2,783 research outputs found
Synthetic biology: advancing biological frontiers by building synthetic systems
Advances in synthetic biology are contributing
to diverse research areas, from basic biology to
biomanufacturing and disease therapy. We discuss the
theoretical foundation, applications, and potential of
this emerging field
A perspective on reactive nitrogen in a global, Asian and Indian context
Reactive nitrogen (Nr) includes the inorganic (NH3, NH+4 , NOx, HNO3, N2O, NO-3) and organic forms (urea, amines, proteins, nucleic acids) that readily participate in various reactions of the global N cycle. Over the last half a century, anthropogenic perturbations of the natural N cycle have led to the increasing accumulation of inorganic Nr in the soil, water and air, intentionally through agriculture and unintentionally through fossil-fuel consumption and other activities, adversely affecting human health, biodiversity, environment and climate change. One of the major emerging challenges of this century will be to ensure adequate availability of Nr inputs for agriculture and other activities, while preventing their unwanted accumulation. This article provides an overall perspective of the emerging issues related to Nr in the global, Asian and Indian contexts
A uniqueness theorem for the adS soliton
The stability of physical systems depends on the existence of a state of
least energy. In gravity, this is guaranteed by the positive energy theorem.
For topological reasons this fails for nonsupersymmetric Kaluza-Klein
compactifications, which can decay to arbitrarily negative energy. For related
reasons, this also fails for the AdS soliton, a globally static, asymptotically
toroidal spacetime with negative mass. Nonetheless, arguing from
the AdS/CFT correspondence, Horowitz and Myers (hep-th/9808079) proposed a new
positive energy conjecture, which asserts that the AdS soliton is the unique
state of least energy in its asymptotic class. We give a new structure theorem
for static spacetimes and use it to prove uniqueness of the AdS
soliton. Our results offer significant support for the new positive energy
conjecture and add to the body of rigorous results inspired by the AdS/CFT
correspondence.Comment: Revtex, 4 pages; Matches published version. More detail in Abstract
and one equation corrected. For details of proofs and further results, see
hep-th/020408
A public health approach to the impact of climate change on health in southern Africa – identifying priority modifiable risks
Anthropogenic climate change and anticipated adverse effects on human health as outlined by the Intergovernmental Panel on Climate Change (IPCC) are taken as givens. A conceptual model for thinking about the spectrum of climate-related health risks ranging from distal and infrastructural to proximal and behavioural and their relation to the burden of disease pattern typical ofsub-Saharan Africa is provided. The model provides a tool for identifying modifiable risk factors with a view to future research, specifically into the performance of interventions to reduce the impact of climate change.S Afr Med J 2011;101:817-820. 
Anomalies, Unparticles, and Seiberg Duality
We calculate triangle anomalies for fermions with non-canonical scaling
dimensions. The most well known example of such fermions (aka unfermions)
occurs in Seiberg duality where the matching of anomalies (including mesinos
with scaling dimensions between 3/2 and 5/2) is a crucial test of duality. By
weakly gauging the non-local action for an unfermion, we calculate the one-loop
three-current amplitude. Despite the fact that there are more graphs with more
complicated propagators and vertices, we find that the calculation can be
completed in a way that nearly parallels the usual case. We show that the
anomaly factor for fermionic unparticles is independent of the scaling
dimension and identical to that for ordinary fermions. This can be viewed as a
confirmation that unparticle actions correctly capture the physics of conformal
fixed point theories like Banks-Zaks or SUSY QCD.Comment: 13 pages, 1 figur
Residual stress generation in tungsten-copper brazed joint using brazing alloy
Understanding the residual stress state in brazed joints is crucial for operational design and life time performance of the part in service. High magnitudes residual stresses are expected in the joined materials following cooling from brazing temperatures (≈950°C) due to large mismatches in material properties such as coefficient of thermal expansion and Young’s modulus. This study aims at further understanding of the generation and distribution of residual stresses when brazing tungsten to copper using a eutectic gold-copper brazing alloy. This configuration is potentially useful for future divertor designs. Finite Element Analysis (FEM) has been used to predict the brazing induced stresses and residual stress measurements were carried out on the brazed joint by X-ray diffraction (XRD) to validate the prediction model. Large residual stresses are predicted and measured in the tungsten; however there is disagreement in the sign of the stress. Predicted stresses are highly tensile in nature close to the brazing interface, whereas the measured stresses are highly compressive. The disagreement is believed to be caused by the model not accurately simulating the complex brazing process. Residual stress measurements on the copper were not possible due to texturing during brazing, grain growth and significant inelastic strains and deformations. Misalignment of parent materials was also observed to significantly affect residual stresses
Residual stress generations in brazed tungsten dissimilar joints
Understanding the residual stress state in brazed joints is crucial for the operational design and lifetime performance of the part in service. High-magnitude residual stresses are expected in the joined materials following cooling from brazing temperatures (≈950 °C) due to large mismatches in the thermal and mechanical properties. This paper aims at further understanding of the residual stresses caused when brazing tungsten to copper and tungsten to 316L austenitic steel using a eutectic gold-copper brazing alloy. These configurations are potentially useful for future diverter designs. Finite element analysis has been used to predict the brazing-induced stresses and residual stress measurements were carried out on the brazed joint by X-ray diffraction to validate the prediction model. Large residual stresses are predicted and measured in the tungsten; however, there is disagreement in the nature of the stress in the tungsten-copper configuration. Predicted stresses are highly tensile in nature close to the brazing interface, whereas the measured stresses are highly compressive. The disagreement is believed to be caused by the model not accurately simulating the complex brazing process. Residual stress measurements on the copper were not possible due to texturing during brazing, grain growth, and significant inelastic strains. There is excellent correlation between the measured and predicted stresses in the tungsten-316L configuration. High-tensile stresses were predicted in the tungsten (magnitude approximately 1000 MPa close to the braze interface) and high tensile stresses were measured (magnitude approximately 800 MPa in the same region). Joint misalignment of parent materials was also observed to significantly affect the residual stresses
Puzzling thermonuclear burst behaviour from the transient low-mass X-ray binary IGR J17473-2721
We investigate the thermonuclear bursting behaviour of IGR J17473-2721, an
X-ray transient that in 2008 underwent a six month long outburst, starting
(unusually) with an X-ray burst. We detected a total of 57 thermonuclear bursts
throughout the outburst with AGILE, Swift, RXTE, and INTEGRAL. The wide range
of inferred accretion rates (between <1% and about 20% of the Eddington
accretion rate m-dot_Edd) spanned during the outburst allows us to study
changes in the nuclear burning processes and to identify up to seven different
phases. The burst rate increased gradually with the accretion rate until it
dropped (at a persistent flux corresponding to about 15% of m-dot_Edd) a few
days before the outburst peak, after which bursts were not detected for a
month. As the persistent emission subsequently decreased, the bursting activity
resumed with a much lower rate than during the outburst rise. This hysteresis
may arise from the thermal effect of the accretion on the surface nuclear
burning processes, and the timescale is roughly consistent with that expected
for the neutron star crust thermal response. On the other hand, an undetected
superburst, occurring within a data gap near the outburst peak, could have
produced a similar quenching of burst activity.Comment: 18 pages, 12 figures, 1 table, accepted for publication in MNRA
Fingerprinting the impacts of global change on tropical forests
Recent observations of widespread changes in mature tropical forests such as increasing tree growth, recruitment and mortality rates and increasing above-ground biomass suggest that 'global change' agents may be causing predictable changes in tropical forests. However, consensus over both the robustness of these changes and the environmental drivers that may be causing them is yet to emerge. This paper focuses on the second part of this debate. We review (i) the evidence that the physical, chemical and biological environment that tropical trees grow in has been altered over recent decades across large areas of the tropics, and (ii) the theoretical, experimental and observational evidence regarding the most likely effects of each of these changes on tropical forests. Ten potential widespread drivers of environmental change were identified: temperature, precipitation, solar radiation, climatic extremes (including El Niño Southern Oscillation events), atmospheric CO2 concentrations, nutrient deposition, O3/acid depositions, hunting, land-use change and increasing liana numbers. We note that each of these environmental changes is expected to leave a unique 'fingerprint' in tropical forests, as drivers directly force different processes, have different distributions in space and time and may affect some forests more than others (e.g. depending on soil fertility). Thus, in the third part of the paper we present testable a priori predictions of forest responses to assist ecologists in attributing particular changes in forests to particular causes across multiple datasets. Finally, we discuss how these drivers may change in the future and the possible consequences for tropical forests
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