17 research outputs found
Generation of ring-shaped optical vortices in dissipative media by inhomogeneous effective diffusion
By means of systematic simulations we demonstrate generation of a variety of
ring-shaped optical vortices (OVs) from a two-dimensional input with embedded
vorticity, in a dissipative medium modeled by the cubic-quintic complex
Ginzburg-Landau equation with an inhomogeneous effective diffusion
(spatial-filtering) term, which is anisotropic in the transverse plane and
periodically modulated in the longitudinal direction. We show the generation of
stable square- and gear-shaped OVs, as well as tilted oval-shaped vortex rings,
and string-shaped bound states built of a central fundamental soliton and two
vortex satellites, or of three fundamental solitons. Their shape can be
adjusted by tuning the strength and modulation period of the inhomogeneous
diffusion. Stability domains of the generated OVs are identified by varying the
vorticity of the input and parameters of the inhomogeneous diffusion. The
results suggest a method to generate new types of ring-shaped OVs with
applications to the work with structured light.Comment: 24 pages, 5 figures; Nonlinear Dynamics, in pres
Case report: Two cases of Poirier-Bienvenu neurodevelopmental syndrome and review of literature
The Poirier-Bienvenu neurodevelopmental syndrome (POBINDS) is a rare disease caused by mutations in the CSNK2B gene, which is characterized by intellectual disability and early-onset epilepsy. Mosaicism has not been previously reported in CSNK2B gene. POBINDS is autosomal dominant and almost all reported cases were de novo variants. Here, we report two patients were diagnosed with POBINDS. Using Whole Exome Sequencing (WES), we detected two novel CSNK2B variants in the two unrelated individuals: c.634_635del (p.Lys212AspfsTer33) and c.142C > T (p.Gln48Ter) respectively. Both of them showed mild developmental delay with early-onset and clustered seizures. The patient with c.634_635del(p.Lys212AspfsTer33) variant was mutant mosaicism, and the proportion of alleles in peripheral blood DNA was 28%. Further, the literature of patients with a de novo mutation of the CSNK2B gene was reviewed, particularly seizure semiology and genotype-phenotype correlations
Mobile Health (mHealth) technology for improved screening, patient involvement and optimising integrated care in atrial fibrillation: The mAFA (mAF-App) II randomised trial
Synchronization analysis of two-time-scale nonlinear complex networks with time-scale-dependent coupling
In this paper, a time-scale-dependent coupling scheme for two-time-scale nonlinear complex networks is proposed. According to this scheme, the inner coupling matrices are related to the fast dynamics of individual subsystems, but are no longer time-scale-independent. Designing time-scale-dependent inner coupling matrices is motivated by the fact that the difference of time scales is an essential feature of modular architecture of two-time-scale systems. Under the novel coupling framework, the previous assumption on individual two-time-scale subsystems that the fast dynamics must be exponentially stable can be removed. The idea of time-scale separation is employed to analyze the stability of synchronization error systems via weighted ϵ-dependent Lyapunov functions. For a given upper bound of the singular perturbation parameter ϵ, it is proved that the exponential decay rate of the synchronization error can be guaranteed to be independent of the value of ϵ. In this way, criteria for local and global exponential synchronization are established. The allowable upper bound of ϵ such that the synchronizability of the considered two-time-scale network is retained can be obtained by solving a set of ϵ-dependent matrix inequalities. Finally, the efficiency of the proposed time-scale-dependent coupling strategy is demonstrated through numerical simulations
CHADS<sub>2</sub> score has a better predictive value than CHA<sub>2</sub>DS<sub>2</sub>-VASc score in elderly patients with atrial fibrillation
Datasheet1_Case report: Two cases of Poirier-Bienvenu neurodevelopmental syndrome and review of literature.doc
The Poirier-Bienvenu neurodevelopmental syndrome (POBINDS) is a rare disease caused by mutations in the CSNK2B gene, which is characterized by intellectual disability and early-onset epilepsy. Mosaicism has not been previously reported in CSNK2B gene. POBINDS is autosomal dominant and almost all reported cases were de novo variants. Here, we report two patients were diagnosed with POBINDS. Using Whole Exome Sequencing (WES), we detected two novel CSNK2B variants in the two unrelated individuals: c.634_635del (p.Lys212AspfsTer33) and c.142C > T (p.Gln48Ter) respectively. Both of them showed mild developmental delay with early-onset and clustered seizures. The patient with c.634_635del(p.Lys212AspfsTer33) variant was mutant mosaicism, and the proportion of alleles in peripheral blood DNA was 28%. Further, the literature of patients with a de novo mutation of the CSNK2B gene was reviewed, particularly seizure semiology and genotype-phenotype correlations.</p
Evaluation of the tissue distribution, excretion, and cytochrome P450 induction studies of a potential antitumor agent, TM-2, in animals using LC-MS/MS
Photoactivation of Boronic Acid Prodrugs via a Phenyl Radical Mechanism: Iridium(III) Anticancer Complex as an Example
Boronic
acid (or ester) is a well-known temporary masking group
for developing anticancer prodrugs responsive to tumoral reactive
oxygen species (ROS), but their clinic application is largely hampered
by the low activation efficiency. Herein, we report a robust photoactivation
approach that can spatiotemporally convert boronic acid-caged iridium(III)
complex IrBA into bioactive IrNH2 under hypoxic tumor microenvironments. Mechanistic
studies show that the phenyl boronic acid moiety in IrBA is in equilibrium with phenyl boronate anion that can be photo-oxidized
to generate phenyl radical, a highly reactive species that is capable
of rapidly capturing O2 at extremely low concentrations
(down to 0.02%). As a result, while IrBA could hardly
be activated by intrinsic ROS in cancer cells, upon light irradiation,
the prodrug is efficiently converted into IrNH2 even in limited O2 supply, along with direct
damage to mitochondrial DNA and potent antitumor activities in hypoxic
2D monolayer cells, 3D tumor spheroids, and mice bearing tumor xenografts.
Of note, the photoactivation approach could be extended to intermolecular
photocatalytic activation by external photosensitizers with red absorption
and to activate prodrugs of clinic compounds, thus offering a general
approach for activation of anticancer organoboron prodrugs
Mobile Photoplethysmographic Technology to Detect Atrial Fibrillation
Background Low detection and nonadherence are major problems in current management approaches for patients with suspected atrial fibrillation (AF). Mobile health devices may enable earlier AF detection and improved AF management. Objectives This study sought to investigate the effectiveness of AF screening in a large population-based cohort using smart device–based photoplethysmography (PPG) technology, combined with a clinical care AF management pathway using a mobile health approach. Methods AF screening was performed with smart devices using PPG technology, which were made available for the population ≥18 years of age across China. Monitoring for at least 14 days with a wristband (Honor Band 4) or wristwatch (Huawei Watch GT, Honor Watch, Huawei Technologies Co., Ltd., Shenzhen, China) was allowed. The patients with “possible AF” episodes using the PPG algorithm were further confirmed by health providers among the MAFA (mobile AF app) Telecare center and network hospitals, with clinical evaluation, electrocardiogram, or 24-h Holter monitoring. Results There were 246,541 individuals who downloaded the PPG screening app, and 187,912 individuals used smart devices to monitor their pulse rhythm between October 26, 2018, and May 20, 2019. Among those with PPG monitoring (mean age 35 years, 86.7% male), 424 (of 187,912, 0.23%) (mean age 54 years, 87.0% male) received a “suspected AF” notification. Of those effectively followed up, 227 individuals (of 262, 87.0%) were confirmed as having AF, with the positive predictive value of PPG signals being 91.6% (95% confidential interval [CI]: 91.5% to 91.8%). Both suspected AF and identified AF markedly increased with age (p for trend <0.001), and individuals in Northeast China had the highest proportion of detected AF of 0.28% (95% CI: 0.20% to 0.39%). Of the individuals with identified AF, 216 (of 227, 95.1%) subsequently entered a program of integrated AF management using a mobile AF application; approximately 80% of high-risk patients were successfully anticoagulated. Conclusions Based on the present study, continuous home monitoring with smart device–based PPG technology could be a feasible approach for AF screening. This would help efforts at screening and detection of AF, as well as early interventions to reduce stroke and other AF-related complications. (Mobile Health [mHealth] Technology for Improved Screening, Patient Involvement and Optimizing Integrated Care in Atrial Fibrillation [MAFA II]; ChiCTR-OOC-17014138