A novel equivalent definition of modified Bessel functions for performance analysis of multi-hop wireless communication systems

A statistical model is derived for the equivalent signal-to-noise ratio of the Source-to-Relay-to-Destination (S-R-D) link for Amplify-and-Forward (AF) relaying systems that are subject to block Rayleigh-fading. The probability density function and the cumulated density function of the S-R-D link SNR involve modified Bessel functions of the second kind. Using fractional-calculus mathematics, a novel approach is introduced to rewrite those Bessel functions (and the statistical model of the S-R-D link SNR) in series form using simple elementary functions. Moreover, a statistical characterization of the total receive-SNR at the destination, corresponding to the S-R-D and the S-D link SNR, is provided for a more general relaying scenario in which the destination receives signals from both the relay and the source and processes them using maximum ratio combining (MRC). Using the novel statistical model for the total receive SNR at the destination, accurate and simple analytical expressions for the outage probability, the bit error probability, and the ergodic capacity are obtained. The analytical results presented in this paper provide a theoretical framework to analyze the performance of the AF cooperative systems with an MRC receiver

Proteasome inhibition alleviates prolonged moderate compression-induced muscle pathology

Background: The molecular mechanism initiating deep pressure ulcer remains to be elucidated. The present study tested the hypothesis that the ubiquitin proteasome system is involved in the signalling mechanism in pressure-induced deep tissue injury. Methods. Adult Sprague Dawley rats were subjected to an experimental compression model to induce deep tissue injury. The tibialis region of the right hind limb was subjected to 100 mmHg of static pressure for six hours on each of two consecutive days. The compression pressure was continuously monitored by a three-axial force transducer within the compression indentor. The left hind limb served as the intra-animal control. Muscle tissues underneath the compressed region were collected and used for analyses. Results: Our results demonstrated that the activity of 20S proteasome and the protein abundance of ubiquitin and MAFbx/atrogin-1 were elevated in conjunction with pathohistological changes in the compressed muscle, as compared to control muscle. The administration of the proteasome inhibitor MG132 was found to be effective in ameliorating the development of pathological histology in compressed muscle. Furthermore, 20S proteasome activity and protein content of ubiquitin and MAFbx/atrogin-1 showed no apparent increase in the MG132-treated muscle following compression. Conclusion: Our data suggest that the ubiquitin proteasome system may play a role in the pathogenesis of pressure-induced deep tissue injury. © 2011 Siu et al; licensee BioMed Central Ltd.Link_to_subscribed_fulltex

A ribose-functionalized NAD+ with unexpected high activity and selectivity for protein poly-ADP-ribosylation.

Nicotinamide adenine dinucleotide (NAD+)-dependent ADP-ribosylation plays important roles in physiology and pathophysiology. It has been challenging to study this key type of enzymatic post-translational modification in particular for protein poly-ADP-ribosylation (PARylation). Here we explore chemical and chemoenzymatic synthesis of NAD+ analogues with ribose functionalized by terminal alkyne and azido groups. Our results demonstrate that azido substitution at 3'-OH of nicotinamide riboside enables enzymatic synthesis of an NAD+ analogue with high efficiency and yields. Notably, the generated 3'-azido NAD+ exhibits unexpected high activity and specificity for protein PARylation catalyzed by human poly-ADP-ribose polymerase 1 (PARP1) and PARP2. And its derived poly-ADP-ribose polymers show increased resistance to human poly(ADP-ribose) glycohydrolase-mediated degradation. These unique properties lead to enhanced labeling of protein PARylation by 3'-azido NAD+ in the cellular contexts and facilitate direct visualization and labeling of mitochondrial protein PARylation. The 3'-azido NAD+ provides an important tool for studying cellular PARylation

Low molecular weight heparin downregulates tissue factor expression and activity by modulating growth factor receptor-mediated induction of nuclear factor-κB

Treatment of cancer patients with low molecular weight heparin (LMWH) appears to have beneficial effects. In this study, the influence of low molecular weight heparin (LMWH) on tissue factor (TF) expression and activity in five cell lines from various tissues was analysed and explored. Incubation of cells with LMWH (0-2000μg/ml) resulted in the downregulation of TF mRNA expression which was both LMWH concentration-dependent and time-dependent. Downregulation of TF was also measured as decreased cellular TF antigen and activity. Consistently, incubation of cells with LMWH suppressed the nuclear localisation and the transcriptional activity of NFκB. Decreased TF mRNA was largely achievable by incubating the cells with an NFκB inhibitor alone whilst incubation with betulinic acid to activate NFκB reversed the inhibitory influence of LMWH. Cells were also incubated with a range of concentrations of EGF (0-10ng/ml), bFGF (0-20ng/ml) or VEGF (0-4ng/ml) in the presence or absence of LMWH (200μg/ml) for 24h and TF antigen measured. Inclusion of LMWH reduced TF expression in response to EGF, bFGF or VEGF but TF expression was partially restored by increasing concentrations of the growth factors. We conclude that LMWH downregulates TF expression in vitro through a mechanism that involves interference with the function of growth factors which in turn is mediated through the downregulation of the transcriptional activity of NFκB. This mechanism may also explain some of the beneficial influences attributed to LMWH therapy in the treatment of cancer patients

Self-healing WS2 tribofilms: An in-situ appraisal of mechanisms

Self-healing tribocoatings are being developed for aerospace applications to improve the lifetime and reduce the surface maintenance of components in motion. Here the tribo-induced self-healing behaviour of a WS2/a-C tribocoating has been evaluated for the first time by in-situ scanning electron microscopy (SEM) to evaluate the mechanisms of damage and self-recovery. In-situ SEM imaging reveals that scratch damage results in coating brittle fracture and spalling, and that Hertzian pressure affects healing rate at early stages of sliding. WS2 nanocrystallites, formed via atomic rearrangement at flexural interfaces, enable the healing of irregular damages and congruently offer superlubrication in vacuum. Such damage control in tribo-service may make flawless coatings an unnecessary prerequisite in tribo-applications

Temperature-Adaptive Ultralubricity of a WS₂/a-C Nanocomposite Coating:Performance from Room Temperature up to 500 °c

[Image: see text] This study reports on the ultralubricity of a high-temperature resilient nanocomposite WS(2)/a-C tribocoating. The coefficient of friction of this coating remains at around 0.02 independently of a thermal treatment up to ∼500 °C, as confirmed by high-temperature tribotests. Moreover, the coating annealed at 450 °C keeps exhibiting a similar ultralubricity when cooled back down to room temperature and tested there, implying a tribological self-adaptation over a broad temperature range. High-resolution TEM observations of the tribofilms on the wear track unveil that WS(2) nanoplatelets form dynamically via atomic rearrangement and extend via unfaulting geometrical defects (bound by partial climb dislocations). The (002) basal planes of the WS(2) nanoplatelets, reoriented parallel to the tribo-sliding direction, contribute to a sustainable ultralubricity. The declining triboperformance beyond 500 °C is associated with sulfur loss rather than the transformation of WS(2) into inferior WO(3) via oxidation as suggested earlier. This self-adaptive WS(2)/a-C tribocoating holds promise for a constant ultralubrication with excellent thermal performance

Investigating the impact of additive manufacturing data exchange standards for re-distributed manufacturing

This is a post-peer-review, pre-copy edit version of an article published in Progress in Additive Manufacturing. The final authenticated version is available online at: https://link.springer.com/article/10.1007%2Fs40964-019-00085-7The paradigm shift towards a decentralised approach of cloud manufacturing requires tighter standardisation and efficient interfaces between additive manufacturing (AM) data and production. In parallel with technology advancements, it is important to consider the digital chain of information. Although a plethora of AM formats exist, only some are commonly used for data transfer. None of these AM data transfer standards specifically addresses the needs of the re-distributed manufacturing (RDM) landscape. The purpose of this study is to identify the required features for AM data transfer standards to support a RDM landscape. The study examined the data flow from CAD to AM and reviewed established shortcomings of existing data exchange standards such as STL. After identifying the data exchange standards for AMF, 3MF, STEP and STEP-NC as promising replacements for STL, their premises, objectives, contributions and advantages were reviewed. The role of AM to support RDM by overcoming tooling costs and the associated need for economies of scale was also reviewed. Focus group interviews and surveys were conducted with AM and RDM experts from industry and academia and the participants’ accounts were analysed for common themes and narratives. Finally, the suitability of existing data transfer formats was examined by compiling existing and expected standard features and having them rated by AM experts. The study showed that STEP-NC and AMF standards are ahead in implementing the most highly valued data transfer features. Open standards are also expected to further facilitate innovation in AM. The survey also identified that the top five features deemed most important by the participants for data exchange formats for RDM were regular internal structures/lattices, manufacturing tolerances, geometric representation, curvature representation, and surface structures. This study has contributed towards evaluating existing standards and their future development and adoption. It is hoped that the results will benefit policy makers and industry leaders to be aware of the importance of data exchange standards for AM so as to pave a clear roadmap for the Digital Economy in a RDM landscape

Seed Dormancy, Seedling Establishment and Dynamics of the Soil Seed Bank of \u3cem\u3eStipa Bungeana\u3c/em\u3e (Poaceae) on the Loess Plateau of Northwestern China

Studying seed dormancy and its consequent effect can provide important information for vegetation restoration and management. The present study investigated seed dormancy, seedling emergence and seed survival in the soil seed bank of Stipa bungeana, a grass species used in restoration of degraded land on the Loess Plateau in northwest China. Dormancy of fresh seeds was determined by incubation of seeds over a range of temperatures in both light and dark. Seed germination was evaluated after mechanical removal of palea and lemma (hulls), chemical scarification and dry storage. Fresh and one-year-stored seeds were sown in the field, and seedling emergence was monitored weekly for 8 weeks. Furthermore, seeds were buried at different soil depths, and then retrieved every 1 or 2 months to determine seed dormancy and seed viability in the laboratory. Fresh seeds (caryopses enclosed by palea and lemma) had non-deep physiological dormancy. Removal of palea and lemma, chemical scarification, dry storage (afterripening), gibberellin (GA3) and potassium nitrate (KNO3) significantly improved germination. Dormancy was completely released by removal of the hulls, but seeds on which hulls were put back to their original position germinated to only 46%. Pretreatment of seeds with a 30% NaOH solution for 60 min increased germination from 25% to 82%. Speed of seedling emergence from fresh seeds was significantly lower than that of seeds stored for 1 year. However, final percentage of seedling emergence did not differ significantly for seeds sown at depths of 0 and 1 cm. Most fresh seeds of S. bungeana buried in the field in early July either had germinated or lost viability by September. All seeds buried at a depth of 5 cm had lost viability after 5 months, whereas 12% and 4% seeds of those sown on the soil surface were viable after 5 and 12 months, respectively