Cosmology seeking friendship with sterile neutrinos

Precision cosmology and big-bang nucleosynthesis mildly favor extra radiation in the universe beyond photons and ordinary neutrinos, lending support to the existence of low-mass sterile neutrinos. We use the WMAP 7-year data, small-scale CMB observations from ACBAR, BICEP and QuAD, the SDSS 7th data release, and measurement of the Hubble parameter from HST observations to derive credible regions for the assumed common mass scale m_s and effective number N_s of thermally excited sterile neutrino states. Our results are compatible with the existence of one or perhaps two sterile neutrinos, as suggested by LSND and MiniBooNE, if m_s is in the sub-eV range.Comment: 4 pages, 1 figure, matches version published in PR

Improved single-swab sample preparation for recovering bacterial and phage DNA from human skin and wound microbiomes.

BackgroundCharacterization of the skin and wound microbiome is of high biomedical interest, but is hampered by the low biomass of typical samples. While sample preparation from other microbiomes (e.g., gut) has been the subject of extensive optimization, procedures for skin and wound microbiomes have received relatively little attention. Here we describe an improved method for obtaining both phage and microbial DNA from a single skin or wound swab, characterize the yield of DNA in model samples, and demonstrate the utility of this approach with samples collected from a wound clinic.ResultsWe find a substantial improvement when processing wound samples in particular; while only one-quarter of wound samples processed by a traditional method yielded sufficient DNA for downstream analysis, all samples processed using the improved method yielded sufficient DNA. Moreover, for both skin and wound samples, community analysis and viral reads obtained through deep sequencing of clinical swab samples showed significant improvement with the use of the improved method.ConclusionUse of this method may increase the efficiency and data quality of microbiome studies from low-biomass samples

Transition to the New Revenue Standard: A Study of Firms’ Decisions to Adopt ASC 606 Early

The Financial Accounting Standards Board has issued a new revenue standard through a series of updates since May 2014 (collectively, ASC 606). The standard allowed firms to adopt it a year early before the required effective date. This study provides evidence of the adoption effects of ASC 606 on firms’ financials and examines the relationship between the likelihood of early adopting ASC 606 and firm-specific characteristics. The results show that early adopters are distributed across 12 industries and 40% of them are concentrated in the computer programming and software industry. Early adopters in the software industry reported the largest cumulative adoption effects in dollars on retained earnings. Overall, the majority of the sample firms (83%) reported positive adoption effects on financial statements and the adoption of ASC 606 increased their retained earnings by 2.95% on average. The results also show that most early adopters chose the full retrospective method while the majority of industry-size-matched non-early adopting peers chose the modified retrospective method. Finally, the multivariate regression analyses suggest that early adopters are associated with decreased earnings in the year before adoption and more favorable adoption effects than non-early adopting peers

Investigating the Role of Charge Separation in Triplet State Formation in Zinc Dipyrrin Photosensitizers

About 85% of the world’s energy is derived from non-renewable sources—coal, petroleum, and natural gas. Solar photocatalysis is one way to potentially generate cheap renewable fuels by harnessing energy from the sun using a photosensitizer and converting it into chemical energy. The efficiency of a photosensitizer depends on its capacity to form a prolonged triplet excited state. Zinc dipyrrin complexes have the potential to be efficient sensitizers for reductive photochemistry, but their ability to form long-lived triplet excited states still needs extensive research. The overall aim of this research is to probe the role charge separation plays in the formation of triplet state in metal complexes of dipyrrin photosensitizers. The specific objectives are to synthesize and characterize zinc and boron dipyrrin complexes, analyze their photophysical properties—such as steady state spectroscopy, low temperature emission spectroscopy—and quantify their triplet states using time-resolved transient absorption spectroscopy

Three Hierarchies in Skeletal Muscle Fibre Classification Allotype, Isotype and Phenotype

Immunocytochemical analyses using specific anti-myosin antibodies of mammalian muscle fibers during regeneration, development, and after denervation have revealed two distinct myogenic components determining fiber phenotype. The jaw-closing muscles of the cat contain superfast fibers which express a unique myosin not found in limb muscles. When superfast muscle is transplanted into a limb muscle bed, regenerating myotubes synthesize superfast myosin independent of innervation. Reinnervation by the nerve to a fast muscle leads to the expression of superfast and not fast myosin, while reinnervation by the nerve to a slow muscle leads to the expression of a slow myosin. When limb muscle is transplanted into the jaw muscle bed, only limb myosins are synthesized. Thus jaw and limb muscles belong to distinct allotypes, each with a unique range of phenotype options, the expressions of which may be modulated by the nerve. Primary and secondary myotubes in developing jaw and limb muscles are observed to belong to different categories characterized by different patterns of myosin gene expression. By taking into consideration the pattern of myosins synthesized and the changes in fiber size after denervation, 3 types of primary (fast, slow, and intermediate) fibers can be distinguished in rat fast limb muscles. All primaries synthesize slow myosin soon after their formation, but this is withdrawn in fast and intermediate primaries at different times. After neonatal denervation, slow and intermediate primaries express slow primaries hypertrophy with other fibers atrophy. In the mature rat, the number of slow fibers in the EDL is less than the number of slow primaries. Upon denervation, hypertrophic slow fibers matching the number and topographic distribution of slow primaries appear, suggesting that a subpopulation of the slow primaries acquire the fast phenotype during adult life, but reveal their original identity as slow primaries in response to denervation by hypertrophying and synthesizing slow myosin. It is proposed that within each muscle allotype, the various isotypes of primary and secondary fibers are myogenically determined, and are derived from different lineage of myoblasts

Perancangan Interior Shinjuku Hairmake Di Surabaya

Interior Design Shinjuku Hairmake Surabaya is a project of designing the interior of a place of beauty and hair care that located in the city of Surabaya. interior design can attract the curiosity and provide comfort for visitors. Facility that will be designed are the lobby, waiting room, haircut hall, hairwash room, hair care hall, makeup hall, nail art hall, retail hall, and staff hall. This design is expected to provide the characteristics and identity of the Shinjuku Hairmake in Surabaya. With an attractive interior and comfortably space can be a plus point for the salon itself, supported with lighting and regular circulatio

Sense-making of consumer wellbeing in information technology-enabled services from a relational ontology position

Information technology (IT) built into products and services have become the key drivers for service innovation. How information technology-enabled services (ITESs) affect consumer wellbeing has increasingly become a concern to service scholars. In response to this, transformative service research (TSR) has emerged as a new stream in service research. This paper investigates consumer wellbeing derived from the consumption of ITESs in consumers’ daily lives. A mixed-method approach was employed in our study, including self-reflective reports, in-depth interviews and visual artistic methods. We demonstrated that a relational ontology, drawing on the ‘focal things’ concept (Borgmann, 1984) and sociomateriality (Orlikowski, 2009), could be used as a lens for us to understand consumer wellbeing in ITESs. We used four vignettes to demonstrate how relational ontology can enhance our understanding of consumer wellbeing in ITESs. Theoretically, this paper contributes to TSR by proposing and demonstrating the need to shift or at least extend the extant predominant technology ontology in marketing literature to make sense of consumer experiences and wellbeing in ITESs. In practice, this research encourages ITESs designers to emphasise the relational entanglement of technology with consumer routine practices in their service innovations for the purposes of consumer wellbeing

One Epic φf Stardusts

A long time ago in a far away galaxy, there was a star shining alone in the deep darkness. The beautiful star aged and exploded into a supernova, where her golden light scattered into the tiniest sparkles of dust, pouring down to Earth. Made of Stardust, humans naturally have responded to the divine light that they carry inside their souls, through diverse acts of enlightenment such as art, religion, and science. . . . As a Stardust, an artist, a Korean, and a woman, I keep walking in between opposing forces and varying perspectives until I transcend their boundaries and reveal their glittery metaphysical bonds