The epidemic of sexually transmitted infections in China: implications for control and future perspectives

China has experienced an increasing epidemic of sexually transmitted infections (STIs), including HIV. High risk groups likely to be infected include female sex workers (FSWs) and their clients, men who have sex with men (MSM), drug users and migrant workers. Prevention can be achieved through education of the population, condom promotion, early detection of symptomatic and asymptomatic people, and effective diagnosis and treatment of these patients and their partners. This article aims to describe the profile of the epidemic in high-risk groups in China as well as to detail the contributing factors and the implications for control. Programmes for the control of STIs should be immediate priorities in China, and primary and secondary prevention strategies are vital to this process

Herpes simplex virus infections among rural residents in eastern China

<p>Abstract</p> <p>Background</p> <p>Herpes simplex virus (HSV) has two types: HSV-1 and HSV-2. Both infect epithelial cells and establish latent infections in neurons causing an infection that persists for life. Information on age- and gender-specific seroprevalence of HSV-1 and HSV-2 is valuable for understanding HSV transmission dynamics and designing population-based prevention and intervention programs for HSV. However, such information is not available for China.</p> <p>Methods</p> <p>Cryopreserved serum samples of all subjects aged 5 to 60 years from two randomly selected rural villages in Zhejiang province in Eastern China who had participated in the China national seroepidemiological survey of hepatitis B virus (HBV) infection conducted in 2006 were tested. Seroprevalence of HSV-1 and HSV-2 infections were determined by type-specific IgG antibody tests using an ELISA technique. Their 95% confidence intervals adjusted for the sampling fraction were calculated according to the Clopper-Pearson method.</p> <p>Results</p> <p>A total of 2,141 residents participated in the survey, with a response rate of 82.3%. HSV-1 seroprevalence was 92.0% overall, 89.1% for males and 94.2% for females. HSV-1 seroprevalence was 61.6% among children aged 5-9 years, 90.3% among 25-29 years, and nearly 100% among those aged > = 40 years. HSV-2 seroprevalence was 13.2% overall, 10.5% for males and 15.3% for females. No children aged 5-14 years were HSV-2 positive, and HSV-2 seroprevalence was 7.1% among 15-19 years and peaked at 24.3% among those aged 45-49 years. Neither HSV-1 nor HSV-2 infections were significantly different by gender. About 11.8% of study subjects were co-infected with both types of HSV. Among 549 participating couples, 8.6% were HSV-1 serodiscordant and 11.8% were HSV-2 serodiscordant. No one tested positive for HIV. The overall prevalence of HBsAg was 16.2%, 16.9% for males and 15.4% for females.</p> <p>Conclusions</p> <p>HSV-1 was highly prevalent among all rural residents aged between 5-60 years in Eastern China, whereas HSV-2 was prevalent among sexually active people. HSV-1 and HSV-2 have different transmission modes and dynamics. Future HSV prevention and control programs in China should be type specific.</p

Broadband random optoelectronic oscillator

[EN] Random scattering of light in transmission media has attracted a great deal of attention in the field of photonics over the past few decades. An optoelectronic oscillator (OEO) is a microwave photonic system offering unbeatable features for the generation of microwave oscillations with ultra-low phase noise. Here, we combine the unique features of random scattering and OEO technologies by proposing an OEO structure based on random distributed feedback. Thanks to the random distribution of Rayleigh scattering caused by inhomogeneities within the glass structure of the fiber, we demonstrate the generation of ultra-wideband (up to 40¿GHz from DC) random microwave signals in an open cavity OEO. The generated signals enjoy random characteristics, and their frequencies are not limited by a fixed cavity length figure. The proposed device has potential in many fields such as random bit generation, radar systems, electronic interference and countermeasures, and telecommunications.Thanks N. Shi and Y. Yang for comments and discussion. This work was supported by the National Key Research and Development Program of China under 2018YFB2201902 and the National Natural Science Foundation of China under 61925505. This work was also partly supported by the National Key Research and Development Program of China under 2018YFB2201901, 2018YFB2201903, and the National Natural Science Foundation of China under 61535012 and 61705217.Ge, Z.; Hao, T.; Capmany Francoy, J.; Li, W.; Zhu, N.; Li, M. (2020). Broadband random optoelectronic oscillator. Nature Communications. 11(1):1-8. https://doi.org/10.1038/s41467-020-19596-xS18111Feng, S., Kane, C., Lee, P. A. & Stone, A. D. Correlations and fluctuations of coherent wave transmission through disordered media. Phys. Rev. Lett. 61, 834 (1988).Wiersma, D. S. & Cavalieri, S. Light emission: a temperature-tunable random laser. Nature 414, 708 (2001).Wiersma, D. S. The physics and applications of random lasers. Nat. Phys. 4, 359 (2008).Turitsyn, S. K. et al. Random distributed feedback fibre laser. Nat. Photonics 4, 231–235 (2010).Babin, S. A., El-Taher, A. E., Harper, P., Podivilov, E. V. & Turitsyn, S. K. Tunable random fiber laser. Phys. Rev. A 84, 021805 (2011).Turitsyn, S. K. et al. Random distributed feedback fibre lasers. Phys. Rep. 542, 133–193 (2014).Barnoski, M., Rourke, M., Jensen, S. M. & Melville, R. T. Optical time domain reflectometer. Appl. Opt. 16, 2375–2379 (1977).Yao, X. S. & Maleki, L. Optoelectronic microwave oscillator. JOSA B 13, 1725–1735 (1996).Maleki, L. Sources: the optoelectronic oscillator. Nat. Photonics 5, 728 (2011).Yao, X. S. & Maleki, L. Multiloop optoelectronic oscillator. IEEE J. Quantum Electron 36, 79–84 (2000).Hao, T. et al. Breaking the limitation of mode building time in an optoelectronic oscillator. Nat. Commun. 9, 1839 (2018).Zhang, W. & Yao, J. Silicon photonic integrated optoelectronic oscillator for frequency-tunable microwave generation. J. Lightwave Technol. 36, 4655–4663 (2018).Hao, T. et al. Toward Monolithic Integration of OEOs: from systems to chips. J. Lightwave Technol. 36, 4565–4582 (2018).Zhang, J. & Yao, J. Parity-time–symmetric optoelectronic oscillator. Sci. Adv. 4, eaar6782 (2018).Liu, Y. et al. Observation of parity-time symmetry in microwave photonics. Light Sci. Appl. 7, 38 (2018).Nakazawa, M. Rayleigh backscattering theory for single-mode optical fibers. JOSA 73, 1175–1180 (1983).Hartog, A. & Gold, M. On the theory of backscattering in single-mode optical fibers. J. Lightwave Technol. 2, 76–82 (1984).Eickhoff, W., & Ulrich, R. Statistics of backscattering in single-mode fiber. In Optical Fiber Communication Conference. Optical Society of America (1981).Alekseev, A. E., Tezadov, Y. A. & Potapov, V. T. Statistical properties of backscattered semiconductor laser radiation with different degrees of coherence. Quantum Electron 42, 76–81 (2012).Gysel, P. & Staubli, R. K. Statistical properties of Rayleigh backscattering in single-mode fibers. J. Lightwave Technol. 8, 561–567 (1990).Staubli, R. K. & Gysel, P. Statistical properties of single-mode fiber rayleigh backscattered intensity and resulting detector current. IEEE Trans. Commun. 40, 1091–1097 (1992).Levy, E. C., Horowitz, M. & Menyuk, C. R. Modeling optoelectronic oscillators. JOSA B 26, 148–159 (2009).Yariv, A. Introduction to Optical Electronics 2nd edn. (Holt, Rinehart and Winston, New York, 1976).Aoki, Y., Tajima, K. & Mito, I. Input power limits of single-mode optical fibers due to stimulated Brillouin scattering in optical communication systems. J. Lightwave Technol. 6, 710–719 (1988).Song, H. J., Shimizu, N., Kukutsu, N., Nagatsuma, T. & Kado, Y. 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Broadband chaotic signals and breather oscillations in an optoelectronic oscillator incorporating a microwave photonic filter. J. Lightwave Technol. 32, 3933–3942 (2014)

Target Deletion of the Cytoskeleton-Associated Protein Palladin Does Not Impair Neurite Outgrowth in Mice

Palladin is an actin cytoskeleton–associated protein which is crucial for cell morphogenesis and motility. Previous studies have shown that palladin is localized to the axonal growth cone in neurons and may play an important role in axonal extension. Previously, we have generated palladin knockout mice which display cranial neural tube closure defect and embryonic lethality before embryonic day 15.5 (E15.5). To further study the role of palladin in the developing nervous system, we examined the innervation of palladin-deficient mouse embryos since the 200 kd, 140 kd, 90–92 kd and 50 kd palladin isoforms were undetectable in the mutant mouse embryo brain. Contrary to the results of previous studies, we found no inhibition of the axonal extension in palladin-deficient mouse embryos. The cortical neurons derived from palladin-deficient mice also showed no significant difference in neurite outgrowth as compared with those from wild-type mice. Moreover, no difference was found in neurite outgrowth of neural stem cell derived-neurons between palladin-deficient mice and wild-type mice. In conclusion, these results suggest that palladin is dispensable for normal neurite outgrowth in mice

Id-1 stimulates cell proliferation through activation of EGFR in ovarian cancer cells

Increased EGFR (epidermal growth factor receptor) expression has been reported in many types of human cancer and its levels are positively associated with advanced cancers. Recently, upregulation of Id-1 (inhibitor of differentiation or DNA binding) protein was found in over 70% of ovarian cancer samples and correlated with poor survival of ovarian cancer patients. However, the molecular mechanisms responsible for the role of Id-1 in ovarian cancer are not clear. The aim of this study was to investigate the effect of Id-1 on ovarian cancer proliferation and its association with the EGFR pathway. To achieve this, we transfected an Id-1 expression vector into three ovarian cancer cell lines and examined cell proliferation rate by flow cytometry and bromodeoxyuridine staining. We found that ectopic Id-1 expression led to increased cell proliferation demonstrated by increased BrdU incorporation rate and S-phase fraction. The Id-1-induced cell growth was associated with upregulation of EGFR at both transcriptional and protein levels. In contrast, inactivation of Id-1 through transfection of an Id-1 antisense vector resulted in downregulation of EGFR. Our results indicate that increased Id-1 in ovarian cancer cells may promote cancer cell proliferation through upregulation of EGFR. Our findings also implicate that Id-1 may be a potential target for the development of novel strategies in the treatment of ovarian cancer. © 2004 Cancer Research UK.link_to_OA_fulltex

Disparities and risks of sexually transmissible infections among men who have sex with men in China: a meta-analysis and data synthesis.

BACKGROUND: Sexually transmitted infections (STIs), including Hepatitis B and C virus, are emerging public health risks in China, especially among men who have sex with men (MSM). This study aims to assess the magnitude and risks of STIs among Chinese MSM. METHODS: Chinese and English peer-reviewed articles were searched in five electronic databases from January 2000 to February 2013. Pooled prevalence estimates for each STI infection were calculated using meta-analysis. Infection risks of STIs in MSM, HIV-positive MSM and male sex workers (MSW) were obtained. This review followed the PRISMA guidelines and was registered in PROSPERO. RESULTS: Eighty-eight articles (11 in English and 77 in Chinese) investigating 35,203 MSM in 28 provinces were included in this review. The prevalence levels of STIs among MSM were 6.3% (95% CI: 3.5-11.0%) for chlamydia, 1.5% (0.7-2.9%) for genital wart, 1.9% (1.3-2.7%) for gonorrhoea, 8.9% (7.8-10.2%) for hepatitis B (HBV), 1.2% (1.0-1.6%) for hepatitis C (HCV), 66.3% (57.4-74.1%) for human papillomavirus (HPV), 10.6% (6.2-17.6%) for herpes simplex virus (HSV-2) and 4.3% (3.2-5.8%) for Ureaplasma urealyticum. HIV-positive MSM have consistently higher odds of all these infections than the broader MSM population. As a subgroup of MSM, MSW were 2.5 (1.4-4.7), 5.7 (2.7-12.3), and 2.2 (1.4-3.7) times more likely to be infected with chlamydia, gonorrhoea and HCV than the broader MSM population, respectively. CONCLUSION: Prevalence levels of STIs among MSW were significantly higher than the broader MSM population. Co-infection of HIV and STIs were prevalent among Chinese MSM. Integration of HIV and STIs healthcare and surveillance systems is essential in providing effective HIV/STIs preventive measures and treatments. TRIAL REGISTRATION: PROSPERO NO: CRD42013003721

CAR-T cell. the long and winding road to solid tumors

Adoptive cell therapy of solid tumors with reprogrammed T cells can be considered the "next generation" of cancer hallmarks. CAR-T cells fail to be as effective as in liquid tumors for the inability to reach and survive in the microenvironment surrounding the neoplastic foci. The intricate net of cross-interactions occurring between tumor components, stromal and immune cells leads to an ineffective anergic status favoring the evasion from the host's defenses. Our goal is hereby to trace the road imposed by solid tumors to CAR-T cells, highlighting pitfalls and strategies to be developed and refined to possibly overcome these hurdles

Observation of a ppb mass threshoud enhancement in \psi^\prime\to\pi^+\pi^-J/\psi(J/\psi\to\gamma p\bar{p}) decay

The decay channel $\psi^\prime\to\pi^+\pi^-J/\psi(J/\psi\to\gamma p\bar{p})$ is studied using a sample of $1.06\times 10^8$ $\psi^\prime$ events collected by the BESIII experiment at BEPCII. A strong enhancement at threshold is observed in the $p\bar{p}$ invariant mass spectrum. The enhancement can be fit with an $S$-wave Breit-Wigner resonance function with a resulting peak mass of $M=1861^{+6}_{-13} {\rm (stat)}^{+7}_{-26} {\rm (syst)} {\rm MeV/}c^2$ and a narrow width that is $\Gamma<38 {\rm MeV/}c^2$ at the 90% confidence level. These results are consistent with published BESII results. These mass and width values do not match with those of any known meson resonance.Comment: 5 pages, 3 figures, submitted to Chinese Physics