21 research outputs found
Ultrafast spectroscopy of propagating coherent acoustic phonons in GaN/InGaN heterostructures
We show that large amplitude, coherent acoustic phonon wavepackets can be
generated and detected in InGaN/GaN epilayers and heterostructures
in femtosecond pump-probe differential reflectivity experiments. The amplitude
of the coherent phonon increases with increasing Indium fraction and unlike
other coherent phonon oscillations, both \textit{amplitude} and \textit{period}
are strong functions of the laser probe energy. The amplitude of the
oscillation is substantially and almost instantaneously reduced when the
wavepacket reaches a GaN-sapphire interface below the surface indicating that
the phonon wavepackets are useful for imaging below the surface. A theoretical
model is proposed which fits the experiments well and helps to deduce the
strength of the phonon wavepackets. Our model shows that localized coherent
phonon wavepackets are generated by the femtosecond pump laser in the epilayer
near the surface. The wavepackets then propagate through a GaN layer changing
the local index of refraction, primarily through the Franz-Keldysh effect, and
as a result, modulate the reflectivity of the probe beam. Our model correctly
predicts the experimental dependence on probe-wavelength as well as epilayer
thickness.Comment: 11 pages, 14 figure
Exceptionally Slow Rise in Differential Reflectivity Spectra of Excitons in GaN: Effect of Excitation-induced Dephasing
Femtosecond pump-probe (PP) differential reflectivity spectroscopy (DRS) and
four-wave mixing (FWM) experiments were performed simultaneously to study the
initial temporal dynamics of the exciton line-shapes in GaN epilayers. Beats
between the A-B excitons were found \textit{only for positive time delay} in
both PP and FWM experiments. The rise time at negative time delay for the
differential reflection spectra was much slower than the FWM signal or PP
differential transmission spectroscopy (DTS) at the exciton resonance. A
numerical solution of a six band semiconductor Bloch equation model including
nonlinearities at the Hartree-Fock level shows that this slow rise in the DRS
results from excitation induced dephasing (EID), that is, the strong density
dependence of the dephasing time which changes with the laser excitation
energy.Comment: 8 figure
Model-based adaptive phase I trial design of post-transplant decitabine maintenance in myelodysplastic syndrome
Validation of the revised IPSS at transplant in patients with myelodysplastic syndrome/transformed acute myelogenous leukemia receiving allogeneic stem cell transplantation : a retrospective analysis of the EBMT chronic malignancies working party
The International Prognostic Scoring System has been revised (IPSS-R) to predict prognosis of patients with myelodysplastic syndromes at diagnosis. To validate the use of the IPSS-R assessed before transplant rather than at diagnosis we performed a retrospective analysis of the EBMT database. A total of 579 patients had sufficient information available to calculate IPSS-R at transplant. Median overall survival (OS) from transplant was significantly different according to IPSS-R: very low 23.6 months, low 55.0 months, intermediate 19.7 months, high 13.5 months, very high 7.8 months (P <0.001). In a multivariate Cox model the following parameters were significant risk factors for OS: IPSS-R, graft source, age and prior treatment. Median relapse free survival also showed significant differences according to IPSS-R: very low: 23.6 months, low: 24.8 months, intermediate 10.6 months, high 7.9 months, very high 5.5 months (P <0.001). Multivariate risk factors for relapse-free survival (RFS) were: IPSS-R, reduced intensity conditioning, graft source and prior treatment. A trend for an increased relapse incidence was noted for very high risk IPSS-R. We conclude that the IPSS-R at transplant is a useful prognostic score for predicting OS and RFS after transplantation, capturing both disease evolution and response to prior treatment before transplant.Peer reviewe
Femtosecond and picosecond nondegenerate four-wave mixing in GaAs/AlGaAs multiple quantum wells by two independently tunable lasers
We have performed femtosecond and picosecond nondegenerate two-beam and three-beam (omega (1), omega (1); omega (2)) four-wave mixing experiments by using two partially synchronized, independently tunable lasers with a simple sample-and-hold switch. When the jitter is compensated for externally, heavy- and light-hole beating is observed with these two mutually incoherent lasers, and the synchronous phases of oscillations with the detuning show that these beats are true quantum beats. We also see the strong completely off-resonant signals, and the below-bandgap signals are stronger than the signals at the continuum for equivalent detunings. This off-resonance signal has a Lorentzian dependence on detuning in both the femtosecond and the picosecond experiments. When omega (2) is completely above or below the excitonic resonance, the spectrum of the diffracted beam is determined mostly by the laser spectrum, which can be explained by semiconductor Bloch equations