmonella thypi, while the chloroform fraction was devoid of activities. NMR analysis disclosed the presence of α-curcumene, xanthorrhizol and an unknown monoterpene in the nhexane fraction. In the chloroform fraction, curcumin was found to be the main compound, together with xanthorrhizol as a minor compound. These results suggest that the antibacterial potency of acetone extract of C. xanthorrhiza is contained in the n-hexane fraction, in which the active constituents are terpenoid compounds. This is the first report of the use of NMR analysis for compound identification contained in an extract or fractions of C. xanthorrhiza

Dihydroflavonol and Flavonol Derivatives from Macaranga recurvata

Two new dihydroflavonol derivatives, macarecurvatins A and B, have been isolated from the leaves of Macaranga recurvata (Euphorbiaceaae), along with the known compounds diisoprenylaromadendrin, glyasperin A and broussoflavonol F. The structures of the new compounds were determined on the basis of of 0.83 M. spectroscopic evidence. Upon cytotoxic evaluation against P-388 cells, macarecurvatin B showed strong activity with an IC 5

Flavonoid and stilbene derivatives from Macaranga trichocarpa

A new farnesylated flavonol (4′-O-methylmacagigantin) and a new geranylated stilbene (macatrichocarpin H), together with eight known phenolic compounds, have been isolated from the leaves of Macaranga trichocarpa. Structures of these compounds were determined based on NMR and mass spectrroscopic data. Cytotoxic properties of the isolated compounds were tested against P-388 cells showing that mactrichocarpin G was the most active compound with IC 50 was 3.5 μM

Macagigantin, a farnesylated flavonol from Macaranga gigantea

A new farnesylated flavonol derivative, macagigantin (1), together with two known flavonoids, glyasperin A (2) and apigenin (3), had been isolated from the acetone extract of the leaves of Macaranga gigantea. The structure of the new compound was elucidated as 6-farnesylkaempferol based on its spectroscopic data, including UV, IR, 1D and 2D NMR, and HR-EI-MS spectra. Compounds 1–3 were evaluated for their cytotoxic properties against P-388 cells, their IC values being 11.3, 6.0, and 5.1 mM, respectively

Senyawa Morusin dari Tumbuhan Murbei Hitam (Morus Nigra)

Tumbuhan murbei hitam merupakan salah satu spesies dari genus Morus. Tumbuhan dari genus ini telah dilaporkan kaya akan senyawa turunan fenol seperti flavonoid, 2-arilbenzofuran dan stilben. Dalam rangka pencarian senyawa turunan fenol dari tumbuhan murbei Indonesia maka telah berhasil diisolasi suatu senyawa flavon terprenilasi yaitu morusin dari ekstrak metanol kayu batang murbei hitam (M. nigra). Struktur senyawa tersebut telah ditetapkan berdasarkan data-data spektroskopi yang meliputi spektrum UV dan IR serta membandingkan KLTnya dengan senyawa morusin standar

Aktivitas Sitotoksik Alkaloid Dari Cryptocarya Archboldiana Allen

Cryptocarya is one of the largest genus of Lauraceae and most of the species grow in the tropical rain forests of Asia-Pacific, include in Indonesian forest. Generally Cryptocarya contains alkaloids, 2-piron, and flavonoids as well as has a variety of biological activities. Three alkaloids have been isolated from Cryptocarya archboldiana; boldine, laurolitsine, and reticuline. The molecular structure of all these compounds have been established by spectroscopic analysis (UV, 1H, and 13C NMR) and comparison with the spectral data of compounds that have been reported. The cytotoxic of laurolitsine showed moderate activity, while boldine and reticuline have weak activity against P388 murine leukemia cells. Key words: C. archboldiana, alkaloid, cytotoxic, aporphine, benzylisoquinoline

Resveratrol Oligomers From Dipterocarpus Hasseltii: Cytotoxic Effect and Chemotaxonomic Significance

Two resveratrol tetramers, (-)-vaticanol B and (-)-hopeaphenol, were isolated from acetoneextract of the tree bark of Dipterocarpus hasseltii (Dipterocarpaceae), together with the knownresveratrol trimer, (-)-α-viniferin. The structures of these compounds were established based onspectroscopic evidence, UV, IR,1H-NMR,13C-NMR and determined by comparison with thestandard compounds. The cytotoxic activities of these compounds were evaluated against murineleukaemia P-388 cells. The IC50 values of all compounds were 42.2, 5.0 and 17.5 μg/ml,respectively. In addition, chemotaxonomic significance relationship between Dipterocarpus, Shoreaand Vatica will also be briefly discussed

Proceeding of The International Seminar on Chemistry

Abstract In recent years the separation chemistry of the rare-earth elements (REE) continue to receive a growing interest. The major reasons for this stand from the high application interest of the REE in many field. Elements such as Ce, La, Sm, Gd, and Nd and their compounds find various commercial applications. Gd is useful in nuclear technology for fuel element fabrication and as control rods, and as refractory material in ceramic industries.The pyrazolone and their derivates compound has been known that can be used for selective extraction and separations of metal ions such as REE. In this experiment, HPMBP has been synthesized and characterized by melting point, TLC, HPLC, FTIR, and NMR spectral data. The sorption of Ce , and sorption capacity of the impregnated resin were investigated by batch method