Methods for Nonparametric and Semiparametric Regressions with Endogeneity: a Gentle Guide

This paper reviews recent advances in estimation and inference for nonparametric and semiparametric models with endogeneity. It first describes methods of sieves and penalization for estimating unknown functions identified via conditional moment restrictions. Examples include nonparametric instrumental variables regression (NPIV), nonparametric quantile IV regression and many more semi-nonparametric structural models. Asymptotic properties of the sieve estimators and the sieve Wald, quasi-likelihood ratio (QLR) hypothesis tests of functionals with nonparametric endogeneity are presented. For sieve NPIV estimation, the rate-adaptive data-driven choices of sieve regularization parameters and the sieve score bootstrap uniform confidence bands are described. Finally, simple sieve variance estimation and over-identification test for semiparametric two-step GMM are reviewed. Monte Carlo examples are included

Peer-to-Peer Grids

We describe Peer-to-Peer Grids built around Integration of technologies from the peer-to-peer and Grid fields. We focus on the role of Web services linked by a powerful event service using uniform XML interfaces and application level routing. We describe how a rich synchronous and asynchronous collaboration environment can support virtual communities built on top of such infrastructure. Universal access mechanisms are discussed

Extended ammonia observations towards the 'Integral-Shaped Filament'

Recent observations suggest a scenario in which filamentary structures in the ISM represent the first step towards clumps/cores and eventually star formation. The densest filaments would then fragment into prestellar cores owing to gravitational instability. We seek to understand the roles filamentary structures play in high-mass star formation. We mapped the integral-shaped filament (ISF) in NH3 (1, 1) and (2, 2). The whole filamentary structure is uniformly and fully sampled. We find that the morphology revealed by the map of velocity-integrated intensity of the NH3 (1, 1) line is closely associated with the dust ridge. We identify 6 "clumps" related to the well known OMC-1 to 5 and 11 "sub-clumps" within the map and they are separated not randomly but in roughly equal intervals along the ISF. The average spacing of clumps is 11.30'$\pm$1.31' (1.36$\pm$0.16 pc ) and the average spacing of sub-clumps is 7.18'$\pm$1.19' (0.86$\pm$0.14 pc). These spacings agree well with the predicted values of the thermal (0.86 pc) and turbulent sausage instability (1.43 pc) by adopting a cylindric geometry of the ISF with an inclination of $60^{\circ}$ with respect to the line of sight. We also find a velocity gradient of about 0.6 km s-1 pc-1 that runs along the ISF which likely arises from an overall rotation of the Orion A molecular cloud. The inferred ratio between rotational and gravitational energy is well below unity. Furthermore, fluctuations are seen in the centroid velocity diagram along the ISF. The OMC-1 to 5 clouds are located close to the local extrema of the fluctuations, which suggests that there exist gas flows associated with these clumps in the ISF. The derived NH3 (1, 1) and (2, 2) rotation temperatures in the OMC-1 are about 30-40 K. In OMC-2, OMC-3, and the northern part of OMC-4, we find higher and lower temperatures at the boundaries and in the interior, respectively.Comment: Accepted by A&A. 14 pages, 14 figure

Media Literasi: Upaya Bijak Menyikapi Terpaan Tayangan Televisi

The television media have transformed into industry. Tight competition among TV stations demands the media people to provide programs based on the market taste. Therefore, mostly TV stations design and produce their programs based on share and rating numbers, instead of quality. On the other side, TV stations have important roles in constructing social and cultural development. Currently, TV programs are merely produced based on the business orientation so that the quality of the TV programs is often ignored. Audience must be wise and smart to protect themselves from poor-quality TV programs exposure. This can be achieved by improving their Media Literacy. In the end, Audience is no longer treated as passive object, but actively takes control on the content selection

PROCESS FOR THE FORMATION OF WEAR- AND SCUFF-RESISTANT CARBON COATINGS

A process for forming an adherent diamond-like carbon coating on a workpiece of suitable material such as an aluminum alloy is disclosed. The workpiece is successively immersed in different plasma atmospheres and subjected to short duration, high voltage, negative electrical potential pulses or constant negative electrical potentials or the like so as to clean the surface of oxygen atoms, implant carbon atoms into the surface of the alloy to form carbide com pounds while codepositing a carbonaceous layer on the surface, bombard and remove the carbonaceous layer, and to thereafter deposit a generally amorphous hydrogen-containing carbon layer on the surface of the article

Parallel Data Mining on Multicore Clusters”, gcc

Abstract-The ever increasing number of cores per chip will be accompanied by a pervasive data deluge whose size will probably increase even faster than CPU core count over the next few years. This suggests the importance of parallel data analysis and data mining applications with good multicore, cluster and grid performance. This paper considers data clustering, mixture models and dimensional reduction presenting a unified framework applicable to bioinformatics, cheminformatics and demographics. Deterministic annealing is used to lessen effect of local minima. We present performance results on clusters of 2-8 core systems identifying effects from cache, runtime fluctuations, synchronization and memory bandwidth. We discuss needed programming model and compare with MPI and other approaches

Binding of Soluble Yeast β-Glucan to Human Neutrophils and Monocytes is Complement-Dependent

The immunomodulatory properties of yeast β-1,3/1,6 glucans are mediated through their ability to be recognized by human innate immune cells. While several studies have investigated binding of opsonized and unopsonized particulate β-glucans to human immune cells mainly via complement receptor 3 (CR3) or Dectin-1, few have focused on understanding the binding characteristics of soluble β-glucans. Using a well-characterized, pharmaceutical grade, soluble yeast β-glucan, this study evaluated and characterized the binding of soluble β-glucan to human neutrophils and monocytes. The results demonstrated that soluble β-glucan bound to both human neutrophils and monocytes in a concentration-dependent and receptor-specific manner. Antibodies blocking the CD11b and CD18 chains of CR3 significantly inhibited binding to both cell types, establishing CR3 as the key receptor recognizing the soluble β-glucan in these cells. Binding of soluble β-glucan to human neutrophils and monocytes required serum and was also dependent on incubation time and temperature, strongly suggesting that binding was complement-mediated. Indeed, binding was reduced in heat-inactivated serum, or in serum treated with methylamine or in serum reacted with the C3-specific inhibitor compstatin. Opsonization of soluble β-glucan was demonstrated by detection of iC3b, the complement opsonin on β-glucan-bound cells, as well as by the direct binding of iC3b to β-glucan in the absence of cells. Binding of β-glucan to cells was partially inhibited by blockade of the alternative pathway of complement, suggesting that the C3 activation amplification step mediated by this pathway also contributed to binding

Histopathological Observation of Immunized Rhesus Macaques with Plague Vaccines after Subcutaneous Infection of Yersinia pestis

In our previous study, complete protection was observed in Chinese-origin rhesus macaques immunized with SV1 (20 µg F1 and 10 µg rV270) and SV2 (200 µg F1 and 100 µg rV270) subunit vaccines and with EV76 live attenuated vaccine against subcutaneous challenge with 6×106 CFU of Y. pestis. In the present study, we investigated whether the vaccines can effectively protect immunized animals from any pathologic changes using histological and immunohistochemical techniques. In addition, the glomerular basement membranes (GBMs) of the immunized animals and control animals were checked by electron microscopy. The results show no signs of histopathological lesions in the lungs, livers, kidneys, lymph nodes, spleens and hearts of the immunized animals at Day 14 after the challenge, whereas pathological alterations were seen in the corresponding tissues of the control animals. Giemsa staining, ultrastructural examination, and immunohistochemical staining revealed bacteria in some of the organs of the control animals, whereas no bacterium was observed among the immunized animals. Ultrastructural observation revealed that no glomerular immune deposits on the GBM. These observations suggest that the vaccines can effectively protect animals from any pathologic changes and eliminate Y. pestis from the immunized animals. The control animals died from multi-organ lesions specifically caused by the Y. pestis infection. We also found that subcutaneous infection of animals with Y. pestis results in bubonic plague, followed by pneumonic and septicemic plagues. The histopathologic features of plague in rhesus macaques closely resemble those of rodent and human plagues. Thus, Chinese-origin rhesus macaques serve as useful models in studying Y. pestis pathogenesis, host response and the efficacy of new medical countermeasures against plague

High Proportion of 22q13 Deletions and SHANK3 Mutations in Chinese Patients with Intellectual Disability

Intellectual disability (ID) is a heterogeneous disorder caused by chromosomal abnormalities, monogenic factors and environmental factors. 22q13 deletion syndrome is a genetic disorder characterized by severe ID. Although the frequency of 22q13 deletions in ID is unclear, it is believed to be largely underestimated. To address this issue, we used Affymetrix Human SNP 6.0 array to detect the 22q13 deletions in 234 Chinese unexplained ID patients and 103 controls. After the Quality Control (QC) test of raw data, 22q13 deletions were found in four out of 230 cases (1.7%), while absent in parents of the cases and 101 controls. A review of genome-wide microarray studies in ID was performed and the frequency of 22q13 deletions from the literatures was 0.24%, much lower than our report. The overlapping region shared by all 4 cases encompasses the gene SHANK3. A heterozygous de novo nonsense mutation Y1015X of SHANK3 was identified in one ID patient. Cortical neurons were prepared from embryonic mice and were transfected with a control plasmid, shank3 wild-type (WT) or mutant plasmids. Overexpression of the Y1015 mutant in neurons significantly affected neurite outgrowth compared with shank3 WT. These findings suggest that 22q13 deletions may be a more frequent cause for Chinese ID patients than previously thought, and the SHANK3 gene is involved in the neurite development