Hepatocyte-specific contrast-enhanced MRI findings of focal nodular hyperplasia-like nodules in the liver following chemotherapy in pediatric cancer patients

PURPOSEWe aimed to assess the MRI findings and follow-up of multiple focal nodular hyperplasia (FNH)- like lesions in pediatric cancer patients diagnosed by imaging findings.METHODSWe retrospectively analyzed clinical data and MRI examinations of 16 pediatric patients, who had been scanned using gadoxetate disodium (n=13) and gadobenate dimeglumine (n=3). Hepatic nodules were reviewed according to their number, size, contour, T1- and T2-weighted signal intensities, arterial, portal, delayed and hepatobiliary phase enhancement patterns. Follow-up images were evaluated for nodule size, number, and appearance.RESULTSAll 16 patients received chemotherapy in due course. Time interval between the initial diagnosis of cancer and detection of the hepatic nodule was 2–14 years. Three patients had a single lesion, 13 patients had multiple nodules. The median size of the largest nodules was 19.5 mm (range, 8–41 mm). Among 16 patients that received hepatocyte-specific agents, FNH-like nodules appeared hyperintense in 11 and isointense in 5 on the hepatobiliary phase. During follow-up, increased number and size of the nodules were seen in 4 patients. The nodules showed growth between 6–15 mm.CONCLUSIONLiver MRI using hepatocyte-specific agents is a significant imaging method for the diagnosis of FNH-like lesions, which can occur in a variety of diseases. Lesions can increase in size and number in pediatric patients

Malzeme ihtiyaç planlaması ve bir ilaç firmasında uygulama çalışması

Bu tezin, veri tabanı üzerinden yayınlanma izni bulunmamaktadır.ÖZET Anahtar Kelimeler: Malzeme İhtiyaç Planlaması, İşletme Kaynaklan Planlaması, Haftalık Detaylı Üretim Planı, Aylık Kapasite Analizi, Haftalık Kapasite Analizi, Kaynakların Optimizasyonu Günümüzde rekabet, yerel bazdan ulusal ve uluslar arası baza tırmanmaktadır. Bu koşullar altında rekabet gücünü korumak ve geliştirmek isteyen işletmelerin vizyon ve stratejilerim gözden geçirmeleri gerekmektedir. Değişimlere hızlı ve ekonomik tepki verebilmek için, işletmenin tüm fonksiyon, süreç ve kaynaklarının entegre bir şekilde planlanması ve kontrol edilmesi gerekmektedir. Planlama departmanı sahip olduğu mevcut bilgiler ışığında haftalık planı hazırlamakta ve yayınlamaktadır. Makinede üretilen ürünler için gerekli olan eleman sayısı, malzeme ihtiyacı ve stoklar yeteri kadar dikkate alınmaksızın, revize edilen satış tahminlerinden bağımsız bir şekilde MPS ( AÜÇ, Ana Üretim Çizelgesi ) hazırlanmaktadır. Mevcut bilgisayar sisteminde MPS sonsuz kapasiteye göre malzeme ihtiyacı çıkarmaktadır. Ancak kapasite kısıtlan ve darboğaz yaşanacak hatlar göz ardı edilerek MRP ( MİP, Malzeme İhtiyaç Planlama ) çalışması yapıldığından malzeme stoklarında şişkinlik ya da açık diğer siparişlerin depo kapasitesi nedeniyle tedarikinde problemler yaşanmaktadır. Malzeme tedarikinde yaşanan sıkıntılar kapasitenin ve işgücünün etkin kullanılamamasına, kapasite ve işgücünün etkin kullanılamaması da üretim ve işçilik maliyetlerinde artışa neden olmaktadır. Ayrıca, aylık satış kotasının karşılanabilmesi için gereksiz yere fazla mesai veya vardiya planlanmaktadır. Projenin amacı; MRP' yi etkin şekilde yöneterek, üretim maliyetlerini minimize edip optimum stok miktarını ve verimliliği sağlayacak, karşılanamayan siparişi önleyecek bir üretim planı hazırlamaktır. Detaylı üretim planında amaç, işgücü kapasite bilgilerim kullanarak haftalık plandaki sapmaları minimize etmek ve tüm üretim girdilerini ve ilgili birimleri etkin ve etkili biçimde kullanarak kaynakların optimizasyonunu sağlamaktır. xiiMATERIAL REQUIREMENT PLANNING AND AN APPLICATION STUDY IN A PHARMACETUCAL COMPANY SUMMARY Key Words: Material Requirements Planning, Enterprise Resources Planning, Weekly Detailed Production Plan, Monthly Capacity Analysis, Optimization of Sources. Nowadays, competition increases from a local base to national and international bases. Under these conditions business enterprises, who want to protect and improve their competitive power, must scrutinize their vision and strategies. In order to achieve fast and economic reaction to changes, all the functions, processes and resources of the business enterprise must be planned and controlled in an integrated fashion. The Planning Department prepares and publishes the weekly plan according to the existing information that they have. Without giving sufficient attention to the number of personel, material needs and stocks which are necessary for the product that are produced by machines, the MPS is prepared independently from revised sale predictions. In the existing computer system, MPS takes out material needs according to needles capacity. MRP has been studied without giving importance to capacity restraints and lines that will have difficulties. Because of this, there is an over-supply material stocks or procurement problems of uncovered other orders according to the store's capacity. Problems in procuring the materials create an inability to the use capacity and productive power fully. Inablitiy to use capacity and productive power to the fullest causes an increase in production and workmanship costs. Also, in order to cover the monthly sale quota there is a plan to have unnecessary extra working hours or shifts. The aim of the project is to prepare a production plan that will direct MRP actively, minimize the production costs so that this plan will realise optimum stock quantity and productivity, prevent unseen costs. The aim of the detailed production plan is to minimize the deviations in the weekly plan by using productive power capacity information and to provide optimization of resources using all the production input and concerned units actively and effectively. Xll

Single Institution Experience on Cancer Among Adolescents 15-19 Years of Age

Adolescent cancers differ from other age groups in terms of cancer types, treatment and outcome. We aimed to present our institutional data on survival of certain types of cancer in adolescents. Hospital files were retrospectively evaluated for distribution of tumor types, clinical features, and overall and event-free survival (OS and EFS) rates in adolescents with malignant tumors. Two hundred ninety-three cases between 15-19 years who were diagnosed with malignant tumor at our department in the last 38 years were included in the study. Mean age was 15.3 and median age was 15 years at time of diagnosis. Male/female ratio was found to be 1.8/1. The most common cancers were non-Hodgkin lymphoma (NHL) (20.5%), Hodgkin's lymphoma (HL) (19.8%), central nervous system (CNS) tumors (10.9%), osteosarcoma (10.6%), Ewing sarcoma/primitive neuroectodermal tumors (EWN/PNET (9.9%) nasopharyngeal carcinoma (NPC) (9.6%). Non-compliance to medical treatment was observed in 10.9% of cases with significantly high noncompliance in NHL and osteosarcoma (p=0.02). Overall survival was 57.6% and EFS was 45.7% at a median follow-up time of 8.75 years. In adolescents, lower OS and EFS rates than the younger age group are observed. The most appropriate management plan should be made according to the physical and psychosocial needs of patients in this age group.WoSScopu

Bilateral Pulmonary Langerhans's Cell Histiocytosis is Surgical Challenge in Children

Background  Pulmonary Langerhans's cell histiocytosis (PLCH) is a rare cause of interstitial lung disease in children and more than half of the cases are bilateral. Persistent respiratory distress due to spontaneous pneumothorax (SP) in bilateral PLCH may refractory to conservative treatment and posed a great challenge to surgical modalities. A 3-year-old boy with SP due to bilateral PLCH is presented to discuss the surgical options of recurrent and refractory PLCH cases in children. , Case Report  The patient was admitted to the emergency department with severe respiratory distress and SP. After chest tube insertion, biopsy from neck mass revealed Langerhans's cell histiocytosis. Chemotherapy including vinblastine and prednisone was initiated. Due to persistent respiratory difficulty and air leaks, talc pleurodesis and thoracoscopic bullae excision with pleural decortication were performed. Two months after the admission, due to nosocomial infection and severe respiratory distress, extracorporeal membranous oxygenation (ECMO) support was initiated. The patient was died of ECMO complications on 24th day of ECMO. , Conclusion  Despite the use of chemotherapy and surgical excision of cystic lesions, bilateral PLCH in children may have lethal outcome. Other treatment options including respiratory support with ECMO and lung transplantation should be considered as last resort of treatment alternative in persistent cases.PubMedWo

Primary Pleuropulmonary Neoplasms in Childhood: Fourteen Cases From a Single Center

Background: We aimed to review clinical characteristics, treatment results and outcome of pediatric patients with primary pleuropulmonary neoplasms. Methods: Medical records of 14 cases diagnosed between 1972-2009 were reviewed retrospectively. Results: The male/female ratio was 5/9 and the mean age at diagnosis was 9.1 years (2-16). All but one were symptomatic, presenting with fever, coughing, dyspnea, or weight loss. One patient presented with hemoptysis, and another with digital clubbing. One mesothelioma was diagnosed incidentally. Some 8/14 patients were initially diagnosed as having pneumonia (median delay in diagnosis of 2.5 months). Diagnoses included pleuropulmonary blastoma (PPB, n=5), inflammatory pseudotumor (n=3), mesothelioma (n=2), mucoepidermoid carcinoma (MEC, n=2), and carcinoid tumor (n=2). Patients with PPB underwent surgery and received chemotherapy +/- radiotherapy. Two carcinoid tumor cases underwent surgery, one further received chemotherapy. Patients with mesothelioma were treated with chemotherapy. Inflammatory pseudotumors were all resected. Two cases with MEC received chemotherapy, one after surgery. 2/5 PPB patients survived without recurrence, 3 died; all carcinoid tumors and inflammatory pseudotumors were alive; 1/2 MEC patients was alive after 252 months, the other one was lost without disease; 1/2 mesothelioma patients was alive without disease, the other was died. For all cases, median follow-up was 30.5 months (0.6-252). Conclusions: Primary pleuropulmonary tumors are rare but clinical presentation can be varied and delay in diagnosis is common. Children with persistent coughs, recurrent pneumonia or hemoptysis should be considered as indicators for early diagnosis, very important because the prognosis of these tumors varies with histology and stage.Wo

The timing database:An open-access, live repository for interval timing studies

Interval timing refers to the ability to perceive and remember intervals in the seconds to minutes range. Our contemporary understanding of interval timing is derived from relatively small-scale, isolated studies that investigate a limited range of intervals with a small sample size, usually based on a single task. Consequently, the conclusions drawn from individual studies are not readily generalizable to other tasks, conditions, and task parameters. The current paper presents a live database that presents raw data from interval timing studies (currently composed of 68 datasets from eight different tasks incorporating various interval and temporal order judgments) with an online graphical user interface to easily select, compile, and download the data organized in a standard format. The Timing Database aims to promote and cultivate key and novel analyses of our timing ability by making published and future datasets accessible as open-source resources for the entire research community. In the current paper, we showcase the use of the database by testing various core ideas based on data compiled across studies (i.e., temporal accuracy, scalar property, location of the point of subjective equality, malleability of timing precision). The Timing Database will serve as the repository for interval timing studies through the submission of new datasets

The timing database: An open-access, live repository for interval timing studies

International audienceInterval timing refers to the ability to perceive and remember intervals in the seconds to minutes range. Our contemporary understanding of interval timing is derived from relatively small-scale, isolated studies that investigate a limited range of intervals with a small sample size, usually based on a single task. Consequently, the conclusions drawn from individual studies are not readily generalizable to other tasks, conditions, and task parameters. The current paper presents a live database that presents raw data from interval timing studies (currently composed of 68 datasets from eight different tasks incorporating various interval and temporal order judgments) with an online graphical user interface to easily select, compile, and download the data organized in a standard format. The Timing Database aims to promote and cultivate key and novel analyses of our timing ability by making published and future datasets accessible as open-source resources for the entire research community. In the current paper, we showcase the use of the database by testing various core ideas based on data compiled across studies (i.e., temporal accuracy, scalar property, location of the point of subjective equality, malleability of timing precision). The Timing Database will serve as the repository for interval timing studies through the submission of new datasets