Traffic simulation of Beijing west railway station north area

Purpose: In recent years the problem of traffic congestion and its management has become increasingly prominent. It is a hot research about how to make full use of computer simulation technology to make transportation more rational and more organized. In this paper, we focus on traffic of Beijing West Railway Station north area, and try to find a way to reduce traffic congestion in this area. Approach: In this paper, we studied the traffic flow by survey. We also built a traffic simulation model with VISSIM software. Different types of vehicles and their speed are set in model according survey data. The simulation model provides different traffic scenarios of Beijing West Railway Station north area. Findings: We found the traffic of this area up is to 1800 vehicles/hour. Heavy traffic burden causes traffic congestion in two positions: the bus hub and car drop-off point. If we can extend bus interval departure time and park cars to south square of Beijing West Railway Station, the traffic condition will be improved. Originality: This paper gives a solution to reduce traffic congestion in Beijing West Railway Station north area. The bus hub and car parking lots are the key point of traffic problem in this area.Peer Reviewe

The balance of Polo-like kinase 1 in tumorigenesis

Polo-like kinase 1 (Plk1) belongs to a family of conserved serine/threonine kinases with a polo-box domain, which have similar but non-overlapping functions in the cell cycle progression. Plk1 plays a key role to ensure the normal mitosis. Interestingly, overexpression of Plk1 is associated with tumor development and could serve as a prognostic marker for many cancers. Due to Plk1 overexpression, several Plk1 inhibitors have been developed and tested for the cancer treatment. However, in a recent study, it has been suggested that down-regulation of Plk1 could also induce aneuploidy and tumor formation in vivo. Therefore, a normal level of Plk1 is important for mitosis. And caution should be taken when Plk1 inhibitors are used in the clinical trial and their side effects including tumorigenesis should be carefully evaluated

Effect of Ag nanopowders on microstructure, hardness and elastic modulus of Sn-Bi solders

This paper presents the microstructure, hardness and elastic modulus of Sn58Bi, Sn57Bi1Ag and Ag nanopowders reinforced Sn58Bi composite solders. Microstructural observations reveal that the Ag nanopowders reinforced Sn58Bi composite solders have smaller grains of Ag3Sn and a more uniform Ag3Sn distribution in comparison with those of Sn57Bi1Ag solder. Nanoindentation test results show that the addition of Ag nanopowders has greatly enhanced the mechanical properties of Sn58Bi solder, i.e., it exhibits 13-30% increase in hardness and 10-22% increase in modulus of the composite solder. Besides, hardness and elastic modulus of solder are dependent on the size, distribution and the quantity of the second-phase

KinD-LCE Curve Estimation And Retinex Fusion On Low-Light Image

Low-light images often suffer from noise and color distortion. Object detection, semantic segmentation, instance segmentation, and other tasks are challenging when working with low-light images because of image noise and chromatic aberration. We also found that the conventional Retinex theory loses information in adjusting the image for low-light tasks. In response to the aforementioned problem, this paper proposes an algorithm for low illumination enhancement. The proposed method, KinD-LCE, uses a light curve estimation module to enhance the illumination map in the Retinex decomposed image, improving the overall image brightness. An illumination map and reflection map fusion module were also proposed to restore the image details and reduce detail loss. Additionally, a TV(total variation) loss function was applied to eliminate noise. Our method was trained on the GladNet dataset, known for its diverse collection of low-light images, tested against the Low-Light dataset, and evaluated using the ExDark dataset for downstream tasks, demonstrating competitive performance with a PSNR of 19.7216 and SSIM of 0.8213.Comment: Accepted by Signal, Image and Video Processin

Automatic Calibration of Process Noise Matrix and Measurement Noise Covariance for Multi-GNSS Precise Point Positioning

The Expectation-Maximization algorithm is adapted to the extended Kalman filter to multiple GNSS Precise Point Positioning (PPP), named EM-PPP. EM-PPP considers better the compatibility of multiple GNSS data processing and characteristics of receiver motion, targeting to calibrate the process noise matrix Qt and observation matrix Rt, having influence on PPP convergence time and precision, with other parameters. It is possibly a feasible way to estimate a large number of parameters to a certain extent for its simplicity and easy implementation. We also compare EM-algorithm with other methods like least-squares (co)variance component estimation (LS-VCE), maximum likelihood estimation (MLE), showing that EM-algorithm from restricted maximum likelihood (REML) will be identical to LS-VCE if certain weight matrix is chosen for LS-VCE. To assess the performance of the approach, daily observations from a network of 14 globally distributed International GNSS Service (IGS) multi-GNSS stations were processed using ionosphere-free combinations. The stations were assumed to be in kinematic motion with initial random walk noise of 1 mm every 30 s. The initial standard deviations for ionosphere-free code and carrier phase measurements are set to 3 m and 0.03 m, respectively, independent of the satellite elevation angle. It is shown that the calibrated Rt agrees well with observation residuals, reflecting effects of the accuracy of different satellite precise product and receiver-satellite geometry variations, and effectively resisting outliers. The calibrated Qt converges to its true value after about 50 iterations in our case. A kinematic test was also performed to derive 1 Hz GPS displacements, showing the RMSs and STDs w.r.t. real-time kinematic (RTK) are improved and the proper Qt is found out at the same time. According to our analysis despite the criticism that EM-PPP is very time-consuming because a large number of parameters are calculated and the first-order convergence of EM-algorithm, it is a numerically stable and simple approach to consider the temporal nature of state-space model of PPP, in particular when Qt and Rt are not known well, its performance without fixing ambiguities can even parallel to traditional PPP-RTK

Undrained shear strength of soft clay reinforce with single 16mm diameter encapsulated bottom ash column

Soft clay soil can be categorized as problematic soil. It consists of low shear strength, low permeability and high compressibility characteristics affect the stability and settlement of the structures constructed on this type of soil. A careful design analysis could be taken for any structure built on it. However, those characteristics could be improved through many methods and the easiest method that is being used in the construction field was stone column. On the other hand, coal is one of the world’s most important sources of energy. Disposal of bottom ash become environmental issues if it is not effectively reused or recycled for other application. This study is to present suitability in term of shear strength by using bottom ash to replace sand or granular material in column for ground improvement technique using laboratory scale model. Since sand is one of non-renewable material so by using by-product or waste material such bottom ash we can reduce the cost of construction as well as keep the non-renewable natural material in balance. Several experimental procedures are carried out to know the physical and mechanical properties of bottom ash and kaolin clay sample. Kaolin is being used as soil sample and bottom ash as the reinforced columns. The shear strength of the encapsulated bottom ash column measured by Unconfined Compression Test. A total 4 batches of kaolin sample had been tested and each batch consist of 5 specimens represent sample without bottom ash, partially penetration and fully penetration for singular bottom ash column. The specimen used were 50mm in diameter and 100mm in height. The diameter of bottom ash is 16mm and the height of the column are 60mm, 80mm and 100mm. The encapsulated bottom ash was installed at the centre of the specimen. The encapsulated bottom ash column with 10.24% area replacement ratio are 58.21%, 58.66% and 42.58% at sample penetration ratio, Hc/Hs of 0.6, 0.8 and 1.0 respectively. It can be concluded that the shear strength of soft clay could be improved by installation of encapsulated bottom ash column. However the value of shear strength of soft clay inserted with partially penetration column increased more significant compared to the fully penetration column

Targeted PI3K/AKT/mTOR therapy for metastatic carcinomas of the cervix: A phase I clinical experience.

BackgroundActivated PI3K/AKT/mTOR pathway frequently occurs in metastatic or recurrent cervical carcinomas. However, the clinical benefits of matched therapy, a therapeutic approach targeting a specific mutational abnormality, have not yet been established.MethodsWe analyzed the outcomes of patients with metastatic or recurrent cervical carcinomas who had a test for PIK3CA mutation and/or PTEN loss/mutation, and received ≥1 phase I therapeutic regimen between January 2006 and June 2013.ResultsPatients with adenocarcinoma had fewer PIK3CA mutations (14%), and survived longer (median, 14.2 months) than those with squamous cell carcinoma (48% and 7.2 months; p = 0.016, and 0.001, respectively). Matched therapy targeting the activated PI3K/AKT/mTOR pathway led to a favorable rate of SD ≥ 6 months/CR/PR (53%) and significantly longer progression-free survival (median, 6.0 months) than non-matched therapy (11% and 1.5 months; p = 0.08 and 0.026; respectively). In patients with squamous cell carcinoma of the cervix, the presence of PIK3CA mutations was associated with a significantly longer overall survival (median, 9.4 months) than the absence of PIK3CA mutations (median, 4.2 months; p = 0.019).ConclusionsMatched therapy targeting the activated PI3K/AKT/mTOR pathway provided meaningful clinical benefits. Thus, further evaluation of PI3K/AKT/mTOR pathway targeted therapy is warranted, especially in metastatic or recurrent squamous cell carcinoma

The role of imaging in 2019 novel coronavirus pneumonia (COVID-19).

Almost the entire world, not only China, is currently experiencing the outbreak of a novel coronavirus that causes respiratory disease, severe pneumonia, and even death. The outbreak began in Wuhan, China, in December of 2019 and is currently still ongoing. This novel coronavirus is highly contagious and has resulted in a continuously increasing number of infections and deaths that have already surpassed the SARS-CoV outbreak that occurred in China between 2002 and 2003. It is now officially a pandemic, announced by WHO on the 11th of March. Currently, the 2019 novel coronavirus (SARS-CoV-2) can be identified by virus isolation or viral nucleic acid detection; however, false negatives associated with the nucleic acid detection provide a clinical challenge and thus make the imaging examination crucial. Imaging exams have been a main clinical diagnostic criteria for the 2019 novel coronavirus disease (COVID-19) in China. Imaging features of multiple patchy areas of ground glass opacity and consolidation predominately in the periphery of the lungs are characteristic manifestations on chest CT and extremely helpful in the early detection and diagnosis of this disease, which aids prompt diagnosis and the eventual control of this emerging global health emergency. Key Points • In December 2019, China, an outbreak of pneumonia caused by a novel, highly contagious coronavirus raised grave concerns and posed a huge threat to global public health. • Among the infected patients, characteristic findings on CT imaging include multiple, patchy, ground-glass opacity, crazy-paving pattern, and consolidation shadows, mainly distributed in the peripheral and subpleural areas of both lungs, which are very helpful for the frontline clinicians. • Imaging examination has become the indispensable means not only in the early detection and diagnosis but also in monitoring the clinical course, evaluating the disease severity, and may be presented as an important warning signal preceding the negative RT-PCR test results

Moderate Geomagnetic Storm Condition, WAAS Alerts and real GPS Positioning Quality

The most significant part of the Wade Area Augmentation System (WAAS) integrity data consists of the User Differential Range Error (UDRE) and the Grid Ionospheric Vertical Error (GIVE). WAAS solutions are not completely appropriate to determine the GIVE term within the entire wade area coverage zone taking in account real irregular structure of the ionosphere. It leads to the larger confidence bounding terms and lower expected positioning availability in comparison to the reality under geomagnetic storm conditions and system outages. Thus a question arises: is the basic WAAS concept appropriate to provide the same efficiency of the integrity monitoring for both “global differential correction (i.e. clock, ephemeris etc)” and “local differential correction (i.e. ionoshrere, troposhpere and multipath)”? The aim of this paper is to compare official WAAS integrity monitoring reports and real positioning quality in US coverage zone (CONUS) and Canada area under geomagnetic storm conditions and system outages. In this research we are interested in comparison between real GPS positioning quality based on one-frequency C/A ranging mode and HAL (VAL) values which correspond to the LP, LPV and LPV200 requirements. Significant mismatch of the information between WAAS integrity data and real positioning quality was unfolded as a result of this comparison under geomagnetic storms and system outages on February, 2011 and June 22, 2015. Based on this result we think that in order to achieve high confidence of WAAS positioning availability alerts real ionospheric measurements within the wide area coverage zone must be involved instead of the WAAS GIVE values. The better way to realize this idea is to combine WAAS solutions to derive “global differential corrections” and LAAS solutions to derive “local differential corrections”