Fano resonances in a three-terminal nanodevice

The electron transport through a quantum sphere with three one-dimensional wires attached to it is investigated. An explicit form for the transmission coefficient as a function of the electron energy is found from the first principles. The asymmetric Fano resonances are detected in transmission of the system. The collapse of the resonances is shown to appear under certain conditions. A two-terminal nanodevice with an additional gate lead is studied using the developed approach. Additional resonances and minima of transmission are indicated in the device.Comment: 11 pages, 5 figures, 2 equations are added, misprints in 5 equations are removed, published in Journal of Physics: Condensed Matte

Lowering IceCube's energy threshold for point source searches in the Southern Sky

Observation of a point source of astrophysical neutrinos would be a "smoking gun" signature of a cosmic-ray accelerator. While IceCube has recently discovered a diffuse flux of astrophysical neutrinos, no localized point source has been observed. Previous IceCube searches for point sources in the southern sky were restricted by either an energy threshold above a few hundred TeV or poor neutrino angular resolution. Here we present a search for southern sky point sources with greatly improved sensitivities to neutrinos with energies below 100 TeV. By selecting charged-current ν μ interacting inside the detector, we reduce the atmospheric background while retaining efficiency for astrophysical neutrino-induced events reconstructed with sub-degree angular resolution. The new event sample covers three years of detector data and leads to a factor of 10 improvement in sensitivity to point sources emitting below 100 TeV in the southern sky. No statistically significant evidence of point sources was found, and upper limits are set on neutrino emission from individual sources. A posteriori analysis of the highest-energy (~100 TeV) starting event in the sample found that this event alone represents a 2.8σ deviation from the hypothesis that the data consists only of atmospheric background.Fil: Aartsen, M. G.. University of Adelaide; AustraliaFil: Abraham, K.. Technische Universität München; AlemaniaFil: Ackermann, M.. Deutsches Elektronen-Synchrotron; AlemaniaFil: Adams, J.. University Of Canterbury; Nueva ZelandaFil: Aguilar, J. A.. Université Libre de Bruxelles; BélgicaFil: Golup, Geraldina Tamara. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; ArgentinaFil: Wallace, A.. University of Adelaide; AustraliaFil: Wallraff, M.. Rwth Aachen University; AlemaniaFil: Wandkowsky, N.. University of Wisconsin; Estados UnidosFil: Weaver, Ch.. University of Alberta; CanadáFil: Wendt, C.. University of Wisconsin; Estados UnidosFil: Westerhoff, S.. University of Wisconsin; Estados UnidosFil: Whelan, B. J.. University of Adelaide; AustraliaFil: Whitehorn, N.. University of California at Berkeley; Estados UnidosFil: Wickmann, S.. Rwth Aachen University; AlemaniaFil: Wiebe, K.. Johannes Gutenberg Universitat Mainz; AlemaniaFil: Wiebusch, C. H.. Rwth Aachen University; AlemaniaFil: Wille, L.. University of Wisconsin; Estados UnidosFil: Williams, D. R.. University of Alabama at Birmingahm; Estados UnidosFil: Wills, L.. Drexel University; Estados UnidosFil: Wissing, H.. University of Maryland; Estados UnidosFil: Wolf, M.. Stockholms Universitet; SueciaFil: Wood, T. R.. University of Alberta; CanadáFil: Woschnagg, K.. University of California at Berkeley; Estados UnidosFil: Xu, D. L.. University of Wisconsin; Estados UnidosFil: Xu, X. W.. Southern University; Estados UnidosFil: Xu, Y.. Stony Brook University; Estados UnidosFil: Yanez, J. P.. Deutsches Elektronen-Synchrotron; AlemaniaFil: Yodh, G.. University of California at Irvine; Estados UnidosFil: Yoshida, S.. Chiba University; JapónFil: Zoll, M.. Stockholms Universitet; Sueci

Tissue multifractality and Born approximation in analysis of light scattering: a novel approach for precancers detection

Multifractal, a special class of complex self-affine processes, are under recent intensive investigations because of their fundamental nature and potential applications in diverse physical systems. Here, we report on a novel light scattering-based inverse method for extraction/quantification of multifractality in the spatial distribution of refractive index of biological tissues. The method is based on Fourier domain pre-processing via the Born approximation, followed by the Multifractal Detrended Fluctuation Analysis. The approach is experimentally validated in synthetic multifractal scattering phantoms, and tested on biopsy tissue slices. The derived multifractal properties appear sensitive in detecting cervical precancerous alterations through an increase of multifractality with pathology progression, demonstrating the potential of the developed methodology for novel precancer biomarker identification and tissue diagnostic tool. The novel ability to delineate the multifractal optical properties from light scattering signals may also prove useful for characterizing a wide variety of complex scattering media of non-biological origin

Copy number variation analysis based on AluScan sequences

BACKGROUND: AluScan combines inter-Alu PCR using multiple Alu-based primers with opposite orientations and next-generation sequencing to capture a huge number of Alu-proximal genomic sequences for investigation. Its requirement of only sub-microgram quantities of DNA facilitates the examination of large numbers of samples. However, the special features of AluScan data rendered difficult the calling of copy number variation (CNV) directly using the calling algorithms designed for whole genome sequencing (WGS) or exome sequencing. RESULTS: In this study, an AluScanCNV package has been assembled for efficient CNV calling from AluScan sequencing data employing a Geary-Hinkley transformation (GHT) of read-depth ratios between either paired test-control samples, or between test samples and a reference template constructed from reference samples, to call the localized CNVs, followed by use of a GISTIC-like algorithm to identify recurrent CNVs and circular binary segmentation (CBS) to reveal large extended CNVs. To evaluate the utility of CNVs called from AluScan data, the AluScans from 23 non-cancer and 38 cancer genomes were analyzed in this study. The glioma samples analyzed yielded the familiar extended copy-number losses on chromosomes 1p and 9. Also, the recurrent somatic CNVs identified from liver cancer samples were similar to those reported for liver cancer WGS with respect to a striking enrichment of copy-number gains in chromosomes 1q and 8q. When localized or recurrent CNV-features capable of distinguishing between liver and non-liver cancer samples were selected by correlation-based machine learning, a highly accurate separation of the liver and non-liver cancer classes was attained. CONCLUSIONS: The results obtained from non-cancer and cancerous tissues indicated that the AluScanCNV package can be employed to call localized, recurrent and extended CNVs from AluScan sequences. Moreover, both the localized and recurrent CNVs identified by this method could be subjected to machine-learning selection to yield distinguishing CNV-features that were capable of separating between liver cancers and other types of cancers. Since the method is applicable to any human DNA sample with or without the availability of a paired control, it can also be employed to analyze the constitutional CNVs of individuals.published_or_final_versio

Theory of Chiral Modulations and Fluctuations in Smectic-A Liquid Crystals Under an Electric Field

Chiral liquid crystals often exhibit periodic modulations in the molecular director; in particular, thin films of the smectic-C* phase show a chiral striped texture. Here, we investigate whether similar chiral modulations can occur in the induced molecular tilt of the smectic-A phase under an applied electric field. Using both continuum elastic theory and lattice simulations, we find that the state of uniform induced tilt can become unstable when the system approaches the smectic-A--smectic-C* transition, or when a high electric field is applied. Beyond that instability point, the system develops chiral stripes in the tilt, which induce corresponding ripples in the smectic layers. The modulation persists up to an upper critical electric field and then disappears. Furthermore, even in the uniform state, the system shows chiral fluctuations, including both incipient chiral stripes and localized chiral vortices. We compare these predictions with observed chiral modulations and fluctuations in smectic-A liquid crystals.Comment: 11 pages, including 9 postscript figures, uses REVTeX 3.0 and epsf.st

Acceleration of the universe, vacuum metamorphosis, and the large-time asymptotic form of the heat kernel

We investigate the possibility that the late acceleration observed in the rate of expansion of the universe is due to vacuum quantum effects arising in curved spacetime. The theoretical basis of the vacuum cold dark matter (VCDM), or vacuum metamorphosis, cosmological model of Parker and Raval is revisited and improved. We show, by means of a manifestly nonperturbative approach, how the infrared behavior of the propagator (related to the large-time asymptotic form of the heat kernel) of a free scalar field in curved spacetime causes the vacuum expectation value of its energy-momentum tensor to exhibit a resonance effect when the scalar curvature R of the spacetime reaches a particular value related to the mass of the field. we show that the back reaction caused by this resonance drives the universe through a transition to an accelerating expansion phase, very much in the same way as originally proposed by Parker and Raval. Our analysis includes higher derivatives that were neglected in the earlier analysis, and takes into account the possible runaway solutions that can follow from these higher-derivative terms. We find that the runaway solutions do not occur if the universe was described by the usual classical FRW solution prior to the growth of vacuum energy-density and negative pressure (i.e., vacuum metamorphosis) that causes the transition to an accelerating expansion of the universe in this theory.Comment: 33 pages, 3 figures. Submitted to Physical Review D15 (Dec 23, 2003). v2: 1 reference added. No other change

Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMT

Ubiquitin-dependent mechanisms have emerged as essential regulatory elements controlling cellular levels of Smads and TGFß-dependent biological outputs such as epithelial–mesenchymal transition (EMT). In this study, we identify a HECT E3 ubiquitin ligase known as WWP2 (Full-length WWP2-FL), together with two WWP2 isoforms (N-terminal, WWP2-N; C-terminal WWP2-C), as novel Smad-binding partners. We show that WWP2-FL interacts exclusively with Smad2, Smad3 and Smad7 in the TGFß pathway. Interestingly, the WWP2-N isoform interacts with Smad2 and Smad3, whereas WWP2-C interacts only with Smad7. In addition, WWP2-FL and WWP2-C have a preference for Smad7 based on protein turnover and ubiquitination studies. Unexpectedly, we also find that WWP2-N, which lacks the HECT ubiquitin ligase domain, can also interact with WWP2-FL in a TGFß-regulated manner and activate endogenous WWP2 ubiquitin ligase activity causing degradation of unstimulated Smad2 and Smad3. Consistent with our protein interaction data, overexpression and knockdown approaches reveal that WWP2 isoforms differentially modulate TGFß-dependent transcription and EMT. Finally, we show that selective disruption of WWP2 interactions with inhibitory Smad7 can stabilise Smad7 protein levels and prevent TGFß-induced EMT. Collectively, our data suggest that WWP2-N can stimulate WWP2-FL leading to increased activity against unstimulated Smad2 and Smad3, and that Smad7 is a preferred substrate for WWP2-FL and WWP2-C following prolonged TGFß stimulation. Significantly, this is the first report of an interdependent biological role for distinct HECT E3 ubiquitin ligase isoforms, and highlights an entirely novel regulatory paradigm that selectively limits the level of inhibitory and activating Smads

Antiferromagnetism from phase disordering of a d-wave superconductor

The unbinding of vortex defects in the superconducting condensate with d-wave symmetry at T=0 is shown to lead to the insulator with incommensurate spin-density-wave order. The transition is similar to the spontaneous generation of the "chiral" mass in the three dimensional quantum electrodynamics, at which the global chiral symmetry one can define in the superconducting state is spontaneously broken. Other symmetry related states and possible relations to recent experiments on uderdoped cuprates are briefly discussed.Comment: RevTex, 4 pages, one ps figure; comments on confinement in the SDW added, references updated; final versio

Full-field implementation of a perfect eavesdropper on a quantum cryptography system

Quantum key distribution (QKD) allows two remote parties to grow a shared secret key. Its security is founded on the principles of quantum mechanics, but in reality it significantly relies on the physical implementation. Technological imperfections of QKD systems have been previously explored, but no attack on an established QKD connection has been realized so far. Here we show the first full-field implementation of a complete attack on a running QKD connection. An installed eavesdropper obtains the entire 'secret' key, while none of the parameters monitored by the legitimate parties indicate a security breach. This confirms that non-idealities in physical implementations of QKD can be fully practically exploitable, and must be given increased scrutiny if quantum cryptography is to become highly secure.Comment: Revised after editorial and peer-review feedback. This version is published in Nat. Commun. 8 pages, 6 figures, 1 tabl

Relativistic Corrections to the Triton Binding Energy

The influence of relativity on the triton binding energy is investigated. The relativistic three-dimensional version of the Bethe-Salpeter equation proposed by Blankenbecler and Sugar (BbS) is used. Relativistic (non-separable) one-boson-exchange potentials (constructed in the BbS framework) are employed for the two-nucleon interaction. In a 34-channel Faddeev calculation, it is found that relativistic effects increase the triton binding energy by about 0.2 MeV. Including charge-dependence (besides relativity), the final triton binding energy predictions are 8.33 and 8.16 MeV for the Bonn A and B potential, respectively.Comment: 25 pages of text (latex), 1 figure (not included, available upon request