The Predictive Value of Inflammatory Indices and CHA2DS2-VASc Score for NOAF in Covid-19 Patients and the Effect of NOAF on In-Hospital Outcomes

INTRODUCTION: It has been reported that atrial fibrillation (AF) is frequently observed in patients with severe COVID-19. Various mechanisms may be involved in the pathogenesis of AF in these patients. COVID-19 infection increases susceptibility to atrial AF acutely during the infectious stages and sometimes in the post-convalescence period. METHODS: The current retrospective multicenter review consists of consecutive patients hospitalized for COVID-19-related infection in 3 different medical centers. Patients hospitalized for COVID-19 infection between September 2021 and February 2022 were studied. RESULTS: The incidence of New-onset AF (NOAF) was 7.8%. N/L ratios on days 1, 3, and 7 were significantly higher in the NOAF group. In-hospital all-cause mortality, embolic events, and major bleeding were significantly higher in the NOAF group. Hospital stay was significantly longer in the NOAF group. DISCUSSION AND CONCLUSION: CHA2DS2VASc score, D-Dimer, and N/L ratio are independent predictors of NOAF in COVID-19 patients. NOAF is associated with worse clinical features during hospitalization in terms of more bleeding events, death, and embolic events. NOAF is also associated with a longer hospital stay

Recent Advances in Health Biotechnology During Pandemic

The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged in 2019, cut the epoch that will make profound fluctuates in the history of the world in social, economic, and scientific fields. Urgent needs in public health have brought with them innovative approaches, including diagnosis, prevention, and treatment. To exceed the coronavirus disease 2019 (COVID-19) pandemic, various scientific authorities in the world have procreated advances in real time polymerase chain reaction (RT-PCR) based diagnostic tests, rapid diagnostic kits, the development of vaccines for immunization, and the purposing pharmaceuticals for treatment. Diagnosis, treatment, and immunization approaches put for- ward by scientific communities are cross-fed from the accrued knowledge of multidisciplinary sciences in health biotechnology. So much so that the pandemic, urgently prioritized in the world, is not only viral infections but also has been the pulsion in the development of novel approaches in many fields such as diagnosis, treatment, translational medicine, virology, mi- crobiology, immunology, functional nano- and bio-materials, bioinformatics, molecular biol- ogy, genetics, tissue engineering, biomedical devices, and artificial intelligence technologies. In this review, the effects of the COVID-19 pandemic on the development of various scientific areas of health biotechnology are discussed

Removal of polycyclic aromatic hydrocarbons (PAHS) from organized industry district treatment sludges with photochemical degradation: Ambient air applications

In the present study, removal of polycyclic aromatic hydrocarbon (PAH) compounds from Bursa organized industry district (OID) treatment sludge with ambient air applications were examined. Effect of titanium dioxide (TiO2) and diethyl amine (DEA) as photocatalysts were determined. Sludge samples without addition of photocatalysts and with addition of photocatalyst at the ratio of 5% and 20% of dry sludge weight were exposed to the ambient air conditions for 24 hours. The initial total 12 PAH (Sigma(12) PAH) concentration in the sludge was measured as 3268 +/- 170 ng/g of dry matter (DM). It was observed that PAH concentrations in the sludge did not decrease during the ambient air applications when photocatalysts were not used. Sigma(12) PAH removal ratio was calculated as 64% with the addition of 5% TiO2 and this value was reached to 76% with increasing of TiO2 amount to 20% Sigma(12) PAH removal ratios in the UV-DEA experiments were calculated as 67% and 47% when 5% and 20% of DEA were employed, respectively. It was concluded that TiO2 was more effective photocatalyst than DEA to remove PAHs from the Bursa OID sludge during the ambient air applications

Acil servise renal kolik ile başvuran hastaların değerlendirilmesi

Objective: This study aimed to assess some demographical and clinical aspects and laboratory findings of patients presenting with the complaint of renal colic to the emergency department. Material and Methods: The study included a total of 150 adult patients presenting to the emergency department of our University hospital with the complaint of renal colic between January 2009 and January 2010. The data were derived from the patient files of our hospital. Demographical data, time of admission, clinical findings together with laboratory and radiologic findings of patients were assessed. Mean values were calculated as mean value ± standard deviation. Results: Of the patients 91 (68,4 %) were male and the mean age was 38,9±16,5 years. Most of the patients were admitted in October (n= 22, 16,6 %). The most common complaint of the patients was flank pain. The erythrocytes was revealed in 72,2 % of the patients by the urinalysis. Calculus formation was determined in 71 (53,4 %) of the patients. The urinary system ultrasonography (USG) was applied to 39,1 % of the patients and localized renal calculus was detected in 52,0 % of those patients. It was identified that the most common region of localization was the ureter and detected in 29 of the patients (40,9 %). Conclusion: Ultrasonography is considerably a valuable method in identifying renal complications that might lead to dysfunctions in these patients. However, the absence of hematuria does not necessarily rule out the renal colic. We think that emergency physicians should rule out the urinary obstruction in such kind of patients.Amaç: Bu çalışmada acil servise renal kolik ile başvuran hastaların bazı demografik ve klinik özelliklerinin ve laboratuvar bulgularının değerlendirilmesi amaçlandı. Gereç ve Yöntem: Çalışmamız Ocak 2009-Ocak 2010 tarihleri arasında Üniversite hastanesi acil servisine renal kolik nedeniyle başvuran, erişkin, 150 hastayı kapsamaktadır. Veriler, hastanemizin hasta dosyalarından elde edilmiştir. Hastaların demografik özellikleri, başvuru zamanı, klinik bulguları, laboratuvar ve radyolojik verileri değerlendirildi. Ortalama değerler, ortalama ± standart sapma olarak verildi. Bulgular: Hastaların 91’i (% 68,4) erkekti ve yaş ortalamaları 38,9±16,5 yıl idi. En fazla hasta başvurusu ekim ayında oldu (n= 22, % 16,6). Hastaların en sık şikayeti yan ağrısı idi. Yapılan idrar analizinde hastaların % 72,2’ sinde eritrosit tespit edildi. Hastaların 71’inde (% 53,4) taşın lokalizasyonu belirlendi. Üriner sistem ultrasonografi (USG)’si uygulanan hastalarda (n=52, % 39,1) taşın görülme oranı % 52,0 idi. Tespit edilen en sık taş yerleşim yerinin 29 hasta (% 40,9) ile üreter olduğu belirlendi. Sonuç: USG, bu hastalarda böbreğin işlev kaybına sebep olabilecek komplikasyonları saptamak için oldukça değerli bir yöntemdir. Renal kolikli hastalarda mutlak hematüri olmayabilir. Acil hekimlerinin bu tür hastalarda üriner obstrüksiyonu dışlamaları gerektiğini düşünmekteyiz

Evaluation of the age and gender related changes in the Blumensaat line

PubMed ID: 31529167Purpose: The position of the patella according to the femur is very important in the evaluation of patella-femoral joint disorders. In 1938, Blumensaat (BS) described the BS line to evaluate the patella femoral congruence. This method is still valuable in clinical use. There is a limited number of studies demonstrating the accuracy of BS method as well as the affected variables. The aim of this study was to evaluate o the age and gender-related changes in the BS line. Methods: Standard lateral knee radiography was performed to all patients at 30° flexion. The relationship between the BS line and the patella inferior pole was examined and the variability of the measurements according to gender and age groups was investigated by statistical methods. Results: Ninety-five patients (43 men and 52 women) were enrolled in the study. Mean age of the patients were 43.7 ± 14.1 years (48.2 ± 11.7, 37.9 ± 14.8 in women and men, respectively). The BS line was passed through the inferior pole of the patella in only 2 (2.1%) of 95 patients. There was a statistically significant difference (p = 0.041) between BS measurement and gender which was found to be higher in females than males. There was no statistically significant correlation with this distance between the age groups (r = ? 0.216, p = 0.427). Conclusion: In our study, it was concluded that BS measurement differs according to gender but did not have any difference between different age groups. © 2019, Springer-Verlag France SAS, part of Springer Nature

Biomechanical and histological effects of intra-articular hyaluronic acid on anterior cruciate ligament in rats

WOS: 000268430600006PubMed: 19464776Background: The histologic and biomechanical effects of intra-articular hyaluronic acid on the anterior cruciate ligaments of rats were investigated. Methods: Thirty rats were divided into three groups, i.e., the hyaluronic acid group, saline group, and control group. The hyaluronic acid and saline groups received a total of four intra-articular injections, whereas no injection was administered to the control group. The hyaluronic acid group was injected with 50 mu g (0.05 cc) hyaluronic acid, and the saline group was injected with 50 mu l (0.05 cc) of 0.9% sodium chloride solution. All of the rats were sacrificed on day 29 and the femur-anterior cruciate ligament-tibia complexes from the right knees were prepared, tested mechanically, and evaluated histologically. Findings: The mode of failure involved the midsubstance of the anterior cruciate ligament in all the specimens. There were no statistically significant differences in the stiffness and ultimate load to failure values between the three groups (P > 0.05). The energy to failure values were evaluated and there was no statistically significant difference between the groups (P = 0.064, chi-square = 3.43). In the histologic analyses, there was a significant difference in the hyalinization values between the hyaluronic acid and saline groups (P = 0.029) and between the hyaluronic acid group and control groups (P = 0.029). Interpretation: The present study shows that intra-articularly delivered hyaluronic acid has no statistically significant effect on the tensile strength of the rat anterior cruciate ligament. Although hyalinization was increased, no difference was found on the other markers for degenerative changes. We conclude that intra-articular hyaluronic acid injections can be performed safely, although the use of a precise injection technique is recommended. (C) 2009 Elsevier Ltd. All rights reserved

A rare cause of ileus: Gallstone ileus

Safra taşı ileusu nadir görülen bir hastalıktır. Mekanik obstruksiyonlu hastaların yaklaşık %1-4’ünü oluşturur. Teşhiste gecikmeden dolayı mortalite ve morbiditesi yüksektir. İnce barsakta tıkanmaya neden olan ve kesin tanısını ameliyat esnasında koyduğumuz safra taşı ileusu vakasını sunduk.Gallstone ileus is a rare disease, which is responsible for about 1-4% of all cases of mechanical obstruction. The morbidity and mortality rate remain very high, mainly because of delayed diagnosis. We report a case of gallstone ileus which caused intestinal obstruction which was definitively diagnosed on operation

High prevalence of cerebral venous sinus thrombosis (CVST) as presentation of cystathionine beta-synthase deficiency in childhood: Molecular and clinical findings of Turkish probands

WOS: 000330013500010PubMed: 24211323Classical homocystinuria is the most commonly inherited disorder of sulfur metabolism, caused by the genetic alterations in human cystathionine beta-synthase (CBS) gene. In this study, we present comprehensive clinical findings and the genetic basis of homocystinuria in a cohort of Turkish patients. Excluding some CBS mutations, detailed genotype-phenotype correlation for different CBS mutations has not been established in literature. We aimed to make clinical subgroups according to main clinical symptoms and discussed these data together with mutational analysis results from our patients. Totally, 16 different mutations were identified; twelve of which had already been reported, and four are novel (p.N93Y, p.L251P, p.D281V and c.829-2A>T). The probands were classified into three major groups according to the clinical symptoms caused by these mutations. A psychomotor delay was the most common diagnostic symptom (n = 12, 46.2% neurological presentation), followed by thromboembolic events (n = 6, 23.1% vascular presentation) and lens ectopia, myopia or marfanoid features (n = 5, 19.2% connective tissue presentation). Pyridoxine responsiveness was 7.7%; however, with partial responsive probands, the ratio was 53.9%. In addition, five thrombophilic nucleotide changes including MTHFR c.677 C>T and c.1298 A>C, Factor V c.1691 G>A, Factor II c.20210 G>A, and SERPINE1 4G/5G were investigated to assess their contributions to the clinical spectrum. We suggest that the effect of these polymorphisms on clinical phenotype of CBS is not very clear since the distribution of thrombophilic polymorphisms does not differ among specific groups. This study provides molecular findings of 26 Turkish probands with homocystinuria and discusses the clinical presentations and putative effects of the CBS mutations. Crown Copyright (C) 2013 Published by Elsevier B.V. All rights reserved.State Planning Organization of Turkey [DPT2006K1206400603]This work was supported by a grant from the State Planning Organization of Turkey (Project number: DPT2006K1206400603)