Association of age-related hearing loss with cognitive impairment and dementia: an umbrella review

BackgroundHearing loss, cognitive impairment and dementia have become common problems for older adults. Currently, systematic reviews and meta-analyses of the association between age-related hearing loss (ARHL) with cognitive impairment and dementia may have inconsistent results. To explore and validate the association between ARHL with cognitive impairment and dementia through summarizing and evaluating existing evidence.MethodsFrom inception to February 01, 2023, PubMed, Web of Science, Embase, and Cochrane Library databases were systematically searched. AMSTAR 2 was used to evaluate methodological quality and GRADE system was used to evaluate evidence quality. We summarized the basic characteristics of the included studies and extracted effect data for ARHL with cognitive impairment and dementia. Forest plots were used to describe the relative risk associated with ARHL and cognitive impairment, and the relative risk associated with ARHL and dementia, respectively.ResultsA total of 11 systematic reviews and meta-analyses met the inclusion criteria. Overall, the methodological quality of the included SRs/MAs was moderate and the quality of the evidence was low. The combined results found that the pooled risk ratio of ARHL and cognitive impairment was 1.30 (random-effects; 95% CI 1.16 to 1.45), and the pooled risk ratio of ARHL and dementia was 1.59 (random-effects; 95% CI 1.34 to 1.90).ConclusionBased on the evidence reported in this umbrella review, age-related hearing loss is significantly associated with cognitive impairment and dementia. Hearing loss may be a high risk factor for cognitive impairment and dementia in older adults

What Forms, Maintains, and Changes the Boldness of Swimming Crabs (Portunus trituberculatus)?

Boldness of personality is an important theme in animal behavior and has significant ecological and evolutionary consequences. Studies on boldness in crustaceans typically focus on their behavior, while relatively few studies have focused on the formation and maintenance of and change in boldness, such as energy metabolism and neurotransmission. In this study, we measured the boldness of swimming crabs (Portunus trituberculatus) and analyzed the relationship between boldness and oxygen consumption rate, energy concentration, and the relative expression of energy-metabolism-related and 5-HT genes in mRNA. The results showed that boldness remained stable across repeated tests but changed under dangerous conditions. Swimming crabs could be divided into bold and shy individuals. Bold individuals consumed oxygen at a significantly higher rate than shy individuals. Lactate and glucose concentrations in hemolymph were significantly lower in bold individuals than in shy individuals, and mRNA relative expression of Na+/K+-ATPase and 5-HT genes was significantly higher in bold than in shy individuals. Preliminary results indicate that energy metabolism and neurotransmitters may underlie the formation and maintenance of personality characteristics of swimming crabs. Swimming crabs also exhibit behavioral flexibility in order to cope with risks. This may be an adaptation to their complex environments

Differences in Agonistic Behavior and Energy Metabolism between Male and Female Swimming Crab <i>Portunus trituberculatus</i> Based on the Analysis of Boldness

Individual differences in metabolism and agonistic behavior have been a key research area in evolution and ecology recently. In this study, we investigated the boldness of swimming crabs Portunus trituberculatus and explored the agonistic behavior between female and male crabs, specifically examining competitions between bold females vs. bold males (BF–BM), bold females vs. shy males (BF–SM), shy females vs. shy males (SF–SM), and shy females vs. bold males (SF_BM) and its relationship with energy metabolism. The main results revealed the following: There was no significant difference in boldness between females and males, while there were more bold individuals than shy in both females and males. Bold individuals initiated significantly more fights than shy individuals, and male initiators won significantly more fights than female initiators. The duration and intensity of fight between bold individuals was significantly higher than fights between shy individuals. For males, the concentration of glucose in the hemolymph was significantly higher in shy crabs than bold crabs, while there was no significant difference between shy and bold individuals in females. After fighting, the concentration of glycogen in claws was lower than that before fighting, and the concentrations of glucose and lactate in hemolymph were significantly higher after fighting than before. We found that the fighting willingness and ability were higher in male crabs than females and higher in bold crabs than shy. Fighting ability varied between sexes and was influenced by boldness and energy state

Fast Target Localization in FMCW-MIMO Radar with Low SNR and Snapshot via Multi-DeepNet

Frequency modulated continuous wave (FMCW) multiple-input multiple-output (MIMO) radars are widely applied in target localization. However, during the process, the estimation accuracy decreases sharply without considerable signal-to-noise ratio (SNR) and sufficient snapshot number. It is therefore necessary to consider estimation schemes that are valid under low signal-to-noise ratio (SNR) and snapshot. In this paper, a fast target localization framework based on multiple deep neural networks named Multi-DeepNet is proposed. In the scheme, multiple interoperating deep networks are employed to achieve accurate target localization in harsh environments. Firstly, we designed a coarse estimate using deep learning to determine the interval where the angle is located. Then, multiple neural networks are designed to realize accurate estimation. After that, the range estimation is determined. Finally, angles and ranges are matched by comparing the Frobenius norm. Simulations and experiments are conducted to verify the efficiency and accuracy of the proposed framework

An FMCW MIMO Radar-Vision Fusion Algorithm for Target Classification and Localization

In order to solve the problems of slow real-time and poor detection of small targets that still exist in multi-sensor information fusion technology, a frequency-modulated continuous wave (FMCW) multiple-input multiple-output (MIMO) radar-vision fusion algorithm for target classification and localization is proposed in this paper. Firstly, the signal model of FMCW MIMO radar is established. Then, the target localization is performed using a forward-backward spatial smoothing (SS) based linear prediction-orthogonal propagator method (LP-OPM) to obtain information about the radar target. Next, the YOLOv7 and the visual ranging algorithms are used to identify and localize the target to get information about the camera target. In addition, a Kalman-weighted fusion algorithm is used to fuse the data from the two sensor targets for output. Finally, the performance of the method is proved to be superior by the experimental results

Evaluation of the Toxicity and Sublethal Effects of Acetamiprid and Dinotefuran on the Predator Chrysopa pallens (Rambur) (Neuroptera: Chrysopidae)

Neonicotinoid insecticides affect the physiology or behavior of insects, posing risks to non-target organisms. In this study, the effects of sublethal doses of two neonicotinoid insecticides, acetamiprid and dinotefuran, against Chrysopa pallens (Rambur) (Neuroptera: Chrysopidae) were determined and compared. The results showed that acetamiprid and dinotefuran at LD10 (8.18 ng a.i. per insect and 9.36 ng a.i. per insect, respectively) and LD30 (16.84 ng a.i. per insect and 15.01 ng a.i. per insect, respectively) significantly prolonged the larval stages and pupal stages (except acetamiprid LD10), compared to control. In addition, acetamiprid and dinotefuran at LD30 significantly prolonged the adult preoviposition period (APOP) and total preoviposition period (TPOP). In contrast, the two insecticides at LD10 and LD30 had no significant effect on the longevity, fecundity, reproductive days, preadult survival rate (%), intrinsic rate of increase (r), net reproductive rate (R0), and finite rate of increase (&lambda;). These results provide a theoretical basis for the rational use of these two insecticides and the utilization and protection of C. pallens