Exploring the College EFL Self-access Writing Mode Based on Automated Feedback

The present study is intended to construct a college EFL self-access writing mode based on automated feedback under the guidance of Formative Assessment Theory and Autonomous Learning Theory and attempts to apply it into college EFL teaching practice. Findings of this empirical-based study suggest that this self-access writing mode contributes to the enhancement of students’ English writing competence, English writing motivation as well as their autonomy in self-revision

Wind Shielding Analysis for Cold Regions Using Experimental and Numerical Techniques

The thesis presents a systematic experimental and numerical study on the interactions among porous fence, airflow, and windblown snowdrifts, a knowledge that will contribute to optimize the performance of porous wind shielding system in Cold Regions. A comprehensive review of the concepts, theories, techniques, and key findings associated with the research work has been undertaken. The key technical parameters influencing fence performance have been systematically studied by means of wind tunnel experimental investigations and Computational Fluid Dynamics (CFD) simulations. The study has found that porosity is the most influential structural parameter affecting the performance of porous fences in many aspects. Fence height stands a significant positive position in terms of its performance. It was found that fence performance is not sensitive to the changes of approaching atmospheric airflow velocity. Nevertheless, a bottom gap can improve snow fence trap efficiency. All of those findings agree with most of the findings of other researchers, which affirms that the research methodology adopted in this research is sound. Physical experimental work was performed to assess the reliability and credibility of the numerical models. Those models have been intentionally simplified, which made them easier to construct and quicker to obtain numerical solutions at a lower computational cost. Furthermore, the numerical models demonstrate the level of competence acquired through this research that is implemented in the optimisation of fence design. Special attention has been paid to the issues where elaborate research work has not been systematically reached in the open literature, this includes areas such as the effects of arrangement of porous holes, fence surface shear, and directions of wind load with respect to the fence, etc. Correlation between the reattachment length, the shelter distance, and the creation and distribution of fence surface shear is reported, to the author’s knowledge, for the first time in the open literature. General guidelines for the design of shelters based on porous fences have been established through this study. For example, the desirable size of hole range should be identified beforehand, and porous holes with sharp angular corners should usually be avoided in the fence design. It is recommended to place the fence within an angle of 30° to the wind load, where the effective shelter distance can be estimated in a linearized equation, and the normal drag coefficient can be described as a function of cos2θ. Optimal design of the arrangement of porous holes will maximize the fence performance, especially when the close fence environment is of concern. Although the definition of fence effective zone is still vague in the research field, the key factors influencing the fence effective zone have been investigated by evaluating the reduction of wind velocity leeward of the fence in this thesis. It is found that the fence effective zone is not sensitive to the change of approaching airflow velocity, and that increasing fence height will increase the physical size of the fence effective zone, but not in a proportional manner. It is also concluded that fence effective zone will be significantly reduced when the non-normal wind load is inclined at an angle greater than 30° to the fence. The effective zone increases effectively when the fence porosity is optimal. In contrast to the majority of published research work, the transient snow transport model presented in this work considers the snow transport rate as a whole without distinguishing the rate in saltation and suspension layer. The numerical study indicated that the position of the snow crest is mainly determined by the fence height, while porosity and bottom gap mainly affect the downwind deposition length. The optimal porosity for snow fences is in the range of 0.4 to 0.5, which is greater than the one for wind fences, which lies in the range from 0.25 to 0.35. Two snow crests have been observed leeward the fence at the onset of snow deposition, when the fence was placed without a bottom gap to the snow ground. This finding has not been encountered in any of the reported research work. Wind tunnel simulations of snowdrift around the fences have marginally under-predicted the sizes of snow deposition. The numerical predictions were quantitatively and qualitatively in good agreement with the field observations. This incompetence of wind tunnel experiments on porous fences implies that numerical modelling can play a more important role in snow fence research

Measurement of Wind Flow Behavior at the Leeward Side of Porous Fences Using Ultrasonic Anemometer Device

Efficiency of wind fences is evaluated by the reduction of wind velocity and the effective shelter area behind the fence. Fence porosity is the most influential structural parameters in the porous fence design, and has significant impact on the structure of wind velocity and turbulence leeward. In this work, three fences with porosity of 23%, 35% and 45% have been tested under 10m/s inlet velocity in an environmental wind tunnel. An ultrasonic anemometer was used to measure three dimensional velocity vectors and the fluctuations of velocity vectors with a designed spatial resolution. The obtained data were used to calculate velocity magnitudes, turbulence intensities and turbulent kinetic energies in the test domain. Porosity influencing the structure of turbulence intensity and effective fence zone were discussed in this paper. Neither the distribution of wind velocities nor the structure of turbulence alone can provide sufficient information to assess the performance of porous fences. Consideration of the targeted reduction rate of wind velocity needs to be taken for optimal fence desig

Morphine Suppresses IFN Signaling Pathway and Enhances AIDS Virus Infection

Background: Opioids exert a profound influence on immunomodulation and enhance HIV infection and replication. However, the mechanism(s) of their action remains to be determined. We thus investigated the impact of morphine on the intracellular innate antiviral immunity. Methodology/Principal Findings: Seven-day-cultured macrophages were infected with equal amounts of cell-free HIV Bal or SIV DeltaB670 for 2 h at 37uC after 24 h of treatment with or without morphine. Effect of morphine on HIV/SIV infection and replication was evaluated by HIV/SIV RT activity assay and indirect immunofluorescence for HIV p24 or SIV p28 antigen. The mRNA expression of cellular factors suppressed or induced by morphine treatment was analyzed by the real-time RT-PCR. We demonstrated that morphine treatment of human blood monocyte-derived macrophages significantly inhibited the expression of interferons (IFN-a, IFN-b and IFN-l) and IFN-inducible genes (APOBEC3C/3F/3G and 3H). The further experiments showed that morphine suppressed the expression of several key elements (RIG-I and IRF-7) in IFN signaling pathway. In addition, morphine treatment induced the expression of suppressor of cytokine signaling protein-1, 2, 3 (SOCS-1, 2, 3) and protein inhibitors of activated STAT-1, 3, X, Y (PIAS-1, 3, X, Y), the key negative regulators of IFN signaling pathway. Conclusions: These findings indicate that morphine impairs intracellular innate antiviral mechanism(s) in macrophages

Evaluation of renal cold ischemia–reperfusion injury with intravoxel incoherent motion diffusion-weighted imaging and blood oxygenation level-dependent MRI in a rat model

Purpose: Cold ischemia-reperfusion injury (CIRI) is one of the most serious complications following renal transplantation. The current study investigated the feasibility of Intravoxel Incoherent Motion (IVIM) imaging and blood oxygenation level-dependent (BOLD) in the evaluation of different degrees of renal cold ischemia-reperfusion injury in a rat model.Methods: Seventy five rats were randomly divided into three groups (N = 25 for each group): T0: sham-operated group, T2/T4: CIRI groups with different cold ischemia hours (2, 4 h, respectively). The rat model of CIRI group was established by left kidney cold ischemia with right nephrectomy. All the rats received a baseline MRI before the surgery. Five rats in each group were randomly selected to undergo an MRI examination at 1 h, day 1, day 2 and day 5 after CIRI. The IVIM and BOLD parameters were studied in the renal cortex (CO), the outer stripe of the outer medulla (OSOM), and the inner stripe of the outer medulla (ISOM) followed by histological analysis to examine Paller scores, peritubular capillary (PTC) density, apoptosis rate and biochemical indicators to obtain the contents of serum creatinine (Scr), blood urea nitrogen (BUN), superoxide dismutase (SOD) and malondialdehyde (MDA).Results: The D, D*, PF and T2* values in the CIRI groups were lower than those in the sham-operated group at all timepoints (all p < 0.05). The prolonged cold ischemia times resulted in gradually lower D, D*, PF and T2* values (all p < 0.05). The D and T2* values of cortex and OSOM in Group T0 and T2 returned to the baseline level (all p > 0.05) except Group T4. The D* and PF values of cortex, OSOM and ISOM in Group T2 and T4 still remained below the normal levels (all p < 0.05) except Group T0. D, D*, PF and T2* values were strongly correlated with histopathological (Paller scores, PTC density and apoptosis rate) and the biochemistry indicators (SOD and MDA) (|r|>0.6, p < 0.001). D*, PF and T2* values were moderately to poorly correlated with some biochemistry indicators (Scr and BUN) (|r|<0.5, p < 0.05).Conclusion: IVIM and BOLD can serve as noninvasive radiologic markers for monitoring different degrees of renal impairment and recovery after renal CIRI