Çatışma, Stres, Tükenmişlik ve İşten Ayrılma Niyeti: Medeni Durum ve Cinsiyete Göre Farklılıkların İncelenmesi Conflict, Work Stress, Job Burnout, and Turnover Intention: Examining Differences Based on Marital Status and Gender

Örgütlerin ve çalışanların karşılıklı beklentilerinin fazlalaşması, rol belirsizliklerinin ve aile-iş/iş-aile çatışmalarının artmasında etkilidir. Eşlerin çalışma durumlarındaki değişiklikler, çocuk bakımı ve yetiştirilmesine ilişkin sorumluluklar, aile üyeleri arası ilişkiler, psiko-sosyal çalışma koşullarına ilişkin özellikler ve ast-üst ilişkileri gibi faktörler aile-iş/iş-aile çatışması, iş stresi, tükenmişlik ve işten ayrılma niyeti üzerinde belirleyici olabilmektedir. Bu araştırmanın amacı; bahsi geçen değişkenlerin, medeni durum ve cinsiyete göre farklılaşıp farklılaşmadığını ortaya çıkarmaktır. Bu doğrultuda, 457 kişilik örnekleme uygulanan anket sonrasında 401 katılımcıdan elde edilen kullanılabilir veriler incelemeye tabi tutulmuştur. Araştırma kapsamında kullanılan ölçeklerin faktöriyel yapıları LISREL 8.8. Scientific Software International Programı kullanılarak incelenmiştir. Araştırmada kullanılan ölçeklerin güvenilirliği ve diğer analizler ise IBM SPSS Statistics 21 programı üzerinden yapılmıştır. Çok yönlü varyans analizi (MANOVA) testi sonuçlarına göre boşanmış çalışanların iş stresi ve tükenmişlik ortalamalarının evli ve bekâr çalışanlara göre daha yüksek olduğu ortaya çıkmıştır. Ayrıca, analiz bulgularına göre kadın çalışanların çatışma algısı ve işten ayrılma niyeti ortalamalarının erkeklere göre daha yüksek olduğu sonucuna ulaşılmıştır. he demanding mutual expectations of employees and organisations can be influential on the way increasing individuals’ role ambiguity along with family– work/work-family conflicts. Changing employment status of partners, responsibilities for child and elderly care, relations between family members, specifications of psycho social working conditions, superior-subordinate communication, and work opportunities may be determinant on employee’s job outcomes such as work stress, job burnout, and turnover intention. This study aims to find out the differences of these variables based on the marital status and gender in the perception of employees. In order to achieve this, a questionnaire was administered on a sample of 457 participants but 401 questionnaires underwent to the analysis after the final check. While the factorial structures of the scales were analysed through LISREL 8.8 Scientific Software International Programme, the validity of scales and the other analysis were tested by IBM SPSS Statistics 21 Programme. According to the multivariate analysis of variance (MANOVA) results, the work stress and burnout levels of the divorced employees were found significantly higher than that of married and single employees. The study also found that the conflict and turnover intention levels of the women employees were significantly higher than that of men employees

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Antioxidative, antimicrobial and cytotoxic properties of Isatis floribunda Boiss. ex Bornm. extracts

The Isatis species has antibacterial, anticancer and antiviral properties and these important endemic plants grow widely in various parts of Anatolian-Turkey. In the present study, the antioxidant activities of Isatis floribunda Boiss. ex Bornm. flower and root extracts were determined with total antioxidant activity, free radical scavenging activity, ferric ion reducing power, and cupric ion reducing antioxidant capacity assay. The total phenolic compounds and flavonoids were also examined for the extracts. The antimicrobial activities of the extracts were investigated by using the disc diffusion and microdilution-broth methods against human and fish pathogen microorganisms. The phenolic composition of I. floribunda root methanolic extract was analyzed by high performance liquid chromatography (HPLC). The major component in the extract was cholorogenic acid (1980.20 μg/g). The cytotoxic effect of the methanolic root extract was also tested on human breast cell (MCF12A). The results showed that I. floribunda could be used as a natural source in the food and feed industry and clinical and food chemistry, and that the antimicrobial agents could be used against human and fish pathogens

Peri-implant hastalıklar

The treatment of partially or totally edentulous subjects with oral implants is a common procedure. Biological complications are occur around implants which are peri-implant mucositis and periimplantitis. Peri-implant mucositis is pathological condition which is normally localized in the soft tissues surrounding an oral implant. Peri-implantitis surrounding oral implants is an inflammatory process affecting the soft and hard tissues resulting in rapid loss of supporting bone associated with bleeding and suppuration. The diagnosis of peri-implant diseases is usually established by assessing probing depth, gingival index, bleeding on probing and radiographic bone resorption examinations. The etiopathogenesis of peri-implant diseases is related to the periimplant environment and to the soft tissues/implant interface, to patient-related factors (smoke, systemic diseases, plaque control) and to host-parasite equilibrium. Peri-implant diseases can be controlled successfully by providing mechanical, antiseptic, antibiotic and surgical supportive therapy, individually or combined.   ÖZET Tam veya kısmi dişsiz hastaların tedavisinde yaygın prosedürlerden biride oral implantlardır. İmplantların etrafında peri-implant mukositis ve peri-implantitis diye biyolojik komplikasyonlar meydana gelir. Peri-implant mukositis bir oral implantın etrafındaki normalde yumuşak dokuda lokalize patolojik bir durumdur. Oral implantların çevresindeki peri-implantitis süpürasyon ve kanama ile ilişkili destek kemiğin hızlı kaybı ile sonuçlanan, sert ve yumuşak dokuları etkileyen inflamatuar bir süreçtir. Peri-implant hastalıkların teşhisi genellikle sondalama cep derinliği, gingival indeks, sondalamada kanama ve radyografik kemik rezorbsiyon muayenesi ile kanıtlanır. Peri-implant hastalıkların etiyopatogenezi, peri-implant çevre ve yumuşak doku-implant yüzleşmesi, hasta ile ilişkili faktörler (sigara içme, sistemik hastalıklar, plak kontrolü) ve konak-parazit dengesi ile ilişkilidir. Peri-implant hastalıklar, tek tek veya kombine olarak mekanik, antiseptik, antibiyotik ve cerrahi destekleyici tedavi ile engellenerek başarılı olarak tedavi edilebilir. Anahtar kelimeler: İmplant, peri-implant hastalıklar, peri-implant mukositis, peri-implantitis ve tedavileri

Personalized reference intervals - Statistical approaches and considerations

Under embargo until: 2022-12-13For many measurands, physicians depend on population-based reference intervals (popRI), when assessing laboratory test results. The availability of personalized reference intervals (prRI) may provide a means to improve the interpretation of laboratory test results for an individual. prRI can be calculated using estimates of biological and analytical variation and previous test results obtained in a steady-state situation. In this study, we aim to outline statistical approaches and considerations required when establishing and implementing prRI in clinical practice. Data quality assessment, including analysis for outliers and trends, is required prior to using previous test results to estimate the homeostatic set point. To calculate the prRI limits, two different statistical models based on ‘prediction intervals’ can be applied. The first model utilizes estimates of ‘within-person biological variation’ which are based on an individual’s own data. This model requires a minimum of five previous test results to generate the prRI. The second model is based on estimates of ‘within-subject biological variation’, which represents an average estimate for a population and can be found, for most measurands, in the EFLM Biological Variation Database. This model can be applied also when there are lower numbers of previous test results available. The prRI offers physicians the opportunity to improve interpretation of individuals’ test results, though studies are required to demonstrate if using prRI leads to better clinical outcomes. We recommend that both popRIs and prRIs are included in laboratory reports to aid in evaluating laboratory test results in the follow-up of patients.publishedVersio

Amyloid Goiter Associated with Amyloidosis Secondary to Rheumatoid Arthritis

Amyloidosis refers to a variety of conditions in which amyloid proteins are abnormally deposited in organs and/or tissues. The most common forms of systemic amyloidosis are primary amyloidosis (PA) of light chains and secondary amyloidosis (SA) caused by chronic inflammatory diseases such as rheumatoid arthritis (RA). Although involvement of the thyroid gland by amyloid is a relatively common phenomenon, clinically significant enlargement of the thyroid owing to amyloid deposition is a rare occurrence. In SA, the deposition of amyloid associated (AA) protein is associated with atrophy of thyroid follicles. The clinical picture of these patients is characterized by rapid, painless thyroid gland enlargement which may be associated with dysphagia, dyspnea, or hoarseness. Thyroid function is not impaired in most cases. Although amyloid goitre secondary to systemic amyloidosis due to chronic inflammatory diseases is relatively common, specifically related to RA is much more uncommon one and it is reported less in the literature. In this report, A 52-old-year female patient with amyloid goiter associated with amyloidosis secondary to rheumatoid arthritis is presented

Relationship Between Sleep Duration and Coronary Artery Disease in Older Adults

Purpose: Insomnia, a frequent geriatric syndrome, is thought to be linked with coronary artery disease and increased mortality. The aim of our study was to examine the relationship between sleep duration and coronary artery disease (CAD) and cardiovascular risk factors. Materials and Methods: In this study, patients who applied to the geriatric outpatient clinic for comprehensive geriatric assessment were retrospectively evaluated. Patients were divided into two groups according to the six hours of ideal sleep assumption: those who slept less than six hours and those who slept six hours or more. Results: A total of 2255 patients (age 72±6 years, 63.3% female) were included in this study. Patients who were sleeping less than 6 hours were older (14.4% vs. 10.3%; p=0.005) and most of them were female (69.5% vs. 60.2%; p<001). Coronary artery disease (31.9% vs. 25.9%; p= 0.003), falls (31.8% vs. 25.3%; p=0.002) and depression (25.7% vs. 21.3%; p=0.022) were more common, while hypertension ( 68.5% and 72.5%; p=0.049) were less common in the short sleep duration group. The regression analysis showed that short sleep duration was significantly associated with CAD (OR:1.39; 95% CI:1.14-1.7; p=0.001), falls history (OR:1.25; 95% CI:1.02-1.5; p=0.026), age (OR:1.01; 95% CI:1.01-1.04; p=0.001), male gender (OR:0.63; 95% CI:0.51-0.76; p<0.001), and hypertension (OR:0.74; %95 CI:0.6-0.9; p=0.003). Conclusion: Similar to the literature, CAD was observed more frequently in patients who slept less than 6 hours in our results. Considering this relationship between short sleep duration and CAD, it is important to question sleep duration in comprehensive geriatric assessment

Ramelteon Protects Intestinal Tissue Against Injury Caused by Methotrexate Via Showing Anti-apoptotic, Antiinflammatory and Antioxidant Properties

Objective:Methotrexate (MTX), a drug used in the treatment of autoimmune diseases and cancers, is a folic acid antagonist, but it has toxic effects on the gastrointestinal system (GIS). In this study, we examined the anti-inflammatory, antioxidant and anti-apoptotic effects of Ramelteon (RAM), a melatonin receptor agonist, on the MTX-induced toxicity in the intestinal tissue of rats.Methods:Thirty-two male Wistar albino rats were randomly divided into 4 groups; Control group, MTX group, MTX + RAM group, and RAM group. Single-dose 0.1 mL 20 mg/kg MTX, saline or 0.1 mL 10 mg/kg RAM orally was administered for 7 days. Animals were sacrificed at the end of 7 days after the last drug administration. Then, intestinal tissues were collected for biochemical, histopathological and immunohistochemical analyses.Results:While normal histological findings and biochemical parameters were observed in the control and RAM groups, in the MTX group, mononuclear cell infiltrations, hemorrhagic areas, degenerations in the submucosa and Lieberkuhn crypts were observed in the intestinal sections. Caspase-3 (Cas-3) and tumor necrosis factor-alpha (TNF-α) expressions, total oxidant status (TOS) and oxidative stress index (OSI) increased and total antioxidant status (TAS) decreased in the MTX group. RAM treatment decreased Cas-3 and TNF-α expressions, TOS, OSI levels and increased TAS levels.Conclusion:In this study, RAM showed anti-apoptotic, antioxidant and anti-inflammatory effects on MTX-induced toxicity in intestinal tissue. Therefore, it was suggested that RAM might be used in MTX-like toxicities to alleviate the side effects on the GIS

Laparoscopy versus open surgery for the surgical management of tubo-ovarian abscess (TOA). Is there a beneficial impact of early endoscopic intervention in terms of fertility rates?

Objectives: To compare success rates and complications in women undergoing laparoscopic versus open surgical management of tubo-ovarian abscess. We further examined whether early laparoscopic intervention has any impact on pregnancy rates in a subgroup of infertile patients following frozen-thawed embryo transfer. Material and methods: Hospital records of 48 patients diagnosed with TOA between January 2015 and December 2020, who underwent surgical intervention or received only medical treatment were analyzed. All patients were hospitalized, and parenteral antibiotics were commenced on admission initially. Laparoscopic or open surgery was performed within 48 hours course of intravenous antibiotherapy (early intervention) or later according to the clinical findings and antibiotherapy response. Results: Of 48 patients with TOA, 18 (37.5%) underwent laparoscopic and 30 (62.5%) underwent open surgical intervention. The median postoperative hospital stay was shorter (4.5 days vs 7.5 days, respectively; p = 0.035), and postoperative opioid analgesic requirement was lesser in the laparoscopy group compared to open surgery group (22% vs 53%, respectively; p = 0.034). Intra- and post-operative complication rates were similar between the groups. Of these 48 patients, seven were diagnosed to have TOA following oocyte retrieval, and four of these conceived with frozen thawed embryo transfer all of whom underwent laparoscopic surgery within 48 hours of diagnosis. Conclusions: Minimal invasive surgery should be preferred even in the presence of severely adhesive and inflammatory TOA in order to improve postoperative outcomes. Moreover, early laparoscopic intervention may be considered in infertile patients with an aim to optimize pregnancy rates in a subsequent frozen-thawed embryo transfer

The frequency of Duchenne muscular dystrophy/Becker muscular dystrophy and Pompe disease in children with isolated transaminase elevation: results from the observational VICTORIA study

IntroductionElevated transaminases and/or creatine phosphokinase can indicate underlying muscle disease. Therefore, this study aims to determine the frequency of Duchenne muscular dystrophy/Becker muscular dystrophy (DMD/BMD) in male children and Pompe disease (PD) in male and female children with isolated hypertransaminasemia.MethodsThis multi-center, prospective study enrolled patients aged 3–216 months with serum alanine transaminase (ALT) and/or aspartate transaminase (AST) levels &gt;2× the upper limit of normal (ULN) for ≥3 months. Patients with a known history of liver or muscle disease or physical examination findings suggestive of liver disease were excluded. Patients were screened for creatinine phosphokinase (CPK) levels, and molecular genetic tests for DMD/BMD in male patients and enzyme analysis for PD in male and female patients with elevated CPK levels were performed. Genetic analyses confirmed PD. Demographic, clinical, and laboratory characteristics of the patients were analyzed.ResultsOverall, 589 patients [66.8% male, mean age of 63.4 months (standard deviation: 60.5)] were included. In total, 251 patients (188 male and 63 female) had CPK levels above the ULN. Of the patients assessed, 47% (85/182) of male patients were diagnosed with DMD/BMD and 1% (3/228) of male and female patients were diagnosed with PD. The median ALT, AST, and CPK levels were statistically significantly higher, and the questioned neurological symptoms and previously unnoticed examination findings were more common in DMD/BMD patients than those without DMD/BMD or PD (p &lt; 0.001).DiscussionQuestioning neurological symptoms, conducting a complete physical examination, and testing for CPK levels in patients with isolated hypertransaminasemia will prevent costly and time-consuming investigations for liver diseases and will lead to the diagnosis of occult neuromuscular diseases. Trial RegistrationClinicaltrials.gov NCT04120168