110 research outputs found
An integrated global chemomics and system biology approach to analyze the mechanisms of the traditional Chinese medicinal preparation Eriobotrya japonica â Fritillaria usuriensis dropping pills for pulmonary diseases
The quality of each herb and CBPP extract, and the targets and pathway predicted by PharmMapper and KEGG. (DOC 4286Â kb
RePAST: A ReRAM-based PIM Accelerator for Second-order Training of DNN
The second-order training methods can converge much faster than first-order
optimizers in DNN training. This is because the second-order training utilizes
the inversion of the second-order information (SOI) matrix to find a more
accurate descent direction and step size. However, the huge SOI matrices bring
significant computational and memory overheads in the traditional architectures
like GPU and CPU. On the other side, the ReRAM-based process-in-memory (PIM)
technology is suitable for the second-order training because of the following
three reasons: First, PIM's computation happens in memory, which reduces data
movement overheads; Second, ReRAM crossbars can compute SOI's inversion in
time; Third, if architected properly, ReRAM crossbars can
perform matrix inversion and vector-matrix multiplications which are important
to the second-order training algorithms.
Nevertheless, current ReRAM-based PIM techniques still face a key challenge
for accelerating the second-order training. The existing ReRAM-based matrix
inversion circuitry can only support 8-bit accuracy matrix inversion and the
computational precision is not sufficient for the second-order training that
needs at least 16-bit accurate matrix inversion. In this work, we propose a
method to achieve high-precision matrix inversion based on a proven 8-bit
matrix inversion (INV) circuitry and vector-matrix multiplication (VMM)
circuitry. We design \archname{}, a ReRAM-based PIM accelerator architecture
for the second-order training. Moreover, we propose a software mapping scheme
for \archname{} to further optimize the performance by fusing VMM and INV
crossbar. Experiment shows that \archname{} can achieve an average of
115.8/11.4 speedup and 41.9/12.8energy saving
compared to a GPU counterpart and PipeLayer on large-scale DNNs.Comment: 13pages, 13 figure
Chemical composition and source apportionment of PM <sub>2.5</sub> in urban areas of Xiangtan, central south China
Xiangtan, South China, is characterized by year-round high relative humidity and very low wind speeds. To assess levels of PM2.5, daily samples were collected from 2016 to 2017 at two urban sites. The mass concentrations of PM2.5 were in the range of 30⁻217 µg/m3, with the highest concentrations in winter and the lowest in spring. Major water-soluble ions (WSIIs) and total carbon (TC) accounted for 58⁻59% and 21⁻24% of the PM2.5 mass, respectively. Secondary inorganic ions (SO42−, NO3−, and NH4+) dominated the WSIIs and accounted for 73% and 74% at the two sites. The concentrations of K, Fe, Al, Sb, Ca, Zn, Mg, Pb, Ba, As, and Mn in the PM2.5 at the two sites were higher than 40 ng/m3, and decreased in the order of winter > autumn > spring. Enrichment factor analysis indicates that Co, Cu, Zn, As, Se, Cd, Sb, Tl, and Pb mainly originates from anthropogenic sources. Source apportionment analysis showed that secondary inorganic aerosols, vehicle exhaust, coal combustion and secondary aerosols, fugitive dust, industrial emissions, steel industry are the major sources of PM2.5, contributing 25⁻27%, 21⁻22%, 19⁻21%, 16⁻18%, 6⁻9%, and 8⁻9% to PM2.5 mass
DHAV-1 2A1 Peptide â A Newly Discovered Co-expression Tool That Mediates the Ribosomal âSkippingâ Function
Duck hepatitis A virus 1 (DHAV-1) belongs to the genus Avihepatovirus in the family Picornaviridae. Little research has been carried out on the non-structural proteins of this virus. This study reports that 2A1 protein, the first non-structural protein on the DHAV-1 genome, has a ribosomal âskippingâ function mediated by a â-GxExNPGP-â motif. In addition, we prove that when the sequence is extended 10aa to VP1 from the N-terminal of 2A1, the ribosome âskipsâ completely. However, as the N-terminus of 2A is shortened, the efficiency of ribosomal âskippingâ reduces. When 2A1 is shortened to 10aa, it does not function. In addition, we demonstrate that N18, P19 G20, and P21 have vital roles in this function. We find that the expression of upstream and downstream proteins linked by 2A1 is different, and the expression of the upstream protein is much greater than that of the downstream protein. In addition, we demonstrate that it is the nature of 2A1 that is responsible for the expression imbalance. We also shows that the protein âcleavageâ is not due to RNA âcleavageâ or RNA transcription abnormalities, and the expressed protein level is independent of RNA transcriptional level. This study provides a systematic analysis of the activity of the DHAV-1 2A1 sequence and, therefore, adds to the âtool-boxâ that can be deployed for the co-expression applications. It provides a reference for how to apply 2A1 as a co-expression tool
Mesoporous Polydopamine Loaded Pirfenidone Target to Fibroblast Activation Protein for Pulmonary Fibrosis Therapy
Recently, fibroblast activation protein (FAP), an overexpressed transmembrane protein of activated fibroblast in pulmonary fibrosis, has been considered as the new target for diagnosing and treating pulmonary fibrosis. In this work, mesoporous polydopamine (MPDA), which is facile prepared and easily modified, is developed as a carrier to load antifibrosis drug pirfenidone (PFD) and linking FAP inhibitor (FAPI) to realize lesion-targeted drug delivery for pulmonary fibrosis therapy. We have found that PFD@MPDA-FAPI is well biocompatible and with good properties of antifibrosis, when ICG labels MPDA-FAPI, the accumulation of the nanodrug at the fibrosis lung in vivo can be observed by NIR imaging, and the antifibrosis properties of PFD@MPDA-FAPI in vivo were also better than those of pure PFD and PFD@MPDA; therefore, the easily produced and biocompatible nanodrug PFD@MPDA-FAPI developed in this study is promising for further clinical translations in pulmonary fibrosis antifibrosis therapy
PSR J1926-0652: A Pulsar with Interesting Emission Properties Discovered at FAST
We describe PSR J1926-0652, a pulsar recently discovered with the
Five-hundred-meter Aperture Spherical radio Telescope (FAST). Using sensitive
single-pulse detections from FAST and long-term timing observations from the
Parkes 64-m radio telescope, we probed phenomena on both long and short time
scales. The FAST observations covered a wide frequency range from 270 to 800
MHz, enabling individual pulses to be studied in detail. The pulsar exhibits at
least four profile components, short-term nulling lasting from 4 to 450 pulses,
complex subpulse drifting behaviours and intermittency on scales of tens of
minutes. While the average band spacing P3 is relatively constant across
different bursts and components, significant variations in the separation of
adjacent bands are seen, especially near the beginning and end of a burst. Band
shapes and slopes are quite variable, especially for the trailing components
and for the shorter bursts. We show that for each burst the last detectable
pulse prior to emission ceasing has different properties compared to other
pulses. These complexities pose challenges for the classic carousel-type
models.Comment: 13pages with 12 figure
Roadmap for Sustainable Mixed IonicâElectronic Conducting Membranes
Mixed ionicâelectronic conducting (MIEC) membranes have gained growing interest recently for various promising environmental and energy applications, such as Hâ and Oâ production, COâ reduction, Oâ and Hâ separation, COâ separation, membrane reactors for production of chemicals, cathode development for solid oxide fuel cells, solarâdriven evaporation and energyâsaving regeneration as well as electrolyzer cells for powerâtoâX technologies. The purpose of this roadmap, written by international specialists in their fields, is to present a snapshot of the stateâofâtheâart, and provide opinions on the future challenges and opportunities in this complex multidisciplinary research field. As the fundamentals of using MIEC membranes for various applications become increasingly challenging tasks, particularly in view of the growing interdisciplinary nature of this field, a better understanding of the underlying physical and chemical processes is also crucial to enable the career advancement of the next generation of researchers. As an integrated and combined article, it is hoped that this roadmap, covering all these aspects, will be informative to support further progress in academics as well as in the industryâoriented research toward commercialization of MIEC membranes for different applications
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