529 research outputs found
Noncoding RNA Landmarks of Pluripotency and Reprogramming
Noncoding RNAs have emerged as important determinants of pluripotency and reprogramming. In this issue of Cell Stem Cell, Kosik and colleagues now provide a detailed map of microRNA expression patterns to infer the biological states of embryonic and induced pluripotent stem cells
Using system simulation to search for the optimal multi-ordering policy for perishable goods
[EN] This paper explores the possibility that perishable goods can be ordered several times in a single period after considering the cost of Marginal contribution, Marginal loss, Shortage, and Purchasing under stochastic demand. In order to determine the optimal ordering quantity to improve the traditional newsvendor and maximize the total expected profits, and then sensitivity analysis is taken to realize the influence of the parameters on total expected profits and decision variables respectively. In addition, this paper designed a multi-order computerized system with Monte Carlo method to solve the optimal solution under stochastic demand. Based on numerical examples, this paper verified the feasibility and efficiency of the proposed model. Finally, several specific conclusions are drawn for practical applications and future studies.Huang, Y.; Chang, X.; Ding, Y. (2019). Using system simulation to search for the optimal multi-ordering policy for perishable goods. International Journal of Production Management and Engineering. 7(1):49-62. https://doi.org/10.4995/ijpme.2019.10745SWORD496271Azoury, K.S., Miller, B.L. (1984). A comparison of the optimal ordering levels of bayesian and non-bayesian inventory models, Management Science, 30(8), 993-1003. https://doi.org/10.1287/mnsc.30.8.993Alfares, H.K., Elmorra, H.H. (2005). The distribution-free newsboy problem: extensions to the shortage penalty case, International Journal of Production Economics, 93-94(8), 465-477. https://doi.org/10.1016/j.ijpe.2004.06.043Chung, C.S., Flynn, J. (2001). A newsboy problem with reactive production, Computers & Operations Research, 28(8), 751-765. https://doi.org/10.1016/S0305-0548(00)00006-XChun, Y.H. (2003). Optimal pricing and ordering policies for perishable commodities, European Journal of Operational Research, 144(1), 68-82. https://doi.org/10.1016/S0377-2217(01)00351-4Chen, L.H., Chen, Y.C. (2009). A newsboy problem with a simple reservation arrangement. Computers & Industrial Engineering, 56(1), 157-160. https://doi.org/10.1016/j.cie.2008.04.010Dian, J.R. (1990). A high-low search algorithm for a newsboy problem with delayed information feedback. Operations Research, 38(5), 838-846. https://doi.org/10.1287/opre.38.5.838Dye, C.Y., Ouyang, L.Y. (2005). An EOQ model for perishable items under stock-dependent selling rate and time-dependent partial backlogging. European Journal of Operational Research, 163(3), 776-783. https://doi.org/10.1016/j.ejor.2003.09.027Fujiwara, O., Soewandi, H., Sedarage, D. (1997). An optimal ordering and issuing policy for a two-stage inventory system for perishable products. European Journal of Operational Research, 99(2), 412-424. https://doi.org/10.1016/S0377-2217(95)00365-7Gallego, G., Moon, I. (1993). The distribution free newsboy problem: review and extensions. Journal of the Operational Research Society, 44(8), 825-834. https://doi.org/10.1057/jors.1993.141Khouja, M. (1999). The single-period (news-vendor) problem: literature review and suggestions for future research. Omega, 27(5), 537-553. https://doi.org/10.1016/S0305-0483(99)00017-1Khouja, M.J. (2000). Optimal ordering, discounting, and pricing in the single-period problem. International Journal of Production Economics, 65(2), 201-216. https://doi.org/10.1016/S0925-5273(99)00027-4Lau, H., Lau, H. (1998). Decision models for single-period products with two ordering opportunities. International Journal of Production Economics, 55(1), 57-70. https://doi.org/10.1016/S0925-5273(98)00040-1Padmanabhan, G., Vrat, P. (1995). EOQ models for perishable items under stock dependent selling rate. European Journal of Operational Research, 86(2), 281-292. https://doi.org/10.1016/0377-2217(94)00103-JPando, V., Luis, A.S.J., Juan, G.L., Sicilia, J. (2013). A newsboy problem with an emergency order under a general backorder rate function. Omega, 41(6), 1020-1028. https://doi.org/10.1016/j.omega.2013.01.003Zheng, M., Wu, K., Shu, Y. (2016). Newsvendor problems with demand forecast updating and supply constraints. Computers & Operations Research, 67, 193-206. https://doi.org/10.1016/j.cor.2015.10.00
Application of the two-step Lax and Wendroff FCT and the CE-SE method to flow transport in wall-flow monoliths
[EN] Gas dynamic codes are computational tools applied to the analysis of air management in internal combustion engines. The governing equations in one-dimensional elements are approached assuming compressible unsteady non-homentropic flow and are commonly solved applying finite difference numerical methods. These techniques can also be applied to the calculation of flow transport in complex systems such as wallflow monoliths. These elements are characterized by alternatively plugged channels with porous walls. It filters the particulates when the flowgoes through thewall from the inlet to the outlet channels. Therefore, this process couples the solution of every pair of inlet and outlet channels. In this study, the adaptation of the two-step Lax and Wendroff method and the space-time Conservation Element and Solution Element method is performed to be applied in the solution of flow transport in wall-flow monolith channels. The influence on the prediction ability is analysed by a shock-tube test and experimental data obtained under impulsive flow conditions.This work has been partially supported by the Spanish Ministerio de Ciencia e Innovacion through grant number DPI2010-20891-C02-02.Serrano, JR.; Arnau Martínez, FJ.; Piqueras, P.; García Afonso, Ó. (2014). Application of the two-step Lax and Wendroff FCT and the CE-SE method to flow transport in wall-flow monoliths. International Journal of Computer Mathematics. 91(1):71-84. https://doi.org/10.1080/00207160.2013.783206S718491
Revisiting the -Meson Production at the Hadronic Colliders
The production of heavy-flavored hadron at the hadronic colliders provides a
challenging opportunity to test the validity of pQCD predictions. There are two
mechanisms for the hadroproduction, i.e. the gluon-gluon fusion
mechanism via the subprocess and the
extrinsic heavy quark mechanism via the subprocesses and , both of which shall have sizable
contributions in proper kinematic region. Different from the
fixed-flavor-number scheme (FFNS) previously adopted in the literature, we
study the hadroproduction under the general-mass
variable-flavor-number scheme (GM-VFNS), in which we can consistently deal with
the double counting problem from the above two mechanisms. Properties for the
hadroproduction are discussed. To be useful reference, a
comparative study of FFNS and GM-VFNS is presented. Both of which can provide
reasonable estimations for the hadroproduction. At the Tevatron,
the difference between these two schemes is small, however such difference is
obvious at the LHC. The forthcoming more precise data on LHC shall provide a
good chance to check which scheme is more appropriate to deal with the
-meson production and to further study the heavy quark components in
hadrons.Comment: 18 pages, 8 figures, 4 tables. To match the published version. To be
published in Eur.Phys.J.
Tissue of origin, but not XCI state, influences germ cell differentiation from human pluripotent stem cells
Stem cells & developmental biolog
Mn clusterisation in Ga1-xMnxN
Local structure of Mn atoms in Ga1-xMnxN has been investigated by the Mn L3
edge x-ray absorption spectrum (XAS) at total electron yield mode, which
preferentially looks at atoms near the surface. A modeling defects
configuration, the Mn5 micro-clusters complexed with substitutional MnGa and
interstitial MnI is found for the higher Mn doping concentration. This new
configuration is also confirmed by the total energy calculations.Comment: 17 pages, 5 figures, to be published in Solid. State Commu
Adjustment of the electric current in pulsar magnetospheres and origin of subpulse modulation
The subpulse modulation of pulsar radio emission goes to prove that the
plasma flow in the open field line tube breaks into isolated narrow streams. I
propose a model which attributes formation of streams to the process of the
electric current adjustment in the magnetosphere. A mismatch between the
magnetospheric current distribution and the current injected by the polar cap
accelerator gives rise to reverse plasma flows in the magnetosphere. The
reverse flow shields the electric field in the polar gap and thus shuts up the
plasma production process. I assume that a circulating system of streams is
formed such that the upward streams are produced in narrow gaps separated by
downward streams. The electric drift is small in this model because the
potential drop in narrow gaps is small. The gaps have to drift because by the
time a downward stream reaches the star surface and shields the electric field,
the corresponding gap has to shift. The transverse size of the streams is
determined by the condition that the potential drop in the gaps is sufficient
for the pair production. This yields the radius of the stream roughly 10% of
the polar cap radius, which makes it possible to fit in the observed
morphological features such as the "carousel" with 10-20 subbeams and the
system of the core - two nested cone beams.Comment: 8 pages, 1 figur
Direct Measurement of the Pseudoscalar Decay Constant fD+
The absolute branching fraction of has been directly
measured by an analysis of a data sample of about 33 collected
around GeV with the BES-II at the BEPC. At these energies,
meson is produced in pair as . A total of mesons are reconstructed from this data set. In the
recoil side of the tagged mesons, purely leptonic decay
events of are observed. This yields a branching fraction of
, and a
corresponding pseudoscalar decay constant
MeV.Comment: 7 pages, 8 figures, Submitted to Physics Letters B in October, 200
Direct Measurements of the Branching Fractions for and and Determinations of the Form Factors and
The absolute branching fractions for the decays and
are determined using singly
tagged sample from the data collected around 3.773 GeV with the
BES-II detector at the BEPC. In the system recoiling against the singly tagged
meson, events for and events for decays are observed. Those yield
the absolute branching fractions to be and . The
vector form factors are determined to be
and . The ratio of the two form
factors is measured to be .Comment: 6 pages, 5 figure
Measurements of J/psi Decays into 2(pi+pi-)eta and 3(pi+pi-)eta
Based on a sample of 5.8X 10^7 J/psi events taken with the BESII detector,
the branching fractions of J/psi--> 2(pi+pi-)eta and J/psi-->3(pi+pi-)eta are
measured for the first time to be (2.26+-0.08+-0.27)X10^{-3} and
(7.24+-0.96+-1.11)X10^{-4}, respectively.Comment: 11 pages, 6 figure
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