Strongly Regular Graphs Constructed from pp-ary Bent Functions

In this paper, we generalize the construction of strongly regular graphs in [Y. Tan et al., Strongly regular graphs associated with ternary bent functions, J. Combin.Theory Ser. A (2010), 117, 668-682] from ternary bent functions to $p$-ary bent functions, where $p$ is an odd prime. We obtain strongly regular graphs with three types of parameters. Using certain non-quadratic $p$-ary bent functions, our constructions can give rise to new strongly regular graphs for small parameters.Comment: to appear in Journal of Algebraic Combinatoric

A Retrospective Analysis to Validate the Alarm Signs Used in the CEDAP-Plus Study

Background and Study Aim. This study aimed to validate the alarm signs used in the 2007 German CEDAP-Plus study for indicating capsule endoscopy in patients who have idiopathic chronic abdominal pain. Patients and Methods. We retrospectively reviewed the cases of all patients who underwent capsule endoscopy at our institution between August 2007 and August 2009 for chronic hitherto undiagnosed abdominal pain, despite previous investigations. The demographic data, indications, findings, and diagnoses were recorded, as were the alarm signs (i.e., 10% loss of weight within 3 months, suspected small intestinal bleed or chronic anemia, and laboratory indications of inflammation). Results. Alarm signs were found in only 4 of the 62 included patients. Capsule endoscopy revealed findings that led to diagnoses of Crohn's disease (n = 4), tuberculosis (n = 1), gastrointestinal stromal tumors (n = 3), and hookworm (n = 1); these diagnoses included 100% (4/4) of the patients with alarm signs, but only 8.6% (5/58) of patients without them. However, 55.6% (5/9) of patients with clinically capsule endoscopy findings reported no alarm signs. Conclusions. Although selecting patients based on the alarm signs may increase the yield of capsule endoscopy, the alarm sign criteria appear to have low sensitivity

Optimization study on longitudinal joints in quasi-rectangular shield tunnels

Featured Application: (1) The damage process of the newly adopted type of longitudinal joint with ductile iron joint panels (DIJPs) in quasi-rectangular tunnels was obtained. (2) The effect of bolt position improvements was investigated through joint tests. (3) Within the service conditions, the joint behavior could be divided into three stages under both positive and negative moments. (4) Effects of the modifications related to concrete and bolt properties were explored. (5) Through comparison, increasing the lever arm between bolts and the compression zone to resist exerted moments is believed to be the most effective optimization method. There are large bending moments in quasi-rectangular shield tunnels due to their deviation from the circular shape, and as for other types of shield tunnels, the longitudinal joints are the most critical parts in the lining structure. A new type of joint with ductile iron joint panels (DIJPs) was installed in quasi-rectangular tunnels to solve these problems. The distance from the bolts to the segment's inner surface was improved for better performance under specific bending moment types. Both tests and finite element modeling (FEM) simulations were conducted to investigate the effect of the bolt position improvements. The resistances to crack appearance increased by 33.6% and 18.0% for positive and negative moment cases, respectively. The resistances to crack penetration increased by 13.8% and 18.4% for positive and negative cases. From the FEM approach, it was found that the behavior of the joint under the design bending moment range can be divided into three stages, whereby the bolts are only active from the second stage on. The effects of other optimizing methods, such as enhancement of concrete properties and increase of bolt diameters and numbers, are explored. Through comparison, it is believed that optimizing the joint section to increase the lever arm between bolts and the compression zone can improve the joint behavior most effectively. This optimization direction is recommended when designing a shield tunnel joint with DIJPs

Current Reversals in a inhomogeneous system with asymmetric unbiased fluctuations

We present a study of transport of a Brownian particle moving in periodic symmetric potential in the presence of asymmetric unbiased fluctuations. The particle is considered to move in a medium with periodic space dependent friction. By tuning the parameters of the system, the direction of current exhibit reversals, both as a function of temperature as well as the amplitude of rocking force. We found that the mutual interplay between the opposite driving factors is the necessary term for current reversals.Comment: 9 pages, 7 figure

Reinforcement Knowledge Graph Reasoning for Explainable Recommendation

Recent advances in personalized recommendation have sparked great interest in the exploitation of rich structured information provided by knowledge graphs. Unlike most existing approaches that only focus on leveraging knowledge graphs for more accurate recommendation, we perform explicit reasoning with knowledge for decision making so that the recommendations are generated and supported by an interpretable causal inference procedure. To this end, we propose a method called Policy-Guided Path Reasoning (PGPR), which couples recommendation and interpretability by providing actual paths in a knowledge graph. Our contributions include four aspects. We first highlight the significance of incorporating knowledge graphs into recommendation to formally define and interpret the reasoning process. Second, we propose a reinforcement learning (RL) approach featuring an innovative soft reward strategy, user-conditional action pruning and a multi-hop scoring function. Third, we design a policy-guided graph search algorithm to efficiently and effectively sample reasoning paths for recommendation. Finally, we extensively evaluate our method on several large-scale real-world benchmark datasets, obtaining favorable results compared with state-of-the-art methods.Comment: Accepted in SIGIR 201

Biomechanical analysis of the acetabular buttress-plate: are complex acetabular fractures in the quadrilateral area stable after treatment with anterior construct plate-1/3 tube buttress plate fixation?

OBJECTIVE: The acetabular buttress-plate has been widely used in treating difficult cases with satisfying clinical results. However, the biomechanical properties of a postoperative acetabular fracture fixed by the buttress-plate are not clear. The purpose of this study was to evaluate the biomechanical properties of stability after the anterior tube buttress-plate fixation of complex acetabular fractures in the quadrilateral area. METHODS: A construct was proposed based on anterior construct plate - 1/3 tube buttress plate fixation for acetabular both-column fractures. Two groups of six formalin-preserved cadaveric pelvises were analyzed: (1) group A, the normal pelvis and (2) group B, anterior construct plate-1/3 tube buttress plate with quadrilateral area fixation. The displacements were measured, and cyclical loads were applied in both standing and sitting simulations. RESULTS: As the load was added, the displacements were

Multifunctional targeting micelle nanocarriers with both imaging and therapeutic potential for bladder cancer.

BackgroundWe previously developed a bladder cancer-specific ligand (PLZ4) that can specifically bind to both human and dog bladder cancer cells in vitro and in vivo. We have also developed a micelle nanocarrier drug-delivery system. Here, we assessed whether the targeting micelles decorated with PLZ4 on the surface could specifically target dog bladder cancer cells.Materials and methodsMicelle-building monomers (ie, telodendrimers) were synthesized through conjugation of polyethylene glycol with a cholic acid cluster at one end and PLZ4 at the other, which then self-assembled in an aqueous solution to form micelles. Dog bladder cancer cell lines were used for in vitro and in vivo drug delivery studies.ResultsCompared to nontargeting micelles, targeting PLZ4 micelles (23.2 ± 8.1 nm in diameter) loaded with the imaging agent DiD and the chemotherapeutic drug paclitaxel or daunorubicin were more efficient in targeted drug delivery and more effective in cell killing in vitro. PLZ4 facilitated the uptake of micelles together with the cargo load into the target cells. We also developed an orthotopic invasive dog bladder cancer xenograft model in mice. In vivo studies with this model showed the targeting micelles were more efficient in targeted drug delivery than the free dye (14.3×; P < 0.01) and nontargeting micelles (1.5×; P < 0.05).ConclusionTargeting micelles decorated with PLZ4 can selectively target dog bladder cancer cells and potentially be developed as imaging and therapeutic agents in a clinical setting. Preclinical studies of targeting micelles can be performed in dogs with spontaneous bladder cancer before proceeding with studies using human patients

LHAASO J2226+6057 as a pulsar wind nebula

The Large High Altitude Air Shower Observatory has reported the detection of cosmic-ray sources in Milky Way that can accelerate particles up to PeV (= 10$^{15}$ eV) energies. These sources, so called ``PeVatrons'', are mostly unidentified. Several classes of sources, such as supernova remnants, pulsar wind nebula, or young stellar clusters can potentially be the counterparts of these PeVatrons. The aim of this work is to study a pulsar wind nebula interpretation of one of these PeVatrons, LHAASO J2226+6057, which has a relatively well covered multi-frequency spectrum. We have performed a leptonic, time-dependent modeling of the pulsar wind nebula (PWN) associated with PSR J2229+6114 considering a time-energy-dependent diffusion-loss equation. Injection, energy losses, as well as escape of particles were considered to balance the time-dependent lepton population. We have also included the dynamics of the PWN and the associated supernova remnant (SNR) and their interaction via the reverse shock to study the reverberation phase of the system. We have considered different values of braking index ($n$) and true age ($t_{age}$) for the fitting of the multi-wavelength (MWL) spectral energy distribution (SED) of LHAASO J2226+6057. The best-fit PWN model parameters and their 1$\sigma$ confidence intervals were evaluated. We have also demonstrated the impact of reverberation on the MWL SED with increasing time. Additionally, we have discussed the resultant large radius and low magnetic field associated with the PWN in question, as caveats for the possible physical connection of the pulsar as the origin of this high energy source.Comment: 10 pages, 5 figures, 1 table; accepted for publication in Astronomy & Astrophysics (A&A