Right for the Right Reason: Training Agnostic Networks

We consider the problem of a neural network being requested to classify images (or other inputs) without making implicit use of a "protected concept", that is a concept that should not play any role in the decision of the network. Typically these concepts include information such as gender or race, or other contextual information such as image backgrounds that might be implicitly reflected in unknown correlations with other variables, making it insufficient to simply remove them from the input features. In other words, making accurate predictions is not good enough if those predictions rely on information that should not be used: predictive performance is not the only important metric for learning systems. We apply a method developed in the context of domain adaptation to address this problem of "being right for the right reason", where we request a classifier to make a decision in a way that is entirely 'agnostic' to a given protected concept (e.g. gender, race, background etc.), even if this could be implicitly reflected in other attributes via unknown correlations. After defining the concept of an 'agnostic model', we demonstrate how the Domain-Adversarial Neural Network can remove unwanted information from a model using a gradient reversal layer.Comment: Author's original versio

The distance to the SNR CTB109 deduced from its environment

We conducted a study of the environment around the supernova remnant CTB109. We found that the SNR is part of a large complex of HII regions extending over an area of 400 pc along the Galactic plane at a distance of about 3 kpc at the closer edge of the Perseus spiral arm. At this distance CTB109 has a diameter of about 24 pc. We demonstrated that including spiral shocks in the distance estimation is an ultimate requirement to determine reliable distances to objects located in the Perseus arm. The most likely explanation for the high concentration of HII regions and SNRs is that the star formation in this part of the Perseus arm is triggered by the spiral shock.Comment: 6 pages, 6 figures. accepted for publication in the Astrophysical Journa

E-Ticaret İşlem Hacmi ve Tüketici Güven Endeksi Arasında Uzun Dönemli İlişki Araştırması::Eşbütünleşme Analizi

Due to continuous technological development of the internet, E-Commerce has become an important part of our lives. Among other things, it is logical to assume a close relatioship between the use of E-Commerce and consumer confidence. In this paper, we look for evidence of cointegration between volume of E-Commerce activities and the Consumer Confidence Index using ARDL and Durbin Watson approaches. We fail to detect any long-term relationship between the two variables.E-Ticaret, teknolojinin gelişmesi ile birlikte hayatımızda önemli bir yer edinmiş bulunmaktadır. Teknolojik gelişmelere oldukça bağlı olmasının yanı sıra tüketicilerin güveni ile de yakından ilgili olduğu aşikardır. Bu çalışmada E-Ticaret işlem hacmi ve tüketici güven endeksi arasındaki ilişki eşbütünleşme analizi yöntemlerinden olan ARDL yaklaşımı ve Durbin Watson yaklaşımı ile araştırılmıştır. Araştırmanın sonucunda sözü edilen iki değişken arasında uzun dönemli ilişki olmadığı saptanmıştır

Contemporaneous Observations of HαH\alpha Luminosities and Photometric Amplitudes for M Dwarfs

While many M dwarfs are known to have strong magnetic fields and high levels of magnetic activity, we are still unsure about the properties of their starspots and the origin of their magnetic dynamos. Both starspots and chromospheric heating are generated by the surface magnetic field; they produce photometric variability and Halpha emission, respectively. Connecting brightness variations to magnetic activity therefore provides a means to examine M dwarf magnetism. We survey 30 M dwarfs previously identified as fast rotating stars (Prot < 10 days). We present time-series optical photometry from the Transiting Exoplanet Survey Satellite (TESS) and contemporaneous optical spectra obtained using the Ohio State Multi-Object Spectrograph (OSMOS) on the 2.4m Hiltner telescope at MDM Observatory in Arizona. We measure rotation periods and photometric amplitudes from TESS light curves using Gaussian Processes. From the OSMOS spectra, we calculate the equivalent width of Halpha, and LHalpha/Lbol. We find a weak positive correlation between Halpha luminosity and the semi-amplitude, Rvar p=0.005_{-0.005}^{+0.075}. We also observe short-term variability (between 20-45 minutes) in Halpha equivalent widths and possible enhancement from flares consistent to recent literature.Comment: 19 pages, 9 Figures, 2 Tables, Poster Presented at Cool Stars 21, Publication post-copy editin

Stable reduction of CCR5 by RNAi through hematopoietic stem cell transplant in non-human primates

RNAi is a powerful method for suppressing gene expression that has tremendous potential for therapeutic applications. However, because endogenous RNAi plays a role in normal cellular functions, delivery and expression of siRNAs must be balanced with safety. Here we report successful stable expression in primates of siRNAs directed to chemokine (c-c motif) receptor 5 (CCR5) introduced through CD34+ hematopoietic stem/progenitor cell transplant. After hematopoietic reconstitution, to date 14 months after transplant, we observe stably marked lymphocytes expressing siRNAs and consistent down-regulation of chemokine (c-c motif) receptor 5 expression. The marked cells are less susceptible to simian immunodeficiency virus infection ex vivo. These studies provide a successful demonstration that siRNAs can be used together with hematopoietic stem cell transplant to stably modulate gene expression in primates and potentially treat blood diseases such as HIV-1

Distribution of selenium in the plume of the Gediz River, Izmir Bay, Aegean Sea

Selenium (Se) variations in the water column, suspended particulate matter, and sediment through the salinity gradient, together with water-quality parameters, were investigated over four different river conditions: lowest–highest runoff and high–low production period between November 2004 and August 2005 in the plume of the Gediz River, Aegean Sea, Turkey. The drainage basin of the Gediz delta is predominantly agricultural and industrial in character. Dissolved Se exceeded the water-quality standard of 5 μg L–1 during high flow and varied from 9.4 μg L–1 to 0.02 μg L–1 through the salinity gradient during the study period. Particulate Se ranged from 5.2 μg L–1 to 0.02 μg L–1. Sediment in the river mouth was highly affected by Se contamination and reached a level greater than four times (7.6 μg L–1 dry wt) the background level. The results indicated that Se supplied by the river was removed rapidly from the water column before the salinity reached an average value of about 20 and accumulated within the delta

Health and socio-demographic characteristics associated with uptake of seasonal influenza vaccination amongst pregnant women: retrospective cohort study

Pregnant women are at increased risk from influenza, yet maternal influenza vaccination levels remain suboptimal. This study aimed to estimate associations between socio-demographic and health characteristics and seasonal influenza vaccination uptake among pregnant women and understand trends over time to inform interventions to improve vaccine coverage. A retrospective cohort study using linked electronic health records of women in North West London with at least one pregnancy overlapping with an influenza season between September 2010 and February 2020. We used a multivariable mixed-effects logistic regression model to identify associations between characteristics of interest and primary outcome of influenza vaccination. 451,954 pregnancies, among 260,744 women, were included. In 85,376 (18.9%) pregnancies women were vaccinated against seasonal influenza. Uptake increased from 8.4% in 2010/11 to 26.3% in 2018/19, dropping again to 21.1% in 2019/20. Uptake was lowest among women: aged 15-19 years (12%) or over 40 years (15%; OR 1.17, 95% CI 1.10 to 1.24); of Black ethnicity (14.1%; OR 0.55, 95% CI 0.53 to 0.57), or unknown ethnicity (9.9%; OR 0.42, 95% CI 0.39 to 0.46), lived in more deprived areas (OR least vs most deprived 1.16, 95% CI 1.11 to 1.21), or with no known risk factors for severe influenza. Seasonal influenza vaccine uptake in pregnant women increased in the past decade, prior to the COVID-19 pandemic, but remained suboptimal. We recommend approaches to reducing health inequalities should focus on women of Black ethnicity, younger and older women, and women living in areas of greater socio-economic deprivation

Recent Advances in Percutaneous Cardioscopy

Percutaneous cardioscopy, using high-resolution fiberoptic imaging, enables direct visualization of the cardiac interior, thereby enabling macroscopic pathological diagnosis. Percutaneous cardioscopy has demonstrated that the endocardial surface exhibits various colors characteristic of different heart diseases. This imaging modality can now be used for evaluation of the severity of myocardial ischemia, and staging of myocarditis. Myocardial blood flow recovery induced by vasodilating agents or percutaneous coronary interventions can be clearly visualized. Morphological and functional changes in the cardiac valves can also be evaluated. Cardioscope-guided endomyocardial biopsy enables pin-point biopsy of the diseased myocardium. Recently, dye-image cardioscopy and fluorescence cardioscopy were developed for evaluation of the subendocardial microcirculation. Cardioscope-guided intracardiac therapies such as myotomy, myectomy, valvulotomy, and transendocardial angiogenic and myogenic therapy have been trialed using animal models in anticipation of future clinical applications. Percutaneous cardioscopy has the potential to contribute to our understanding of heart disease, and to assist in guidance for intracardiac therapies

A Drosophila screen identifies NKCC1 as a modifier of NGLY1 deficiency

N-Glycanase 1 (NGLY1) is a cytoplasmic deglycosylating enzyme. Loss-of-function mutations in the NGLY1 gene cause NGLY1 deficiency, which is characterized by developmental delay, seizures, and a lack of sweat and tears. To model the phenotypic variability observed among patients, we crossed a Drosophila model of NGLY1 deficiency onto a panel of genetically diverse strains. The resulting progeny showed a phenotypic spectrum from 0 to 100% lethality. Association analysis on the lethality phenotype, as well as an evolutionary rate covariation analysis, generated lists of modifying genes, providing insight into NGLY1 function and disease. The top association hit was Ncc69 (human NKCC1/2), a conserved ion transporter. Analyses in NGLY1-/- mouse cells demonstrated that NKCC1 has an altered average molecular weight and reduced function. The misregulation of this ion transporter may explain the observed defects in secretory epithelium function in NGLY1 deficiency patients