GENERATING DSS GRAPH BY EDGE SUBDIVISION AND EDGE CONTRACTION

A graph G is said to be domination subdivision stable ( DSS ) if g ( Gsd uv ) = g ( G ), for all u, v ÃŽ V ( G ), u adjacent to v. In this paper we have provided two methods of obtaining a DSS graph from a non DSS graph

DRUG pKa VALUE PREDICTION – FROM COMPRESSED GRAPH

Objective: Topological indices are interesting since they capture some of the properties of a molecule in a single number. pKa value indicates the strength of the acid in each molecule of the chemical compounds or drugs. The objective of this research was to predict the pKa value of drugs using graph theory. Method: In this paper, we use a graph property eccentricity and the regression, a statistical model to predict the value of pKa by compressing the hexagonal system of the graph structure of drugs which reduces the calculation of eccentricity. Results: pKa value of the new medicine can be determined using regression analysis by fitting in a linear equation of a straight line. Conclusion: The results obtained in this research work clearly indicated that we found out the pKa value of local anesthesia which has similar structures. Further, we can use this method for other physicochemical properties such as boiling point, melting point, and vapor pressure by compressing the drug graph

Isolation and description of keratinase producing marine actinobacteria from South Indian Coastal Region

A unique standard starch casein medium has been implemented for the isolation of actinobacteria from the south Indian marine sediments. A combination of techniques, morphological, physiological and biochemical tests provided the evidence for the isolated actinobacteria. All the 56 isolates were inoculated on milk agar and soya meal agar plates for the primary proteolytic screening and the proportional study was made by ANOVA. Among the 56 isolates, nine showed proteolytic activity in terms of making clear zone around their colony on the plates. Then, nine isolates were subjected to the secondary screening on feather broth where three isolates (IS -1, 2 and 18) showed degradation of feather between seven and ten days. The keratinolytic characters of crude enzymes were scrutinized by feather keratin as substrate and the protein concentration was determined. Then, the isolates were identified at molecular level by 16S rRNA gene amplification technique.Key words: Actinobacteria, keratinase, milk agar, soya meal agar, 16S rRNA gene amplification

INSERTION METHOD USING MUSIC NOTES

Communication signals are openly available as they are propagated. Secured transmission is always a question and various methods are devised.  Use of music notes is not in wide use in encryption of data. Any musical note consists of seven basic keys. In this paper we propose an insertion method with the seven music keys are used as a tool of encryption

ROLE OF NON-WOOD FOREST PRODUCTS IN POVERTY REDUCTION AMONG TRIBALS IN WESTERN GHATS OF TAMILNADU

The enormous natural resources of India's forests including Non-Wood forest products (NWFPs), such as medicinal and aromatic plants, leaves, seeds, nuts, fruits and gums offer employment that provide up to half the income of about 25 % of the country's rural labor force. Despite of the potential benefits that are offered by non-wood forest products, it has been widely documented that forest still offers little in terms of opportunities for expanding livelihood options and assets required to reduce livelihood vulnerability. Based on this, a study was carried out to determine the contribution of NWFPs towards poverty reduction by assessing potentials and constraints experienced by adjacent local communities towards their exploitation. The specific objective of the study is to assess the role of NWFPs contribution to tribal income and also influence on the poverty reduction. The study was conducted in Kodaikanal and Palani range in Dindigul district of Tamil Nadu state. The data were collected personally in cooperation with forest officers and other officials of the district by using pre-tested interview schedule. The findings reveals that the 65 selected households involved for collection of myrobalam (kadukkai), honey, amla, broom grass, stone flower, pepper, and coffee. These products were easily accessible and available to them and these activities are the important source of employment and income. The tribes earned at an average per day, from the collection of NWFPs of Rs700 for broom grass, Rs.650 for kadukkai, Rs.600 for amla, Rs.500 for pepper, and Rs.400 for coffee and stone flower. Regarding honey collection, the tribes earned Rs.400 per liter. Majority of the respondents (92.3 %) were facing the problems related to lack of transport facilities for NWFPs existence of bad weather (76.9 %), deforestation(69.2 %), fluctuated market price (61.5 %), lack of storage facilities for NWFPs (56.9 %), over collection of outsiders (38.4 %), low infrastructure facilities for NWFPs (18.4 %), lack of skill oriented training for NWFPs(16.9 %) and lack of timely information for marketing of NWFPs (15.3 %). It is suggested that there is a need to take necessary steps by the government to eliminate these existing problems faced by the respondent of study area. Respondents expected nearby Ration shop and Primary health centre from the district authority

A study on the influence of plasma concentrations of adriamycin, cyclophosphamide and paclitaxel on the clinical outcome of patients with breast cancer in a tertiary care hospital

BACKGROUND: Chemotherapy is a well-established therapeutic modality known for ages for the treatment of breast cancer. Both adjuvant and neoadjuvant chemotherapy has significantly reduced the morbidity and mortality associated with breast cancer. However, chemotherapy is associated with an increased incidence of adverse effects attributed to the drug as well as patient characteristics. In majority of patients, the dose which produces the therapeutic effect may also be responsible for toxic effects. Therefore, optimizing the drug dosage to reduce the exposure may have the therapeutic advantage of maximizing the efficacy of the drug while reducing the adverse effects. AIM OF THE STUDY: To study the influence of plasma concentration of Adriamycin, Cyclophosphamide and Paclitaxel on the liver and renal functions, tumour size reduction, receptor status (ER/PR) and adverse drug effects of patients with breast cancer. METHODOLOGY: This study was done in the Department of Pharmacology, PSG Institute of Medical Sciences and Research (PSG IMS&R), Coimbatore during the period of November 2016 to October 2017. A total of 30 patients with breast cancer on AC/T regimen (Adriamycin and Cyclophosphamide 4 cycles followed by Paclitaxel 4 cycles) were enrolled and were grouped into 3, with 10 patients for each drug under study. The data pertaining to the treatment of breast cancer such as tumour size, drug and dosage, Estrogen/Progesterone receptor (ER/PR) status, laboratory parameters including liver and renal function test and complete blood count (CBC), nature of chemotherapy (adjuvant /neoadjuvant) and number of cycles completed were obtained from the medical records of the patient. Patients were also asked about the occurrence of adverse effects like nausea, vomiting, etc. About two ml of venous blood was collected from the study participants at the end of infusion of the drug and centrifuged to separate plasma. The samples were then analyzed using HPLC and the plasma concentration of the drugs was determined. RESULTS: The mean plasma concentration of Adriamycin, Cyclophosphamide and Paclitaxel was found to be 3460.50, 1592.44 and 3038.29 ng/ml respectively. We found that the plasma concentration of the drugs showed inter-individual variations which were consistent with the previous studies. The statistical analysis was done using Pearson correlation. No significant correlation of plasma concentration of these chemotherapeutic drugs was found with the other clinical, biochemical and hormonal parameters. CONCLUSION: From our study we conclude that the plasma concentration alone is not a determinant of clinical outcome or toxicities in these patients. Dose optimisation has to be validated prospectively in a large group of patients with more pharmacokineticpharmacodynamic parameters

A Range Query Algorithm to Process KNN Queries in Cloud Computing

In Public Cloud environment, security and data confidentiality is the major problem facing by all the data controller. The service user can take the service from the cloud by getting authorization from the service provider and he can only pay for the service by using the server, for that the service provider lose the control so there may have chances of leaking the information. For that reason the data controller does not want the data to shift to the Cloud. There may have only chance of storing the data is providing the privacy gurantee to the Cloud. The requirement to building privacy is based on CPEL criteria which is confidentiality, privacy, efficiency, low in-house processing cost. By satisfying these requirement will increase the difficulty to store data in the Cloud. In order to eliminate this problem, We are using Random Space Perturbation method for providing the security and efficiency for processing the data. This method is used to building a practical query services in the Cloud. This approach will balance all the requirements by using range query and KNN query services.It provides multifaceted distances , which allows actual listing techniques to increase distances processing. DOI: 10.17762/ijritcc2321-8169.150311

Genetic diversity analysis using molecular marker in Terminalia chebula

Terminalia chebula is an important medicinal plant, extensively used in Ayurveda, Unani and Homoeopathic medicines. The present study was aimed to reveal its genetic diversity based on molecular markers from twelve T. chebula accessions. Molecular diversity was studied using RAPD markers. A total of 8 polymorphic primers produced 314 polymorphic bands and 195 monomorphic bands. Unweighted Pair Group Method with Arithmetic Mean (UPMGA) dendrogram divided the accessions into 2 major clusters. Accession IIHRTc2 and IIHRTc10 showed maximum genetic diversity with 55% similarity. This characterization based on molecular markers will help in identification of economically useful accessions for further crop improvement programme

INTERAKSI ANTARA KARAKTERISTIK ALIRAN DAN MATERIAL DASAR PADA PROSES PENGGERUSAN SUNGAI SUNGAI COMAL PEMALANG, JAWA TENGAH

Sungai Comal merupakan salah satu sungai dinamik di Pulau Jawa, dan sangat intensif berkembang. Salah satu proses yang terjadi di sungai comal adalah proses penggerusan sungai yang telah mengakibatkan ambruknya Jembatan Comal dewasa ini. Tujuan dari penelitian ini adalah mempelajari interaksi antara aliran sungai dengan material dasar sungai dalam dinamika proses penggerusan sungai, dan persebarannya di Sungai Comal, Pemalang. Data didapatkan melalui pengukuran langsung di lapangan meliputi: pengukuran aliran dengan current meter, sampel material dasar dengan metode pebble count dengan jalur zig-zag, dan pengukuran morfologi menggunakan alat bantu abney level dan meteran Pengukuran dilakukan pada lokasi penelitian yang telah ditentukan dengan metode purposive sampling. Berdasarkan analisis Kurva Hjulstrom menunjukan variasi interaksi yang spesifik di setiap lokasi. Lokasi penelitian ke-7 merupakan lokasi yang paling rentan terhadap penggerusan karena memiliki kecepatan rerata tinggi sebesar 233 cm/detik dengan material yang kecil sebesar 36,1 mm