The Very First Changes in the Tongue with the Development of Cancer

We describe the case of an elderly man with a 3-month history of pain at the tip of his tongue due to a lingual cancer. The lesion appeared slightly depressed and reddish. Our images show the very first changes in the tongue with the development of cancer. Patients with tongue pain often visit the internal medicine department first, so highlighting this case will help physicians detect lingual cancer quickly

Advanced Oropharyngeal Cancer Can Be Easily Missed During Esophagogastroduodenoscopy

The case of an elderly man with an advanced oropharyngeal cancer that was missed during esophagogastroduodenoscopy is described. He was referred for endoscopic resection of superficial esophageal squamous cell neoplasms. He died a month after referral due to an advanced oropharyngeal cancer with a metastatic lesion to the brain. Patients with esophageal squamous cell carcinoma are high risk for head and neck cancer. The pharynx is the most common site for cancer in the head and neck region. Consequently, the pharynx should be observed carefully when patients with esophageal squamous cell carcinoma undergo esophagogastroduodenoscopy

Mechanical properties of epithelial cells in domes investigated using atomic force microscopy

As epithelial cells in vitro reach a highly confluent state, the cells often form a microscale dome-like architecture that encloses a fluid-filled lumen. The domes are stabilized by mechanical stress and luminal pressure. However, the mechanical properties of cells that form epithelial domes remain poorly characterized at the single-cell level. In this study, we used atomic force microscopy (AFM) to measure the mechanical properties of cells forming epithelial domes. AFM showed that the apparent Young’s modulus of cells in domes was significantly higher when compared with that in the surrounding monolayer. AFM also showed that the stiffness and tension of cells in domes were positively correlated with the apical cell area, depending on the degree of cell stretching. This correlation disappeared when actin filaments were depolymerized or when the ATPase activity of myosin II was inhibited, which often led to a large fluctuation in dome formation. The results indicated that heterogeneous actomyosin structures organized by stretching single cells played a crucial role in stabilizing dome formation. Our findings provide new insights into the mechanical properties of three-dimensional deformable tissue explored using AFM at the single-cell level

Practical Study for Conservation of Giant Salamander Andrias japonicus in Toyosaka, Higashi-Hiroshima, Japan <Article>

オオサンショウウオAndrias japonicus は,日本の固有種であり国の特別天然記念物である。環境省のレッドリストでは絶滅危惧Ⅱ類(VU)に指定され,全国的に生息状況の悪化が危惧されている。東広島市豊栄町椋梨川においても,河川の人工化等によりその数が減少し,保護活動の担い手の高齢化に伴い,本種の生息状況に関する情報が極めて乏しい状況であった。そこで,本河川での本種の分布・生態を明らかにする野外調査を実施した。その結果,2011 年からの約2年間の調査で成体21個体と幼生10個体を確認し,本河川が本種の生息地であるだけでなく貴重な繁殖地であることを確認した。しかし,幼生を除けば全長60 - 86cm の大型個体しか確認されず,弱齢個体の個体群への新規加入が正常に起こっていない危険性も示唆された。本稿では,本河川における本種の現状が危機的であることを具体的に報告し,本種の保全にむけた持続的な活動の構築を目指した普及活動の成果と課題についても報告する。The giant salamander Andrias japonicas, which is endemic to Japan, is ranked as vulnerable. It is designated as a national special natural monument. Information on the giant salamander in Higashi-Hiroshima city is extremely scarce. To determine the current habitat of A. japonicas, we surveyed the Mukunashi River including areas where the giant salamander had lived in the past. Our surveys did find 21 adults and 10 larvae of A. japonicas within a two year period (from 2011 to 2013). However, we did not discover any young individuals of total length of 50 mm - 600 mm. This suggests that larval recruitment is not successful. This paper specifically reports that a critical situation exists for the giant salamander in the Mukunashi River in Higashi-Hiroshima City. And the publicity work aiming at conservation and its result are also reported

A Report on a Stargazing Session Conducted by Graduate and Undergraduate Students: Observing the Shapes of Moon and Saturn through Telescopes by Kindergarten Children

Aspiring secondary school science teachers must experientially learn the way of using a telescope and teaching star watching through a stargazing session. As a part of experiential activities, a stargazing session to observe the moon and Saturn was organized for 5-year-old kindergarten children on October 27, 2017, by graduate and undergraduate students; the session was conducted on the roof of building C of the Faculty of Education, Hiroshima University. The preparation for the session was a good opportunity for the students to review the knowledge that they had learned in class. The students interviewed the children about the shape of moon and Saturn immediately after they observed the planets. The two kinds of telescope used in star observing and the order of the planets that the children watched did not have much effect on the visibility of the planets. The results of interviews on the shape of the Moon indicated that the children understood the rough shape of the moon; however, they could not make an accurate understanding of the difference of the shape on the right and left sides. Furthermore, a possible effect of visual information, such as drawings, on the form of stars was confirmed.本研究の一部にJSPS科研費(JP26350235, JP17H00820) を使用した

X-ray study of ferroic octupole order producing anomalous Hall effect

放射光でついに見えた磁気オクタポール --熱を電気に変える新たな担い手--. 京都大学プレスリリース. 2021-09-27.Recently found anomalous Hall, Nernst, magnetooptical Kerr, and spin Hall effects in the antiferromagnets Mn₃X (X = Sn, Ge) are attracting much attention for spintronics and energy harvesting. Since these materials are antiferromagnets, the origin of these functionalities is expected to be different from that of conventional ferromagnets. Here, we report the observation of ferroic order of magnetic octupole in Mn₃Sn by X-ray magnetic circular dichroism, which is only predicted theoretically so far. The observed signals are clearly decoupled with the behaviors of uniform magnetization, indicating that the present X-ray magnetic circular dichroism is not arising from the conventional magnetization. We have found that the appearance of this anomalous signal coincides with the time reversal symmetry broken cluster magnetic octupole order. Our study demonstrates that the exotic material functionalities are closely related to the multipole order, which can produce unconventional cross correlation functionalities

The 3rd DBCLS BioHackathon: improving life science data integration with Semantic Web technologies.

BACKGROUND: BioHackathon 2010 was the third in a series of meetings hosted by the Database Center for Life Sciences (DBCLS) in Tokyo, Japan. The overall goal of the BioHackathon series is to improve the quality and accessibility of life science research data on the Web by bringing together representatives from public databases, analytical tool providers, and cyber-infrastructure researchers to jointly tackle important challenges in the area of in silico biological research. RESULTS: The theme of BioHackathon 2010 was the 'Semantic Web', and all attendees gathered with the shared goal of producing Semantic Web data from their respective resources, and/or consuming or interacting those data using their tools and interfaces. We discussed on topics including guidelines for designing semantic data and interoperability of resources. We consequently developed tools and clients for analysis and visualization. CONCLUSION: We provide a meeting report from BioHackathon 2010, in which we describe the discussions, decisions, and breakthroughs made as we moved towards compliance with Semantic Web technologies - from source provider, through middleware, to the end-consumer.RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are

Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones

The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this area is still limited. Several lines of investigation have been used to elucidate the structure and function of the genes in the human genome. Even so, gene prediction remains a difficult task, as the varieties of transcripts of a gene may vary to a great extent. We thus performed an exhaustive integrative characterization of 41,118 full-length cDNAs that capture the gene transcripts as complete functional cassettes, providing an unequivocal report of structural and functional diversity at the gene level. Our international collaboration has validated 21,037 human gene candidates by analysis of high-quality full-length cDNA clones through curation using unified criteria. This led to the identification of 5,155 new gene candidates. It also manifested the most reliable way to control the quality of the cDNA clones. We have developed a human gene database, called the H-Invitational Database (H-InvDB; http://www.h-invitational.jp/). It provides the following: integrative annotation of human genes, description of gene structures, details of novel alternative splicing isoforms, non-protein-coding RNAs, functional domains, subcellular localizations, metabolic pathways, predictions of protein three-dimensional structure, mapping of known single nucleotide polymorphisms (SNPs), identification of polymorphic microsatellite repeats within human genes, and comparative results with mouse full-length cDNAs. The H-InvDB analysis has shown that up to 4% of the human genome sequence (National Center for Biotechnology Information build 34 assembly) may contain misassembled or missing regions. We found that 6.5% of the human gene candidates (1,377 loci) did not have a good protein-coding open reading frame, of which 296 loci are strong candidates for non-protein-coding RNA genes. In addition, among 72,027 uniquely mapped SNPs and insertions/deletions localized within human genes, 13,215 nonsynonymous SNPs, 315 nonsense SNPs, and 452 indels occurred in coding regions. Together with 25 polymorphic microsatellite repeats present in coding regions, they may alter protein structure, causing phenotypic effects or resulting in disease. The H-InvDB platform represents a substantial contribution to resources needed for the exploration of human biology and pathology