8 research outputs found
Fat Graft for Parotidectomy Defect Reconstruction in the Setting of Malignant Disease
- Author
- Publication venue
- Jefferson Digital Commons
- Publication date
- 30/01/2021
- Field of study
Objectives: Currently, limited data examines the safety of utilizing fat transfers in the setting of malignant parotid disease. Here we evaluate the safety of fat graft reconstruction of parotidectomy defects in the setting of malignant disease.
Study Design: Retrospective cohort study
Methods: Electronic chart review of patients who underwent parotidectomy from 2012-2020 were reviewed.
Results: Three hundred and sixty-one patients were identified at a single institution who underwent parotidectomy, and 113 (31.3%) were for malignancy. One hundred and thirty-two patients underwent fat graft reconstruction (49.2%, n=65 for umbilical, 50.8%, n=67 for dermal). One-third of patients had malignant pathology (34.8%, n=46). The most common malignant tumors were squamous cell carcinoma (n=15), acinic cell carcinoma (n=9), and mucoepidermoid carcinoma (n=6). Twenty patients (45.5%) received postoperative radiation therapy. Complications included: surgical site necrosis (13%), hematoma (4.3%), and infection (2.2%). Overall incidence of malignant recurrence was 4.4% with a mean time of follow-up of 10.3 (range 0 – 77.3) months. Incidence of malignant recurrence in the fat graft reconstruction subset was 0% with a mean follow-up of 9.8 (range 0.2 – 49.3) months. There was no association with use of fat graft and recurrence (p\u3e0.05).
Conclusion: Parotidectomy defects for malignant neoplasms can be reconstructed with fat graft transfers with no impact on surveillance for disease recurrence.https://jdc.jefferson.edu/otoposters/1010/thumbnail.jp
Selection Criteria for Posterior Circulation Stroke and Functional Outcome Following Mechanical Thrombectomy
- Author
- Publication venue
- Jefferson Digital Commons
- Publication date
- 01/02/2019
- Field of study
Objective: 20% of all acute ischemic strokes (AIS) are caused by posterior circulation strokes, which carry an intensified mortality touching 95%. Early recanalization improves outcome as shown by several reports; however, safety, patient selection, and prognostic factors remain lacking. An investigation of the safety and prognostic factors for posterior circulation mechanical thrombectomy (MT) was performed.
Methods: A retrospective review of patients presenting with posterior circulation AIS, who underwent MT between 2010 and 2018.
Results: Of 443 patients who underwent MT for AIS, 83 patients had posterior circulation strokes. 95% of procedures were conducted under general anesthesia. The median NIHSS upon admission was 19.1. Half of the patients underwent MT 8 hours from symptom onset, and half required a salvage contact thrombus aspiration after a stent retriever trial with an average of two passes for successful recanalization. The time to achieve revascularization was 61.6 minutes. Mortality rate was 28%, and modified Rankin Scale (mRS) \u3c 2 at three months was seen in 40.1% of surviving patients. A higher functional outcome trend (mRS\u3c2) was seen in patients who underwent MT within 8 hours of symptom onset. The overall complication rate was 28%. Regression analysis showed that stroke subtype, baseline NIHSS, and posterior circulation Alberta Stroke Program Early CT Score (pc-ASPECTS) before thrombectomy were independent predictive factors of positive clinical outcomes.
Conclusions: MT is an effective intervention for posterior circulation strokes, and long-term functional independence relies upon proper patient selection. Baseline NIHSS and pc-ASPECTS are independent predictive factors
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.
- Author
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- Zin NHM
- Zingerle N
- Zingg U
- Zoerner F
- Zonneveldt H
- Zou X
- Zoulamoglou M
- Zsisku L
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700
Nec-1 Protects against Nonapoptotic Cell Death in Cisplatin-Induced Kidney Injury
- Author
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Upconversion Spectrophotofluorometry
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- A Pirie
- AG Szabo
- AJ Grosvenor
- AJ Ruggiero
- AN Macpherson
- B Christiaens
- B Halle
- B Halle
- BS Berlett
- CP Pan
- D Roccatano
- D Toptygin
- DC Paik
- DP Zhong
- GA Elove
- J Peon
- JA Schauerte
- JH Xu
- JH Xu
- JM Beechem
- JR Alcala
- JR Knutson
- JR Lakowicz
- JT Vivian
- JTM Kennis
- JW Longworth
- L Davenport
- LA Hallidy
- LI Grossweiner
- LY Zhang
- LY Zhang
- M Halder
- M Maroncelli
- MA Kahlow
- MR Eftink
- PA Franken
- PD Adams
- PR Callis
- PR Callis
- R Jimenez
- RF Chen
- RS Davidson
- SE Bradforth
- SK Pal
- SK Pal
- SM Janes
- TES Dahms
- W Wang
- WH Qiu
- XH Shen
- Y Chen
- Y Chen
- Y Fukunaga
- Z Gryczynski
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Co-activator candidate interactions for orphan nuclear receptor NR2E1
- Author
- A Kanda
- A Koppen
- A Yokoyama
- B He
- B Xu
- Bibiana K. Y. Wong
- BS Abrahams
- C Benod
- C Leo
- CA Schneider
- Charles N. de Leeuw
- CL Zhang
- CL Zhang
- D Kamiya
- D Wu
- D Zhou
- Diana Melchers
- DL Stenoien
- DM Heery
- E Nishihara
- EB Askew
- Elizabeth M. Simpson
- F Duclot
- F Mercurio
- G Sun
- H Wurdak
- HK Liu
- JD Chen
- JF Schmouth
- JF Schmouth
- JF Schmouth
- JM Zhang
- K Brannvall
- K Nakashima
- K Roy
- KA Young
- KH Song
- L Castagnoli
- L Wang
- M Elmi
- M Ichida
- M Kikuchi
- M Kurusu
- M Okamoto
- N Kurotaki
- NB Haider
- Q Qu
- René Houtman
- RH Goodman
- RK Vadlamudi
- S Surapureddi
- S Takezawa
- S Wang
- SB Estruch
- SB McMahon
- SW Kruse
- T Bessho
- T Liu
- T Miyawaki
- U Andersson
- V Cavailles
- V Kaltezioti
- Vivian Alonso
- W Niu
- X Corso-Diaz
- X Corso-Diaz
- X Hu
- X Zhi
- Ximena Corso-Díaz
- Y Benjamini
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Kuluttajabarometri maakunnittain 2000, 2. neljännes
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- Zamudio D
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- Zonneveldt H
- Zou X
- Zoulamoglou M
- Zsisku L
- Publication venue
- Tilastokeskus
- Publication date
- 11/07/2000
- Field of study
Suomen virallinen tilasto (SVT
Use of failure-to-rescue to identify international variation in postoperative care in low-, middle- and high-income countries: a 7-day cohort study of elective surgery
- Author
- Ab Majid MA
- Ab Rahman AS
- Ab Rahman R
- Abayasinghe C
- Abbott T
- Abdullah NH
- Abdur-Rahman L
- Abeloos J
- Abernethy C
- Abidin UN
- Abrunhosa A
- Absar M
- Adam S
- Adams D
- Adams G
- Adamson M
- Adekola O
- Adelaja Y
- Ademola A
- Adenekan A
- Adenike O
- Adeolu AA
- Adetoye A
- Adewale B
- Adigun T
- Adolfsson A
- Aflori L
- Africander C
- Afshari A
- Agarwal V
- Agodirin O
- Aguero Vera M
- Aguzzoli C
- Ahmad A
- Ahmad N
- Ahmad T
- Ahmad T
- Ahmad Y
- Ahmed A
- Ahmed J
- Ai Y
- Aignatoaie M
- Aimoniotou-Georgiou E
- Akanmu O
- Akerman N
- Akinwale M
- Akring I
- Al 'Amri K
- Al Anizi M
- Al hussaini S
- Al-Soudaine Y
- Aladin H
- Alagbe-Briggs O
- Alaman Laguarda G
- Albaj S
- Alcock D
- Alcock L
- Aldecoa C
- Aldecoa C
- Aleixo FB
- Alexander H
- Alexander M
- Alexander-Sefre F
- Alherz F
- Ali H
- Ali M
- Ali S
- Alias A
- Alias AH
- Alias RLR
- Alit MA
- Allen S
- Allen SJ
- Allison J
- Alloj C
- Allorto NL
- Allsop J
- Almeida W
- Alonso E
- Alphonsus C
- Alvares D
- Alves MJ
- Amador JCB
- Ameer Y
- Amendola CP
- Ami N
- Amstrup-Hansen L
- Anagnou A
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- Anderson C
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- Anderson P
- Andreadaki E
- Andreou A
- Andreou P
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- Angermair S
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- Anillo V
- Antal O
- Antill P
- Antoniadou E
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- Apostolou K
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- Ardern D
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- Asudo F
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- Attwood C
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- Avila Sanchez FJ
- Avila EJD
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- Cirstea E
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- Clyde A
- Cobzaru I
- Codita A
- Colangelo A
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- Sibilio A
- Siddiqui F
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- Xu G-J
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- Xue R
- Yagnik A
- Yan Y
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- Yassaee A
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- Yeh E
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- Yip CP
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- Yuliana A
- Zaimi D
- Zakynthinos S
- Zamudio D
- Zangrillo A
- Zapata DDM
- Zbitnew G
- Zeidan L
- Zeng Q
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- Zettergren J
- Zhang B
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- Zhang Y
- Zhang Y
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- Zhao B
- Zhao B
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- Zhao J
- Zhao J
- Zhao L
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- Zhao T
- Zhao W
- Zhao W
- Zhao X
- Zhen J
- Zheng K
- Zheng L
- Zheng T
- Zhong Y
- Zhou C
- Zhou D
- Zhou H
- Zhou H
- Zhou J
- Zhou J
- Zhou J
- Zhou X-J
- Zhu X
- Zhu X
- Zhu Y
- Zhu Z
- Zhuang X
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- Zingerle N
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- Zoerner F
- Zonneveldt H
- Zou X
- Zoulamoglou M
- Zsisku L
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2017
- Field of study
This was an investigator-initiated study funded by Nestle Health Sciences through an unrestricted research grant and by a National Institute for Health Research (UK) Professorship held by R.P. The study was sponsored by Queen Mary University of London