Efficacy of Zhenjingdingzhi decoction in treating insomnia with Qi-deficiency of heart and gallbladder: a randomized, double-blind, controlled trial

AbstractObjectiveTo evaluate the clinical efficacy of Zhenjingdingzhi decoction in treating insomnia with Qi-deficiency of heart and gallbladder.MethodsWe conducted a double-blind, randomized, controlled trial involving 100 patients with insomnia of Qi-deficiency of heart and gallbladder. Patients were randomly divided into the treatment group (n = 50) and the control group (n = 50) according to a random number table. The treatment group was given Zhenjingdingzhi decoction, while the control group was treated with Suanzaoren decoction. the pharmacological treatment lasted for 8 weeks. The clinical efficacy was assessed by using Spiegel scale, Pittsburgh sleep quality index (PSQI) and Traditional Chinese Medicine (TCM) syndrome scores.ResultsComparing Spiegel scores between the two groups at 4 and 8 weeks, the differences in curative effect between the two groups were both significant (both P < 0.05). The total effective rate was 46% in the treatment group and 27.7% in the control group at 4 weeks, and 80% and 53.2% at 8 weeks, respectively; After 8 weeks, PSQI scores showed that the total effective rates differed significantly between the two groups (P < 0.01): 84% in the treatment group and 59.6% in the control group; In improving sleep quality and sleep duration, the curative effect of the treatment group was better than that of the control group (P < 0.05). TCM syndrome, especially insomnia and palpitation, was improved better in the treatment group after 8 weeks as compared to that in the control group (P < 0.05). The total effective rate of the two groups was 84% and 66%, respectively.ConclusionZhenjingdingzhi decoction is effective and safe for the treatment of insomnia with Qi-deficiency of heart and gallbladder, especially for improving sleep quality and sleep duration

Residual Stress Analyses in a Pipe Welding Simulation: 3D Pipe Versus Axi-symmetric Models

AbstractThis paper numerically studied the residual stress in a butt-welded steel pipe. A comparison of 3D pipe and axi-symmetric finite element model under the condition of same welding simulation parameters was carried out. The results showed that axi- symmetric model share similar residual stress distribution with 3D model in the condition of same heat source shape parameters. However, the stress values of the two concerned models were quite different. Meanwhile the scale of welding pool for 3D model was almost twice bigger than that of axi-symmetric model. Both welding experiment and simulation results of 3D model showed that peak temperature of welding pool along the welding path increased during the welding process, and welding pool width and depth also increased with the moving of heat source

Almost-tight Identity Based Encryption against Selective Opening Attack

The paper presented an identity based encryption (IBE) under selective opening attack (SOA) whose security is almost-tightly related to a set of computational assumptions. Our result is a combination of Bellare, Waters, and Yilek\u27s method [TCC, 2011] for constructing (not tightly) SOA secure IBE and Hofheinz, Koch, and Striecks\u27 technique [PKC, 2015] on building almost-tightly secure IBE in the multi-ciphertext setting. In particular, we first tuned Bellare et al.\u27s generic construction for SOA secure IBE to show that a one-bit IBE achieving ciphertext indistinguishability under chosen plaintext attack in the multi-ciphertext setting (with one-sided publicly openability) tightly implies a multi-bit IBE secure under selective opening attack. Next, we almost-tightly reduced such a one-bit IBE to static assumptions in the composite-order bilinear groups employing the technique of Hofheinz et al. This yielded the first SOA secure IBE with almost-tight reduction

Atlas of Mineral Deposits Distribution in China (2020)

This open access book includes instruction of national mineral database 2020 and atlas of national mineral deposits distribution derived from national mineral database 2020. National mineral database 2020 is based on data from National Geological Archives China(NGAC). Moreover, it introduces the construction method and updates maintenance mechanism of the mineral deposits database and proposes the concept of updating data based on collected archives. The construction guideline on national mineral deposits database provides guiding framework for the future development on geological database

Extended Nested Dual System Groups, Revisited

The notion of extended nested dual system groups (ENDSG) was recently proposed by Hofheinz et al. [PKC 2015] for constructing almost-tight identity based encryptions (IBE) in the multi-instance, multi-ciphertext (MIMC) setting. However only a composite-order instantiation was proposed and more efficient prime-order instantiations are absent. The paper fills the blank by presenting two constructions. We revise the definition of ENDSG and realize it using prime-order bilinear groups based on Chen and Wee\u27s prime-order instantiation of nested dual system groups [CRYPTO 2013]. This yields the first almost-tight IBE in the prime-order setting achieving weak adaptive security in MIMC scenario under the $d$-linear ($d$-Lin) assumption. We further enhanced the revised ENDSG to capture stronger security notions for IBE, including $B$-weak adaptive security and full adaptive security. We show that our prime-order instantiation is readily $B$-weak adaptive secure and full adaptive secure without introducing extra assumption. We then try to find better solution by fine-tuning ENDSG again and realizing it using the technique of Chen, Gay, and Wee [EUROCRYPT 2015]. This leads to an almost-tight secure IBE in the same setting with better performance than our first result, but the security relies on a non-standard assumption, $d$-linear assumption with auxiliary input ($d$-LinAI) for an even positive integer $d$. However we note that, the $2$-LinAI assumption is implied by the external decisional linear (XDLIN) assumption. This concrete instantiation could also be realized using symmetric bilinear groups under standard decisional linear assumption

3-Cinnamoyl-4-hydroxy-6-methyl-2H-pyran-2-one ameliorates diabetic peripheral neuropathy in type 2 diabetes mellitus rats via PI3K/Akt signaling pathway

Purpose: To investigate the curative effects of 3-cinnamoyl-4-hydroxy-6-methyl-2H-pyran-2-one (CHMP) on streptozotocin (STZ)-induced model of diabetic SD rats, and the underlying mechanism. Method: Diabetes was induced in rats using single intraperitoneal injection of STZ. Subsequently, diabetic and non-diabetic rats were randomly grouped into five experimental groups. Six weeks after the STZ-injection, the diabetic animals were orally administered test compound (CHMP) at two doses of 10 and 20 mg/kg body weight for 6 weeks. Thereafter, the rats were anesthetised, and body weight, blood sugar, and motor nerve conduction velocity (MNCV) were determined. Moreover, real time-polymerase chain reaction (RT-PCR) and western blot analysis were used to assay the expression levels of genes in PIK3/Akt pathway and Glut4. Results: Treatment of diabetic rats with CHMP significantly reduced levels of fasting blood glucose and enhanced average rat body weight, relative to diabetic control (p ˂ 0.05). Motor nerve conduction velocity (MNCV) was remarkably increased in CHMP-treated rats (54.2 ± 2.2), when compared to the diabetic control rats (46 ± 4.1, p &lt; 0.01). Results from RT-PCR and western blot indicated increased expressions of PI3K, Akt and IRS-1, and down regulation of GSK-3B expression in skeletal muscle. The CHMP treatment also upregulated the Glut4 expression in skeletal muscle. Conclusion: These findings show that CHMP may be beneficial in the management of diabetic neuropath

PRODUCTION, DIELECTRIC PROPERTY AND MICROWAVE ABSORPTION PROPERTY OF SiC(Fe) SOLID SOLUTION POWDER BY SOL-GEL METHOD

SiC(Fe) solid solution powders were synthesized by sol–gel method under different reaction time, using methyltriethoxysilane as the silicon and carbon source and analytic ferric chloride as the dopant, respectively. The synthesized powders have been characterized by XRD, SEM and Raman spectra. Results show that the lattice constant decreases with increasing reaction time. The electric permittivities of SiC samples were determined in the frequency range of 8.2 ~ 12.4 GHz. Results show that the permittivity of SiC decreases with increasing reaction time. The SiC(Fe) solid solution powder with reaction time of 4 h with 2 mm thickness exhibit the best microwave absorption property in X-band range (8.2 - 12.4 GHz). The microwave absorption mechanism has been discussed

The Epitope Study on the SARS-CoV Nucleocapsid Protein

The nucleocapsid protein (N protein) has been found to be an antigenic protein in a number of coronaviruses. Whether the N protein in severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is antigenic remains to be elucidated. Using Western blot and Enzyme-linked Immunosorbent Assay (ELISA), the recombinant N proteins and the synthesized peptides derived from the N protein were screened in sera from SARS patients. All patient sera in this study displayed strong positive immunoreactivities against the recombinant N proteins, whereas normal sera gave negative immunoresponses to these proteins, indicating that the N protein of SARS-CoV is an antigenic protein. Furthermore, the epitope sites in the N protein were determined by competition experiments, in which the recombinant proteins or the synthesized peptides competed against the SARS-CoV proteins to bind to the antibodies raised in SARS sera. One epitope site located at the C-terminus was confirmed as the most antigenic region in this protein. A detailed screening of peptide with ELISA demonstrated that the amino sequence from Codons 371 to 407 was the epitope site at the C-terminus of the N protein. Understanding of the epitope sites could be very significant for developing an effective diagnostic approach to SARS

Morphology, composition and mixing state of individual airborne particles: Effects of the 2017 Action Plan in Beijing, China

Beijing is one of the most important Chinese megacities with extremely serious air pollution problems and human health impacts. In response to the air pollution the central and municipal governments of China have implemented a series of actions; one of which is the “Action Plan for Comprehensive Prevention and Control of Autumn and Winter Air Pollution in Beijing-Tianjin-Hebei and Surrounding Areas 2017–2018” (the Action Plan) issued in 2017. The morphology, composition and mixing state of individual particles collected after the Action Plan was implemented were analyzed by high resolution-transmission electron microscopy coupled with an energy-dispersive X-ray spectrometer (TEM-EDX). The relative percentages of different individual particle types and the main sources of the particulate pollution before and after the Action Plan were compared. The results showed that sulfur was most frequently detected in the individual particles, and the particle types were mainly composed of soot aggregates, mineral particles, organic particles, metal particles, coal fly ashes, sulfate particles, and mixture particles. The mixture and sulfate particles dominated in the autumn samples, both for the haze and non-haze days. In winter the mineral and mixture particles dominated in samples for the non-haze days, while mixture particles and sulfate dominated in the samples for the haze days. The mixture particles in autumn were mainly the soot aggregates internally mixed with sulfate (S-soot type), while the mixture particles in winter were mainly the S-soot type and the mineral particles internally mixed with sulfate (S-mineral type). After the Action Plan, the relative percentages of sulfate particles, organic particles, and soot aggregates increased, while the relative percentages of mineral particles, metal particles and fly ashes decreased. The contribution from coal�fired sources was reduced significantly as evidenced by the decrease in the fly ash particles. The vehicle emis�sions and secondary reaction of particulate matter became the main sources of atmospheric particulate matters as evidenced by increase in sulfate particles, organic particles, and soot aggregates. The results presented in this study will assist in other plans to improve air quality and human health in megacities around the world

Imaging CF\u3csub\u3e3\u3c/sub\u3eI conical intersection and photodissociation dynamics with ultrafast electron diffraction

Conical intersections play a critical role in excited-state dynamics of polyatomic molecules because they govern the reaction pathways of many nonadiabatic processes. However, ultrafast probes have lacked sufficient spatial resolution to image wave-packet trajectories through these intersections directly. Here, we present the simultaneous experimental characterization of one-photon and two-photon excitation channels in isolated CF3I molecules using ultrafast gas-phase electron diffraction. In the two-photon channel, we have mapped out the real-space trajectories of a coherent nuclear wave packet, which bifurcates onto two potential energy surfaces when passing through a conical intersection. In the one-photon channel, we have resolved excitation of both the umbrella and the breathing vibrational modes in the CF3 fragment in multiple nuclear dimensions. These findings benchmark and validate ab initio nonadiabatic dynamics calculations. Includes supplementary materials. Movie S1 attached below