Displacement of the South Pole from 2006 to 2021: Role of sea ice and Antarctic surface temperature

The effect of global warming on the southern polar regions necessitates careful monitoring of glacier deformations and their movements, as well as an understanding of atmospheric physics. For this purpose, the yearly movements of UNAVCO stations-South Pole Station (AMU2) (winter-summer) and other stations in the South Pole region have been observed in this paper for about a fifteen-year period (2006–2021). In addition, the area differences of the Antarctic continent due to seasonal changes (winter-summer) between 1980 and 2021 were investigated in this study. Moreover, the height values of the stations on the Antarctic continent were observed seasonally. The subglacial lakes in the Antarctic continent cause the differences in the height values as a result of the seasonal changes. A decrease in sea ice of 0.91 million km2 for the winter season and 0.55 million km2 for the summer season during a 41-year period has been determined for four sectors of the Antarctic continent. The temperature changes on the Antarctic continent in the summer and winter seasons (2005–2022) were also evaluated in this paper. Air temperature increases was apparent especially in the Antarctic Peninsula, East Antarctic and West Antarctic coasts. The Weddell Sea and the Amundsen Sea regions have had the most sea ice loss, each with 1.24 million km2. On the other hand, it can be observed that the East Antarctic sector has expanded by 0.32 million km2

ON THE PERFORMANCE OF GNSS LEVELLING OVER STEEP SLOPES

In geodetic applications variety, one of the main current focuses is recently to determine the heights of ground stations with high accuracy. Specially the possibility of acquiring 3D information of the point positioning with high accuracy is opening up new strategies of investigating the heighting. Global Navigation Satellite System (GNSS) for 3D positioning is undergoing rapid developments andGNSS heighting can be an alternative to terrestrial techniques of height measurements. This paper presents a research study on the use of GNSS heighting in the case of steep slopes and multipath issue. Short baseline solution strategieswere performed by using Bernese Software v. 5.0. The analysis results are also compared to the results of techniques of the terrestrial levelling. The results showthat GNSS can be used as an practical surveying method to the terrestrial levelling with comparable accuracies. Furthermore, one can save up to 1 hour using GNSSinstead of geometric levelling over a steep slope of a 100 m. On the other hand, as usual multipath is the primary error source decreasing the efficiency of GNSS, and it has been studied experimentally in this paper

The effects of peritoneal dialysis and hemodialysis on serum tumor necrosis factor-alpha, interleukin-6, interleukin-10 and C-reactive-protein levels.

BACKGROUND: Markers of an acute phase reaction, such as C-reactive protein (CRP) or tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6, are predictive for cardiovascular morbidity and mortality in normal subjects and in chronic renal failure patients. In this study, we aimed to investigate serum TNF-alpha, IL-6, IL-10 and CRP levels in continuous ambulatory peritoneal dialysis (CAPD) and hemodialysis (HD) patients. MATERIALS AND METHODS: Serum levels of TNF-alpha, IL-6, IL-10 and CRP levels were measured in 30 patients who were just diagnosed with end-stage renal failure and treated, with 16 CAPD (nine female, seven male) and 14 HD (eight female, six male) patients, before CAPD or HD treatment and after 3 months from the beginning of CAPD or HD in patients with no clinical signs of infection. The control groups were 20 healthy persons of similar age and sex. Serum levels of TNF-alpha, IL-6, IL-10 and CRP were measured by enzyme-linked immunosorbent assay in stable CAPD and HD patients and in healthy persons. RESULTS: The mean serum levels of TNF-alpha, IL-6, IL-10 and CRP showed no significant differences between the CAPD and HD patients for the beginning values and the third month of treatment. However, serum TNF-alpha, IL-6, IL-10 and CRP levels were higher than the control group in the CAPD and HD patients regarding the beginning values and the third month of treatment (p < 0.001). CONCLUSIONS: CAPD and HD of the renal replacement therapy have no effects on serum CRP and cytokines

Explode: an extensible platform for differentially private data analysis

Differential privacy (DP) has emerged as a popular standard for privacy protection and received great attention from the research community. However, practitioners often find DP cumbersome to implement, since it requires additional protocols (e.g., for randomized response, noise addition) and changes to existing database systems. To avoid these issues we introduce Explode, a platform for differentially private data analysis. The power of Explode comes from its ease of deployment and use: The data owner can install Explode on top of an SQL server, without modifying any existing components. Explode then hosts a web application that allows users to conveniently perform many popular data analysis tasks through a graphical user interface, e.g., issuing statistical queries, classification, correlation analysis. Explode automatically converts these tasks to collections of SQL queries, and uses the techniques in [3] to determine the right amount of noise that should be added to satisfy DP while producing high utility outputs. This paper describes the current implementation of Explode, together with potential improvements and extensions

Therapeutic and protective effects of montelukast against doxorubicin-induced acute kidney damage in rats

Objective(s): The current study was designed to investigate the therapeutic and protective effects of montelukast (ML) against doxorubicin (DOX)-induced acute kidney damage in rats.Materials and Methods: Thirty-five Wistar albino female rats were randomly divided into 5 groups as follows: Group I: Control; Group II: Control+ML; Group III: DOX; Group IV: DOX+ML; Group V: ML+DOX. At the end of the experiment, the kidney tissues of rats were collected. Thiobarbituric acid reactive substance (TBARS), reduced glutathione, superoxide dismutase (SOD), and catalase levels were determined from the kidney tissues. In addition, the kidney tissues were examined histologically.Results: DOX induced a significant increase in the kidney TBARS levels, whereas SOD contents significantly decreased when compared with the control group.  On the other hand, ML administration before and after DOX injection caused significant decreases in TBARS production and also increases in SOD levels. Histologically, the most remarkable damage was glomerulosclerosis and tubular changes in the DOX group. Moreover, marked tubular necrosis and swelling in tubular epithelial cells were observed in this group. Contrarily, although glomerulosclerosis was recognized as alleviated also in both DOX+ML and ML+DOX groups, the lesions did not completely ameliorate. However, treatment with ML after DOX injection was more effective than treatment with ML before DOX injection with respect to the protection of tubular structures. Conclusion: It was determined that ML treatment after DOX injection caused therapeutic effects against DOX-induced kidney damage. Thence, ML treatment is of some clinical properties for oxidative stress damage in kidney tissues

Proanthocyanidin to prevent formation of the reexpansion pulmonary edema

<p>Abstract</p> <p>Background</p> <p>We aimed to investigate the preventive effect of Proanthocyanidine (PC) in the prevention of RPE formation.</p> <p>Methods</p> <p>Subjects were divided into four groups each containing 10 rats. In the Control Group (CG): RPE wasn't performed. Then subjects were followed up for three days and they were sacrificed after the follow up period. Samplings were made from tissues for measurement of biochemical and histopathologic parameters. In the Second Group (PCG): The same protocol as CG was applied, except the administration of PC to the subjects. In the third RPE Group (RPEG): Again the same protocol as CG was applied, but as a difference, RPE was performed. In the Treatment Group (TG): The same protocol as RPEG was applied except the administration of PC to the subjects.</p> <p>Results</p> <p>In RPEG group, the most important histopathological finding was severe pulmonary edema with alveolar damage and acute inflammatory cells. These findings were less in the TG group. RPE caused increased MDA levels, and decreased GPx, SOD and CAT activity significantly in lung tissue.</p> <p>Conclusion</p> <p>PC decreased MDA levels. Oxidative stress plays an important role in pathophysiology of RPE and PC treatment was shown to be useful to prevent formation of RPE.</p

Elevated gamma glutamyl transferase levels are associated with the location of acute pulmonary embolism. Cross-sectional evaluation in hospital setting

ABSTRACT CONTEXT AND OBJECTIVE: The location of embolism is associated with clinical findings and disease severity in cases of acute pulmonary embolism. The level of gamma-glutamyl transferase increases under oxidative stress-related conditions. In this study, we investigated whether gamma-glutamyl transferase levels could predict the location of pulmonary embolism. DESIGN AND SETTING: Hospital-based cross-sectional study at Cumhuriyet University, Sivas, Turkey. METHODS : 120 patients who were diagnosed with acute pulmonary embolism through computed tomography-assisted pulmonary angiography were evaluated. They were divided into two main groups (proximally and distally located), and subsequently into subgroups according to thrombus localization as follows: first group (thrombus in main pulmonary artery; n = 9); second group (thrombus in main pulmonary artery branches; n = 71); third group (thrombus in pulmonary artery segmental branches; n = 34); and fourth group (thrombus in pulmonary artery subsegmental branches; n = 8). RESULTS : Gamma-glutamyl transferase levels on admission, heart rate, oxygen saturation, right ventricular dilatation/hypokinesia, pulmonary artery systolic pressure and cardiopulmonary resuscitation requirement showed prognostic significance in univariate analysis. The multivariate logistic regression model showed that gamma-glutamyl transferase level on admission (odds ratio, OR = 1.044; 95% confidence interval, CI: 1.011-1.079; P = 0.009) and pulmonary artery systolic pressure (OR = 1.063; 95% CI: 1.005-1.124; P = 0.033) remained independently associated with proximally localized thrombus in pulmonary artery. CONCLUSIONS : The findings revealed a significant association between increased existing embolism load in the pulmonary artery and increased serum gamma-glutamyl transferase levels