Involvement of sting-activating cyclic Di-nucleotides on T-cell differentiation and function: An unresolved issue [Sting’i etkinleştiren siklik dinükleotidlerin T hücre diferansiyasyonu ve fonksiyonuna olan etkisi: Çözülmemiş bir sorun]

STING is the pivotal mediator for the recognition of host and pathogenic cytosolic dsDNA as well as cyclic di-nucleotide metabolites from microbes. Studies demonstrated that DNA released from cancerous cells are internalized by innate immune cells such as macrophages and dendritic cells in tumor microenvironment and trigger the production of interferon beta and other pro-inflammatory cytokines including interleukin 6, tumor necrosis factor alpha, and interleukin 12 through STING triggered signaling pathway. Later, these cytokines increase the cytotoxic activity of CD8+ T-cells by increasing the production of interferon gamma. This review discusses the importance of the involvement of STING during the establishment of immunity against intracellular pathogens and its direct effect on T-cells. © 2016 Turkish Journal of Immunology. All rights reserved

The morphological investigations on the heart and some vessels of bovine foetus between the 15th and 25th weeks of gestation

Background: The aim of this study was to define the morphological and morphometric development of the foetus heart obtained from the domestic cattle in the gestation period of 15–25 weeks. Materials and methods: For this purpose, a total of 30 hearts belonging to cattle foetuses (15 males, 15 females) were used. The ages of foetuses were calculated according to the forehead-to-tail length and examined in three different groups. After dissection; biometric, macroanatomic, morphometric and histological findings were obtained from the foetal hearts according to the groups. In addition, mean values of the morphometric findings were determined. Results: As a result of the study, it was found that with the advancing age the convexity of margo ventricularis dexter increased and margo ventricularis sinister transformed from a convex-concave shape to a flat shape. The heart-to-body weight ratio was determined as 0.08% for Group II female foetuses and 0.09% for all other groups. The heart heights for Groups I, II, and III females were identified as 26.21, 41.00, and 46.27 mm, respectively, and for the males 26.45, 34.89, and 47.15 mm, respectively. In the statistical analysis, it was determined that all the morphometric values measured from the heart correlated significantly with the forehead-to-tail length. Conclusions: The data obtained as a result of the study is thought to help understand the morphological and morphometrical development of the heart, pioneer the attempts to create a foetal cattle heart model, and thus help in the diagnosis of the foetal heart pathologies.acieleck

Mucinous Cystadenocarcinoma of the Breast with Estrogen Receptor Expression: A Case Report and Review of the Literature

Primary mucinous cystadenocarcinoma (MCA) of the breast was first described by Koenig and Tavassoli in 1998. To our knowledge, only 9 cases of MCA of the breast have been reported. The optimal treatment of MCA could not be defined yet. This article aims to increase the knowledge about this rare variant of breast cancer and to review the literature

Kırmataşla Üretilen Hazır Betonların Donma-Çözülmeye Karşı Dayanıklılığının Araştırılması

Bu çalışmada; farklı hazır beton santrallerinde kırmataş ile üretilen hazır betonların donma-çözülmeye karşı dayanıklılığı araştırılmıştır. Kırmataş ile hazırlanan beton numuneler üzerinde, donma-çözülme, donma- çözülme sonrası ağırlık kaybı ve basınç dayanımı deneyleri gerçekleştirilmiştir. Deneyler, üç ayrı santralde üretilmiş olan C16, C18, C20, C25 ve C30 sınıflarındaki beton numuneler üzerinde yapılmıştır. Ayrıca, beton numunelerin üretiminde kullanılan agregalar üzerinde elek analizi, aşınma kaybı, ince madde oranı ve su emme deneyleri de gerçekleştirilmiştir. Yapılan çalışma sonucunda, farklı santrallerde kırmataş ile üretilen hazır betonların donma-çözülme dayanıklılıklarının farklılık gösterdiği ancak, donma-çözülme deneyi sonucunda numunelerin fiziksel özelliklerinde meydana gelen değişimlerin standartlarda belirlenen sınırlar içerisinde kaldığı belirlenmiştir

Ultralow background periods in CAST Micromegas detectors and tests in the Canfranc underground laboratory

Yıldız, Süleyman Cenk (Dogus Author)Micromegas detectors have shown a low and stable background level in the CAST experiment due to their low radioactive materials, good energy resolution and spatial resolution. Since 2008, four ultralow background periods have been observed with the new microbulk detectors. During these periods, the background level reduced one order of magnitude, reaching a value around 10-7 s-1 keV-1 cm-2 between 2 and 7 keV. In all cases, the intensity of the three fluorescence lines (at 3, 6 and 8 keV) presented at the background spectrum reduced but the relative ratio remained stable. To clarify the origin of these periods and might determine the ultimate background level of these readouts, a CAST-like detector has been installed at the Canfranc Underground Laboratory. The actual level is compatible with the one measured in CAST. A new Micromegas detectors is being developped for working in CAST experiment during 2011, based on the conclusions of this work

High-J CO emission in the Cepheus E protostellar outflow observed with SOFIA/GREAT

We present and analyze two spectrally resolved high-J CO lines towards the molecular outflow Cep E, driven by an intermediate-mass class 0 protostar. Using the GREAT receiver on board SOFIA, we observed the CO (12--11) and (13--12) transitions (E_u ~ 430 and 500 K, respectively) towards one position in the blue lobe of this outflow, that had been known to display high-velocity molecular emission. We detect the outflow emission in both transitions, up to extremely high velocities (~ 100 km/s with respect to the systemic velocity). We divide the line profiles into three velocity ranges that each have interesting spectral features: standard, intermediate, and extremely high-velocity. One distinct bullet is detected in each of the last two. A large velocity gradient analysis for these three velocity ranges provides constraints on the kinetic temperature and volume density of the emitting gas, >~ 100 K and > ~ 10^4 cm^-3, respectively. These results are in agreement with previous ISO observations and are comparable with results obtained by Herschel for similar objects. We conclude that high-J CO lines are a good tracer of molecular bullets in protostellar outflows. Our analysis suggests that different physical conditions are at work in the intermediate velocity range compared with the standard and extremely high-velocity gas at the observed position.Comment: Accepted for publication in A&A (SOFIA/GREAT special issue

Evaluating functional capacity, and mortality effects in the presence of atrial electromechanical conduction delay in patients with systolic heart failure

Objective: Atrial functions are relatively suppressed in heart failure (HF). We aimed to investigate the associations of intra- and inter-atrial electromechanical conduction delay (EMCD) with functional class and mortality over a 12-month follow-up period. Methods: The prospective study included 65 patients with systolic HF and 65 healthy subjects with normal sinus rhythm. Left ventricular (LV) systolic functions and left atrial (LA) dimensions and volumes were evaluated by transthoracic echocardiography. Tissue Doppler imaging (TDI) signals at the lateral border of the mitral annulus (lateral PA’), septal mitral annulus (septal PA’), and tricuspid annulus (tricuspid PA’) were measured. Intra- and inter-atrial EMCD were calculated. Results: Mitral inflow velocities were studied using pulsed-wave Doppler after placing the sample volume at the leaflets’ tips. The peak early (E wave) and late (A wave) velocities were measured. The septal annular E/E’ ratio was relatively higher and lateral, septal, and right ventricular S, E’, and A’ waves were significantly lower in the HF group than in the control group (12.49±6.03 - 7.16±1.75, pE/E’ <0.0001). Intra-atrial EMCD was detected as 117.5 ms and inter-atrial EMCD as 127.5 ms in patients with prolonged atrial EMCD. A significant increase was found in prolonged intra- and inter-atrial EMCD according to functional capacity increase (p=0.012 and p=0.031, respectively). The incidence of mortality was significantly higher in patients with prolonged atrial EMCD (p=0.025), and 5 patients in the HF group died during the study over the 12-month follow-up period. Conclusions: In this study, we found a relationship between prolonged atrial conduction time and increased functional class and mortality in patients with systolic HF. © 2016 by Turkish Society of Cardiology

Single-center experience with routine clinical use of 3D technologies in surgical planning for pediatric patients with complex congenital heart disease

PURPOSEThis study was planned to assess the application of three-dimensional (3D) cardiac modeling in preoperative evaluation for complex congenital heart surgeries.METHODSFrom July 2015 to September 2019, 18 children diagnosed with complex congenital heart diseases (CHDs) were enrolled in this study (double outlet right ventricle in nine patients, complex types of transposition of the great arteries in six patients, congenitally corrected transposition of the great arteries in two patients, and univentricular heart in one patient). The patients’ age ranged from 7 months to 19 years (median age, 14 months). Before the operation, 3D patient-specific cardiac models were created based on computed tomography (CT) data. Using each patient’s data, a virtual computer model (3D mesh) and stereolithographic (SLA) file that would be printed as a 3D model were generated. These 3D cardiac models were used to gather additional data about cardiac anatomy for presurgical decision-making.RESULTSAll 18 patients successfully underwent surgeries, and there were no mortalities. The 3D patient-specific cardiac models led to a change from the initial surgical plans in 6 of 18 cases (33%), and biventricular repair was considered feasible. Moreover, the models helped to modify the planned biventricular repair in five cases, for left ventricular outflow tract obstruction removal and ventricular septal defect enlargement. 3D cardiac models enable pediatric cardiologists to better understand the spatial relationships between the ventricular septal defect and great vessels, and they help surgeons identify risk structures more clearly for detailed planning of surgery. There was a strong correlation between the models of the patients and the anatomy encountered during the operation.CONCLUSION3D cardiac models accurately reveal the patient’s anatomy in detail and are therefore beneficial for planning surgery in patients with complex intracardiac anatomy

Uncertainties in models of stellar structure and evolution

Numerous physical aspects of stellar physics have been presented in Ses- sion 2 and the underlying uncertainties have been tentatively assessed. We try here to highlight some specific points raised after the talks and during the general discus- sion at the end of the session and eventually at the end of the workshop. A table of model uncertainties is then drawn with the help of the participants in order to give the state of the art in stellar modeling uncertainties as of July 2013.Comment: Proc. of the workshop "Asteroseismology of stellar populations in the Milky Way" (Sesto, 22-26 July 2013), Astrophysics and Space Science Proceedings, (eds. A. Miglio, L. Girardi, P. Eggenberger, J. Montalban