OBJECTIVE VOICE QUALITY PREDICTION FOR IP NETWORKS IN REAL TIME VOICE OVER INTERNET PROTOCOL APPLICATIONS

Presented herein is a system for monitoring/predicting objective voice quality in Voice Over Internet Protocol (VoIP) applications. The system is configured to , collect training datasets and generate online-training prediction models of voice quality

Krein Space-Based H

This paper investigates the finite-time H∞ fault estimation problem for linear time-delay systems, where the delay appears in both state and measurement equations. Firstly, the design of finite horizon H∞ fault estimation is converted into a minimum problem of certain quadratic form. Then we introduce a stochastic system in Krein space, and a sufficient and necessary condition for the minimum is derived by applying innovation analysis approach and projection theory. Finally, a solution to the H∞ fault estimation is obtained by recursively computing a partial difference Riccati equation, which has the same dimension as the original system. Compared with the conventional augmented approach, the solving of a high dimension Riccati equation is avoided

Metabolomic analysis of human oral cancer cells with adenylate kinase 2 or phosphorylate glycerol kinase 1 inhibition.

The purpose of this study was to use liquid chromatography-mass spectrometry (LC-MS) with XCMS for a quantitative metabolomic analysis of UM1 and UM2 oral cancer cells after knockdown of metabolic enzyme adenylate kinase 2 (AK2) or phosphorylate glycerol kinase 1 (PGK1). UM1 and UM2 cells were initially transfected with AK2 siRNA, PGK1 siRNA or scrambled control siRNA, and then analyzed with LC-MS for metabolic profiles. XCMS analysis of the untargeted metabolomics data revealed a total of 3200-4700 metabolite features from the transfected UM1 or UM2 cancer cells and 369-585 significantly changed metabolites due to AK2 or PGK1 suppression. In addition, cluster analysis showed that a common group of metabolites were altered by AK2 knockdown or by PGK1 knockdown between the UM1 and UM2 cells. However, the set of significantly changed metabolites due to AK2 knockdown was found to be distinct from those significantly changed by PGK1 knockdown. Our study has demonstrated that LC-MS with XCMS is an efficient tool for metabolomic analysis of oral cancer cells, and knockdown of different genes results in distinct changes in metabolic phenotypes in oral cancer cells

Global Practical Tracking by Output Feedback for Nonlinear Systems with Unknown Growth Rate and Time Delay

This paper is the further investigation of work of Yan and Liu, 2011, and considers the global practical tracking problem by output feedback for a class of uncertain nonlinear systems with not only unmeasured states dependent growth but also time-varying time delay. Compared with the closely related works, the remarkableness of the paper is that the time-varying time delay and unmeasurable states are permitted in the system nonlinear growth. Motivated by the related tracking results and flexibly using the ideas and techniques of universal control and dead zone, an adaptive output-feedback tracking controller is explicitly designed with the help of a new Lyapunov-Krasovskii functional, to make the tracking error prescribed arbitrarily small after a finite time while keeping all the closed-loop signals bounded. A numerical example demonstrates the effectiveness of the results

Primary biliary cirrhosis associated with rheumatoid arthritis

Primary biliary cirrhosis(PBC) is a slowly progressive autoimmune disease of the liver which mainly affects women aged between 35 and 45 years.Prolonged liver inflammation can cause scarring, leading to cirrhosis. Although 50 to 60 percent of patients are asymptomatic at diagnosis, they will develop symptoms later. PBC can be associated with arthralgia and other non-hepatic autoimmune diseases, such as Sjögren’s syndrome, sicca syndrome, thyroiditis and scleroderma. PBC and rheumatoid arthritis (RA) have been suggested to coexist in 1.8 to 5.6% of patients with PBC, but data supporting this association are scarce. We report two cases of such an association and discuss how to improve threapy

A single nucleotide mutation in Nppc is associated with a long bone abnormality in lbab mice

BACKGROUND: The long bone abnormality (lbab) mouse is a new autosomal recessive mutant characterized by overall smaller body size with proportionate dwarfing of all organs and shorter long bones. Previous linkage analysis has located the lbab mutation on chromosome 1 between the markers D1Mit9 and D1Mit488. RESULTS: A genome-based positional approach was used to identify a mutation associated with lbab disease. A total of 122 genes and expressed sequence tags at the lbab region were screened for possible mutation by using genomic DNA from lbabl/lbab, lbab/+, and +/+ B6 mice and high throughput temperature gradient capillary electrophoresis. A sequence difference was identified in one of the amplicons of gene Nppc between lbab/lbab and +/+ mice. One-step reverse transcriptase polymerase chain reaction was performed to validate the difference of Nppc in different types of mice at the mRNA level. The mutation of Nppc was unique in lbab/lbab mice among multiple mouse inbred strains. The mutation of Nppc is co-segregated with lbab disease in 200 progenies produced from heterozygous lbab/+ parents. CONCLUSION: A single nucleotide mutation of Nppc is associated with dwarfism in lbab/lbab mice. Current genome information and technology allow us to efficiently identify single nucleotide mutations from roughly mapped disease loci. The lbab mouse is a useful model for hereditary human achondroplasia

An Improved LMI Approach for Static Output Feedback Fault-tolerant Control With Application to Flight Tracking Control

Abstract-This paper proposes an improved Linear Matrix Inequality (LMI) approach for the synthesis of Static Output Feedback (SOF) Fault-Tolerant Control (FTC). A novel slack variable is introduced into the matrix inequalities, which provides an additional degree of freedom to compute the numerical solution. Subsequently, an improved iterative algorithm is developed to obtain an optimal SOF gain with less conservativeness. In this paper, designs of the SOF gain are shown in the framework of tracking control. The nonlinear simulations of the ADMIRE aircraft are included to demonstrate the effectiveness of the proposed method

An Improved LMI Approach for Static Output Feedback Fault-tolerant Control With Application to Flight Tracking Control

Abstract-This paper proposes an improved Linear Matrix Inequality (LMI) approach for the synthesis of Static Output Feedback (SOF) Fault-Tolerant Control (FTC). A novel slack variable is introduced into the matrix inequalities, which provides an additional degree of freedom to compute the numerical solution. Subsequently, an improved iterative algorithm is developed to obtain an optimal SOF gain with less conservativeness. In this paper, designs of the SOF gain are shown in the framework of tracking control. The nonlinear simulations of the ADMIRE aircraft are included to demonstrate the effectiveness of the proposed method