Highest performance computing machines

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/29854/1/0000201.pd

A Study of Quantum Error Correction by Geometric Algebra and Liquid-State NMR Spectroscopy

Quantum error correcting codes enable the information contained in a quantum state to be protected from decoherence due to external perturbations. Applied to NMR, quantum coding does not alter normal relaxation, but rather converts the state of a ``data'' spin into multiple quantum coherences involving additional ancilla spins. These multiple quantum coherences relax at differing rates, thus permitting the original state of the data to be approximately reconstructed by mixing them together in an appropriate fashion. This paper describes the operation of a simple, three-bit quantum code in the product operator formalism, and uses geometric algebra methods to obtain the error-corrected decay curve in the presence of arbitrary correlations in the external random fields. These predictions are confirmed in both the totally correlated and uncorrelated cases by liquid-state NMR experiments on 13C-labeled alanine, using gradient-diffusion methods to implement these idealized decoherence models. Quantum error correction in weakly polarized systems requires that the ancilla spins be prepared in a pseudo-pure state relative to the data spin, which entails a loss of signal that exceeds any potential gain through error correction. Nevertheless, this study shows that quantum coding can be used to validate theoretical decoherence mechanisms, and to provide detailed information on correlations in the underlying NMR relaxation dynamics.Comment: 33 pages plus 6 figures, LaTeX article class with amsmath & graphicx package

Saturation of a spin 1/2 particle by generalized Local control

We show how to apply a generalization of Local control design to the problem of saturation of a spin 1/2 particle by magnetic fields in Nuclear Magnetic Resonance. The generalization of local or Lyapunov control arises from the fact that the derivative of the Lyapunov function does not depend explicitly on the control field. The second derivative is used to determine the local control field. We compare the efficiency of this approach with respect to the time-optimal solution which has been recently derived using geometric methods.Comment: 12 pages, 4 figures, submitted to new journal of physics (2011

Invisible Higgs and Scalar Dark Matter

In this proceeding, we show that when we combined WMAP and the most recent results of XENON100, the invisible width of the Higgs to scalar dark matter is negligible(<10%), except in a small region with very light dark matter (< 10 GeV) not yet excluded by XENON100 or around 60 GeV where the ratio can reach 50% to 60%. The new results released by the Higgs searches of ATLAS and CMS set very strong limits on the elastic scattering cross section.Comment: 4 pages, 2 figures, proceeding TAUP2011 References adde

Complementarity of Galactic radio and collider data in constraining WIMP dark matter models

In this work we confront dark matter models to constraints that may be derived from radio synchrotron radiation from the Galaxy, taking into account the astrophysical uncertainties and we compare these to bounds set by accelerator and complementary indirect dark matter searches. Specifically we apply our analysis to three popular particle physics models. First, a generic effective operator approach, in which case we set bounds on the corresponding mass scale, and then, two specific UV completions, the Z' and Higgs portals. We show that for many candidates, the radio synchrotron limits are competitive with the other searches, and could even give the strongest constraints (as of today) with some reasonable assumptions regarding the astrophysical uncertainties.Comment: 22 pages, 12 figure

The Inert Doublet Model and Inelastic Dark Matter

The annual modulation observed by DAMA/NaI and DAMA/Libra may be interpreted in terms of elastic or inelastic scattering of dark matter particles. In this paper we confront these two scenarios within the framework of a very simple extension of the Standard Model, the Inert Doublet Model (IDM). In this model the dark matter candidate is a scalar, the lightest component of an extra Higgs doublet. We first revisit the case for the elastic scattering of a light scalar WIMP, M_DM~10 GeV, a scenario which requires that a fraction of events in DAMA are channelled. Second we consider the possibility of inelastic Dark Matter (iDM). This option is technically natural in the IDM, in the sense that the mass splitting between the lightest and next-to-lightest neutral scalars may be protected by a Peccei-Quinn (PQ) symmetry. We show that candidates with a mass M_DM between ~535 GeV and ~50 TeV may reproduce the DAMA data and have a cosmic abundance in agreement with WMAP. This range may be extended to candidates as light as ~50 GeV if we exploit the possibility that the approximate PQ symmetry is effectively conserved and that a primordial asymmetry in the dark sector may survive until freeze-out.Comment: 16 pages, 7 figures. v2: minor changes and discussion on the embedding in SO(10) added. v3: matches the published version in JCA

The Yuan-Tseh Lee Array for Microwave Background Anisotropy

The Yuan-Tseh Lee Array for Microwave Background Anisotropy (AMiBA) is the first interferometer dedicated to studying the cosmic microwave background (CMB) radiation at 3mm wavelength. The choice of 3mm was made to minimize the contributions from foreground synchrotron radiation and Galactic dust emission. The initial configuration of seven 0.6m telescopes mounted on a 6-m hexapod platform was dedicated in October 2006 on Mauna Loa, Hawaii. Scientific operations began with the detection of a number of clusters of galaxies via the thermal Sunyaev-Zel'dovich effect. We compare our data with Subaru weak lensing data in order to study the structure of dark matter. We also compare our data with X-ray data in order to derive the Hubble constant.Comment: accepted for publication in ApJ (13 pages, 7 figures); a version with high resolution figures available at http://www.asiaa.sinica.edu.tw/~keiichi/upfiles/AMiBA7/pho_highreso.pd

Ground-based terahertz CO spectroscopy towards Orion

Using a superconductive hot-electron bolometer heterodyne receiver on the 10-m Heinrich Hertz Telescope on Mount Graham, Arizona, we have obtained velocity-resolved 1.037 THz CO (J = 9 → 8) spectra toward several positions along the Orion Molecular Cloud (OMC-1) ridge. We confirm the general results of prior observations of high-J CO lines that show that the high temperature, T_(kin) ≥ 130 K, high density molecular gas, N ≥ 10^6 cm^(-3), is quite extended, found along a ~ 4' region centered on BN/KL. However, our observations have significantly improved angular resolution, and with a beam size of θ_(FWHP) we are able to spatially and kinematically discriminate the emission originating in the extended quiescent ridge from the very strong and broadened emission originating in the compact molecular outflow. The ridge emission very close to the BN/KL region appears to originate from two distinct clouds along the line of sight with v_(LSR) ≈ +6(1)kms^(-1) and ≈ +10(1)km s^(-1). The former component dominates the emission to the south of BN/KL and the latter to the north, with a turnover point coincident with or near BN/KL. Our evidence precludes a simple rotation of the inner ridge and lends support to a model in which there are multiple molecular clouds along the line of sight towards the Orion ridge

Targeting the IL-6 Dependent Phenotype Can Identify Novel Therapies for Cholangiocarcinoma

The need for new therapies for cholangiocarcinoma is highlighted by their poor prognosis and refractoriness to chemotherapy. Increased production of Interleukin-6 promotes cholangiocarcinoma growth and contributes to chemoresistance by activating cell survival mechanisms. We sought to identify biologically active compounds capable of ameliorating the phenotypic effects of IL-6 expression and to explore their potential therapeutic use for cholangiocarcinoma.A genomic signature associated with Interleukin-6 expression in Mz-ChA-1 human malignant cholangiocytes was derived. Computational bioinformatics analysis was performed to identify compounds that induced inverse gene changes to the signature. The effect of these compounds on cholangiocarcinoma growth was then experimentally verified in vitro and in vivo. Interactions with other therapeutic agents were evaluated using median effects analysis.A group of structurally related compounds, nitrendipine, nifedipine and felodipine was identified. All three compounds were cytotoxic to Mz-ChA-1 cells with an IC50 for felodipine of 26 µM, nitrendipine, 44 µM and nifedipine, 15 µM. Similar results were observed in KMCH-1, CC-LP-1 and TFK-1 cholangiocarcinoma cell lines. At a fractional effect of 0.5, all three agents were synergistic with either camptothecin or gemcitabine in Mz-ChA-1 cells in vitro. Co-administration of felodipine and gemcitabine decreased the growth of Mz-ChA-1 cell xenografts in nude athymic mice.Computational bioinformatics analysis of phenotype-based genomic expression can be used to identify therapeutic agents. Using this drug discovery approach based on targeting a defined tumor associated phenotype, we identified compounds with the potential for therapeutic use in cholangiocarcinoma