Generation of ring-shaped optical vortices in dissipative media by inhomogeneous effective diffusion

By means of systematic simulations we demonstrate generation of a variety of ring-shaped optical vortices (OVs) from a two-dimensional input with embedded vorticity, in a dissipative medium modeled by the cubic-quintic complex Ginzburg-Landau equation with an inhomogeneous effective diffusion (spatial-filtering) term, which is anisotropic in the transverse plane and periodically modulated in the longitudinal direction. We show the generation of stable square- and gear-shaped OVs, as well as tilted oval-shaped vortex rings, and string-shaped bound states built of a central fundamental soliton and two vortex satellites, or of three fundamental solitons. Their shape can be adjusted by tuning the strength and modulation period of the inhomogeneous diffusion. Stability domains of the generated OVs are identified by varying the vorticity of the input and parameters of the inhomogeneous diffusion. The results suggest a method to generate new types of ring-shaped OVs with applications to the work with structured light.Comment: 24 pages, 5 figures; Nonlinear Dynamics, in pres

Case report: Two cases of Poirier-Bienvenu neurodevelopmental syndrome and review of literature

The Poirier-Bienvenu neurodevelopmental syndrome (POBINDS) is a rare disease caused by mutations in the CSNK2B gene, which is characterized by intellectual disability and early-onset epilepsy. Mosaicism has not been previously reported in CSNK2B gene. POBINDS is autosomal dominant and almost all reported cases were de novo variants. Here, we report two patients were diagnosed with POBINDS. Using Whole Exome Sequencing (WES), we detected two novel CSNK2B variants in the two unrelated individuals: c.634_635del (p.Lys212AspfsTer33) and c.142C > T (p.Gln48Ter) respectively. Both of them showed mild developmental delay with early-onset and clustered seizures. The patient with c.634_635del(p.Lys212AspfsTer33) variant was mutant mosaicism, and the proportion of alleles in peripheral blood DNA was 28%. Further, the literature of patients with a de novo mutation of the CSNK2B gene was reviewed, particularly seizure semiology and genotype-phenotype correlations

Synchronization analysis of two-time-scale nonlinear complex networks with time-scale-dependent coupling

In this paper, a time-scale-dependent coupling scheme for two-time-scale nonlinear complex networks is proposed. According to this scheme, the inner coupling matrices are related to the fast dynamics of individual subsystems, but are no longer time-scale-independent. Designing time-scale-dependent inner coupling matrices is motivated by the fact that the difference of time scales is an essential feature of modular architecture of two-time-scale systems. Under the novel coupling framework, the previous assumption on individual two-time-scale subsystems that the fast dynamics must be exponentially stable can be removed. The idea of time-scale separation is employed to analyze the stability of synchronization error systems via weighted ϵ-dependent Lyapunov functions. For a given upper bound of the singular perturbation parameter ϵ, it is proved that the exponential decay rate of the synchronization error can be guaranteed to be independent of the value of ϵ. In this way, criteria for local and global exponential synchronization are established. The allowable upper bound of ϵ such that the synchronizability of the considered two-time-scale network is retained can be obtained by solving a set of ϵ-dependent matrix inequalities. Finally, the efficiency of the proposed time-scale-dependent coupling strategy is demonstrated through numerical simulations

Synchronization Analysis of Two-Time-Scale Nonlinear Complex Networks With Time-Scale-Dependent Coupling

In this paper, a time-scale-dependent coupling scheme for two-time-scale nonlinear complex networks is proposed. According to this scheme, the inner coupling matrices are related to the fast dynamics of individual subsystems, but are no longer time-scale-independent. Designing time-scale-dependent inner coupling matrices is motivated by the fact that the difference of time scales is an essential feature of modular architecture of two-time-scale systems. Under the novel coupling framework, the previous assumption on individual two-time-scale subsystems that the fast dynamics must be exponentially stable can be removed. The idea of time-scale separation is employed to analyze the stability of synchronization error systems via weighted ϵ-dependent Lyapunov functions. For a given upper bound of the singular perturbation parameter ϵ, it is proved that the exponential decay rate of the synchronization error can be guaranteed to be independent of the value of ϵ. In this way, criteria for local and global exponential synchronization are established. The allowable upper bound of ϵ such that the synchronizability of the considered two-time-scale network is retained can be obtained by solving a set of ϵ-dependent matrix inequalities. Finally, the efficiency of the proposed time-scale-dependent coupling strategy is demonstrated through numerical simulations

Datasheet1_Case report: Two cases of Poirier-Bienvenu neurodevelopmental syndrome and review of literature.doc

The Poirier-Bienvenu neurodevelopmental syndrome (POBINDS) is a rare disease caused by mutations in the CSNK2B gene, which is characterized by intellectual disability and early-onset epilepsy. Mosaicism has not been previously reported in CSNK2B gene. POBINDS is autosomal dominant and almost all reported cases were de novo variants. Here, we report two patients were diagnosed with POBINDS. Using Whole Exome Sequencing (WES), we detected two novel CSNK2B variants in the two unrelated individuals: c.634_635del (p.Lys212AspfsTer33) and c.142C > T (p.Gln48Ter) respectively. Both of them showed mild developmental delay with early-onset and clustered seizures. The patient with c.634_635del(p.Lys212AspfsTer33) variant was mutant mosaicism, and the proportion of alleles in peripheral blood DNA was 28%. Further, the literature of patients with a de novo mutation of the CSNK2B gene was reviewed, particularly seizure semiology and genotype-phenotype correlations.</p

Photoactivation of Boronic Acid Prodrugs via a Phenyl Radical Mechanism: Iridium(III) Anticancer Complex as an Example

Boronic acid (or ester) is a well-known temporary masking group for developing anticancer prodrugs responsive to tumoral reactive oxygen species (ROS), but their clinic application is largely hampered by the low activation efficiency. Herein, we report a robust photoactivation approach that can spatiotemporally convert boronic acid-caged iridium(III) complex IrBA into bioactive IrNH2 under hypoxic tumor microenvironments. Mechanistic studies show that the phenyl boronic acid moiety in IrBA is in equilibrium with phenyl boronate anion that can be photo-oxidized to generate phenyl radical, a highly reactive species that is capable of rapidly capturing O2 at extremely low concentrations (down to 0.02%). As a result, while IrBA could hardly be activated by intrinsic ROS in cancer cells, upon light irradiation, the prodrug is efficiently converted into IrNH2 even in limited O2 supply, along with direct damage to mitochondrial DNA and potent antitumor activities in hypoxic 2D monolayer cells, 3D tumor spheroids, and mice bearing tumor xenografts. Of note, the photoactivation approach could be extended to intermolecular photocatalytic activation by external photosensitizers with red absorption and to activate prodrugs of clinic compounds, thus offering a general approach for activation of anticancer organoboron prodrugs