Calculation of subsonic and supersonic steady and unsteady aerodynamic forces using velocity potential aerodynamic elements

Expressions for calculation of subsonic and supersonic, steady and unsteady aerodynamic forces are derived, using the concept of aerodynamic elements applied to the downwash velocity potential method. Aerodynamic elements can be of arbitrary out of plane polygon shape, although numerical calculations are restricted to rectangular elements, and to the steady state case in the supersonic examples. It is suggested that the use of conforming, in place of rectangular elements, would give better results. Agreement with results for subsonic oscillating T tails is fair, but results do not converge as the number of collocation points is increased. This appears to be due to the form of expression used in the calculations. The methods derived are expected to facilitate automated flutter analysis on the computer. In particular, the aerodynamic element concept is consistent with finite element methods already used for structural analysis. The method is universal for the complete Mach number range, and, finally, the calculations can be arranged so that they do not have to be repeated completely for every reduced frequency

Depressed clad hollow optical fiber with fundamental LP01 mode cut-off

We propose a depressed clad hollow optical fiber with fundamental (LP01) mode cut-off suitable for high power short-wavelength, especially three-level, fiber laser operation by introducing highly wavelength dependent losses at longer wavelengths. The cut-off characteristic of such fiber structure was investigated. A Yb-doped depressed clad hollow optical fiber laser generating 59.1W of output power at 1046nm with 86% of slope efficiency with respect to the absorbed pump power was realised by placing the LP01 mode cut-off at ~1100nm

Attitude Control System Design & Verification for CNUSAIL-1 with Solar/Drag Sail

CNUSAIL-1, to be launched into low-earth orbit, is a cubesat-class satellite equipped with a 2 m × 2 m solar sail. One of CNUSAIL’s missions is to deploy its solar sail system, thereby deorbiting the satellite, at the end of the satellite’s life. This paper presents the design results of the attitude control system for CNUSAIL-1, which maintains the normal vector of the sail by a 3-axis active attitude stabilization approach. The normal vector can be aligned in two orientations: i) along the anti-nadir direction, which minimizes the aerodynamic drag during the nadir-pointing mode, or ii) along the satellite velocity vector, which maximizes the drag during the deorbiting mode. The attitude control system also includes a B-dot controller for detumbling and an eigen-axis maneuver algorithm. The actuators for the attitude control are magnetic torquers and reaction wheels. The feasibility and performance of the design are verified in high-fidelity nonlinear simulations

Pathogenicity of the H1N1 influenza virus enhanced by functional synergy between the NPV100I and NAD248N pair

By comparing and measuring covariations of viral protein sequences from isolates of the 2009 pH1N1 influenza A virus (IAV), specific substitutions that co-occur in the NP-NA pair were identified. To investigate the effect of these co-occurring substitution pairs, the V100I substitution in NP and the D248N substitution in NA were introduced into laboratory-adapted WSN IAVs. The recombinant WSN with the covarying NPV100I-NAD248N pair exhibited enhanced pathogenicity, as characterized by increased viral production, increased death and inflammation of host cells, and high mortality in infected mice. Although direct interactions between the NPV100I and NAD248N proteins were not detected, the RNA-binding ability of NPV100I was increased, which was further strengthened by NAD248N, in expression-plasmid- transfected cells. Additionally, the NAD248N protein was frequently recruited within lipid rafts, indirectly affecting the RNA-binding ability of NP as well as viral release. Altogether, our data indicate that the covarying NPV100I-NAD248N pair obtained from 2009 pH1N1 IAV sequence information function together to synergistically augment viral assembly and release, which may explain the observed enhanced viral pathogenicity. © 2019 Kim et al.11Ysciescopu

The Mre11-Rad50-Nbs1 complex mediates activation of TopBP1 by ATM

The activation of ATR-ATRIP in response to double-stranded DNA breaks (DSBs) depends upon ATM in human cells and Xenopus egg extracts. One important aspect of this dependency involves regulation of TopBP1 by ATM. In Xenopus egg extracts, ATM associates with TopBP1 and thereupon phosphorylates it on S1131. This phosphorylation enhances the capacity of TopBP1 to activate the ATR-ATRIP complex. We show that TopBP1 also interacts with the Mre11-Rad50-Nbs1 (MRN) complex in egg extracts in a checkpoint-regulated manner. This interaction involves the Nbs1 subunit of the complex. ATM can no longer interact with TopBP1 in Nbs1-depleted egg extracts, which suggests that the MRN complex helps to bridge ATM and TopBP1 together. The association between TopBP1 and Nbs1 involves the first pair of BRCT repeats in TopBP1. In addition, the two tandem BRCT repeats of Nbs1 are required for this binding. Functional studies with mutated forms of TopBP1 and Nbs1 suggested that the BRCT-dependent association of these proteins is critical for a normal checkpoint response to DSBs. These findings suggest that the MRN complex is a crucial mediator in the process whereby ATM promotes the TopBP1-dependent activation of ATR-ATRIP in response to DSBs

Multi-Cluster Reconfiguration with Traffic Prediction in Hyper-Flex-LION Architecture

We study the performance of Hyper-Flex-LION optical interconnect architecture under dynamic traffic with traffic-prediction-aided multi-cluster reconfiguration. The simulation results show a 17.2% latency improvement and 36.9% packet loss reduction as compared to a fixed topology

Machine-Learning-Aided Dynamic Reconfiguration in Optical DC/HPC Networks (Invited)

The high bandwidth and low latency requirements of modern computing applications with their dynamic and nonuniform traffic patterns impose severe challenges to current data center (DC) and high performance computing (HPC) networks. Therefore, we present a dynamic network reconfiguration mechanism that could satisfy the time-varying applications' demands in an optical DC/HPC network. We propose a direct and an indirect topology extraction methods based on a machine learning-Aided traffic prediction approach under multi-Application scenario. The traffic prediction for topology extraction and bandwidth reconfiguration (PredicTER) method could lead to frequent topology and bandwidth reconfiguration. In contrast, the indirect approach, namely traffic prediction with clustering for topology extraction and bandwidth reconfiguration (PrediCLUSTER), utilizes an unsupervised learning-based clustering model to first associate the predicted traffic to one of possible traffic clusters, and then extracts a common topology for the cluster. This restricts the reconfigured topology set to the number of traffic clusters. Our simulation results show that the time-Average of mean packet latencies (and total dropped packets) over 60 seconds of timevarying traffic under the PredicTER, PrediCLUSTER and a static topology are 37.7μs,41.2μs, and 50.2μs (and 37,967, 12,305, and 36,836), respectively. Overall, the PredicTER (and PrediCLUSTER) method(s) can improve the end-To-end packet latency by 24.9% (and 17.8%), and the packet loss rate by-3.1% (and 66.6%), as compared to the static flat Hyper-X-like topology

Ultramafic xenoliths from the Bearpaw Mountains, Montana, USA: evidence for multiple metasomatic events in the lithospheric mantle beneath the Wyoming craton

Ultramafic xenoliths in Eocene minettes of the Bearpaw Mountains volcanic field (Montana, USA), derived from the lower lithosphere of the Wyoming craton, can be divided based on textural criteria into tectonite and cumulate groups. The tectonites consist of strongly depleted spinel lherzolites, harzburgites and dunites. Although their mineralogical compositions are generally similar to those of spinel peridotites in off-craton settings, some contain pyroxenes and spinels that have unusually low Al2O3 contents more akin to those found in cratonic spinel peridotites. Furthermore, the tectonite peridotites have whole-rock major element compositions that tend to be significantly more depleted than non-cratonic mantle spinel peridotites (high MgO, low CaO, Al2O3 and TiO2) and resemble those of cratonic mantle. These compositions could have been generated by up to 30% partial melting of an undepleted mantle source. Petrographic evidence suggests that the mantle beneath the Wyoming craton was re-enriched in three ways: (1) by silicate melts that formed mica websterite and clinopyroxenite veins; (2) by growth of phlogopite from K-rich hydrous fluids; (3) by interaction with aqueous fluids to form orthopyroxene porphyroblasts and orthopyroxenite veins. In contrast to their depleted major element compositions, the tectonite peridotites are mostly light rare earth element (LREE)-enriched and show enrichment in fluid-mobile elements such as Cs, Rb, U and Pb on mantle-normalized diagrams. Lack of enrichment in high field strength elements (HFSE; e.g. Nb, Ta, Zr and Hf) suggests that the tectonite peridotites have been metasomatized by a subduction-related fluid. Clinopyroxenes from the tectonite peridotites have distinct U-shaped REE patterns with strong LREE enrichment. They have 143Nd/144Nd values that range from 0·5121 (close to the host minette values) to 0·5107, similar to those of xenoliths from the nearby Highwood Mountains. Foliated mica websterites also have low 143Nd/144Nd values (0·5113) and extremely high 87Sr/86Sr ratios in their constituent phlogopite, indicating an ancient (probably mid-Proterozoic) enrichment. This enriched mantle lithosphere later contributed to the formation of the high-K Eocene host magmas. The cumulate group ranges from clinopyroxene-rich mica peridotites (including abundant mica wehrlites) to mica clinopyroxenites. Most contain >30% phlogopite. Their mineral compositions are similar to those of phenocrysts in the host minettes. Their whole-rock compositions are generally poorer in MgO but richer in incompatible trace elements than those of the tectonite peridotites. Whole-rock trace element patterns are enriched in large ion lithophile elements (LILE; Rb, Cs, U and Pb) and depleted in HFSE (Nb, Ta Zr and Hf) as in the host minettes, and their Sr–Nd isotopic compositions are also identical to those of the minettes. Their clinopyroxenes are LREE-enriched and formed in equilibrium with a LREE-enriched melt closely resembling the minettes. The cumulates therefore represent a much younger magmatic event, related to crystallization at mantle depths of minette magmas in Eocene times, that caused further metasomatic enrichment of the lithosphere