Know-how of primary eye care among Health Extension Workers (HEWs) in Southern Ethiopia

Background/ Aim: Frontline health personnel can play key role in preventing and controlling blindness if they have good understanding of primary eye care (PEC). This study determined knowledge, attitude and practice of PEC among health extension workers (HEWs) in southern Ethiopia. Methods: A cross sectional community based study was conducted between June and July 2007 in five randomly selected woredas of Gurage Zone. Quantitative data were collected using a questionnaire completed in a face-faceinterview with 111 HEWs. And this was supported with qualitative information from two focus group discussions. Result: HEWs (87%) had poor understanding of the functional definition of blindness. They identified cataract (85%), trachoma (96%) and trauma (64%) as causes of blindness. Although most (89%) correctly mentioned signs and symptoms of trachoma, but only 10% could describe its control strategy. Refractive error was wrongly perceived by most (77%) as only a near vision problem. Glaucoma was barely known but causes of childhood blindness were well identified.. Their main source of information for eye health care was pre-service training (50%) and refresher trainings by international organizations (46%). HEWs practiced mainly preventive aspects of PEC. Group discussions revealed that HEWs have good will to participate in PEC but barriers such as inadequate knowledge and lack of basic suppliesare limiting their contribution. Conclusion: Know-how of blinding eye disease among HEWs is too low to enable them contribute meaningfullytowards prevention of blindness. It is recommended that PEC be incorporated in their training curriculum

Diaspididae (Hemiptera: Coccoidea) of Espírito Santo, Brazil

Twenty-seven species of armored scale insects (Hemiptera: Diaspididae) are newly recorded from Espírito Santo, Brazil, and information on the host plants and geographic distribution of the 31 species of Diaspididae that have been identified in the State is provided. New plant host records are reported for 11 of the diaspidid species studied and results are discussed with respect to development of agriculture in this and similar areas with objectives of modernization and diversification

Prognostic value of temporal patterns of left atrial reservoir strain in patients with heart failure with reduced ejection fraction

Background: We investigated whether repeatedly measured left atrial reservoir strain (LASr) in heart failure with reduced ejection fraction (HFrEF) patients provides incremental prognostic value over a single baseline LASr value, and whether temporal patterns of LASr provide incremental prognostic value over temporal patterns of other echocardiographic markers and NT-proBNP. Methods: In this prospective observational study, 153 patients underwent 6-monthly echocardiography, during a median follow-up of 2.5 years. Speckle tracking echocardiography was used to measure LASr. Hazard ratios (HRs) were calculated for LASr from Cox models (baseline) and joint models (repeated measurements). The primary endpoint (PEP) comprised HF hospitalization, left ventricular assist device, heart transplantation, and cardiovascular death. Results: Mean age was 58 ± 11 years, 76% were men, 82% were in NYHA class I/II, mean LASr was 20.9% ± 11.3%, and mean LVEF was 29% ± 10%. PEP was reached by 50 patients. Baseline and repeated measurements of LASr (HR per SD change (95% CI) 0.20 (0.10–0.41) and (0.13 (0.10–0.29), respectively) were both significantly associated with the PEP, independent of both baseline and repeated measurements of other echo-parameters and NT-proBNP. Although LASr was persistently lower over time in patients with PEP, temporal trajectories did not diverge in patients with versus without the PEP as the PEP approached. Conclusion: LASr was associated with adverse events in HFrEF patients, independent of baseline and repeated other echo-parameters and NT-proBNP. Temporal trajectories of LASr showed decreased but stable values in patients with the PEP, and do not provide incremental prognostic value for clinical practice compared to single measurements of LASr. Graphical abstract: [Figure not available: see fulltext.].</p

N-type graphene induced by dissociative H-2 adsorption at room temperature

Studies of the interaction between hydrogen and graphene have been increasingly required due to the indispensable modulation of the electronic structure of graphene for device applications and the possibility of using graphene as a hydrogen storage material. Here, we report on the behaviour of molecular hydrogen on graphene using the gate voltage-dependent resistance of single-, bi-, and multi-layer graphene sheets as a function of H-2 gas pressure up to 24 bar from 300 K to 345 K. Upon H-2 exposure, the charge neutrality point shifts toward the negative gate voltage region, indicating n-type doping, and distinct Raman signature changes, increases in the interlayer distance of multi-layer graphene, and a decrease in the d-spacing occur, as determined by TEM. These results demonstrate the occurrence of dissociative H-2 adsorption due to the existence of vacancy defects on graphene.open12

Performance evaluation on an air-cooled heat exchanger for alumina nanofluid under laminar flow

This study analyzes the characteristics of alumina (Al2O3)/water nanofluid to determine the feasibility of its application in an air-cooled heat exchanger for heat dissipation for PEMFC or electronic chip cooling. The experimental sample was Al2O3/water nanofluid produced by the direct synthesis method at three different concentrations (0.5, 1.0, and 1.5 wt.%). The experiments in this study measured the thermal conductivity and viscosity of nanofluid with weight fractions and sample temperatures (20-60°C), and then used the nanofluid in an actual air-cooled heat exchanger to assess its heat exchange capacity and pressure drop under laminar flow. Experimental results show that the nanofluid has a higher heat exchange capacity than water, and a higher concentration of nanoparticles provides an even better ratio of the heat exchange. The maximum enhanced ratio of heat exchange and pressure drop for all the experimental parameters in this study was about 39% and 5.6%, respectively. In addition to nanoparticle concentration, the temperature and mass flow rates of the working fluid can affect the enhanced ratio of heat exchange and pressure drop of nanofluid. The cross-section aspect ratio of tube in the heat exchanger is another important factor to be taken into consideration

Saharan dust and association between particulate matter and case-specific mortality: a case-crossover analysis in Madrid (Spain)

<p>Abstract</p> <p>Background</p> <p>Saharan dust intrusions are a common phenomenon in the Madrid atmosphere, leading induce exceedances of the 50 μg/m³- EU 24 h standard for PM₁₀.</p> <p>Methods</p> <p>We investigated the effects of exposure to PM₁₀between January 2003 and December 2005 in Madrid (Spain) on daily case-specific mortality; changes of effects between Saharan and non-Saharan dust days were assessed using a time-stratified case-crossover design.</p> <p>Results</p> <p>Saharan dust affected 20% of days in the city of Madrid. Mean concentration of PM₁₀was higher during dust days (47.7 μg/m³) than non-dust days (31.4 μg/m³). The rise of mortality per 10 μg/m³PM₁₀concentration were always largely for Saharan dust-days. When stratifying by season risks of PM₁₀, at lag 1, during Saharan dust days were stronger for respiratory causes during cold season (IR% = 3.34% (95% CI: 0.36, 6.41) versus 2.87% (95% CI: 1.30, 4.47)) while for circulatory causes effects were stronger during warm season (IR% = 4.19% (95% CI: 1.34, 7.13) versus 2.65% (95% CI: 0.12, 5.23)). No effects were found for cerebrovascular causes.</p> <p>Conclusions</p> <p>We found evidence of strongest effects of particulate matter during Saharan dust days, providing a suggestion of effect modification, even though interaction terms were not statistically significant. Further investigation is needed to understand the mechanism by which Saharan dust increases mortality.</p

The Ras Antagonist, Farnesylthiosalicylic Acid (FTS), Decreases Fibrosis and Improves Muscle Strength in dy2J/dy2J Mouse Model of Muscular Dystrophy

The Ras superfamily of guanosine-triphosphate (GTP)-binding proteins regulates a diverse spectrum of intracellular processes involved in inflammation and fibrosis. Farnesythiosalicylic acid (FTS) is a unique and potent Ras inhibitor which decreased inflammation and fibrosis in experimentally induced liver cirrhosis and ameliorated inflammatory processes in systemic lupus erythematosus, neuritis and nephritis animal models. FTS effect on Ras expression and activity, muscle strength and fibrosis was evaluated in the dy2J/dy2J mouse model of merosin deficient congenital muscular dystrophy. The dy2J/dy2J mice had significantly increased RAS expression and activity compared with the wild type mice. FTS treatment significantly decreased RAS expression and activity. In addition, phosphorylation of ERK, a Ras downstream protein, was significantly decreased following FTS treatment in the dy2J/dy2J mice. Clinically, FTS treated mice showed significant improvement in hind limb muscle strength measured by electronic grip strength meter. Significant reduction of fibrosis was demonstrated in the treated group by quantitative Sirius Red staining and lower muscle collagen content. FTS effect was associated with significantly inhibition of both MMP-2 and MMP-9 activities. We conclude that active RAS inhibition by FTS was associated with attenuated fibrosis and improved muscle strength in the dy2J/dy2J mouse model of congenital muscular dystrophy

Immunity to Lutzomyia intermedia Saliva Modulates the Inflammatory Environment Induced by Leishmania braziliensis

Transmission of Leishmania parasites occurs during blood feeding, when infected female sand flies inject humans with parasites and saliva. Chemokines and cytokines are secreted proteins that regulate the initial immune responses and have the potential of attracting and activating cells. Herein, we studied the expression of such molecules and the cellular recruitment induced by salivary proteins of the Lutzomyia intermedia sand fly. Of note, Lutzomyia intermedia is the main vector of Leishmania braziliensis, a parasite species that causes cutaneous leishmaniasis, a disease associated with the development of destructive skin lesions that can be fatal if left untreated. We observed that L. intermedia salivary proteins induce a potent cellular recruitment and modify the expression profile of chemokines and cytokines in mice. More importantly, in mice previously immunized with L. intermedia saliva, the alteration in the initial inflammatory response was even more pronounced, in terms of the number of cells recruited and in terms of gene expression pattern. These findings indicate that an existing immunity to L. intermedia sand fly induces an important modulation in the initial immune response that may, in turn, promote parasite multiplication, leading to the development of cutaneous leishmaniasis

Defining complementary tools to the IVI. The Infrastructure Degradation Index (IDI) and the Infrastructure Histogram (HI)

[EN] The Infrastructure Value Index (IVI) is quickly becoming a standard as a valuable tool to quickly assess the state of urban water infrastructure. However, its simple nature (as a single metric) can mask some valuable information and lead to erroneous conclusions. This paper introduces two complementary tools to IVI: The Infrastructure Degradation Index (IDI) and the Infrastructure Histogram (HI). The IDI is focused on time (compared to the IVI, focused on value), represents an intuitive concept and behaves in a linear way. The joint analysis of IVI and IDI provides results in a more complete understanding of the state of the assets, while maintaining the simplicity of the tools. The Infrastructure Histogram allows for a full evaluation of the infrastructure state and provides a detailed picture of network age compared to its expected life, as well as an order of magnitude of the required investments in the following years.Cabrera Rochera, E.; Estruch-Juan, ME.; Gomez Selles, E.; Del Teso-March, R. (2019). Defining complementary tools to the IVI. The Infrastructure Degradation Index (IDI) and the Infrastructure Histogram (HI). Urban Water Journal. 16(5):343-352. https://doi.org/10.1080/1573062X.2019.1669195S343352165Alegre, H., Vitorino, D., & Coelho, S. (2014). Infrastructure Value Index: A Powerful Modelling Tool for Combined Long-term Planning of Linear and Vertical Assets. Procedia Engineering, 89, 1428-1436. doi:10.1016/j.proeng.2014.11.469Amaral, R., Alegre, H., & Matos, J. S. (2016). A service-oriented approach to assessing the infrastructure value index. Water Science and Technology, 74(2), 542-548. doi:10.2166/wst.2016.250Aware-p.org. 2014. “AWARE-P/Software.” Accessed 25 November 2018. http://www.aware-p.org/np4/software/Baseform. 2018. “Baseform.” Accessed 24 November 2018. https://baseform.com/np4/productCanal de Isabel II Gestión. 2012. Normas Para Redes de Abastecimiento. [Standards for Water Supply Networks.]. https://www.canalgestion.es/es/galeria_ficheros/pie/normativa/normativa/Normas_redes_abastecimiento2012_CYIIG.pdfFrost, and Sullivan. 2011. “Western European Water and Wastewater Utilities Market.” https://store.frost.com/western-european-water-and-wastewater-utilities-market.html#section1Leitão, J. P., Coelho, S. T., Alegre, H., Cardoso, M. A., Silva, M. S., Ramalho, P., … Carriço, N. (2014). Moving urban water infrastructure asset management from science into practice. Urban Water Journal, 13(2), 133-141. doi:10.1080/1573062x.2014.939092Marchionni, V., Cabral, M., Amado, C., & Covas, D. (2016). Estimating Water Supply Infrastructure Cost Using Regression Techniques. Journal of Water Resources Planning and Management, 142(4), 04016003. doi:10.1061/(asce)wr.1943-5452.0000627Marchionni, V., Lopes, N., Mamouros, L., & Covas, D. (2014). Modelling Sewer Systems Costs with Multiple Linear Regression. Water Resources Management, 28(13), 4415-4431. doi:10.1007/s11269-014-0759-zPulido-Velazquez, M., Cabrera Marcet, E., & Garrido Colmenero, A. (2014). Economía del agua y gestión de recursos hídricos. Ingeniería del agua, 18(1), 95. doi:10.4995/ia.2014.3160Rokstad, M. M., Ugarelli, R. M., & Sægrov, S. (2015). Improving data collection strategies and infrastructure asset management tool utilisation through cost benefit considerations. Urban Water Journal, 13(7), 710-726. doi:10.1080/1573062x.2015.102469