Influence of abattoir effluents on abundance of freshwater prawns Macrobrachium vollenhovenii, M. macrobrahion and M. felicinum of Lower Ogun River, Western Nigeria

The implications of the abattoir effluents discharge into the Lower Ogun River in Isheri-Olofin area on the abundance of three African fresh water prawns: Macrobrachium vollenhovenii, M macrobrachion and M. felicinum were assessed. Monthly prawn collections were undertaken using a scooping bag net with 0.05mm mesh size at three stations with 100m intervals in each of Ishasi (upstream) and Isheri-Olofin (downstream) areas of the river for 24months (January, 2006-December, 2007). For the 24month period, the upstream (pooled data from stations 1,2 and 3) had M. vollenhovenii of total and mean density of 27,938.33 prawn/m2 and 1164.60prawn/m2 1131.04 respectively, while total and mean M. vollenhovenii density of 5,815.43prawn/m2 and 243.81 prawn/m2 231.45 were obtained in the downstream (pooled stations 4, Sand 6 data). T-test showed the entire upstream to have significantly higher M. vollenhovenii density than the entire downstream (p<0.05). The entire upstream had higher M. macrobrachium total and monthly mean density (19,092prawn/m and 816.44prawn/m2 1,354.28) than the entire downstream (6,384.47prwn/m2 and 266.02m2524.94) (p<0.05). Also, significantly higher total and monthly mean density of M felicinum were obtained upstream (20,9S6.S0prawn/m2 and 873.46prawn/m21615.06) than downstream (10,9668.11prawn/m2 and 461.16prawn/m2975.19) (p<0.05). The significance of the decline in abundance of each of the three Macrobrachium prawn species in the downstream area was discussed

Food habits, sexual dimorphism and sex ratio of three Palaemonid prawns of the Nun River, Niger Delta, Nigeria

The food habits, sex ratio and differences of three freshwater prawns ? Macrobrachium vollenhovenii, M. macrobrachion and M. felicinum from Nun River, Niger Delta were studied. It was found that although the prawns had an omnivorous diet feeding on a wide range of organisms including plants, detritus, insect parts, phytoplankton and zooplankton the food habits indicate a tendency towards a plant-based (herbivorous) diet. The adult prawns exhibit sexual dimorphism with males being larger than females; however the males were fewer in number than the females with mean ratios of 1:2.79, 1:1.58 and 1:9.12 for M. vollenhovenii, M. macrobrachion and M. felicinum. Sexual dimorphism exists in the species and brood-stock are available in the Nun River system of the Niger Delta region

Seasonal Variations in the Composition and Distribution of Planktonic Fauna in the Eastern Lagos Lagoon, Nigeria

The composition and distribution of planktonic fauna (adult form of zooplankton and planktonic juvenile forms of higher animals) within the eastern part of the Lagos Lagoon were investigated in July, 2008 and March, 2009 representing rainy and dry season respectively. Samples of water and planktonic fauna were collected from twelve stations within the eastern axis of the Lagoon and analyzed using standard methods. The study area had brackish water characteristics with fresh water condition (0\u2030 salinity across the 12 stations) in the rainy season whereas the salinity ranged from 11.4\u2030 to 30.5\u2030 in the dry season. The adult forms zooplankton recorded in the rainy season were mainly Crustaceans, Chaetognathans and Rotifers while those collected during dry season belonged to Crustacean, Cnidaria and Chordata. Crustaceans dominate both adult zooplankton and planktonic juvenile fauna in the two seasons. The rainy season adult zooplankton count (515) was lower than that of dry season (580) but the reverse was the case for the juvenile stages count (520 and 325 in rainy and dry season respectively). Higher species abundance was recorded for both adult zooplankton (20) and juvenile stages (10) in rainy than dry season when 14 and 8 were recorded for the two groups respectively. Higher values were also of community structure indices (Margalef species richness and Shannon-Wiener species diversity) were recorded in the rainy than dry season for the two groups of planktonic fauna. The findings show the influence of salinity gradients on distribution of planktonic fauna of the Lagos Lagoon

High-precision molecular dynamics simulation of UO2-PuO2: Anion self-diffusion in UO2

Our series of articles is devoted to high-precision molecular dynamics simulation of mixed actinide-oxide (MOX) fuel in the approximation of rigid ions and pair interactions (RIPI) using high-performance graphics processors (GPU). In this article we study self-diffusion mechanisms of oxygen anions in uranium dioxide (UO2) with the ten recent and widely used sets of interatomic pair potentials (SPP) under periodic (PBC) and isolated (IBC) boundary conditions. Wide range of measured diffusion coefficients (from 10^-3 cm^2/s at melting point down to 10^-12 cm^2/s at 1400 K) made possible a direct comparison (without extrapolation) of the simulation results with the experimental data, which have been known only at low temperatures (T < 1500 K). A highly detailed (with the temperature step of 1 K) calculation of the diffusion coefficient allowed us to plot temperature dependences of the diffusion activation energy and its derivative, both of which show a wide (~1000 K) superionic transition region confirming the broad lambda-peaks of heat capacity obtained by us earlier. It is shown that regardless of SPP the anion self-diffusion in model crystals without surface or artificially embedded defects goes on via exchange mechanism, rather than interstitial or vacancy mechanisms suggested by the previous works. The activation energy of exchange diffusion turned out to coincide with the anti-Frenkel defect formation energy calculated by the lattice statics.Comment: 18 pages, 11 figures, 5 table

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK.

BACKGROUND: A safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of the COVID-19 pandemic. We evaluated the safety and efficacy of the ChAdOx1 nCoV-19 vaccine in a pooled interim analysis of four trials. METHODS: This analysis includes data from four ongoing blinded, randomised, controlled trials done across the UK, Brazil, and South Africa. Participants aged 18 years and older were randomly assigned (1:1) to ChAdOx1 nCoV-19 vaccine or control (meningococcal group A, C, W, and Y conjugate vaccine or saline). Participants in the ChAdOx1 nCoV-19 group received two doses containing 5 × 1010 viral particles (standard dose; SD/SD cohort); a subset in the UK trial received a half dose as their first dose (low dose) and a standard dose as their second dose (LD/SD cohort). The primary efficacy analysis included symptomatic COVID-19 in seronegative participants with a nucleic acid amplification test-positive swab more than 14 days after a second dose of vaccine. Participants were analysed according to treatment received, with data cutoff on Nov 4, 2020. Vaccine efficacy was calculated as 1 - relative risk derived from a robust Poisson regression model adjusted for age. Studies are registered at ISRCTN89951424 and ClinicalTrials.gov, NCT04324606, NCT04400838, and NCT04444674. FINDINGS: Between April 23 and Nov 4, 2020, 23 848 participants were enrolled and 11 636 participants (7548 in the UK, 4088 in Brazil) were included in the interim primary efficacy analysis. In participants who received two standard doses, vaccine efficacy was 62·1% (95% CI 41·0-75·7; 27 [0·6%] of 4440 in the ChAdOx1 nCoV-19 group vs71 [1·6%] of 4455 in the control group) and in participants who received a low dose followed by a standard dose, efficacy was 90·0% (67·4-97·0; three [0·2%] of 1367 vs 30 [2·2%] of 1374; pinteraction=0·010). Overall vaccine efficacy across both groups was 70·4% (95·8% CI 54·8-80·6; 30 [0·5%] of 5807 vs 101 [1·7%] of 5829). From 21 days after the first dose, there were ten cases hospitalised for COVID-19, all in the control arm; two were classified as severe COVID-19, including one death. There were 74 341 person-months of safety follow-up (median 3·4 months, IQR 1·3-4·8): 175 severe adverse events occurred in 168 participants, 84 events in the ChAdOx1 nCoV-19 group and 91 in the control group. Three events were classified as possibly related to a vaccine: one in the ChAdOx1 nCoV-19 group, one in the control group, and one in a participant who remains masked to group allocation. INTERPRETATION: ChAdOx1 nCoV-19 has an acceptable safety profile and has been found to be efficacious against symptomatic COVID-19 in this interim analysis of ongoing clinical trials. FUNDING: UK Research and Innovation, National Institutes for Health Research (NIHR), Coalition for Epidemic Preparedness Innovations, Bill & Melinda Gates Foundation, Lemann Foundation, Rede D'Or, Brava and Telles Foundation, NIHR Oxford Biomedical Research Centre, Thames Valley and South Midland's NIHR Clinical Research Network, and AstraZeneca

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

Background A safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of the COVID-19 pandemic. We evaluated the safety and efficacy of the ChAdOx1 nCoV-19 vaccine in a pooled interim analysis of four trials. Methods This analysis includes data from four ongoing blinded, randomised, controlled trials done across the UK, Brazil, and South Africa. Participants aged 18 years and older were randomly assigned (1:1) to ChAdOx1 nCoV-19 vaccine or control (meningococcal group A, C, W, and Y conjugate vaccine or saline). Participants in the ChAdOx1 nCoV-19 group received two doses containing 5 × 1010 viral particles (standard dose; SD/SD cohort); a subset in the UK trial received a half dose as their first dose (low dose) and a standard dose as their second dose (LD/SD cohort). The primary efficacy analysis included symptomatic COVID-19 in seronegative participants with a nucleic acid amplification test-positive swab more than 14 days after a second dose of vaccine. Participants were analysed according to treatment received, with data cutoff on Nov 4, 2020. Vaccine efficacy was calculated as 1 - relative risk derived from a robust Poisson regression model adjusted for age. Studies are registered at ISRCTN89951424 and ClinicalTrials.gov, NCT04324606, NCT04400838, and NCT04444674. Findings Between April 23 and Nov 4, 2020, 23 848 participants were enrolled and 11 636 participants (7548 in the UK, 4088 in Brazil) were included in the interim primary efficacy analysis. In participants who received two standard doses, vaccine efficacy was 62·1% (95% CI 41·0–75·7; 27 [0·6%] of 4440 in the ChAdOx1 nCoV-19 group vs71 [1·6%] of 4455 in the control group) and in participants who received a low dose followed by a standard dose, efficacy was 90·0% (67·4–97·0; three [0·2%] of 1367 vs 30 [2·2%] of 1374; pinteraction=0·010). Overall vaccine efficacy across both groups was 70·4% (95·8% CI 54·8–80·6; 30 [0·5%] of 5807 vs 101 [1·7%] of 5829). From 21 days after the first dose, there were ten cases hospitalised for COVID-19, all in the control arm; two were classified as severe COVID-19, including one death. There were 74 341 person-months of safety follow-up (median 3·4 months, IQR 1·3–4·8): 175 severe adverse events occurred in 168 participants, 84 events in the ChAdOx1 nCoV-19 group and 91 in the control group. Three events were classified as possibly related to a vaccine: one in the ChAdOx1 nCoV-19 group, one in the control group, and one in a participant who remains masked to group allocation. Interpretation ChAdOx1 nCoV-19 has an acceptable safety profile and has been found to be efficacious against symptomatic COVID-19 in this interim analysis of ongoing clinical trials

Seasonal Variations in the Composition and Distribution of Planktonic Fauna in the Eastern Lagos Lagoon, Nigeria

The composition and distribution of planktonic fauna (adult form of zooplankton and planktonic juvenile forms of higher animals) within the eastern part of the Lagos Lagoon were investigated in July, 2008 and March, 2009 representing rainy and dry season respectively. Samples of water and planktonic fauna were collected from twelve stations within the eastern axis of the Lagoon and analyzed using standard methods. The study area had brackish water characteristics with fresh water condition (0‰ salinity across the 12 stations) in the rainy season whereas the salinity ranged from 11.4‰ to 30.5‰ in the dry season. The adult forms zooplankton recorded in the rainy season were mainly Crustaceans, Chaetognathans and Rotifers while those collected during dry season belonged to Crustacean, Cnidaria and Chordata. Crustaceans dominate both adult zooplankton and planktonic juvenile fauna in the two seasons. The rainy season adult zooplankton count (515) was lower than that of dry season (580) but the reverse was the case for the juvenile stages count (520 and 325 in rainy and dry season respectively). Higher species abundance was recorded for both adult zooplankton (20) and juvenile stages (10) in rainy than dry season when 14 and 8 were recorded for the two groups respectively. Higher values were also of community structure indices (Margalef species richness and Shannon-Wiener species diversity) were recorded in the rainy than dry season for the two groups of planktonic fauna. The findings show the influence of salinity gradients on distribution of planktonic fauna of the Lagos Lagoon