Pharmacological effects of the synthetic analogue of the indolicidin on the regeneration of burn and cold wounds in the experiment

There were studied the effects of the use of the synthetic analogue of indolicidin 21 on the processes of regeneration of thermal wounds, the systemic inflammatory response, the functional activity of neutrophils and macrophages, lipid peroxidation processes for IIIA-B degree burns and II-III degree frostbites in rat

Influence of the composition on the thermoelectric and electro-physical properties of Ge-Sb-Te thin films for phase change memory application

Influence of the composition variation along the quasi-binary line GeTe-Sb2Te3 on the thermoelectric and electro-physical properties of thin films was investigated. GST amorphous thin films have high Seebeck coefficients, which drops nearly on the order of magnitude after the crystallization. Temperature dependences of the resistivities were studied, and it was determined that crystallization temperature increases with moving along the quasi-binary line GeTe-Sb2Te3 from GeSb4Te7 to GeSb2Te4, and then to Ge2Sb2Te5, while the phase transition temperature range decreases. Current-voltage characteristics of amorphous thin films have three voltage ranges with different dependencies due to the different mechanisms of charge carrier transport

Синдром Такоцубо у пациентки со злокачественным новообразованием почки

RELEVANCE. The increasing availability of invasive methods for assessing the coronary vessels contributes to the growth in the diagnosis of myocardial damage in intact coronary arteries. One of the least studied diseases that mimic the course of myocardial infarction is Takotsubo syndrome, which quite often remains undiagnosed in real clinical practice. The medical and economic significance of this disease is determined by the high risk of developing life-threatening complications and the need to provide emergency specialized medical care.AIM OF STUDY. The paper presents an analytical review of scientific medical literature from the perspective of illustrating modern concepts of the most common risk factors, etiopathogenesis, diagnosis and treatment of Takotsubo syndrome. A clinical observation of a patient with verified secondary Takotsubo syndrome against a malignant neoplasm of the kidney is also presented.CONCLUSIONS. For a detailed understanding of the potential mechanisms for the development of Takotsubo syndrome, determining the most informative methods for its diagnosis, developing effective strategies for providing medical care and criteria for long-term prognosis, further large-scale studies are needed. Raising the level of awareness of doctors about Takotsubo syndrome, in turn, will allow timely detection of this disease, which will improve the prognosis for patients and minimize the economic costs of treatment. The exclusion of the possibility of overdiagnosis will also help determine the true prevalence of this disease.АКТУАЛЬНОСТЬ. Возрастающая доступность инвазивных методик оценки коронарного русла способствует увеличению случаев диагностики повреждений миокарда при интактных коронарных артериях. Одним из наименее изученных заболеваний, имитирующих течение инфаркта миокарда, является синдром Такоцубо (СТ), который в реальной клинической практике довольно часто остается недиагностированным. Медико-экономическое значение данного заболевания определяется высоким риском развития жизнеугрожающих осложнений и необходимостью оказания экстренной специализированной медицинской помощи.ЦЕЛЬ ИССЛЕДОВАНИЯ. В работе представлен аналитический обзор научной медицинской литературы с позиций иллюстрации современных представлений о наиболее распространенных факторах риска, этиопатогенезе, диагностике и лечении СТ. Также приведено клиническое наблюдение пациентки с верифицированным вторичным СТ на фоне злокачественного новообразования почки.ВЫВОДЫ. Для детального понимания потенциальных механизмов развития СТ, определения наиболее информативных методов его диагностики, разработки эффективных стратегий оказания медицинской помощи и критериев отдаленного прогноза необходимы дальнейшие масштабные исследования. Повышение уровня информированности врачей о СТ, в свою очередь, позволит своевременно выявлять данное заболевание, что улучшит прогноз для пациентов и позволит минимизировать экономические затраты на лечение. Исключение возможности гипердиагностики также будет способствовать определению истинной распространенности данного заболевания

Recognition of Anesthetic Barbiturates by a Protein Binding Site: A High Resolution Structural Analysis

Barbiturates potentiate GABA actions at the GABAA receptor and act as central nervous system depressants that can induce effects ranging from sedation to general anesthesia. No structural information has been available about how barbiturates are recognized by their protein targets. For this reason, we tested whether these drugs were able to bind specifically to horse spleen apoferritin, a model protein that has previously been shown to bind many anesthetic agents with affinities that are closely correlated with anesthetic potency. Thiopental, pentobarbital, and phenobarbital were all found to bind to apoferritin with affinities ranging from 10–500 µM, approximately matching the concentrations required to produce anesthetic and GABAergic responses. X-ray crystal structures were determined for the complexes of apoferritin with thiopental and pentobarbital at resolutions of 1.9 and 2.0 Å, respectively. These structures reveal that the barbiturates bind to a cavity in the apoferritin shell that also binds haloalkanes, halogenated ethers, and propofol. Unlike these other general anesthetics, however, which rely entirely upon van der Waals interactions and the hydrophobic effect for recognition, the barbiturates are recognized in the apoferritin site using a mixture of both polar and nonpolar interactions. These results suggest that any protein binding site that is able to recognize and respond to the chemically and structurally diverse set of compounds used as general anesthetics is likely to include a versatile mixture of both polar and hydrophobic elements

The peroxisome proliferator-activated receptor (PPAR) alpha agonist fenofibrate maintains bone mass, while the PPAR gamma agonist pioglitazone exaggerates bone loss, in ovariectomized rats

<p>Abstract</p> <p>Background</p> <p>Activation of peroxisome proliferator-activated receptor (PPAR)gamma is associated with bone loss and increased fracture risk, while PPARalpha activation seems to have positive skeletal effects. To further explore these effects we have examined the effect of the PPARalpha agonists fenofibrate and Wyeth 14643, and the PPARgamma agonist pioglitazone, on bone mineral density (BMD), bone architecture and biomechanical strength in ovariectomized rats.</p> <p>Methods</p> <p>Fifty-five female Sprague-Dawley rats were assigned to five groups. One group was sham-operated and given vehicle (methylcellulose), the other groups were ovariectomized and given vehicle, fenofibrate, Wyeth 14643 and pioglitazone, respectively, daily for four months. Whole body and femoral BMD were measured by dual X-ray absorptiometry (DXA), and biomechanical testing of femurs, and micro-computed tomography (microCT) of the femoral shaft and head, were performed.</p> <p>Results</p> <p>Whole body and femoral BMD were significantly higher in sham controls and ovariectomized animals given fenofibrate, compared to ovariectomized controls. Ovariectomized rats given Wyeth 14643, maintained whole body BMD at sham levels, while rats on pioglitazone had lower whole body and femoral BMD, impaired bone quality and less mechanical strength compared to sham and ovariectomized controls. In contrast, cortical volume, trabecular bone volume and thickness, and endocortical volume were maintained at sham levels in rats given fenofibrate.</p> <p>Conclusions</p> <p>The PPARalpha agonist fenofibrate, and to a lesser extent the PPARaplha agonist Wyeth 14643, maintained BMD and bone architecture at sham levels, while the PPARgamma agonist pioglitazone exaggerated bone loss and negatively affected bone architecture, in ovariectomized rats.</p

Pharmacological effects of the synthetic analogue of the indolicidin on the regeneration of burn and cold wounds in the experiment

There were studied the effects of the use of the synthetic analogue of indolicidin 21 on the processes of regeneration of thermal wounds, the systemic inflammatory response, the functional activity of neutrophils and macrophages, lipid peroxidation processes for IIIA-B degree burns and II-III degree frostbites in rat

Influence of the composition on the thermoelectric and electro-physical properties of Ge-Sb-Te thin films for phase change memory application

Influence of the composition variation along the quasi-binary line GeTe-Sb2Te3 on the thermoelectric and electro-physical properties of thin films was investigated. GST amorphous thin films have high Seebeck coefficients, which drops nearly on the order of magnitude after the crystallization. Temperature dependences of the resistivities were studied, and it was determined that crystallization temperature increases with moving along the quasi-binary line GeTe-Sb2Te3 from GeSb4Te7 to GeSb2Te4, and then to Ge2Sb2Te5, while the phase transition temperature range decreases. Current-voltage characteristics of amorphous thin films have three voltage ranges with different dependencies due to the different mechanisms of charge carrier transport