Analysis, Visualization, and Transformation of Audio Signals Using Dictionary-based Methods

date-added: 2014-01-07 09:15:58 +0000 date-modified: 2014-01-07 09:15:58 +0000date-added: 2014-01-07 09:15:58 +0000 date-modified: 2014-01-07 09:15:58 +000

Interference effects in two-photon ATI by multiple orders high harmonics with random or locked phases

We numerically study 2-photon processes using a set of harmonics from a Ti:Sapphire laser and in particular interference effects in the Above Threshold Ionization spectra. We compare the situation where the harmonic phases are assumed locked to the case where they have a random distribution. Suggestions for possible experiments, using realistic parameters are discussed.Comment: 11 pages, 13 figures, LaTe

Cumulative hydropathic topology of a voltage-gated sodium channel at atomic resolution

Voltage-gated sodium channels (NavChs) are biological pores that control the ow of sodium ions through the cell membrane. In humans, mutations in genes encoding NavChs can disrupt physiological cellular activity thus leading to a wide spectrum of diseases. Here, we present a topological connection between the functional architecture of a NavAb bacterial channel and accumulation of atomic hydropathicity around its pore. This connection is established via a scaling analysis methodology that elucidates how intrachannel hydropathic density variations translate into hydropathic dipole field configurations along the pore. Our findings suggest the existence of a non random cumulative hydropathic topology that is organized parallel to the membrane surface so that pore's stability, as well as, gating behavior are guaranteed. Given the biophysical significance of the hydropathic effect, our study seeks to provide a computational framework for studying cumulative hydropathic topological properties of NavChs and pore-forming proteins in general. This article is protected by copyright. All rights reserved

Testing a Spectral Model of Tonal Affinity with Microtonal Melodies and Inharmonic Spectra

Tonal affinity is the perceived goodness of fit of successive tones. It is important because a preference for certain intervals over others would likely influence preferences for, and prevalences of, “higher-order” musical structures such as scales and chord progressions. We hypothesize that two psychoacoustic (spectral) factors—harmonicity and spectral pitch similarity—have an impact on affinity. The harmonicity of a single tone is the extent to which its partials (frequency components) correspond to those of a harmonic complex tone (whose partials are a multiple of a single fundamental frequency). The spectral pitch similarity of two tones is the extent to which they have partials with corresponding, or close, frequencies. To ascertain the unique effect sizes of harmonicity and spectral pitch similarity, we constructed a computational model to numerically quantify them. The model was tested against data obtained from 44 participants who ranked the overall affinity of tones in melodies played in a variety of tunings (some microtonal) with a variety of spectra (some inharmonic). The data indicate the two factors have similar, but independent, effect sizes: in combination, they explain a sizeable portion of the variance in the data (the model-data squared correlation is r2 = .64). Neither harmonicity nor spectral pitch similarity require prior knowledge of musical structure, so they provide a potentially universal bottom-up explanation for tonal affinity. We show how the model—as optimized to these data—can explain scale structures commonly found in music, both historical and contemporary, and we discuss its implications for experimental microtonal and spectral music

Prostate-specific antigen (PSA) screening and follow-up investigations in Māori and non-Māori men in New Zealand

Text. Pairwise sequence alignment between human SCN9A and homologous genes. (DOCX 34 kb

Boreal permafrost thaw amplified by fire disturbance and precipitation increases

Permafrost soils store huge amounts of organic carbon, which could be released if climate change promotes thaw. Currently, modelling studies predict that thaw in boreal regions is mainly sensitive to warming, rather than changes in precipitation or vegetation cover. We evaluate this conclusion for North American boreal forests using a detailed process-based model parameterised and validated on field measurements. We show that soil thermal regimes for dominant forest types are controlled strongly by soil moisture and thus the balance between evapotranspiration and precipitation. Under dense canopy cover, high evapotranspiration means a 30% increase in precipitation causes less thaw than a 1 °C increase in temperature. However, disturbance to vegetation promotes greater thaw through reduced evapotranspiration, which results in wetter, more thermally conductive soils. In such disturbed forests, increases in precipitation rival warming as a direct driver of thaw, with a 30% increase in precipitation at current temperatures causing more thaw than 2 °C of warming. We find striking non-linear interactive effects on thaw between rising precipitation and loss of leaf area, which are of concern given projections of greater precipitation and disturbance in boreal forests. Inclusion of robust vegetation-hydrological feedbacks in global models is therefore critical for accurately predicting permafrost dynamics; thaw cannot be considered to be controlled solely by rising temperatures

Composing first species counterpoint with a variable neighbourhood search algorithm

In this article, a variable neighbourhood search (VNS) algorithm is developed that can generate musical fragments consisting of a melody for the cantus firmus and the first species counterpoint. The objective function of the algorithm is based on a quantification of existing rules for counterpoint. The VNS algorithm developed in this article is a local search algorithm that starts from a randomly generated melody and improves it by changing one or two notes at a time. A thorough parametric analysis of the VNS reveals the significance of the algorithm's parameters on the quality of the composed fragment, as well as their optimal settings. A comparison of the VNS algorithm with a developed genetic algorithm shows that the VNS is more efficient. The VNS algorithm has been implemented in a user-friendly software environment for composition, called Optimuse. Optimuse allows a user to specify a number of characteristics such as length, key and mode. Based on this information, Optimuse 'composes' both cantus firmus and first species counterpoint. Alternatively, the user may specify a cantus firmus, and let Optimuse compose the accompanying first species counterpoint. © 2012 Taylor & Francis

Effect of Interlaminar Epidural Steroid Injection in Acute and Subacute Pain Due to Lumbar Disk Herniation: A Randomized Comparison of 2 Different Protocols

In order to assess the efficacy of epidural steroid injections (ESI) in acute and subacute pain due to lumbar spine disk herniation, we conducted a randomized trial, comparing 2 different protocols. Fourty patients with radicular pain due to L4-L5 and L5-S1 disc herniation were assigned to receive either 3 consecutive ESI every 24 hours through a spinal catheter (group A) or 3 consecutive ESI every 10 days with an epidural needle (group B). All patients had improved Oswestry Disabilty Index (ODI) and the Visual Analog Scale (VAS) for pain scores at 1 month of follow-up compared to baseline, while no significant differences were observed between the 2 groups. The scores for group B were statistically significant lower at 2 months of follow-up compared to those of group A. The improvement in the scores of group B was continuous since the mean scores at 2 months of follow up were lower compared to the respective scores at 1 month. Protocol B (3 consecutive ESI every 10 days) was found more effective in the treatment of subacute pain compared to Protocol A (3 consecutive ESI every 24 hours) with statistically significant differences in the ODI and VAS scores at 2 months of follow-up