857 research outputs found
The in-medium isovector pi N amplitude from low energy pion scattering
Differential cross sections for elastic scattering of 21.5 MeV positive and
negative pions by Si, Ca, Ni and Zr have been measured as part of a study of
the pion-nucleus potential across threshold. The `anomalous' repulsion in the
s-wave term was observed, as is the case with pionic atoms. The extra repulsion
can be accounted for by a chiral-motivated model where the pion decay constant
is modified in the medium. Unlike in pionic atoms, the anomaly cannot be
removed by merely introducing an empirical on-shell energy dependence.Comment: 9 pages, 2 figures. Minor changes, to appear in PR
Elastic scattering of low energy pions by nuclei and the in-medium isovector pi N amplitude
Measurements of elastic scattering of 21.5 MeV pi+ and pi- by Si, Ca, Ni and
Zr were made using a single arm magnetic spectrometer. Absolute calibration was
made by parallel measurements of Coulomb scattering of muons. Parameters of a
pion-nucleus optical potential were obtained from fits to all eight angular
distributions put together. The `anomalous' s-wave repulsion known from pionic
atoms is clearly observed and could be removed by introducing a
chiral-motivated density dependence of the isovector scattering amplitude,
which also greatly improved the fits to the data. The empirical energy
dependence of the isoscalar amplitude also improves the fits to the data but,
contrary to what is found with pionic atoms, on its own is incapable of
removing the anomaly.Comment: 20 pages, 5 figures, 5 tables. V2 added details on
uncertainties,extended discussion. To appear in PR
Ambiguity and public good provision in large societies
ArticleIn this paper, we consider the effect of ambiguity on the private provision of public goods. Equilibrium is shown to exist and be unique. We examine how provision of the public good changes as the size of the population increases. We show that when there is uncertainty, there may be less free-riding in large societies
Adverse Selection in Private Annuity Markets and the Role of Mandatory Social Annuitization
We study the effects on the macroeconomic equilibrium, the wealth distribution, and welfare of adverse selection in private annuity markets in a closed economy inhabited by overlapping generations of heterogeneous agents who are distinguished by their health status. If an agent's health type is private information there will be a pooling equilibrium in the private annuity market. We also study the implications for the macro-economy and welfare of a social security system with mandatory contributions that are constant across health types. These social annuities are immune to adverse selection and therefore offer a higher rate of return than private annuities do. However, they have a negative effect on the steady-state capital intensity and welfare. The positive effect of a fair pooled rate of return on a fixed part of savings and a higher return on capital in equilibrium is outweighed by the negative consequences of increased adverse selection in the private annuity market and a lower wage rate
The immune cell infiltrate populating meningiomas is composed of mature, antigen-experienced T and B cells
BACKGROUND: Meningiomas often harbor an immune cell infiltrate that can include substantial numbers of T and B cells. However, their phenotype and characteristics remain undefined. To gain a deeper understanding of the T and B cell repertoire in this tumor, we characterized the immune infiltrate of 28 resected meningiomas representing all grades. METHODS: Immunohistochemistry was used to grossly characterize and enumerate infiltrating lymphocytes. A molecular analysis of the immunoglobulin variable region of tumor-infiltrating B cells was used to characterize their antigen experience. Flow cytometry of fresh tissue homogenate and paired peripheral blood lymphocytes was used to identify T cell phenotypes and characterize the T cell repertoire. RESULTS: A conspicuous B and T cell infiltrate, primarily clustered in perivascular spaces, was present in the microenvironment of most tumors examined. Characterization of 294 tumor-infiltrating B cells revealed clear evidence of antigen experience, in that the cardinal features of an antigen-driven B cell response were present. Meningiomas harbored populations of antigen-experienced CD4+ and CD8+ memory/effector T cells, regulatory T cells, and T cells expressing the immune checkpoint molecules PD-1 and Tim-3, indicative of exhaustion. All of these phenotypes were considerably enriched relative to their frequency in the circulation. The T cell repertoire in the tumor microenvironment included populations that were not reflected in paired peripheral blood. CONCLUSION: The tumor microenvironment of meningiomas often includes postgerminal center B cell populations. These tumors invariably include a selected, antigen-experienced, effector T cell population enriched by those that express markers of an exhausted phenotype
Universality, limits and predictability of gold-medal performances at the Olympic Games
Inspired by the Games held in ancient Greece, modern Olympics represent the
world's largest pageant of athletic skill and competitive spirit. Performances
of athletes at the Olympic Games mirror, since 1896, human potentialities in
sports, and thus provide an optimal source of information for studying the
evolution of sport achievements and predicting the limits that athletes can
reach. Unfortunately, the models introduced so far for the description of
athlete performances at the Olympics are either sophisticated or unrealistic,
and more importantly, do not provide a unified theory for sport performances.
Here, we address this issue by showing that relative performance improvements
of medal winners at the Olympics are normally distributed, implying that the
evolution of performance values can be described in good approximation as an
exponential approach to an a priori unknown limiting performance value. This
law holds for all specialties in athletics-including running, jumping, and
throwing-and swimming. We present a self-consistent method, based on normality
hypothesis testing, able to predict limiting performance values in all
specialties. We further quantify the most likely years in which athletes will
breach challenging performance walls in running, jumping, throwing, and
swimming events, as well as the probability that new world records will be
established at the next edition of the Olympic Games.Comment: 8 pages, 3 figures, 1 table. Supporting information files and data
are available at filrad.homelinux.or
Heterogeneous consumption in OLG model with horizontal innovations
The paper develops a general equilibrium endogenous growth model involving heterogeneous consumption by an age-structured population with uncertain but limited life span and balanced life-time budget without bequests. The heterogeneity is introduced via weights which the individuals attribute in their utility function to consumption of different goods depending on the vintage of the good. The goods are produced by monopolistically competitive firms and the variety of available goods/technologies is determined endogenously through R&D investments. A competitive bank sector provides financial resources for investments, secured by agentsâ savings and future firms profits. The general equilibrium is characterized by a system of functional equations and is analytically or numerically determined for several particular weight functions. It is shown that the investments by agents alone may be insufficient to sustain growth, while additional investments provided by the bank sector may lead to growth. The resulting imbalance between agentsâ assets and the total value of firms can grow unboundedly in the case of homogeneous consumption. The results exhibit the qualitative difference between the dynamics of the model with heterogeneous versus homogeneous consumption. In particular heterogeneous con- sumption (when old goods are discounted) reduces the additional investments by the financial sector so that the values of firms become balanced by the assets of agents in the long run.info:eu-repo/semantics/publishedVersio
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