Measurement of atmospheric neutrino oscillations with very large volume neutrino telescopes

Neutrino oscillations have been probed during the last few decades using multiple neutrino sources and experimental set-ups. In the recent years, very large volume neutrino telescopes have started contributing to the field. First ANTARES and then IceCube have relied on large and sparsely instrumented volumes to observe atmospheric neutrinos for combinations of baselines and energies inaccessible to other experiments. Using this advantage, the latest result from IceCube starts approaching the precision of other established technologies, and is paving the way for future detectors, such as ORCA and PINGU. These new projects seek to provide better measurements of neutrino oscillation parameters, and eventually determine the neutrino mass ordering. The results from running experiments and the potential from proposed projects are discussed in this review, emphasizing the experimental challenges involved in the measurements.Comment: Review paper to appear in the special issue "Neutrino Masses and Oscillations" of Advances in High Energy Physics (accepted); 22 pages, 24 figure

Clinical presentation and treatment of multifocal epitrichial sweat gland carcinoma in a horse

Epitrichial gland carcinoma is a very rare type of skin tumour in horses. This report describes a horse presenting multiple nodules with associated normal, alopecic and ulcerated skin diagnosed via histopathology as epitrichial gland carcinoma. Treatment consisted of combined surgical excision, topical therapy for ulcerated nodules and cryotherapy for non-ulcerated tumours. Six months following therapy, the excised masses had not regrown and only 10 out of 25 small tumours previously treated with cryotherapy were noticeable

Introduction and evaluation of the ACS BCon basic course in Zaragoza, Spain

Background: The American College of Surgeons Bleeding Control Basic (BCon) course aimed at teaching hemorrhage control techniques in the USA had not yet been taught in Spain. The purpose of this study is to assess its implementation among students and healthcare employees in the Lozano Blesa University Hospital of Zaragoza, a middle-sized Spanish city. Methods: The study was conducted in a University Hospital and at the University of Zaragoza, scheduling four free B-Con sessions from 2017 to 2018. Two groups were identified as forming the population: healthcare employees and medical students. An anonymous questionnaire was completed at the end of the course regarding content, applicability, usefulness, relevance, and satisfaction. Study variables were ranked from 0 to 10: poor (when graded from 0 to 3), fair (4 to 6) and good (7 to 10). Results were compared between the groups, expressed in percentages and ¿ 2 tested to analyze significant differences if any. Results: Among the 83 individuals who completed the course, 46 were medical students and 37 healthcare employees; 61% women and 39% men; aged 21 years to 52 years. Attendees evaluated satisfaction with the highest grade (84%), followed by usefulness (73%), applicability (70%), and relevance (66%). There was no variable graded as poor. The comparison of perceptions between groups did not reveal statistical differences based on a 0.05 significance level. Conclusion: We concluded that the B-Con course was valued as good for relevance, usefulness, applicability, and satisfaction by the majority of the studied population. Level of Evidence: Level III

Design, manufacturing and set-up tests of a wave energy converter prototype in the context of the European Project LIFE-Demowave

LifeDemoWave Project is a real case of development of a R&D project, from the initial idea to the final construction and installation of a prototype for testing in operational environment. This project was born from an idea of the main researcher of the CIMA Group that finally led to two patents of two wave generation systems. Based on these patents, CIMA sought different ways for funding with the aim of developing prototypes with a high TRL and being able to test the operating principle of the patented systems. Finally, funding was obtained through the Life Program of the European Union and in collaboration with five other partners. The main objective of the LifeDemoWave project (http://www. life-demowave.eu/en/) is the demonstration of the feasibility of the use of wave power for electric generation in order to reduce greenhouse gases' emissions. For demonstration purposes, prototypes of wave power generation, reproducible and scalable at high level, are installed in the Galician coast. LifeDemoWave project considers, as well as its design and implementation, the environmental impact in the installation areas and its effect on biodiversity.Peer Reviewe

Hypoglycaemic and Antioxidant Effects of Propolis of Chihuahua in a Model of Experimental Diabetes

Propolis is a bee-collected natural product that has been proven to have various bioactivities. This study tested the effects of a Mexican propolis on streptozotocin-induced diabetes mellitus in a murine model. The results showed that an ethanolic extract of propolis of Chihuahua (EEPCh) significantly inhibited increases in blood glucose and the loss of body weight in diabetic mice. EEPCh increased plasma insulin levels in STZ-diabetic mice, whereas, in untreated diabetic mice, there was no detection of insulin. EEPCh had a high antioxidant capacity (SA50 = 15.75 μg/mL), which was directly related to the concentrations of total phenols (314 mg GAE/g of extract) and flavonoids (6.25 mg QE/g of extract). In addition, increased activities of the enzymes superoxide dismutase, catalase, and glutathione peroxidase were observed in diabetic mice treated with EEPCh. Compounds such as pinocembrin, quercetin, naringin, naringenin, kaempferol, acacetin, luteolin, and chrysin were identified by HPLC-MS analysis. This investigation demonstrated that propolis of Chihuahua possesses hypoglycaemic and antioxidant activities and can alleviate symptoms of diabetes mellitus in mice. These effects may be directly related to the chemical composition of propolis, as most of the compounds identified in propolis are reportedly active in terms of the different parameters evaluated in this work

Efecto de la ganancia de peso invernal sobre el desarrollo genital de vaquillas a los 18 meses

La edad de primer servicio en vaquillas es una de las grandes limitantes en el nordeste argentino. El objetivo de este trabajo fue determinar el efecto de diferentes ganancias de peso vivo en el primer invierno en confinamiento, con recría estival en pastizal natural, sobre el crecimiento, desarrollo corporal y score genital en vaquillas a los 18 meses de edad. Para el ensayo se utilizaron 45 ter neras de tipo Brangus y en la primer parte del estudio se las distribuyó en 3 corrales, asignándoles cantidades diferentes de la dieta: tratamiento ad–libitum (T1, ganancia esperada 800 g/día), tratamiento con 15% de restricción (T2), y tratamiento con 30% de restricción (T3), continuando luego todas juntas en pastoreo. Las variables medidas fueron altura a la grupa (AG), perímetro torácico (PT), peso vivo (PV), grasa subcutánea de cadera (P8) y score genital (SG). El diseño fue completamente al azar con tres tratamientos y 15 repeticiones. Los resultados obtenidos en T1 fueron AG 116,6 y 131,3 cm; PT de 153,3 y 158,6 cm; PV de 290 y 301,2 kg; P8 de 5,85 y 3,76 mm; SG de 2,80 y 3,23, para el final del período de confinamiento y final del período pastoril, respectivamente. Estos resultados permiten afirmar que los animales se encontraban en condiciones de recibir el primer servicio. A los 18 meses, las vaquillas T2 no presentaron diferencias con T1 en ninguno de los parámetros evaluados. El T3 fue diferente de T1 en todas las variables, excepto en el SG, para el cual no se observaron diferencias estadísticas, atribuible a la gran variabilidad de los datos. La restricción del 15% de la dieta en el período de recría invernal a corral no afectó el desarrollo corporal ni genital de las vaquillas

El joven Nelson : discursos

Discursos de Nelson Gutiérrez, presidente de la federación de estudiantes de la Universidad de Concepción y dirigente de la Comisión Política del MIRPrólogo. Pág. 5 Debate con Salvador Allende. Pág. 20 Bienvenida a Fidel castro. Pág. 3

N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor

On the basis of N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine (II, ASS234) and QSAR predictions, in this work we have designed, synthesized, and evaluated a number of new indole derivatives from which we have identified N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine (2, MBA236) as a new cholinesterase and monoamine oxidase dual inhibitor.PostprintPostprintPeer reviewe

Population genetics of ectoparasitic mites Varroa spp. in Eastern and Western honey bees.

Host shifts of parasites are often causing devastating effects in the new hosts. The Varroa genus is known for a lineage of Varroa destructor that shifted to the Western honey bee, Apis mellifera, with disastrous effects on wild populations and the beekeeping industry. Despite this, the biology of Varroa spp. remains poorly understood in its native distribution range, where it naturally parasitizes the Eastern honey bee, Apis cerana. Here, we combined mitochondrial and nuclear DNA analyses with the assessment of mite reproduction to determine the population structure and host specificity of V. destructor and Varroa jacobsonii in Thailand, where both hosts and several Varroa species and haplotypes are sympatric. Our data confirm previously described mite haplogroups, and show three novel haplotypes. Multiple infestations of single host colonies by both mite species and introgression of alleles between V. destructor and V. jacobsonii suggest that hybridization occurs between the two species. Our results indicate that host specificity and population genetic structure in the genus Varroa is more labile than previously thought. The ability of the host shifted V. destructor haplotype to spillback to A. cerana and to hybridize with V. jacobsonii could threaten honey bee populations of Asia and beyond