Aqueous electrosynthesis of an electrochromic material based water-soluble EDOT-MeNH2 hydrochloride

2\u27-Aminomethyl-3,4-ethylenedioxythiophene (EDOT-MeNH2) showed unsatisfactory results when its polymerization occurred in organic solvent in our previous report. Therefore, a water-soluble EDOT derivative was designed by using hydrochloric modified EDOT-MeNH2 (EDOT-MeNH2·HCl) and electropolymerized in aqueous solution to form the corresponding polymer with excellent electrochromic properties. Moreover, the polymer was systematically explored, including electrochemical, optical properties and structure characterization. Cyclic voltammetry showed low oxidation potential of EDOT-MeNH2·HCl (0.85 V) in aqueous solution, leading to the facile electrodeposition of uniform the polymer film with outstanding electroactivity. Compared with poly(2′-aminomethyl- 3,4-ethylenedioxythiophene) (PEDOT-MeNH2), poly(2′-aminomethyl-3,4-ethylenedioxythiophene salt) (PEDOT-MeNH3 +A-) revealed higher efficiencies (156 cm2 C-1), lower bandgap (1.68 eV), and faster response time (1.4 s). Satisfactory results implied that salinization can not only change the polymerization system, but also adjust the optical absorption, thereby increase the electrochromic properties

Aqueous electrosynthesis of an electrochromic material based water-soluble EDOT-MeNH2 hydrochloride

2\u27-Aminomethyl-3,4-ethylenedioxythiophene (EDOT-MeNH2) showed unsatisfactory results when its polymerization occurred in organic solvent in our previous report. Therefore, a water-soluble EDOT derivative was designed by using hydrochloric modified EDOT-MeNH2 (EDOT-MeNH2·HCl) and electropolymerized in aqueous solution to form the corresponding polymer with excellent electrochromic properties. Moreover, the polymer was systematically explored, including electrochemical, optical properties and structure characterization. Cyclic voltammetry showed low oxidation potential of EDOT-MeNH2·HCl (0.85 V) in aqueous solution, leading to the facile electrodeposition of uniform the polymer film with outstanding electroactivity. Compared with poly(2′-aminomethyl- 3,4-ethylenedioxythiophene) (PEDOT-MeNH2), poly(2′-aminomethyl-3,4-ethylenedioxythiophene salt) (PEDOT-MeNH3 +A-) revealed higher efficiencies (156 cm2 C-1), lower bandgap (1.68 eV), and faster response time (1.4 s). Satisfactory results implied that salinization can not only change the polymerization system, but also adjust the optical absorption, thereby increase the electrochromic properties

A Universal strategy for the facile synthesis of a sandwich-structured Pt-graphene-Pt nanocomposite for salbutamol sensing

In this work, a sandwich-structured Pt-graphene-Pt (P-Gr-P) nanocomposite has been prepared by a two-step method including (i) a chemical and (ii) an electrochemical reduction process. The P-graphene oxide-P (P-GO-P) nanocomposite was firstly synthesized by an in situ growth method, during which platinum nanoparticles (PtNPs) grew on both sides of GO. In the second step, P-GO-P was coated onto a glass carbon electrode (GCE). In this process, GO in the P-GO-P nanocomposite was reduced to a more conductive form of graphene (Gr). The obtained sandwich-structured P-Gr-P can effectively separate the individual layers of Gr sheets from each other, prevent the agglomeration of Gr sheets and improve the conductivity of the Gr film. In addition, the electrocatalytic properties of the as-prepared P-Gr-P nanocomposite towards the oxidation of salbutamol (SAL) were investigated. Results revealed that the sandwich-structured P-Gr-P nanocomposite with higher electrochemically active surface area showed better electrocatalytic activity toward SAL oxidation than PtNPs-Gr prepared by using the one-step electrochemical co-deposition method. On the basis of the excellent electrochemical activity of the P-Gr-P nanocomposite, a highly sensitive electrochemical platform was developed for the rapid detection of SAL. The present work provides an interesting strategy to prepare a Gr-based nanocomposite for electrochemical sensors.8 page(s

Application of poly(3,4-ethylenedioxythiophene)/manganese dioxide composite-modified electrode for sensitive electrochemical detection of luteolin

In this work, the electrochemical determination of luteolin using poly(3,4-ethylenedioxythiophene)/manganese dioxide nanocomposite modified glassy carbon electrode (PEDOT/MnO₂/GCE) is reported. PEDOT/MnO₂ nanocomposite has been proposed via a simple two-step deposition approach. Electrochemical results revealed that PEDOT/MnO₂ showed enhanced electrocatalytic performance toward luteolin, which might be attributed to good conductivity and accelerated electron transfer of PEDOT and good catalytic effect of MnO₂. Experimental conditions, including pH values and scan rates were optimized. In optimal conditions, a good linear relationship was found between oxidation peak currents and the concentration of luteolin in 5.0 nM-7.0 μM range. The detection limit was calculated to be 1.8 nM at a signal-to-noise ratio of 3. Finally, the applicability for luteolin determination in real samples was successfully demonstrated.10 page(s

DataSheet_1_Safety and immunogenicity of heterologous recombinant protein subunit vaccine (ZF2001) booster against COVID-19 at 3–9-month intervals following two-dose inactivated vaccine (CoronaVac).docx

BackgroundIn response to SARS-CoV-2 mutations and waning antibody levels after two-dose inactivated vaccines, we assessed whether a third dose of recombinant protein subunit vaccine (ZF2001) boosts immune responses.MethodsAn open-label single-center non-random trial was conducted on people aged 18 years and above at five sites in China. All participants received a two-dose inactivated vaccine (CoronaVac) as their prime doses within 3–9 months of the trial. Primary outcomes were safety and immunogenicity, primarily the geometric mean titers (GMTs) of neutralizing antibodies to live wildtype SARS-CoV-2.ResultsA total of 480 participants (median age, 51; range 21–84 years) previously vaccinated with two-dose CoronaVac received a third booster dose of ZF2001 3–4, 5–6, or 7–9-months later. The overall incidence of adverse reactions within 30 days after vaccination was 5.83% (28/480). No serious adverse reactions were reported after the third dose of ZF2001. GMTs in the 3–4-, 5–6-, and 7–9-month groups before vaccination were 3.96, 4.60, and 3.78, respectively. On Day 14, GMTs increased to 33.06, 47.51, and 44.12, respectively. After the booster, GMTs showed no significant difference among the three prime-boost interval groups (all P>0.05). Additionally, GMTs in older adults were lower than those in younger adults on Day 14 for the three groups (P=0.0005, PConclusionHeterologous boosting with ZF2001 was safe and immunogenic, and prime-boost intervals did not affect the immune response. The immune response was weaker in older than younger adults.</p